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The investigation involved 90 patients aged 23\u201345 years, systematically examining viral seropositivity for HSV (herpes simplex virus), HZ (herpes zoster), HBV (hepatitis B virus), HIV (human immunodeficiency virus), and HCV (hepatitis C virus) through ELISA testing. The findings revealed notable active or recent viral infection rates: 8.9% HSV positivity, 2.2% HZ antibody detection, 4.4% HCV positivity, and 4.4% HIV positivity. The research can contribute to current knowledge gaps, broaden the knowledge regarding the relationship between psoriasis and viral infection, and assess resistance, as it can mediate the interaction. The results can lead to improved diagnosis, treatment, and patient care options. This study emphasizes the importance of thorough viral testing for psoriasis patients, as well as focused therapeutic regimens that take into account viral co-infections. It elucidates the complex networks of biological relationships between immune factors, contributes information that is critical to our understanding of the multifactorial etiology of psoriasis, and concludes with a strong argument for investigating the mechanisms of viral involvement in this chronic-relapsing inflammatory disease.<\/jats:p>","DOI":"10.3390\/life15071054","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T13:06:17Z","timestamp":1751288777000},"page":"1054","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Linkage Between Resistin and Viral Seropositivity in Psoriasis: Evidence from a Tertiary Centre"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5093-0623","authenticated-orcid":false,"given":"Habeeb Ali","family":"Baig","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Northern Border University, Arar 91431, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2437-8968","authenticated-orcid":false,"given":"Waseema","family":"Sultana","sequence":"additional","affiliation":[{"name":"ICMR\/DHR\u2014Viral Research and Diagnostic Laboratory, Department of Microbiology, Osmania Medical College, Hyderabad 500079, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Northern Border University, Arar 91431, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-2231","authenticated-orcid":false,"given":"Dhaifallah","family":"Alenizi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Northern, Border University, Arar 91431, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awwad","family":"Alenezy","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Faculty of Medicine, Northern Border University, Arar 91431, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinath","family":"Mote","sequence":"additional","affiliation":[{"name":"ICMR\/DHR\u2014Viral Research and Diagnostic Laboratory, Department of Microbiology, Osmania Medical College, Hyderabad 500079, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M. 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Fam. Med. Prim. Care Rev."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Tokura, Y., Phadungsaksawasdi, P., Kurihara, K., Fujiyama, T., and Honda, T. (2021). Pathophysiology of Skin Resident Memory T Cells. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.618897"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Boehncke, W.H., and Brembilla, N.C. (2019). Autoreactive T-Lymphocytes in Inflammatory Skin Diseases. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01198"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","article-title":"The pathogenesis of psoriatic arthritis","volume":"391","author":"Veale","year":"2018","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jaad.2019.08.023","article-title":"Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and \u03b2-defensin 2 in spongioticpsoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor \u03b1 inhibitor\u2013associated dermatitis","volume":"82","author":"Cohen","year":"2020","journal-title":"J. Am. Acad. Derm."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Ji, Y.-Z., and Liu, S.-R. (2019). Koebner phenomenon leading to the formation of new psoriatic lesions: Evidences and mechanisms. Biosci. Rep., 39.","DOI":"10.1042\/BSR20193266"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: Systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0733-8635(18)30144-X","article-title":"Psoriasis in the tropics: Epidemiologic, genetic, clinical, and therapeutic aspects","volume":"12","author":"Farber","year":"1994","journal-title":"Dermatol. Clin."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(03)12954-6","article-title":"Psoriasis","volume":"361","author":"Lebwohl","year":"2003","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4103\/0378-6323.72443","article-title":"Psoriasis in India: Prevalence and pattern","volume":"76","author":"Dogra","year":"2010","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Li, Y., Yang, Q., Cai, D., Guo, H., Fang, J., Cui, H., Gou, L., Deng, J., Wang, Z., and Zuo, Z. (2021). Resistin, a novel host defense peptide of innate immunity. