{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:33:12Z","timestamp":1788582792808,"version":"build-2803163510"},"reference-count":25,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Lung cancer is one of the most common and deadly forms of cancer worldwide, despite sustained efforts to encourage smoking cessation and raise awareness of the risk factors. In Romania, lung cancer is a significant health challenge, being the leading cause of death caused by cancer, especially amongst men. The incidence of lung cancer in connective tissue disease (CTD) varies in different studies from 4.5% in rheumatoid arthritis (RA), to 4.4% in polymyositis or dermatomyositis, and up to 11.1% in systemic sclerosis. However, older studies have shown an increased risk of cancer in patients with rheumatoid arthritis (RA), ranging from 10% to 30% compared to the general population, particularly in those undergoing methotrexate therapy. Rheumatoid arthritis affects approximately 40 per 100,000 people annually worldwide, with a three- to four-fold higher incidence in women. Non-small cell lung cancer (NSCLC), the most common lung cancer subtype, has been linked to RA, yet the association remains poorly defined, with limited insight into the underlying molecular mechanisms. We present the case of a 61-year-old male with a 49-pack-year smoking history and a known diagnosis of rheumatoid arthritis, currently managed with methotrexate therapy. He was admitted for evaluation due to a progressive decline in general condition, characterized by worsening dyspnea and chest pain, symptoms that had been longstanding but had markedly exacerbated over the past two weeks. Based on a chest CT performed prior to the patient\u2019s admission to our clinic, subsequent diagnostic investigations established the diagnosis of pulmonary adenocarcinoma. The diagnostic process proved to be particularly challenging due to the presence of multiple comorbidities, which significantly impacted both the diagnostic approach and the overall clinical trajectory.<\/jats:p>","DOI":"10.3390\/life15071118","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T10:33:47Z","timestamp":1752748427000},"page":"1118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Beyond Comorbidity: Pulmonary Adenocarcinoma in a Patient with Rheumatoid Arthritis\u2014A Case Report and Literature Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6742-6334","authenticated-orcid":false,"given":"Ancu\u021ba-Alina","family":"Constantin","sequence":"first","affiliation":[{"name":"Department of Cardio-Thoracic Pathology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Institute of Pneumology \u201cMarius Nasta\u201d, 050159 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai Alexandru","family":"Arghir","sequence":"additional","affiliation":[{"name":"Institute of Pneumology \u201cMarius Nasta\u201d, 050159 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Avasilc\u0103i","sequence":"additional","affiliation":[{"name":"Institute of Pneumology \u201cMarius Nasta\u201d, 050159 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-9545","authenticated-orcid":false,"given":"Florin-Dumitru","family":"Mih\u0103l\u021ban","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Pathology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Institute of Pneumology \u201cMarius Nasta\u201d, 050159 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"ref_1","unstructured":"Myers, D.J., and Wallen, J.M. (2025). Lung Adenocarcinoma. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_2","first-page":"375","article-title":"Lung Cancer in Non-Smokers","volume":"117","author":"Dubin","year":"2020","journal-title":"Mo. Med."},{"key":"ref_3","first-page":"5","article-title":"Adenocarcinoma classification: Patterns and prognosis","volume":"110","author":"Kuhn","year":"2018","journal-title":"Pathologica"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100768","DOI":"10.1016\/j.lanepe.2023.100768","article-title":"Risk of cancer for patients with rheumatoid arthritis versus general population: A national claims database cohort study","volume":"35","author":"Beydon","year":"2023","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101964","DOI":"10.1016\/j.tranon.2024.101964","article-title":"Identification of potential hub genes and biological mechanism in rheumatoid arthritis and non-small cell lung cancer via integrated bioinformatics analysis","volume":"45","author":"An","year":"2024","journal-title":"Transl. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/ar2404","article-title":"A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis","volume":"10","author":"Smitten","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e002465","DOI":"10.1136\/rmdopen-2022-002465","article-title":"Risk of lung cancer in rheumatoid arthritis and in relation to autoantibody positivity and smoking","volume":"8","author":"Chatzidionysiou","year":"2022","journal-title":"RMD Open"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Garc\u00eda, M.