{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:35:49Z","timestamp":1774478149062,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Disorders of Gut\u2013Brain Interaction (DGBIs) are present in 23.0% of the paediatric population, according to Rome IV. Latin American (LA) prevalence of DGBIs in children with Autism Spectrum Disorder (ASD) is unknown. The aim of this study was to determine the prevalence of DGBIs and possible associations in schoolchildren and adolescents with ASD from LA. Methods: An observational analytical study was conducted in LA cities. Caregivers of children with ASD completed the Rome IV Questionnaire for Pediatric Gastrointestinal Symptoms to identify DGBIs. Sociodemographic, clinical, and family variables were included. Statistical analysis involved central tendency measures, univariate and bivariate analysis, calculation odds ratios (ORs), and 95% confidence intervals (95%CIs), with p &lt; 0.05 significance. Results: The study included 353 children with ASD. Predominantly male (78.8%), white (56.1%), attending private schools (79.3%), altered nutritional status (43.9%), born by c-section (57.5%), firstborn (54.7%), level of autism not classified at the time of the study (49.0%). A total of 58.9% presented DGBI. Functional constipation (FC) was the most frequent (27.2%). Those from Central America (CA) had a higher likelihood of presenting a DGBI (OR = 1.98, 95% CI = 1.25\u20133.12, p = 0.0018). Conclusions: Over half of LA schoolchildren and adolescents with ASD presented DGBI, FC being the most common, and higher likelihood of DGBI in CA.<\/jats:p>","DOI":"10.3390\/life15060912","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T10:10:16Z","timestamp":1749031816000},"page":"912","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring Disorders of Gut\u2013Brain Interaction in Schoolchildren and Adolescents with Autism"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4062-5326","authenticated-orcid":false,"given":"Carlos Alberto","family":"Velasco-Ben\u00edtez","sequence":"first","affiliation":[{"name":"Departamento de Pediatr\u00eda, Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali 76001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Andr\u00e9s","family":"Rojas-Cer\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda, Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali 76001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Jimena","family":"Ortiz-Rivera","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Universidad Libre, Cali 760031, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6430-0905","authenticated-orcid":false,"given":"Daniela Alejandra","family":"Velasco-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Gastrohnup Research Group, Universidad del Valle, Hospital Universitario del Valle, Cali 76001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2246-5607","authenticated-orcid":false,"given":"Mar\u00eda Carolina","family":"Juvinao-Quintero","sequence":"additional","affiliation":[{"name":"Gastrohnup Research Group, Universidad del Valle, Hospital Universitario del Valle, Cali 76001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia Elena","family":"Zubiri","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Sor Mar\u00eda Ludovica de La Plata, Buenos Aires 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n Mart\u00edn","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital Materno Infantil Dr. Florencio Escard\u00f3 de Tigre, Buenos Aires 1648, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rom\u00e1n","family":"Bigliardi","sequence":"additional","affiliation":[{"name":"Hospital Nacional Profesor Alejandro Posadas, Buenos Aires 1684, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anabella","family":"Zosi","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Sor Mar\u00eda Ludovica de La Plata, Buenos Aires 1900, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A.","family":"Chanis \u00c1guila","sequence":"additional","affiliation":[{"name":"Hospital del Ni\u00f1o Dr. Jos\u00e9 Ren\u00e1n Esquivel, Ciudad de Panama 0801, Panama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina","family":"Guzm\u00e1n Acevedo","sequence":"additional","affiliation":[{"name":"Hospital Internacional La Cat\u00f3lica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima Azereth","family":"Reynoso Zarzosa","sequence":"additional","affiliation":[{"name":"Hospital \u00c1ngeles Puebla, Universidad UPAEP, Puebla 72190, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Arturo","family":"Zablah Cordova","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Benjam\u00edn Bloom, San Salvador, El Salvador"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1118529","DOI":"10.3389\/fmicb.2023.1118529","article-title":"Communication of gut microbiota and brain via immune and neuroendocrine signaling","volume":"14","author":"Kasarello","year":"2023","journal-title":"Front. 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