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.699807"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1126\/science.1093466","article-title":"Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones","volume":"304","author":"Patel","year":"2004","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1093\/emboj\/19.15.4046","article-title":"FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family","volume":"19","author":"Holcomb","year":"2000","journal-title":"EMBO J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.chom.2019.04.004","article-title":"Resistin-like molecule \u03b1 provides vitamin-A-dependent antimicrobial protection in the skin","volume":"25","author":"Harris","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-1119(02)01213-1","article-title":"The Genomic Organization of Mouse Resistin Reveals Major Differences from the Human Resistin: Functional Implications","volume":"305","author":"Ghosh","year":"2003","journal-title":"Gene"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1210\/jc.2005-0437","article-title":"Serum resistin levels of obese and lean children and adolescents: Biochemical analysis and clinical relevance","volume":"90","author":"Gerber","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1021\/bi801266k","article-title":"Biophysical analyses of human resistin: Oligomer formation suggests novel biological function","volume":"47","author":"Aruna","year":"2008","journal-title":"Biochemistry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.bbrc.2005.06.202","article-title":"Human Resistin Stimulates the Pro-Inflammatory Cytokines TNF-a and IL-12 in Macrophages by NF-\u03bab-Dependent Pathway","volume":"334","author":"Silswal","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"10554","DOI":"10.1021\/bi034782v","article-title":"Human recombinant resistin protein displays a tendency to aggregate by forming intermolecular disulfide linkages","volume":"42","author":"Aruna","year":"2003","journal-title":"Biochemistry"},{"key":"ref_21","first-page":"479739","article-title":"Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro","volume":"2013","author":"Novelle","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jbspin.2011.04.009","article-title":"Serum resistin level is associated with radiographic changes in hand osteoarthritis: Cross-sectional study","volume":"79","author":"Choe","year":"2012","journal-title":"Jt. Bone Spine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0014-5793(02)03450-6","article-title":"Lipopolysaccharide Increases Resistin Gene Expression In Vivo and In Vitro","volume":"530","author":"Lu","year":"2002","journal-title":"FEBS Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbrc.2003.07.003","article-title":"Resistin Messenger-RNA Expression Is Increased by Proinflammatory Cytokines In Vitro","volume":"309","author":"Kaser","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clim.2009.07.013","article-title":"The role of resistin as a regulator of inflammation: Implications for various human pathologies","volume":"133","author":"Gay","year":"2009","journal-title":"Clin. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1365-2133.2008.08655.x","article-title":"Obesity in psoriasis: Leptin and resistin as mediators of cutaneous inflammation","volume":"159","author":"Johnston","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"S\u0142uczanowska-G\u0142abowska, S., Staniszewska, M., Marchlewicz, M., Duchnik, E., \u0141uczkowska, K., Safranow, K., Machali\u0144ski, B., and Pawlik, A. (2023). Adiponectin, leptin and resistin in patients with psoriasis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12020663"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5380792","DOI":"10.1155\/2016\/5380792","article-title":"Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients","volume":"2016","author":"Vachatova","year":"2016","journal-title":"J. Immunol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-0781.2011.00575.x","article-title":"Phototherapy reduces serum resistin levels in psoriasis patients","volume":"27","author":"Kawashima","year":"2011","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.clim.2009.11.008","article-title":"Increased Th17 cells are accompanied by FoxP3+ Treg cell accumulation and correlated with psoriasis disease severity","volume":"135","author":"Zhang","year":"2010","journal-title":"Clin. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2230.2012.04465.x","article-title":"Clear association between serum levels of adipokines and T-helper 17-related cytokines in patients with psoriasis","volume":"38","author":"Nakajima","year":"2013","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jaad.2007.09.010","article-title":"Adalimumab therapy for moderate to severe psoriasis: A randomized, controlled phase III trial","volume":"58","author":"Menter","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3892\/etm.2021.9999","article-title":"Infection-Provoked Psoriasis: Induced or Aggravated (Review)","volume":"21","author":"Teng","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s12325-024-02873-2","article-title":"Management of Psoriasis Patients with Serious Infectious Diseases","volume":"41","author":"Megna","year":"2024","journal-title":"Adv. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Campanati, A., Marani, A., Martina, E., Diotallevi, F., Radi, G., and Offidani, A. (2021). Psoriasis as an immune-mediated and inflammatory systemic disease: From pathophysiology to novel therapeutic approaches. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111511"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41584-022-00776-6","article-title":"Psoriatic arthritis from a mechanistic perspective","volume":"18","author":"Schett","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/08820139.2023.2288836","article-title":"Resistin\u2013A plausible therapeutic target in the pathogenesis of psoriasis","volume":"53","author":"Srikanth","year":"2024","journal-title":"Immunol. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kie\u0142bowski, K., Bakinowska, E., Ostrowski, P., Pala, B., Gromowska, E., Gurazda, K., Dec, P., Modrzejewski, A., and Pawlik, A. (2023). The role of adipokines in the pathogenesis of psoriasis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076390"},{"key":"ref_39","first-page":"S39","article-title":"HCV infection: Pathogenesis, clinical manifestations and therapy","volume":"26","author":"Antonelli","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1111\/jdv.14310","article-title":"Increased prevalence of HCV and hepatic decompensation in adults with psoriasis: A population-based study in the United Kingdom","volume":"31","author":"Noe","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/1346-8138.12240","article-title":"Possible association of hepatitis C virus infection with late-onset psoriasis: A hospital-based observational study","volume":"40","author":"Imafuku","year":"2013","journal-title":"J. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/0956462419827673","article-title":"Psoriasis in HIV Infection: An Update","volume":"30","author":"Filipe","year":"2019","journal-title":"Int. J. STD AIDS"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S1473-3099(10)70101-8","article-title":"HIV-Associated Psoriasis: Pathogenesis, Clinical Features, and Management","volume":"10","author":"Morar","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Colombo, D., Chimenti, S., Grossi, P., Marchesoni, A., Di Nuzzo, S., Griseta, V., Gargiulo, A., Parodi, A., Simoni, L., and Bellia, G. (2014). Prevalence of past and reactivated viral infections and efficacy of cyclosporine A as monotherapy or in combination in patients with psoriatic arthritis\u2014Synergy study: A longitudinal observational study. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/941767"},{"key":"ref_45","first-page":"1","article-title":"Prevalence of acute and chronic viral seropositivity and characteristics of disease in patients with psoriatic arthritis treated with cyclosporine: A post hoc analysis from a sex point of view on the observational study of infectious events in psoriasis complicated by active psoriatic arthritis","volume":"22","author":"Colombo","year":"2015","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Tsai, S.Y., Chen, H.J., Lio, C.F., Ho, H.P., Kuo, C.F., Jia, X., Chen, C., Chen, Y.T., Chou, Y.T., and Yang, T.Y. (2017). Increased risk of herpes zoster in patients with psoriasis: A population-based retrospective cohort study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0179447"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2147\/PTT.S102202","article-title":"Herpes zoster in psoriasis patients undergoing treatment with biological agents: Prevalence, impact, and management challenges","volume":"6","author":"Colson","year":"2016","journal-title":"Psoriasis Targets Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.2147\/CCID.S439110","article-title":"Advancements in the study of biologic agents in comorbidities of psoriasis: A literature review","volume":"31","author":"Wang","year":"2023","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"589","DOI":"10.15252\/emmm.201607027","article-title":"RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease","volume":"9","author":"Zhu","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.7326\/0003-4819-106-1-165_2","article-title":"Psoriasis, gamma-interferon, and the acquired immunodeficiency syndrome","volume":"106","author":"Fuchs","year":"1987","journal-title":"Ann. Intern. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/08916930310001637986","article-title":"Paradoxical exacerbation of psoriasis in AIDS: Proposed explanations including the potential roles of substance P and gramnegative bacteria","volume":"37","author":"Namazi","year":"2004","journal-title":"Autoimmunity"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jaad.2016.04.005","article-title":"Serious Infections in Hospitalized Patients with Psoriasis in the United States","volume":"75","author":"Hsu","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Edwards, R.J., Lavia, L.O., Edwards, J., and Boyce, G. (2022). Psoriasis in Patients Attending a Large HIV Clinic in Trinidad. Med. Sci., 10.","DOI":"10.3390\/medsci10010009"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/jdv.13578","article-title":"Hepatitis C may enhance key amplifiers of psoriasis","volume":"31","author":"Chun","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"983991","DOI":"10.1111\/jvh.12465","article-title":"Memory redifferentiation and reduced lymphocyte activation in chronic HCVinfected patients receiving directacting antivirals","volume":"22","author":"Burchill","year":"2015","journal-title":"J. Viral Hepat."