{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:50:46Z","timestamp":1788580246632,"version":"build-2803163510"},"reference-count":206,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["25-24-20176"],"award-info":[{"award-number":["25-24-20176"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Colorectal carcinoma remains one of the primary contributors to cancer deaths; however, it is also considered a preventable type of cancer, because the prognosis of the disease is directly dependent on its timely detection. Developing accurate risk prediction models for colorectal cancer is crucial for identifying individuals at both low and high risk, as risk stratification determines the need for additional interventions, which carry their own risks. The development of new non-invasive diagnostic methods based on biomaterial analysis, alongside standard diagnostic techniques such as colonoscopy with biopsy, computed tomography scanning, and magnetic resonance imaging, can address multiple objectives: improving screening accuracy, providing a comprehensive assessment of minimal residual disease, identifying patients at a high risk of colorectal cancer, and evaluating the effectiveness of ongoing treatments. The lack of sensitive diagnostic methods drives contemporary research toward the discovery of new tools for detecting tumor cells, particularly through the examination of biological materials, including blood, exhaled air, and tumor tissue itself. In this article, we analyze current studies regarding biomarkers in colorectal cancer and prognostic significance.<\/jats:p>","DOI":"10.3390\/life15071100","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:56:54Z","timestamp":1752487014000},"page":"1100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Significance of the Comprehensive Biomarker Analysis in Colorectal Cancer"],"prefix":"10.3390","volume":"15","author":[{"given":"Vera","family":"Potievskaya","sequence":"first","affiliation":[{"name":"Russian Medical Academy of Postgraduate Education of Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency, Volokolamskoye Shosse, 91, 125371 Moscow, Russia"},{"name":"P. Hertsen Moscow Oncology Research Institute\u2014Branch or the Federal State Budgetary Institution \u201cNational Medical Research Radiological Centre\u201d of the Ministry of Health of the Russian Federation, 2nd Botkinsky Proezd, 3, 125284 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-1290","authenticated-orcid":false,"given":"Elizaveta","family":"Tyukanova","sequence":"additional","affiliation":[{"name":"Oncology Department of Antitumor Drug Therapy, Sechenov University Clinical Hospital No.4, I.M. Sechenov First Moscow State Medical University, Str. Dovatora, 15, Bldg. 2, 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Sekacheva","sequence":"additional","affiliation":[{"name":"World-Class Reserch Centre \u00abDigital Biodesign and Personalized Healthcare\u00bb, I.M. Sechenov First Moscow State Medical University (Sechenov University), Str. Bolshaya Pirogovskaya, 6, Bldg. 1, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5473-3101","authenticated-orcid":false,"given":"Zaki","family":"Fashafsha","sequence":"additional","affiliation":[{"name":"P. Hertsen Moscow Oncology Research Institute\u2014Branch or the Federal State Budgetary Institution \u201cNational Medical Research Radiological Centre\u201d of the Ministry of Health of the Russian Federation, 2nd Botkinsky Proezd, 3, 125284 Moscow, Russia"},{"name":"The Institute for Personalized Cardiology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Str. Bolshaya Pirogovskaya, 6, Bldg. 1, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Fatyanova","sequence":"additional","affiliation":[{"name":"Oncology Department of Antitumor Drug Therapy, Sechenov University Clinical Hospital No.4, I.M. Sechenov First Moscow State Medical University, Str. Dovatora, 15, Bldg. 2, 119048 Moscow, Russia"},{"name":"The Department of Oncology, Radiotherapy and Reconstructive Surgery, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str., Bldg. 8\/2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Potievskiy","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cNational Medical Research Radiological Centre\u201d of the Ministry of Health of the Russian Federation, 4, Koroleva Street, 249036 Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kononova","sequence":"additional","affiliation":[{"name":"P. Hertsen Moscow Oncology Research Institute\u2014Branch or the Federal State Budgetary Institution \u201cNational Medical Research Radiological Centre\u201d of the Ministry of Health of the Russian Federation, 2nd Botkinsky Proezd, 3, 125284 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kholstinina","sequence":"additional","affiliation":[{"name":"Oncology Department of Antitumor Drug Therapy, Sechenov University Clinical Hospital No.4, I.M. Sechenov First Moscow State Medical University, Str. Dovatora, 15, Bldg. 2, 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekatherina","family":"Polishchuk","sequence":"additional","affiliation":[{"name":"Oncology Department of Antitumor Drug Therapy, Sechenov University Clinical Hospital No.4, I.M. Sechenov First Moscow State Medical University, Str. Dovatora, 15, Bldg. 2, 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Shegai","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cNational Medical Research Radiological Centre\u201d of the Ministry of Health of the Russian Federation, 4, Koroleva Street, 249036 Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Kaprin","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cNational Medical Research Radiological Centre\u201d of the Ministry of Health of the Russian Federation, 4, Koroleva Street, 249036 Obninsk, Russia"},{"name":"Peoples\u2019 Friendship University of Russia\u2014RUDN University, Miklukho-Maklaya Str. Bld. 6, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"ref_1","unstructured":"(2024, August 06). Cancer Today [Internet]. Available online: https:\/\/gco.iarc.who.int\/today\/en\/dataviz\/pie?mode=population&group_populations=0."},{"key":"ref_2","unstructured":"(2024, August 06). Cancer Tomorrow [Internet]. Available online: https:\/\/gco.iarc.who.int\/tomorrow\/en\/dataviz\/bars?years=2050&mode=cancer&group_populations=1&multiple_cancers=1&cancers=8."