{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:47:20Z","timestamp":1789051640457,"version":"build-2803163510"},"reference-count":62,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Accurate lymph node staging is crucial for both prognosis (in the event of early-stage disease) and treatment (for local control of disease) in patients with breast cancer. Sentinel lymph node biopsy (SLNB) has been studied in numerous international trials, showing that it allows about 70% of axillary lymph node dissection (ALND) to be avoided and thus significantly reduces the morbidity associated with ALND. SLNB represents a necessary step in the diagnostic algorithm for breast neoplasms because the surgical treatment for breast cancer has become progressively less invasive. We present a case of a 70-year-old woman with multicentric breast cancer (MBC) treated by surgery at \u201cCuza Vod\u0103\u201d Women\u2019s University Hospital, Iassy, Romania. In this case, only the ultrasonography established the diagnosis of left MBC with certainty. Conclusion: The detection of sentinel lymph nodes (SLNs) for MBC must be indicated. In this type of cancer, SLNB is accurate and practical, with sufficient quality control and interdisciplinary collaboration between surgical, nuclear medicine, and pathology units. Lymphoscintigraphy allows the patient to avoid axillary clearance surgery if the sentinel node is negative for metastatic disease. The variability of Ki67, PR, HER2, and ER status supports the idea that all individual foci should be tested in MBC cases to provide the best management and prognosis.<\/jats:p>","DOI":"10.3390\/life15071018","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T05:53:13Z","timestamp":1750917193000},"page":"1018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is Sentinel Lymph Node Biopsy Feasible in Multicentric Breast Cancer? A Case Report and Literature Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Mihaela Camelia","family":"T\u00eernovanu","sequence":"first","affiliation":[{"name":"Department of Mother and Child Medicine-Obstetrics and Gynecology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7859-840X","authenticated-orcid":false,"given":"Elena","family":"Cojocaru","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences I, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad Gabriel","family":"T\u00eernovanu","sequence":"additional","affiliation":[{"name":"St. Josef Hospital, 65189 Wiesbaden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-8011","authenticated-orcid":false,"given":"Elena","family":"\u021aarc\u0103","sequence":"additional","affiliation":[{"name":"Department of Surgery II, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Medical Bioscience, Faculty of Bioengineering, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan Florin","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences I, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorana","family":"Anton","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine-Obstetrics and Gynecology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2624-8890","authenticated-orcid":false,"given":"\u0218tefan Drago\u0219","family":"T\u00eernovanu","sequence":"additional","affiliation":[{"name":"Department of Surgery II, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7386-0859","authenticated-orcid":false,"given":"Roxana Ana","family":"Covali","sequence":"additional","affiliation":[{"name":"Department of Medical Bioscience, Faculty of Bioengineering, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cipriana","family":"\u0218tef\u0103nescu","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences II, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-5407","authenticated-orcid":false,"given":"Irena Cristina","family":"Grierosu","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences II, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/tbj.12361","article-title":"Milestones in Breast Cancer Treatment","volume":"21","author":"Zirruda","year":"2015","journal-title":"Breast J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/bjs.9955","article-title":"Two decades of axillary management in breast cancer","volume":"102","author":"Beek","year":"2015","journal-title":"Br. J. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S1470-2045(07)70278-4","article-title":"Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: Results from the NSABP B-32 randomised phase III trial","volume":"8","author":"Krag","year":"2007","journal-title":"Lancet Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1055\/s-0029-1233989","article-title":"The PRISMA Statement\u2014What should be reported about systematic reviews?","volume":"134","author":"Antes","year":"2009","journal-title":"Dtsch. Med. Wochenschr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1245\/s10434-010-0945-z","article-title":"Sentinel node identification rate and nodal involvement in the EORTC 10981-22023 AMAROS trial","volume":"17","author":"Straver","year":"2010","journal-title":"Ann. Surg. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1007\/s00259-013-2544-2","article-title":"The EANM and SNMMI practice guideline for lymphoscintigraphy and sentinel node localization in breast cancer","volume":"40","author":"Giammarile","year":"2013","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/PPO.0000000000000090","article-title":"Sentinel lymph node biopsy in breast cancer: A work in progress","volume":"21","author":"Chatterjee","year":"2015","journal-title":"Cancer J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.21037\/cco-20-207","article-title":"Narrative review of sentinel lymph node biopsy in breast cancer: A technique in constant evolution with still numerous unresolved questions","volume":"10","author":"Mathelin","year":"2021","journal-title":"Chin. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1200\/JCO.2016.71.0947","article-title":"Sentinel Lymph Node Biopsy for Patients With Early-Stage Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update","volume":"35","author":"Lyman","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ejso.2011.01.011","article-title":"Accuracy of sentinel lymph node biopsy in large and multifocal\/multicentric breast carcinoma\u2014A systematic review","volume":"37","author":"Spillane","year":"2011","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.breast.2012.05.004","article-title":"Unifocal, multifocal and diffuse carcinomas: A reproducibility study of breast cancer distribution","volume":"22","author":"Cserni","year":"2013","journal-title":"Breast"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/00313020802563502","article-title":"Synchronous multiple ipsilateral breast cancers: Implications for patient management","volume":"41","author":"Jain","year":"2009","journal-title":"Pathology"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"\u021aarc\u0103, V., \u021aarc\u0103, E., and Moscalu, M. (2024). Social and Economic Determinants of Life Expectancy at Birth in Eastern Europe. Healthcare, 12.","DOI":"10.3390\/healthcare12111148"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1200\/JCO.2005.02.1147","article-title":"Multifocal and multicentric breast cancer: Does each focus matter?","volume":"23","author":"Coombs","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/jnci\/djr240","article-title":"Role of science in the treatment of breast cancer when tumor multicentricity is present","volume":"103","author":"Fisher","year":"2011","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00006231-200403000-00004","article-title":"The impact of radiopharmaceutical particle size on the visualization and identification of sentinel nodes in breast cancer","volume":"25","author":"Leidenius","year":"2004","journal-title":"Nucl. Med. Commun."},{"key":"ref_17","first-page":"1198","article-title":"Radioguided sentinel lymph node biopsy in breast cancer surgery","volume":"42","author":"Mariani","year":"2001","journal-title":"J. Nucl. Med."},{"key":"ref_18","first-page":"951","article-title":"A synthetic macromolecule for sentinel node detection: (99m)Tc-DTPA-mannosyl-dextran","volume":"42","author":"Vera","year":"2001","journal-title":"J. Nucl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"620","DOI":"10.2967\/jnumed.120.252064","article-title":"Sentinel Lymph Node Biopsy in Breast Cancer with (99m)Tc-Tilmanocept: A Multicenter Study on Real-Life Use of a Novel Tracer","volume":"62","author":"Rioja","year":"2021","journal-title":"J. Nucl. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/bjs.18004620004","article-title":"The lymphatics of the breast","volume":"46","year":"1959","journal-title":"Br. J. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1053\/j.semnuclmed.2022.01.006","article-title":"Sentinel Lymph Node Methods in Breast Cancer","volume":"52","author":"Giammarile","year":"2022","journal-title":"Semin. Nucl. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.2967\/jnumed.114.153643","article-title":"Results of a Prospective Multicenter International Atomic Energy Agency Sentinel Node Trial on the Value of SPECT\/CT Over Planar Imaging in Various Malignancies","volume":"56","author":"Ellmann","year":"2015","journal-title":"J. Nucl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.amjsurg.2020.02.001","article-title":"Use of indocyanine green fluorescence compared to radioisotope for sentinel lymph node biopsy in early-stage breast cancer: Systematic review and meta-analysis","volume":"220","author":"Goonawardena","year":"2020","journal-title":"Am. J. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1200\/GO.20.00165","article-title":"Diagnostic Performance of Indocyanine Green Plus Methylene Blue Versus Radioisotope Plus Methylene Blue Dye Method for Sentinel Lymph Node Biopsy in Node-Negative Early Breast Cancer","volume":"6","author":"Agrawal","year":"2020","journal-title":"JCO Glob. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10549-016-3809-9","article-title":"The Nordic SentiMag trial: A comparison of super paramagnetic iron oxide (SPIO) nanoparticles versus Tc(99) and patent blue in the detection of sentinel node (SN) in patients with breast cancer and a meta-analysis of earlier studies","volume":"157","author":"Karakatsanis","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/bjs.10283","article-title":"Meta-analysis of sentinel lymph node biopsy in breast cancer using the magnetic technique","volume":"103","author":"Zada","year":"2016","journal-title":"Br. J. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ejso.2013.03.026","article-title":"Validation of a technique using microbubbles and contrast enhanced ultrasound (CEUS) to biopsy sentinel lymph nodes (SLN) in pre operative breast cancer patients with a normal grey-scale axillary ultrasound","volume":"39","author":"Cox","year":"2013","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.21037\/atm-20-5996","article-title":"Sentinel lymph node biopsy should be considered for clinically node-negative breast cancer regardless of BRCA1\/2 mutation status","volume":"8","author":"Huang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1245\/s10434-011-1694-3","article-title":"Sentinel lymph node biopsy in multicentric breast cancer: Five-year results in a large series from a single institution","volume":"18","author":"Gentilini","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1200\/JCO.2006.05.7372","article-title":"Multicentric breast cancer: A new indication for sentinel node biopsy\u2014A multi-institutional validation study","volume":"24","author":"Knauer","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1001\/jama.2017.11470","article-title":"Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women with Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial","volume":"318","author":"Giuliano","year":"2017","journal-title":"JAMA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.ejso.2013.11.004","article-title":"A prospective validation study of sentinel lymph node biopsy in multicentric breast cancer: SMMaC trial","volume":"40","author":"Contant","year":"2014","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1200\/JCO-25-00099","article-title":"Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer: ASCO Guideline Update","volume":"43","author":"Park","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ejso.2017.10.215","article-title":"Controversies and recommendations regarding sentinel lymph node biopsy in primary breast cancer: A comprehensive review of current data","volume":"44","author":"Charalampoudis","year":"2018","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_35","unstructured":"Ho, C., and Arg\u00e1ez, C. (2019). Sentinel Lymph Node Biopsy for the Management of Breast Cancer: A Review of Guidelines CADTH Rapid Response Reports, Canadian Agency for Drugs and Technologies in Health."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.6004\/jnccn.2020.0016","article-title":"Breast Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology","volume":"18","author":"Gradishar","year":"2020","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1245\/s10434-019-08154-5","article-title":"The landmark series: Axillary management in breast cancer","volume":"27","author":"Fisher","year":"2020","journal-title":"Ann. Surg. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4103\/wjnm.wjnm_32_18","article-title":"Triple-site radiotracer application in breast lymphoscintigraphy and sentinel node discordance","volume":"18","author":"Freebody","year":"2019","journal-title":"World J. Nucl. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jss.2011.11.343","article-title":"Indications for Sentinel Lymph Node Biopsy in Multifocal and Multicentric Breast Cancer","volume":"172","author":"Moody","year":"2012","journal-title":"J. Surg. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"370","DOI":"10.21147\/j.issn.1000-9604.2016.03.12","article-title":"A mini-review on factors and countermeasures associated with false-negative sentinel lymph node biopsies in breast cancer","volume":"28","author":"Han","year":"2016","journal-title":"Chin. J. Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/cncr.10331","article-title":"Pathologic analysis of tumor size and lymph node status in multifocal\/multicentric breast carcinoma","volume":"94","author":"Andea","year":"2002","journal-title":"Cancer"},{"key":"ref_42","first-page":"4593","article-title":"Multifocal and Multicentric Breast Carcinoma: A Significantly More Aggressive Tumor than Unifocal Breast Cancer","volume":"37","author":"Lang","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbrc.2009.04.051","article-title":"Molecular mechanisms controlling E-cadherin expression in breast cancer","volume":"384","author":"Baranwal","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Klopp, A.H., Lacerda, L., Gupta, A., Debeb, B.G., Solley, T., Li, L., Spaeth, E., Xu, W., Zhang, X., and Lewis, M.T. (2010). Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012180"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"St\u0103tescu, L., Trandafir, L.M., \u021aarc\u0103, E., Moscalu, M., Leon Constantin, M.M., Butnariu, L.I., Trandafirescu, M.F., T\u00eernovanu, M.C., Heredea, R., and P\u0103tra\u0219cu, A.V. (2023). Advancing Cancer Research: Current Knowledge on Cutaneous Neoplasia. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241311176"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Weissenbacher, T., Hirte, E., Kuhn, C., Janni, W., Mayr, D., Karsten, U., Rack, B., Friese, K., Jeschke, U., and Heublein, S. (2013). Multicentric and multifocal versus unifocal breast cancer: Differences in the expression of E-cadherin suggest differences in tumor biology. BMC Cancer, 13.","DOI":"10.1186\/1471-2407-13-361"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12957-017-1299-9","article-title":"Prognostic parameters of luminal A and luminal B intrinsic breast cancer subtypes of Pakistani patients","volume":"16","author":"Hashmi","year":"2018","journal-title":"World J. Surg. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.critrevonc.2016.12.006","article-title":"How could breast cancer molecular features contribute to locoregional treatment decision making?","volume":"110","author":"Tsoutsou","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.soc.2017.08.005","article-title":"Molecular Subtypes and Local-Regional Control of Breast Cancer","volume":"27","author":"Fragomeni","year":"2018","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3332\/ecancer.2017.715","article-title":"Bone metastasis risk factors in breast cancer","volume":"11","author":"Pulido","year":"2017","journal-title":"Ecancermedicalscience"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.21037\/atm-21-4052","article-title":"Clinicopathological characteristics and prognostic risk factors of breast cancer patients with bone metastasis","volume":"9","author":"Pan","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Hernandez, R.K., Wade, S.W., Reich, A., Pirolli, M., Liede, A., and Lyman, G.H. (2018). Incidence of bone metastases in patients with solid tumors: Analysis of oncology electronic medical records in the United States. BMC Cancer, 18.","DOI":"10.1186\/s12885-017-3922-0"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"27990","DOI":"10.18632\/oncotarget.15856","article-title":"Breast cancer subtypes predict the preferential site of distant metastases: A SEER based study","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00428-017-2065-7","article-title":"Breast carcinoma subtypes show different patterns of metastatic behavior","volume":"470","author":"Fekete","year":"2017","journal-title":"Virchows Arch."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Diessner, J., Wischnewsky, M., St\u00fcber, T., Stein, R., Krockenberger, M., H\u00e4usler, S., Janni, W., Kreienberg, R., Blettner, M., and Schwentner, L. (2016). Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2345-7"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.ejca.2014.04.002","article-title":"Age at diagnosis and distant metastasis in breast cancer\u2014A surprising inverse relationship","volume":"50","author":"Purushotham","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"165","DOI":"10.62951\/ijhm.v1i4.103","article-title":"Identification of Risk Factors of Bone Metastasis Among Iraqi Breast Cancer Women","volume":"1","author":"Ali","year":"2024","journal-title":"Int. J. Health Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1200\/JCO.2007.11.2854","article-title":"Fusion of metabolic function and morphology: Sequential [18F] fluorodeoxyglucose positron-emission tomography\/computed tomography studies yield new insights into the natural history of bone metastases in breast cancer","volume":"25","author":"Du","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10954","DOI":"10.1073\/pnas.1830978100","article-title":"A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases","volume":"100","author":"Yin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"100205","DOI":"10.1016\/j.jbo.2018.10.004","article-title":"Metastatic bone disease: Pathogenesis and therapeutic options","volume":"15","author":"Coleman","year":"2019","journal-title":"J. Bone Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1387\/ijdb.041817lv","article-title":"Pain control by ionizing radiation of bone metastasis","volume":"48","author":"Vakaet","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4329\/wjr.v7.i8.202","article-title":"Imaging of bone metastasis: An update","volume":"7","author":"Carty","year":"2015","journal-title":"World J. Radiol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/7\/1018\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:58:58Z","timestamp":1760032738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/7\/1018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":62,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["life15071018"],"URL":"https:\/\/doi.org\/10.3390\/life15071018","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]}}}