\u00c1., Gaga, M., and Fong, K.M. (2022). Other interstitial lung diseases: The risk of cancer and the impact on cancer care. Lung Diseases and Cancer, European Respiratory Society.","DOI":"10.1183\/2312508X.erm9822"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Smolarz, B., \u0141ukasiewicz, H., Samulak, D., Piekarska, E., Ko\u0142aci\u0144ski, R., and Romanowicz, H. (2025). Lung Cancer\u2014Epidemiology, Pathogenesis, Treatment and Molecular Aspect (Review of Literature). Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26052049"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1186\/ar4498","article-title":"Cigarette smoking and risk of rheumatoid arthritis: A dose-response meta-analysis","volume":"16","author":"Discacciati","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/thx.2003.018291","article-title":"COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma","volume":"59","author":"Papi","year":"2004","journal-title":"Thorax"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.rmed.2009.11.025","article-title":"Link between COPD and lung cancer","volume":"104","author":"Young","year":"2010","journal-title":"Respir. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.lungcan.2015.08.017","article-title":"The relationship between COPD and lung cancer","volume":"90","author":"Durham","year":"2015","journal-title":"Lung Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.lungcan.2014.10.004","article-title":"COPD-related adenocarcinoma presents low aggressiveness morphological and molecular features compared to smoker tumours","volume":"86","author":"Schiavon","year":"2014","journal-title":"Lung Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jss.2015.09.004","article-title":"Pulmonary emphysema and tumor microenvironment in primary lung cancer","volume":"200","author":"Murakami","year":"2016","journal-title":"J. Surg. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"776","DOI":"10.7326\/0003-4819-157-11-201212040-00005","article-title":"Estimating overdiagnosis in low-dose computed tomography screening for lung cancer: A cohort study","volume":"157","author":"Veronesi","year":"2012","journal-title":"Ann. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"18513","DOI":"10.18632\/oncotarget.14505","article-title":"Lung cancer and chronic obstructive pulmonary disease: From a clinical perspective","volume":"8","author":"Dai","year":"2017","journal-title":"Oncotarget"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jtho.2023.10.006","article-title":"Rheumatoid Arthritis and Risk of Lung Cancer: A Nationwide Cohort Study","volume":"19","author":"Cho","year":"2024","journal-title":"J. Thorac. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s41065-025-00396-6","article-title":"Exploring the association between rheumatoid arthritis and non-small cell lung cancer risk: A transcriptomic and drug target-based analysis","volume":"162","author":"Wang","year":"2025","journal-title":"Hereditas"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"594","DOI":"10.33192\/Smj.2021.77","article-title":"Differentiation Between the Malignant Mesothelioma of Pleura and Pleural Metastasis with Contrast Enhanced CT, Is It Possible?","volume":"73","author":"Butnian","year":"2021","journal-title":"Siriraj Med. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e11383","DOI":"10.1016\/j.heliyon.2022.e11383","article-title":"Differentiating malignant pleural mesothelioma and metastatic pleural disease based on a machine learning model with primary CT signs: A multicentre study","volume":"8","author":"Li","year":"2022","journal-title":"Heliyon"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.radcr.2022.11.049","article-title":"Pleural metastasis of pulmonary adenocarcinoma mimicking diffuse mesothelioma: A case report and literature study","volume":"18","author":"Shalahuddin","year":"2022","journal-title":"Radiol. Case Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3348\/kjr.2016.17.4.545","article-title":"Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea","volume":"17","author":"Kim","year":"2016","journal-title":"Korean J. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"A752","DOI":"10.1016\/j.chest.2017.08.782","article-title":"Clinical and Imaging Features Distinguish Rheumatoid Pulmonary Nodules From Malignancy in Rheumatoid Patients","volume":"152","author":"Koslow","year":"2017","journal-title":"Chest"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1759720X20981221","DOI":"10.1177\/1759720X20981221","article-title":"Methotrexate at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with rheumatoid arthritis: A nationwide population-based cohort study","volume":"12","author":"Perng","year":"2020","journal-title":"Ther. Adv. Musculoskelet. Dis."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/7\/1118\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:11:03Z","timestamp":1760033463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/7\/1118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":25,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["life15071118"],"URL":"https:\/\/doi.org\/10.3390\/life15071118","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]}}}