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1001\/jama.2021.4417","article-title":"Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force","volume":"325","author":"Lin","year":"2021","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1001\/jama.2021.6238","article-title":"Screening for colorectal cancer: US Preventive Services Task Force Recommendation Statement","volume":"325","author":"Davidson","year":"2021","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e032773","DOI":"10.1136\/bmjopen-2019-032773","article-title":"Colorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: A systematic review and network meta-analysis","volume":"9","author":"Jodal","year":"2019","journal-title":"BMJ Open"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Piscitello, A., Saoud, L., Fendrick, A.M., Borah, B.J., Hassmiller Lich, K., Matney, M., Ozbay, A.B., Parton, M., and Limburg, P.J. (2020). Estimating the impact of differential adherence on the comparative effectiveness of stool-based colorectal cancer screening using the CRC-AIM microsimulation model. PLoS ONE, 15.","DOI":"10.1101\/2020.08.30.271858"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.14309\/ajg.0000000000001122","article-title":"ACG clinical guidelines: Colorectal cancer screening 2021","volume":"116","author":"Shaukat","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1053\/j.gastro.2020.11.049","article-title":"Participation in competing strategies for colorectal cancer screening: A randomized health services study (PICCOLINO Study)","volume":"160","author":"Pilonis","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jnci\/djaa103","article-title":"Comparing the cost-effectiveness of innovative colorectal cancer screening tests","volume":"113","author":"Peterse","year":"2021","journal-title":"J. Nat. Cancer Inst."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/0969141320903756","article-title":"Cross-sectional adherence with the multi-target stool DNA test for colorectal cancer screening: Real-world data from a large cohort of older adults","volume":"28","author":"Weiser","year":"2021","journal-title":"J. Med. Screen."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1148\/radiol.2020201018","article-title":"Diagnostic performance of multitarget stool DNA and CT colonography for noninvasive colorectal cancer screening","volume":"297","author":"Pickhardt","year":"2020","journal-title":"Radiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.mayocp.2020.07.035","article-title":"Cost-effectiveness of multitarget stool DNA testing vs colonoscopy or fecal immunochemical testing for colorectal cancer screening in Alaska native people","volume":"96","author":"Redwood","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7326\/M16-0758","article-title":"Effectiveness of screening colonoscopy to prevent colorectal cancer among Medicare beneficiaries aged 70 to 79 years: A prospective observational study","volume":"166","author":"Hsu","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1056\/NEJMoa1301969","article-title":"Long-term colorectal-cancer incidence and mortality after lower endoscopy","volume":"369","author":"Nishihara","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ko, C.W., Doria-Rose, V.P., Barrett, M.J., Kamineni, A., Enewold, L., and Weiss, N.S. (2019). Screening colonoscopy and flexible sigmoidoscopy for reduction of colorectal cancer incidence: A case-control study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0226027"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sha, J., Chen, J., Lv, X., Liu, S., Chen, R., and Zhang, Z. (2020). Computed tomography colonography versus colonoscopy for detection of colorectal cancer: A diagnostic performance study. BMC Med. Imaging, 20.","DOI":"10.1186\/s12880-020-00446-7"},{"key":"ref_17","first-page":"236","article-title":"CT and MR Imaging in Colorectal Carcinoma: A Tool for Diagnosis, Staging, Response Evaluation, and Follow-Up","volume":"13","author":"Ghuman","year":"2025","journal-title":"South. Asian J. Cancer"},{"key":"ref_18","first-page":"612","article-title":"Comparison of Imaging Modalities in the Diagnosis and Tumor Staging of Colorectal Adenocarcinoma","volume":"19","year":"2023","journal-title":"Curr. Med. Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.12659\/MSM.915472","article-title":"Diagnostic Value and Clinical Significance of Methylated SEPT9 for Colorectal Cancer: A Meta-Analysis","volume":"25","author":"Hu","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e000355","DOI":"10.1136\/bmjgast-2019-000355","article-title":"Utility of the methylated SEPT9 test for the early detection of colorectal cancer: A systematic review and meta-analysis of diagnostic test accuracy","volume":"7","author":"Hariharan","year":"2020","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sun, Q., and Long, L. (2024). Diagnostic performances of methylated septin9 gene, CEA, CA19-9 and platelet-to-lymphocyte ratio in colorectal cancer. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12670-3"},{"key":"ref_22","first-page":"100748","article-title":"Methylated Septin9 identified patients with colorectal carcinoma and showed higher sensitivity than conventional biomarkers in detecting tumor","volume":"36","author":"Leerhoff","year":"2023","journal-title":"Cancer Treat. Res. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1200\/JCO.2022.40.4_suppl.009","article-title":"Association of circulating tumor DNA dynamics with clinical outcomes in the adjuvant setting for patients with colorectal cancer from an observational GALAXY study in CIRCULATE-Japan","volume":"40","author":"Kotaka","year":"2022","journal-title":"JCO"},{"key":"ref_24","first-page":"953","article-title":"Circulating Tumour DNA as a Potential Cost-Effective Biomarker to Reduce Adjuvant Chemotherapy Overtreatment in Stage II Colorectal Cancer","volume":"39","author":"To","year":"2021","journal-title":"JPPM"},{"key":"ref_25","first-page":"329","article-title":"Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology","volume":"19","author":"Benson","year":"2021","journal-title":"JNCCN"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mamtimin, M., Pinarci, A., Han, C., Braun, A., Anders, H.J., Gudermann, T., and Mammadova-Bach, E. (2022). Extracellular DNA Traps: Origin, Function and Implications for Anti-Cancer Therapies. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.869706"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s41571-021-00495-z","article-title":"Precision oncology in metastatic colorectal cancer\u2014From biology to medicine","volume":"18","author":"Vitiello","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nm0715-827b","article-title":"Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients","volume":"21","author":"Siravegna","year":"2015","journal-title":"Nat. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.annonc.2022.05.520","article-title":"ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: A report from the ESMO Precision Medicine Working Group","volume":"33","author":"Pascual","year":"2022","journal-title":"Ann. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1001\/jamaoncol.2018.5080","article-title":"Rechallenge for Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer With Acquired Resistance to First-line Cetuximab and Irinotecan","volume":"5","author":"Cremolini","year":"2019","journal-title":"JAMA Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1001\/jamaoncol.2021.2915","article-title":"Cetuximab Rechallenge Plus Avelumab in Pretreated Patients With RAS Wild-type Metastatic Colorectal Cancer","volume":"7","author":"Martinelli","year":"2021","journal-title":"JAMA Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-1-0716-3346-5_15","article-title":"Role of Circulating Tumor DNA in Colorectal Cancer","volume":"2695","author":"Li","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Herrero, E., Serna-Blasco, R., Robado de Lope, L., Gonz\u00e1lez-Rumayor, V., Romero, A., and Provencio, M. (2022). Circulating Tumor DNA as a Cancer Biomarker: An Overview of Biological Features and Factors That may Impact on ctDNA Analysis. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.943253"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cccn.2004.04.023","article-title":"Diagnostic potential of breath analysis\u2014Focus on volatile organic compounds","volume":"347","author":"Miekisch","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1038\/s41467-018-07466-6","article-title":"Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease","volume":"9","author":"Moss","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1080\/15384047.2019.1598759","article-title":"Life and death of circulating cell-free DNA","volume":"20","author":"Kustanovich","year":"2019","journal-title":"Cancer Biol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gde.2016.12.003","article-title":"Circulating-tumor DNA as an early detection and diagnostic tool","volume":"42","author":"Butler","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_38","first-page":"203","article-title":"Detection of tumor-derived cell-free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluid","volume":"7","author":"Rovers","year":"2021","journal-title":"J. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13148-023-01518-5","article-title":"Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection","volume":"15","author":"Fang","year":"2023","journal-title":"Clin. Epigenetics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3892\/ol.2024.14681","article-title":"Liquid biopsy: Comprehensive overview of circulating tumor DNA (Review)","volume":"28","author":"Ge","year":"2024","journal-title":"Oncol. Lett."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-023-06225-y","article-title":"Practical recommendations for using ctDNA in clinical decision making","volume":"619","author":"Cohen","year":"2023","journal-title":"Nature"},{"key":"ref_42","first-page":"53","article-title":"Molecular residual Disease-guided adjuvant treatment in resected colorectal cancer: Focus on CIRCULATE-Japan","volume":"22","author":"Sato","year":"2023","journal-title":"Clin. Color. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"12695","DOI":"10.18632\/oncotarget.24268","article-title":"Detection of circulating tumor DNA in patients with osteosarcoma","volume":"9","author":"Barris","year":"2018","journal-title":"Oncotarget"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41551-021-00837-3","article-title":"Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics","volume":"6","author":"Song","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4103\/crst.crst_225_23","article-title":"The clinical utility of circulating tumor DNA in colorectal cancer: A narrative review","volume":"7","author":"Osumi","year":"2024","journal-title":"Cancer Res. Stat. Treat."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Rowlands, V., Rutkowski, A.J., Meuser, E., Carr, T.H., Harrington, E.A., and Barrett, J.C. (2019). Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-49043-x"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1373\/clinchem.2019.305805","article-title":"Comparison of BEAMing and Droplet Digital PCR for Circulating Tumor DNA Analysis","volume":"65","author":"Hrebien","year":"2019","journal-title":"Clin. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1126\/science.aar3247","article-title":"Detection and localization of surgically resectable cancers with a multi-analyte blood test","volume":"359","author":"Cohen","year":"2018","journal-title":"Science"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/1354750X.2024.2340663","article-title":"BCAT1, IKZF1 and SEPT9: Methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas","volume":"29","author":"Kichenadasse","year":"2024","journal-title":"Biomarkers"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s40291-020-00473-8","article-title":"Epi proColon\u00ae for Colorectal Cancer Screening: A Profile of Its Use in the USA","volume":"24","author":"Shirley","year":"2020","journal-title":"Mol. Diagn. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ned, R.M., Melillo, S., and Marrone, M. (2011). Fecal DNA testing for Colorectal Cancer Screening: The ColoSure\u2122 test. PLoS Curr., 3.","DOI":"10.1371\/currents.RRN1220"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Bao, H., Yang, S., Chen, X., Dong, G., Mao, Y., Wu, S., Cheng, X., Wu, X., Tang, W., and Wu, M. (2025). Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics. Nat. Med.","DOI":"10.1038\/s41591-025-03735-2"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/gutjnl-2024-333533","article-title":"Early detection of colorectal cancer using aberrant circulating cell-free mitochondrial DNA fragmentomics","volume":"74","author":"Wang","year":"2025","journal-title":"Gut"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/gutjnl-2014-308859","article-title":"Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery","volume":"65","author":"Reinert","year":"2016","journal-title":"Gut"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/jamaoncol.2019.0528","article-title":"Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer","volume":"5","author":"Reinert","year":"2019","journal-title":"JAMA Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"v867","DOI":"10.1093\/annonc\/mdz394.019","article-title":"Analysis of circulating tumour DNA (ctDNA) from patients enrolled in the IDEA-FRANCE phase III trial: Prognostic and predictive value for adjuvant treatment duration","volume":"30","author":"Taieb","year":"2019","journal-title":"Ann. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1001\/jamaoncol.2019.3616","article-title":"Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer","volume":"5","author":"Tie","year":"2019","journal-title":"JAMA Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Tie, J., Wang, Y., Cohen, J., Li, L., Hong, W., Christie, M., Wong, H.L., Kosmider, S., Wong, R., and Thomson, B. (2021). Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study. PLoS Med., 18.","DOI":"10.1371\/journal.pmed.1003620"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"346ra92","DOI":"10.1126\/scitranslmed.aaf6219","article-title":"Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer","volume":"8","author":"Tie","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41416-022-01769-8","article-title":"Liquid biopsies to monitor and direct cancer treatment in colorectal cancer","volume":"127","author":"Mauri","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.annonc.2020.06.022","article-title":"Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"31","author":"Tabernero","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/nm.1789","article-title":"Circulating mutant DNA to assess tumor dynamics","volume":"14","author":"Diehl","year":"2008","journal-title":"Nat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00384-024-04656-1","article-title":"Assessing circulating tumour DNA (ctDNA) as a prognostic biomarker in locally advanced rectal cancer: A systematic review and meta-analysis","volume":"39","author":"Temperley","year":"2024","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Negro, S., Pulvirenti, A., Trento, C., Indraccolo, S., Ferrari, S., Scarpa, M., Urso, E.D.L., Bergamo, F., Pucciarelli, S., and Deidda, S. (2025). Circulating Tumor DNA as a Real-Time Biomarker for Minimal Residual Disease and Recurrence Prediction in Stage II Colorectal Cancer: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26062486"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1007\/s00216-015-9200-6","article-title":"Detection of volatile organic compounds (VOCs) from exhaled breath as noninvasive methods for cancer diagnosis Young Investigators in Analytical and Bioanalytical Science","volume":"408","author":"Sun","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"E614","DOI":"10.1002\/ijc.29166","article-title":"Assessment of ovarian cancer conditions from exhaled breath","volume":"136","author":"Amal","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.cgh.2014.05.005","article-title":"The Scent of Colorectal Cancer: Detection by Volatile Organic Compound Analysis","volume":"12","author":"Oort","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Jia, Z., Jiang, Y., Shang, T., Cao, H., Li, J., Cong, L., Pu, P., Xu, H., Liu, Y., and Huang, Y. (2025). Advanced strategy for cancer detection based on volatile organic compounds in breath. J. Nanobiotechnology, 23.","DOI":"10.1186\/s12951-025-03526-4"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1021\/cr300174a","article-title":"Volatile Organic Compounds of Lung Cancer and Possible Biochemical Pathways","volume":"112","author":"Hakim","year":"2012","journal-title":"Chem. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wang, C., Sun, B., Guo, L., Wang, X., Ke, C., Liu, S., Zhao, W., Luo, S., Guo, Z., and Zhang, Y. (2014). Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy and Mammary Gland Fibroma. Sci. Rep., 4.","DOI":"10.1038\/srep05383"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"016015","DOI":"10.1088\/1752-7163\/aa5e76","article-title":"Exhaled breath and oral cavity VOCs as potential biomarkers in oral cancer patients","volume":"11","author":"Bouza","year":"2017","journal-title":"J. Breath Res."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Vernia, F., Valvano, M., Fabiani, S., Stefanelli, G., Longo, S., Viscido, A., and Latella, G. (2021). Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases?. Cancers, 13.","DOI":"10.3390\/cancers13102361"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2174\/1389203716666150630133657","article-title":"Metabolites of Dietary Protein and Peptides by Intestinal Microbes and their Impacts on Gut","volume":"16","author":"Fan","year":"2015","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3748\/wjg.v22.i2.501","article-title":"Gut microbiota imbalance and colorectal cancer","volume":"22","author":"Raisch","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"034001","DOI":"10.1088\/1752-7155\/8\/3\/034001","article-title":"The human volatilome: Volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva","volume":"8","author":"Amann","year":"2014","journal-title":"J. Breath Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1158\/1535-7163.363.3.3","article-title":"Cytochrome P450 enzymes: Novel options for cancer therapeutics","volume":"3","author":"McFadyen","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"ref_77","first-page":"2057","article-title":"Cytochrome P450: Polymorphisms and Roles in Cancer, Diabetes and Atherosclerosis","volume":"19","author":"Elfaki","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"034002","DOI":"10.1088\/1752-7163\/ab0bee","article-title":"The potential of breath analysis to improve outcome for patients with lung cancer","volume":"13","author":"Antoniou","year":"2019","journal-title":"J. Breath Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/codi.13271","article-title":"Volatile organic compounds as new biomarkers for colorectal cancer: A review","volume":"18","author":"Porcelli","year":"2016","journal-title":"Colorectal Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/apt.15622","article-title":"Volatile organic compounds in breath can serve as a non-invasive diagnostic biomarker for the detection of advanced adenomas and colorectal cancer","volume":"51","author":"Jansen","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/bjs.8942","article-title":"Exhaled volatile organic compounds identify patients with colorectal cancer","volume":"100","author":"Altomare","year":"2012","journal-title":"Br. J. Surg."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1007\/s00216-014-7865-x","article-title":"Noninvasive detection of colorectal cancer by analysis of exhaled breath","volume":"406","author":"Wang","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ags3.12056","article-title":"Detection of gas components as a novel diagnostic method for colorectal cancer","volume":"2","author":"Ishibe","year":"2018","journal-title":"Ann. Gastroenterol. Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/bjs5.50354","article-title":"Chemical signature of colorectal cancer: Case\u2013control study for profiling the breath print","volume":"4","author":"Altomare","year":"2020","journal-title":"BJS Open"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/SLA.0000000000001471","article-title":"Effects of Curative Colorectal Cancer Surgery on Exhaled Volatile Organic Compounds and Potential Implications in Clinical Follow-up","volume":"262","author":"Altomare","year":"2015","journal-title":"Ann. Surg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/SLA.0000000000002539","article-title":"Breath Volatile Organic Compound Profiling of Colorectal Cancer Using Selected Ion Flow-tube Mass Spectrometry","volume":"269","author":"Markar","year":"2019","journal-title":"Ann. Surg."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wang, Q., Fang, Y., Tan, S., Li, Z., Zheng, R., Ren, Y., Jiang, Y., and Huang, X. (2024). Diagnostic performance of volatile organic compounds analysis and electronic noses for detecting colorectal cancer: A systematic review and meta-analysis. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1397259"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Buszewski, B., Kesy, M., Ligor, T., and Amann, A. (2007). Human exhaled air analytics: Biomarkers of diseases. Biomed. Chromatogr., 21.","DOI":"10.1002\/bmc.835"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Xiang, L., Wu, S., Hua, Q., Bao, C., and Liu, H. (2021). Volatile Organic Compounds in Human Exhaled Breath to Diagnose Gastrointestinal Cancer: A Meta-Analysis. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.606915"},{"key":"ref_90","unstructured":"Shaji, J., and Jadhav, D. (2010). Breath biomarker for clinical diagnosis and different analysis technique. Res. J. Pharm. Biol. Chem. Sci., 1."