{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:46:40Z","timestamp":1765234000689,"version":"build-2065373602"},"reference-count":85,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Carbohydrate consumption during pregnancy represents an important source of energy; its consumption, however, can cause gestational diabetes mellitus (GDM), body weight gain, inflammation, increased glucose transport to the fetus, adiposity, and a risk of macrosomia. The objective was to research the impact of sucrose consumption during pregnancy on the metabolic, immune, and redox profile in female mice with GDM. A total of 24 female CD1 mice were used, divided into two groups: Control and GDM. Each group was subdivided into two subgroups: (a) Without sucrose and (b) With sucrose. The females were mated, and, once pregnancy was confirmed, GDM was induced by administering 230 mg\/kg of streptozotocin subcutaneously. GDM was confirmed by glucose \u2265 200 mg\/dL and the presence of polyphagia, polydipsia, and change in body weight. Metabolic, immune, and redox profile parameters were determined. Sucrose consumption groups increase HOMA-IR and the secretion of insulin, adiponectin, and leptin; it also increased the secretion of proinflammatory cytokines and the production of IgA and IgG antibodies, decreased the activity of the Glutathione Reductase enzyme, and increased the production of TBARS and AGE. High sucrose consumption increases the inflammatory response mediated mainly by CD8+ lymphocytes and the production of proinflammatory cytokines; it can trigger a compensatory humoral response and alter redox mechanisms, causing a state of Oxidant Stress.<\/jats:p>","DOI":"10.3390\/life15070989","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T06:10:27Z","timestamp":1750399827000},"page":"989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6364-0775","authenticated-orcid":false,"given":"Cristian \u00c1ngel","family":"Rosales-G\u00f3mez","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Nutrici\u00f3n, Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Paseo Tollocan Esquina Jes\u00fas Carranza s\/n, Colonia Moderna de la Cruz, Toluca C.P. 50180, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-5202","authenticated-orcid":false,"given":"Beatriz Elina","family":"Mart\u00ednez-Carrillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Nutrici\u00f3n, Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Paseo Tollocan Esquina Jes\u00fas Carranza s\/n, Colonia Moderna de la Cruz, Toluca C.P. 50180, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-2515","authenticated-orcid":false,"given":"Ana Laura","family":"Guadarrama-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Multidisciplinaria de Salud, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Jes\u00fas Carranza Esquina Venustiano Carranza No.205, Colonia Universidad, Toluca C.P. 50130, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-5524","authenticated-orcid":false,"given":"Aldo Arturo","family":"Res\u00e9ndiz-Albor","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda de Mucosas, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n s\/n, Colonia Casco de Santo Tom\u00e1s, Alcald\u00eda Miguel Hidalgo, Ciudad de M\u00e9xico C.P. 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-7952","authenticated-orcid":false,"given":"Ivonne Maciel","family":"Arciniega-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunonutrici\u00f3n, Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n s\/n, Colonia Casco de Santo Tom\u00e1s, Alcald\u00eda Miguel Hidalgo, Ciudad de M\u00e9xico C.P. 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-0928","authenticated-orcid":false,"given":"Efr\u00e9n","family":"Aguilar-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Nutrici\u00f3n, Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Paseo Tollocan Esquina Jes\u00fas Carranza s\/n, Colonia Moderna de la Cruz, Toluca C.P. 50180, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23987","DOI":"10.3402\/gha.v7.23987","article-title":"The burden of diabetes mellitus during pregnancy in low- and middle-income countries: A systematic review","volume":"7","author":"Kanguru","year":"2014","journal-title":"Glob. 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