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Changes in the respiratory tract microbiome, and hence the physiology of the respiratory tract, are believed to influence the course of sarcoidosis; this is not unlikely, as research indicates that the state of the microbiota inhabiting individual ontocenoses, such as the intestines or blood, may be related to the health of the entire body. This review therefore discusses the microbiological factors that are believed to be involved in the development of the disease; however, as the aetiological factors of sarcoidosis are diverse and are based on highly complex mechanisms, our analysis is restricted to only the most likely factors.<\/jats:p>","DOI":"10.3390\/life15071069","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T05:54:52Z","timestamp":1751608492000},"page":"1069","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microbiome Against the Background of the Complex Aetiology in Sarcoidosis\u2014What Do We Already Know?"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5517-3837","authenticated-orcid":false,"given":"Maciej","family":"Szyma\u0144ski","sequence":"first","affiliation":[{"name":"\u201eSzko\u0142a Or\u0142\u00f3w\u201d, Project by Academic Career Office, Medical University of Lodz, 90-752 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"G\u00f3ralska","sequence":"additional","affiliation":[{"name":"Department of Biology and Parasitology, Chair of Biology and Medical Microbiology, Medical University of Lodz, 90-752 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Brzezia\u0144ska-Lasota","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Genetics, Chair of Biology and Medical Microbiology, Medical University of Lodz, 90-752 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e175264","DOI":"10.1172\/JCI175264","article-title":"Immune mechanisms of granuloma formation in sarcoidosis and tuberculosis","volume":"134","author":"Weeratunga","year":"2024","journal-title":"J. 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