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"037562","DOI":"10.1149\/1945-7111\/ab67a6","article-title":"Review\u2014Non-Invasive Monitoring of Human Health by Exhaled Breath Analysis: A Comprehensive Review","volume":"167","author":"Das","year":"2020","journal-title":"J. Electrochem. Soc."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3322\/caac.21670","article-title":"Metabolomics in cancer research and emerging applications in clinical oncology","volume":"71","author":"Schmidt","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s13238-015-0185-x","article-title":"Functional metabolomics: From biomarker discovery to metabolome reprogramming","volume":"6","author":"Peng","year":"2015","journal-title":"Protein Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tibs.2017.01.004","article-title":"Metabolomics: A Primer","volume":"42","author":"Liu","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s12264-012-1272-0","article-title":"Metabolomics: A novel approach to identify potential diagnostic biomarkers and pathogenesis in Alzheimer\u2019s disease","volume":"28","author":"Xu","year":"2012","journal-title":"Neurosci. Bull."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The Emerging Hallmarks of Cancer Metabolism","volume":"23","author":"Pavlova","year":"2016","journal-title":"Cell Metab."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2016.12.039","article-title":"Understanding the Intersections between Metabolism and Cancer Biology","volume":"168","author":"DeBerardinis","year":"2017","journal-title":"Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.chembiol.2017.08.028","article-title":"Targeting Metabolism for Cancer Therapy","volume":"24","author":"Luengo","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1158\/2159-8290.CD-16-0615","article-title":"Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions","volume":"6","author":"Vernieri","year":"2016","journal-title":"Cancer Discov."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e1600200","DOI":"10.1126\/sciadv.1600200","article-title":"Fundamentals of cancer metabolism","volume":"2","author":"DeBerardinis","year":"2016","journal-title":"Sci. Adv."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1158\/1078-0432.CCR-14-2425","article-title":"Metabolic Dependencies in RAS\u2014Driven Cancers","volume":"21","author":"Kimmelman","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1146\/annurev-biochem-082411-113907","article-title":"PTEN","volume":"83","author":"Worby","year":"2014","journal-title":"Annu. Rev. Biochem"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of Cancer: The Next Generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation","volume":"324","author":"Cantley","year":"2009","journal-title":"Science"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrc3038","article-title":"Otto Warburg\u2019s contributions to current concepts of cancer metabolism","volume":"11","author":"Koppenol","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.molcel.2020.12.012","article-title":"Increased demand for NAD+ relative to ATP drives aerobic glycolysis","volume":"81","author":"Luengo","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e27713","DOI":"10.7554\/eLife.27713","article-title":"Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition","volume":"6","author":"Muir","year":"2017","journal-title":"eLife"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2016.01.007","article-title":"Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer","volume":"23","author":"Davidson","year":"2016","journal-title":"Cell Metab."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"15965","DOI":"10.1038\/ncomms15965","article-title":"Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism","volume":"8","author":"Biancur","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"13041","DOI":"10.1038\/ncomms13041","article-title":"Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival","volume":"7","author":"Gaude","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.aaf5171","article-title":"Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers","volume":"353","author":"Mayers","year":"2016","journal-title":"Science"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nbt.2530","article-title":"Heterogeneity of tumor-induced gene expression changes in the human metabolic network","volume":"31","author":"Hu","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s42255-020-00317-z","article-title":"Metabolites and the tumour microenvironment: From cellular mechanisms to systemic metabolism","volume":"3","author":"Elia","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.tcb.2017.06.003","article-title":"Metabolic Interactions in the Tumor Microenvironment","volume":"27","author":"Lyssiotis","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41580-019-0108-4","article-title":"Identification of bioactive metabolites using activity metabolomics","volume":"20","author":"Rinschen","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1021\/pr3010106","article-title":"1H HR-MAS NMR Spectroscopy of Tumor-Induced Local Metabolic \u201cField-Effects\u201d Enables Colorectal Cancer Staging and Prognostication","volume":"12","author":"Mirnezami","year":"2013","journal-title":"J. Proteome Res."},{"key":"ref_117","first-page":"785","article-title":"The applications of metabolomics in the molecular diagnostics of cancer. Expert Rev","volume":"19","author":"Cheung","year":"2019","journal-title":"Mol. Diagn."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1074\/mcp.M113.030387","article-title":"Investigations on Aberrant Glycosylation of Glycosphingolipids in Colorectal Cancer Tissues Using Liquid Chromatography and Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry (MALDI-TOF-MS)","volume":"12","author":"Holst","year":"2013","journal-title":"Mol. Cell Proteom."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1021\/pr400337b","article-title":"Metabonomics Identifies Serum Metabolite Markers of Colorectal Cancer","volume":"12","author":"Tan","year":"2013","journal-title":"J. Proteome Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.3748\/wjg.v26.i20.2514","article-title":"Metabolomics profile in gastrointestinal cancers: Update and future perspectives","volume":"26","author":"Nannini","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1634\/theoncologist.2010-0025","article-title":"A Review of the Most Promising Biomarkers in Colorectal Cancer: One Step Closer to Targeted Therapy","volume":"15","author":"Deschoolmeester","year":"2010","journal-title":"Oncologist"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"869","DOI":"10.12998\/wjcc.v6.i15.869","article-title":"Biomarkers in colorectal cancer: Current clinical utility and future perspectives","volume":"6","author":"Vacante","year":"2018","journal-title":"World J. Clin. Cases"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1200\/JCO.2016.71.9807","article-title":"Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and the American Society of Clinical Oncology","volume":"35","author":"Sepulveda","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"283ra53","DOI":"10.1126\/scitranslmed.aaa7161","article-title":"Personalized genomic analyses for cancer mutation discovery and interpretation","volume":"7","author":"Jones","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.2013.276573","article-title":"Revealing the Incidentalome When Targeting the Tumor Genome","volume":"310","author":"Bombard","year":"2013","journal-title":"JAMA"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Migliore, L., Migheli, F., Spisni, R., and Copped\u00e8, F. (2011). Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer. J. Biomed. Biotechnol., 2011.","DOI":"10.1155\/2011\/792362"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3748\/wjg.v20.i4.943","article-title":"Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer","volume":"20","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"120","DOI":"10.20892\/j.issn.2095-3941.2015.0103","article-title":"Colorectal cancer carcinogenesis: A review of mechanisms","volume":"13","author":"Tariq","year":"2016","journal-title":"Cancer Biol. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"18654","DOI":"10.1073\/pnas.0704652104","article-title":"Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer","volume":"104","author":"Shen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2012.06.008","article-title":"Cancer Genetics and Epigenetics: Two Sides of the Same Coin?","volume":"22","author":"You","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/DCR.0000000000001322","article-title":"Detection of Pathogenic Germline Variants Among Patients With Advanced Colorectal Cancer Undergoing Tumor Genomic Profiling for Precision Medicine","volume":"62","author":"You","year":"2019","journal-title":"Dis. Colon Rectum"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/gim.2016.190","article-title":"Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): A policy statement of the American College of Medical Genetics and Genomics","volume":"19","author":"Kalia","year":"2017","journal-title":"Genet. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1200\/JCO.2015.63.0996","article-title":"American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility","volume":"33","author":"Robson","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/jama.2017.11137","article-title":"Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing","volume":"318","author":"Mandelker","year":"2017","journal-title":"JAMA"},{"key":"ref_135","first-page":"2044","article-title":"Hereditary and Familial Colon Cancer","volume":"138","author":"Jasperson","year":"2010","journal-title":"J. Gastroenterol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Su, M.W., Chang, C.K., Lin, C.W., Chu, H.W., Tsai, T.N., Su, W.C., Chen, Y.C., Chang, T.K., Huang, C.W., and Tsai, H.L. (2022). Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers. Cells, 11.","DOI":"10.3390\/cells11030527"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00428-009-0857-0","article-title":"Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers","volume":"455","author":"Kim","year":"2009","journal-title":"Virchows. Archiv."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1440-1827.2007.02197.x","article-title":"Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS\/BRAF mutation","volume":"58","author":"Lee","year":"2008","journal-title":"Pathol. Int."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1111\/j.1572-0241.2008.02088.x","article-title":"A Simplified, Noninvasive Stool DNA Test for Colorectal Cancer Detection","volume":"103","author":"Itzkowitz","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1038\/ctg.2016.66","article-title":"Diagnostic Accuracy of Methylated SEPT9 for Blood-based Colorectal Cancer Detection: A Systematic Review and Meta-Analysis. Clin","volume":"8","author":"Nian","year":"2017","journal-title":"Transl. Gastroenterol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Perez-Carbonell, L., Balaguer, F., Toiyama, Y., Egoavil, C., Rojas, E., Guarinos, C., Andreu, M., Llor, X., Castells, A., and Jover, R. (2014). IGFBP3 Methylation Is a Novel Diagnostic and Predictive Biomarker in Colorectal Cancer. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104285"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"18698","DOI":"10.18632\/oncotarget.24617","article-title":"Consensus molecular subtypes classification of colorectal cancer as a predictive factor for chemotherapeutic efficacy against metastatic colorectal cancer","volume":"9","author":"Okita","year":"2018","journal-title":"Oncotarget"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/bjc.2017.398","article-title":"How the evolution of multicellularity set the stage for cancer","volume":"118","author":"Trigos","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"eaay9691","DOI":"10.1126\/sciadv.aay9691","article-title":"The clonal evolution of metastatic colorectal cancer","volume":"26","author":"Dang","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Network (2012). Comprehensive molecular characterization of human colon and rectal cancer. Nature, 487, 330\u2013337.","DOI":"10.1038\/nature11252"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.molonc.2012.10.006","article-title":"Epigenetic alterations involved in cancer stem cell reprogramming","volume":"6","author":"Iliou","year":"2012","journal-title":"Mol. Oncol."},{"key":"ref_147","unstructured":"(2025, June 25). Clinomics Inc. Available online: https:\/\/www.emis.com\/php\/company-profile\/KR\/Clinomics_Inc_en_12001806.html."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0140-6736(23)02830-1","article-title":"GRAIL-Galleri: Why the special treatment?","volume":"403","author":"Turnbull","year":"2024","journal-title":"Lancet"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Yang, H.H., and Han, M.R. (2024). MethylCallR: A comprehensive analysis framework for Illumina Methylation Beadchip. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-77914-5"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2333660","DOI":"10.1080\/15592294.2024.2333660","article-title":"Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays","volume":"19","author":"Zhang","year":"2024","journal-title":"Epigenetics"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Pidsley, R., Wong, C.C.Y., Volta, M., Lunnon, K., Mill, J., and Schalkwyk, L.C. (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genom., 14.","DOI":"10.1186\/1471-2164-14-293"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s43682-023-00021-5","article-title":"Comprehensive Evaluation of The Infinium Human MethylationEPIC v2 BeadChip","volume":"3","author":"Kaur","year":"2023","journal-title":"Epigenetics Commun."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Kho, Z.Y., and Lal, S.K. (2018). The human gut microbiome\u2014A potential controller of wellness and disease. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01835"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/s12967-021-03154-0","article-title":"Analysis of changes in microbiome compositions related to the prognosis of colorectal cancer patients based on tissue-derived 16S rRNA sequences","volume":"19","author":"Choi","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Parker, B.J., Wearsch, P.A., Veloo, A.C.M., and Rodriguez-Palacios, A. (2020). The genus Alistipes: Gut bacteria with emerging implications to inflammation, cancer, and mental health. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00906"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"McGowan, E.M., Lin, Y., and Chen, S. (2022). Targeting chronic inflammation of the digestive system in cancer prevention: Modulators of the bioactive sphingolipid sphingosine-1-Phosphate pathway. Cancers, 14.","DOI":"10.3390\/cancers14030535"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Zhang, H., Zuo, L., Li, J., Geng, Z., Ge, S., Song, X., Wang, Y., Zhang, X., Wang, L., and Zhao, T. (2023). Construction of a fecal immune-related protein-based biomarker panel for colorectal cancer diagnosis: A multicenter study. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1126217"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"8382","DOI":"10.4049\/jimmunol.181.12.8382","article-title":"Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress","volume":"181","author":"Ando","year":"2008","journal-title":"J. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Rico, G., Drago-Serrano, M.E., Le\u00f3n-Sicairos, N., and de la Garza, M. (2022). Lactoferrin: A nutraceutical with activity against colorectal cancer. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.855852"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13073-020-00780-z","article-title":"Small-molecule MMP2\/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1","volume":"12","author":"Ye","year":"2020","journal-title":"Genome Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1161\/CIRCRESAHA.122.321295","article-title":"Retinol and retinol binding protein 4 levels and cardiometabolic disease risk","volume":"131","author":"Schiborn","year":"2022","journal-title":"Circ. Res."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Soman, A., and Asha Nair, S. (2022). Unfolding the cascade of SERPINA3: Inflammation to cancer. Biochim. Biophys. Acta (BBA) Rev. Cancer, 1877.","DOI":"10.1016\/j.bbcan.2022.188760"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.semcancer.2021.03.011","article-title":"An integrated workflow for biomarker development using microRNAs in extracellular vesicles for cancer precision medicine","volume":"74","author":"Chen","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41375-020-01104-1","article-title":"Clinical relevance of extracellular vesicles in hematological neoplasms: From liquid biopsy to cell biopsy","volume":"35","author":"Trino","year":"2021","journal-title":"Leukemia"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Ogata-Kawata, H., Izumiya, M., Kurioka, D., Honma, Y., Yamada, Y., Furuta, K., Gunji, T., Ohta, H., Okamoto, H., and Sonoda, H. (2014). Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092921"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Shi, X., Zhao, X., Xue, J., and Jia, E. (2024). Extracellular vesicle biomarkers in circulation for colorectal cancer detection: A systematic review and meta-analysis. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12312-8"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Wu, Z., Xu, Z., Yu, B., Zhang, J., and Yu, B. (2020). The Potential Diagnostic Value of Exosomal Long Noncoding RNAs in Solid Tumors: A Meta-Analysis and Systematic Review. Biomed. Res. Int., 2020.","DOI":"10.1155\/2020\/6786875"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Liu, S.Y., Liao, Y., Hosseinifard, H., Imani, S., and Wen, Q.L. (2021). Diagnostic Role of Extracellular Vesicles in Cancer: A Comprehensive Systematic Review and Meta-Analysis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.705791"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1245\/s10434-022-12641-7","article-title":"Circulating Tumor DNA, Imaging, and Carcinoembryonic Antigen: Comparison of Surveillance Strategies Among Patients Who Underwent Resection of Colorectal Cancer-A Systematic Review and Meta-analysis","volume":"30","author":"Dawood","year":"2023","journal-title":"Ann. Surg. Oncol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.annonc.2023.09.3113","article-title":"High accuracy of a blood ctDNA-based multimodal test to detect colorectal cancer","volume":"34","author":"Bessa","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"S-978","DOI":"10.1016\/S0016-5085(24)02723-9","article-title":"Mo123 Volatile organic compounds as biomarkers for non-invasive detection of colorectal cancer: A systematic review and diagnostic accuracy meta-analysis","volume":"166","author":"Elhadi","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.2217\/fon.10.107","article-title":"Metabolomics and detection of colorectal cancer in humans: A systematic review","volume":"6","author":"Wang","year":"2010","journal-title":"Future Oncol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1609784","DOI":"10.3389\/pore.2021.1609784","article-title":"Integrative Analysis of DNA Methylation and Gene Expression Profiles Identifies Colorectal Cancer-Related Diagnostic Biomarkers","volume":"27","author":"Xu","year":"2021","journal-title":"Pathol. Oncol. Res."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Wang, Y., Zhang, B., Li, P., and Zhao, Y. (2023). Methods and biomarkers for early detection, prediction, and diagnosis of colorectal cancer. Biomed. Pharmacother., 163.","DOI":"10.1016\/j.biopha.2023.114786"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"\u017ddralevi\u0107, M., Radovi\u0107, A., Raoni\u0107, J., Popovic, N., Klisic, A., and Vu\u010dkovi\u0107, L. (2024). Advances in microRNAs as Emerging Biomarkers for Colorectal Cancer Early Detection and Diagnosis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252011060"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Dohmen, J., Semaan, A., Kobilay, M., Zaleski, M., Branchi, V., Schlierf, A., Hettwer, K., Uhlig, S., Hartmann, G., and Kalff, J.C. (2022). Diagnostic Potential of Exosomal microRNAs in Colorectal Cancer. Diagnostics, 12.","DOI":"10.3390\/diagnostics12061413"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Li, Y., Luo, Y., Ran, Y., Lu, F., and Qin, Y. (2025). Biomarkers of inflammation and colorectal cancer risk. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1514009"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Medici, B., Benatti, S., Dominici, M., and Gelsomino, F. (2025). New Frontiers of Biomarkers in Metastatic Colorectal Cancer: Potential and Critical Issues. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26115268"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"100868","DOI":"10.1016\/j.neo.2022.100868","article-title":"A systematic review of microbiome-derived biomarkers for early colorectal cancer detection","volume":"36","author":"Sivov","year":"2023","journal-title":"Neoplasia"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"e70641","DOI":"10.1002\/cam4.70641","article-title":"Health Economic Evaluations of Circulating Tumor DNA Testing for Cancer Screening: Systematic Review","volume":"14","author":"Rui","year":"2025","journal-title":"Cancer Med."