{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:23:54Z","timestamp":1791397434839,"version":"4.3.3"},"reference-count":15,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Endoscopic surgery is useful and helpful especially to access areas with limited visibility. The combination of this technique with innovative approaches could be the solution to improve quality of surgery and patients\u2019 outcome. This study aimed to illustrate how Endoscopic-Assisted Transoral Approach (EATA) can be used to successfully remove specific extracranial tumors with defined characteristics. Eleven patients with extracranial tumors underwent surgical resection using an EATA between 2003 and 2025. All patients underwent clinical examination and fiberoptic laryngoscopy. Preoperative CT and\/or MRI was performed in all cases. All patients were successfully treated utilizing an EATA. Histological examination revealed nine parapharyngiomas, comprising five pleomorphic adenomas, two schwannomas, one ectopic thyroid gland, one lipoma, one masticator space schwannoma, and one nasopharyngeal pleomorphic adenoma. No intra-operative nor peri-operatory complications were observed. The only long-term sequela observed was Horner\u2019s syndrome in the two schwannomas originating from the parapharyngeal-carotid space. The mean hospital stay was 2.6 days, while the mean follow-up duration was 9.8 years. The EATA represents a valid surgical technique for the treatment of benign, encapsulated, and non-vascular parapharyngeal space (PPS) tumors exhibiting posterior displacement of major vessels. This approach may also prove beneficial for the management of other benign, encapsulated, and non-vascular tumors located in the nasopharynx and masticator space.<\/jats:p>","DOI":"10.3390\/life15060975","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T09:36:00Z","timestamp":1750239360000},"page":"975","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Endoscopic-Assisted Transoral Approach (EATA) for Extracranial Tumors: A Multicentric Case Series"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4570-4899","authenticated-orcid":false,"given":"Giovanni","family":"Motta","sequence":"first","affiliation":[{"name":"Otolaryngology Head and Neck Surgery Unit, \u201cAzienda Ospedaliera di Rilievo Nazionale dei Colli, Ospedale Monaldi\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5510-3814","authenticated-orcid":false,"given":"Arianna","family":"Di Stadio","sequence":"additional","affiliation":[{"name":"ENT Unit, Department of Mental, Physical Health and Preventive Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-326X","authenticated-orcid":false,"given":"Luca","family":"D\u2019Ascanio","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Head and Neck Surgery, Azienda Ospedaliera \u201cOspedale Riuniti Marche Nord\u201d, 61122 Pesaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"D\u2019avino","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery Unit, \u201cAzienda Ospedaliera di Rilievo Nazionale dei Colli, Ospedale Monaldi\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"della Peruta","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery Unit, \u201cAzienda Ospedaliera di Rilievo Nazionale dei Colli, Ospedale Monaldi\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-3938","authenticated-orcid":false,"given":"Francesco","family":"Chiari","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head and Neck Unit, \u201cSanto Spirito\u201d Hospital, 65124 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Magno","sequence":"additional","affiliation":[{"name":"Clinica Vesuvio, 80147 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tortoriello","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery Unit, \u201cAzienda Ospedaliera di Rilievo Nazionale dei Colli, Ospedale Monaldi\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Motta","sequence":"additional","affiliation":[{"name":"ENT Unit, Department of Mental, Physical Health and Preventive Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.3390\/curroncol30040297","article-title":"Transoral approach to parapharyngeal space tumours: Preliminary reports from a single-centre retrospective analysis","volume":"30","author":"Motta","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/jamaoto.2013.3866","article-title":"Salvage surgery for recurrent cancers of the oropharynx: Comparing TORS with standard open surgical approaches","volume":"139","author":"White","year":"2013","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/hed.23809","article-title":"Functional outcomes, feasibility, and safety of resection of transoral robotic surgery: Single-institution series of 35 consecutive cases of transoral robotic surgery for oropharyngeal squamous cell carcinoma","volume":"37","author":"Busch","year":"2015","journal-title":"Head Neck"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.otc.2020.07.010","article-title":"Open Versus Robotic Surgery for Oropharyngeal Cancer","volume":"53","author":"Jefferson","year":"2020","journal-title":"Otolaryngol. Clin. N. 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Otorhinolaryngol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/alr.23000","article-title":"Open and endoscopic surgery improve survival for squamous and nonsquamous cell nasopharyngeal carcinomas: An NCDB cohort study","volume":"12","author":"Finegersh","year":"2022","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.bjorl.2018.03.015","article-title":"Endoscope-assisted retrosigmoid approach in hemifacial spasm: Our experience","volume":"85","author":"Ricci","year":"2019","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Gioacchini, F.M., Re, M., Scarpa, A., Chiarella, G., Viola, P., Pisani, D., Iannella, G., Ralli, M., and Di Stadio, A. (2024). Proposal of a Theoretically Feasible Method to Perform Perilymph Sampling in Clinical Settings. 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Otolaryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"104581","DOI":"10.1016\/j.oraloncology.2020.104581","article-title":"Trans-oral robotic surgery in the management of parapharyngeal space tumors: A systematic review","volume":"103","author":"Costantino","year":"2020","journal-title":"Oral Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/hed.23557","article-title":"Transoral robotic surgery of the parapharyngeal space: A case series and systematic review","volume":"37","author":"Chan","year":"2015","journal-title":"Head Neck"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/6\/975\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:54:22Z","timestamp":1760032462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/6\/975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["life15060975"],"URL":"https:\/\/doi.org\/10.3390\/life15060975","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}