{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:56:22Z","timestamp":1789235782919,"version":"build-2803163510"},"reference-count":307,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Cholinergic projections from the basal forebrain to the cortex and hippocampus play a critical role in cognitive functions, many of which rely on signaling through the alpha7 nicotinic acetylcholine receptor (\u03b17nAChR). The Alzheimer\u2019s disease (AD) brain is characterized by the profound impairment of the basal forebrain cholinergic system, including alterations in the levels of \u03b17nAChR in various brain areas. In addition, \u03b17nAChR binds with high affinity to beta amyloid (A\u03b2), suggesting \u03b17nAChR might mediate some of A\u03b2\u2019s effects in the brain. Under normal physiological conditions, the interaction between A\u03b2 and \u03b17nAChR appears to be beneficial, supporting normal neurotransmission, synaptic plasticity, and memory functions. However, when levels of A\u03b2 are pathologically elevated, their interaction leads to deleterious effects, implicating \u03b17nAChR in the pathophysiology of AD. In addition to expression in neurons, \u03b17nAChR is expressed in astrocytes and microglia, where it serves as a key component of a cholinergic pathway that regulates neuroinflammation. This review article will cover the role of \u03b17nAChR in neurons, astrocytes and microglia under normal conditions, summarize changes in the expression or function of \u03b17nAChR in neurons and glia in the AD brain, and discuss cell-type specific contributions of \u03b17nAChR to AD pathology with an emphasis on interactions of \u03b17nAChR with A\u03b2.<\/jats:p>","DOI":"10.3390\/life15071032","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T03:54:28Z","timestamp":1751255668000},"page":"1032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neuronal and Glial \u03b17 Nicotinic Acetylcholine Receptors: Role in Alzheimer\u2019s Disease Pathophysiology"],"prefix":"10.3390","volume":"15","author":[{"given":"Kerry","family":"Rennie","sequence":"first","affiliation":[{"name":"Human Health Therapeutics, National Research Council, Ottawa, ON K1A 0R6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The Neuropathological Diagnosis of Alzheimer\u2019s Disease","volume":"14","author":"Deture","year":"2019","journal-title":"Mol. 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