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Golfinopoulou, R., Hatziagapiou, K., Mavrikou, S., and Kintzios, S. (2024). Unveiling Colorectal Cancer Biomarkers: Harnessing Biosensor Technology for Volatile Organic Compound Detection. Sensors, 24.","DOI":"10.3390\/s24144712"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejca.2023.03.002","article-title":"Urinary volatile organic compounds for colorectal cancer screening: A systematic review and meta-analysis","volume":"186","author":"Bosch","year":"2023","journal-title":"Eur. J. Cancer"},{"key":"ref_183","first-page":"795","article-title":"Exhaled volatile organic compounds in the detection of colorectal cancer: A systematic review and meta-analysis","volume":"23","author":"Alsaadi","year":"2024","journal-title":"EXCLI J."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1200\/JCO.21.02615","article-title":"Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices","volume":"40","author":"Malla","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2217\/pgs-2018-0155","article-title":"Integrating metabolomics with genomics","volume":"19","author":"Telenti","year":"2018","journal-title":"Pharmacogenomics"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e805","DOI":"10.1002\/ctm2.805","article-title":"Discovery of plasma biomarkers for colorectal cancer diagnosis via untargeted and targeted quantitative metabolomics","volume":"12","author":"Wang","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1053\/j.gastro.2024.03.011","article-title":"Comparative Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With Blood-Based Biomarkers (Liquid Biopsy) vs. Fecal Tests or Colonoscopy","volume":"167","author":"Ladabaum","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e2343392","DOI":"10.1001\/jamanetworkopen.2023.43392","article-title":"Cost-Effectiveness of Liquid Biopsy for Colorectal Cancer Screening in Patients Who Are Unscreened","volume":"6","author":"Aziz","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1586\/14737159.2016.1156535","article-title":"Exosomal microRNA Biomarkers: Emerging Frontiers in Colorectal and Other Human Cancers","volume":"16","author":"Toden","year":"2016","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1111\/jgh.15033","article-title":"Cost-effectiveness analysis of colorectal cancer screening using colonoscopy, fecal immunochemical test, and risk score","volume":"35","author":"Sekiguchi","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1053\/j.gastro.2022.06.089","article-title":"Liquid Biopsy Signature for the Detection of Patients With Early-Onset Colorectal Cancer","volume":"163","author":"Nakamura","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/jcag\/gwad014","article-title":"Cost-effectiveness of Artificial Intelligence-Aided Colonoscopy for Adenoma Detection in Colon Cancer Screening","volume":"6","author":"Barkun","year":"2023","journal-title":"J. Can. Assoc. Gastroenterol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/j.gastro.2020.04.062","article-title":"Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial","volume":"159","author":"Repici","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s00535-021-01808-w","article-title":"Reducing adenoma miss rate of colonoscopy assisted by artificial intelligence: A multicenter randomized controlled trial","volume":"56","author":"Kamba","year":"2021","journal-title":"J. Gastroenterol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13045-023-01514-5","article-title":"Novel research and future prospects of artificial intelligence in cancer diagnosis and treatment","volume":"16","author":"Zhang","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Ferrari, A., Neefs, I., Hoeck, S., Peeters, M., and Van Hal, G. (2021). Towards novel non-invasive colorectal cancer screening methods: A comprehensive review. Cancers, 13.","DOI":"10.20944\/preprints202103.0448.v1"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Su, Y., Tian, X., Gao, R., Guo, W., Cheng, C., Chen, C., Jia, D., Li, H., and Lv, X. (2022). Colon cancer diagnosis and staging classification based on machine learning and bioinformatics analysis. Comput. Biol. Med., 145.","DOI":"10.1016\/j.compbiomed.2022.105409"},{"key":"ref_198","first-page":"167","article-title":"Circulating tumor DNA as a biomarker of prognosis prediction in colorectal cancer: A systematic review and meta-analysis","volume":"5","author":"Zhou","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Radhakrishnan, S.K., Nath, D., Russ, D., Merodio, L.B., Lad, P., Daisi, F.K., and Acharjee, A. (2025). Machine learning-based identification of proteomic markers in colorectal cancer using UK Biobank data. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1505675"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"e70175","DOI":"10.1002\/ctm2.70175","article-title":"Immune profiling of the macroenvironment in colorectal cancer unveils systemic dysfunction and plasticity of immune cells","volume":"15","author":"Ke","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Bahado-Singh, R., Vlachos, K.T., Aydas, B., Gordevicius, J., Radhakrishna, U., and Vishweswaraiah, S. (2022). Precision Oncology: Artificial Intelligence and DNA Methylation Analysis of Circulating Cell-Free DNA for Lung Cancer Detection. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.790645"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Yang, H., Yang, M., Chen, J., Yao, G., Zou, Q., and Jia, L. (2024). Multimodal deep learning approaches for precision oncology: A comprehensive review. Brief. Bioinform., 26.","DOI":"10.1093\/bib\/bbae699"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e436","DOI":"10.1016\/S2589-7500(22)00042-5","article-title":"Cost-effectiveness of artificial intelligence for screening colonoscopy: A modelling study","volume":"4","author":"Areia","year":"2022","journal-title":"Lancet Digit. Health"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/0969141319898732","article-title":"Economic evaluation of colorectal cancer screening programs: Affordability for the health service","volume":"27","author":"Coretti","year":"2020","journal-title":"J. Med. Screen."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Young, E., Edwards, L., and Singh, R. (2023). The Role of Artificial Intelligence in Colorectal Cancer Screening: Lesion Detection and Lesion Characterization. Cancers, 15.","DOI":"10.3390\/cancers15215126"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.3390\/curroncol28030149","article-title":"Artificial Intelligence in Colorectal Cancer Screening, Diagnosis and Treatment. A New Era","volume":"28","author":"Mitsala","year":"2021","journal-title":"Curr. Oncol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/7\/1100\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:09:32Z","timestamp":1760033372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/7\/1100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":206,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["life15071100"],"URL":"https:\/\/doi.org\/10.3390\/life15071100","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]}}}