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"216223","DOI":"10.1093\/infdis\/jiv391","article-title":"Immunological Analysis During InterferonFree Therapy for Chronic Hepatitis C Virus Infection Reveals Modulation of the Natural Killer Cell Compartment","volume":"213","author":"Spaan","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"724735","DOI":"10.1136\/gutjnl-2015-310033","article-title":"Rapid decrease in hepatitis C viremia by direct acting antivirals improves the natural killer cell response to IFN\u03b1","volume":"66","author":"Serti","year":"2017","journal-title":"Gut"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4254\/wjh.v10.i2.329","article-title":"Outcomes assessment of hepatitis C virus-positive psoriatic patients treated using pegylated interferon in combination with ribavirin compared to new Direct-Acting Antiviral agents","volume":"10","author":"Damiani","year":"2018","journal-title":"World J. Hepatol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Bu, J., Ding, R., Zhou, L., Chen, X., and Shen, E. (2022). Epidemiology of psoriasis and comorbid diseases: A narrative review. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.880201"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ting, S.W., Ting, S.Y., Lin, Y.S., Lin, M.S., and Kuo, G. (2021). Risk of herpes zoster in psoriasis patients receiving systemic therapies: A nationwide population-based cohort study. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-91356-3"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1007\/s13555-023-00988-y","article-title":"Burden of herpes zoster among patients with psoriasis in the United States","volume":"13","author":"Singer","year":"2023","journal-title":"Dermatol. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"744","DOI":"10.4103\/0378-6323.183630","article-title":"The risk of herpes zoster in patients with psoriasis: A retrospective records-based observational study","volume":"82","author":"Megna","year":"2016","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/0019-5154.96197","article-title":"Psoriasis Herpeticum due to Varicella Zoster Virus: A Kaposi\u2019s Varicelliform Eruption in Erythrodermic Psoriasis","volume":"57","author":"Garg","year":"2012","journal-title":"Indian J. Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"11425","DOI":"10.1128\/JVI.76.22.11425-11433.2002","article-title":"Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers","volume":"76","author":"Ku","year":"2002","journal-title":"J. Virol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrmicro3215","article-title":"Molecular mechanisms of varicella zoster virus pathogenesis","volume":"12","author":"Zerboni","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/jid.2011.371","article-title":"CXCL16 and CXCR6 are upregulated in psoriasis and mediate cutaneous recruitment of human CD8+ T cells","volume":"132","author":"Gunther","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2249.2001.01688.x","article-title":"The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease","volume":"126","author":"Sigmundsdottir","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s004030000167","article-title":"Flow cytometric characterization of lesional T cells in psoriasis: Intracellular cytokine and surface antigen expression indicates an activated, memory\/effector type 1 immunophenotype","volume":"292","author":"Friedrich","year":"2000","journal-title":"Arch. Dermatol. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/23495","article-title":"The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells","volume":"400","author":"Campbell","year":"1999","journal-title":"Nature"},{"key":"ref_70","first-page":"17","article-title":"Improvement of psoriasis after initiation of antiviral therapy for hepatitis B","volume":"29","author":"Chung","year":"2023","journal-title":"Dermatol. Online J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"822","DOI":"10.5021\/ad.2017.29.6.822","article-title":"Association of Hepatitis B Virus Infection and Psoriasis","volume":"29","author":"Suh","year":"2017","journal-title":"Ann. Dermatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/j.1468-3083.2012.04563.x","article-title":"Association between Psoriasis and Viral Infections in the United States: Focusing on Hepatitis B, Hepatitis C and Human Immunodeficiency Virus","volume":"27","author":"Kanada","year":"2013","journal-title":"J. Eur. Acad. Dermatol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.36740\/WLek202009213","article-title":"Complex treatment the patients with psoriasis and concomitant activated herpes virus infection, types 1, 2","volume":"73","author":"Fedorova","year":"2020","journal-title":"Wiad Lek"},{"key":"ref_74","first-page":"5319425","article-title":"Management of psoriasis herpeticum in pregnancy: A clinical conundrum","volume":"2016","author":"Almario","year":"2016","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1067\/mjd.2002.123487","article-title":"Herpes simplex virus-induced psoriatic flares in a patient previously treated with tamoxifen: A follow-up","volume":"46","author":"Boyd","year":"2002","journal-title":"J. Am. Acad. 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