{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:25:49Z","timestamp":1777044349418,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Oradea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>A psoriasis vulgaris flare is characterized by a rapid intensification of symptoms, which is often triggered by various factors that can worsen the condition. The risk factors for these exacerbations are numerous and include obesity, antihypertensive drugs, and psychological stress. Moreover, links have been documented between type II diabetes, hypertension, and psoriasis vulgaris. The present case report describes a 52-year-old female patient who presented at the clinic with disseminated erythematous-squamous plaques and patches covered by thick, white-pearly, easily detachable scales, along with stress, fatigue, anxiety, severe pruritus, irritability, insomnia, and decreased self-esteem. Her past medical regimen included various conventional topical options, including calcipotriol combined with betamethasone, clobetasol, betamethasone combined with salicylic acid, and betamethasone combined with gentamicin, yet the condition remained refractory, with periodic flare-ups. The integrated and personalized therapeutic approach aimed to target both the dermatological issues and the associated systemic and psychological factors contributing to the condition. The therapeutic strategy implemented in this case combined psychological counseling sessions, a very low-calorie ketogenic diet, oral supplementation with anti-inflammatory and antioxidant vitamins and minerals, topical treatments utilizing urea and Dead Sea-mineral-based formulations, and rosemary extract-based scalp care, without requiring additional conventional treatment. This comprehensive approach led to significant improvement, ultimately achieving complete remission of the patient\u2019s psoriasis. The associated comorbidities were well controlled with the specified medication, without any further complications. Thus, the importance of alternative options was emphasized, particularly in the context of an incurable disease, along with the need for continued research to improve the ongoing therapeutic management of psoriasis vulgaris. Such approaches are essential to reducing the risk of flare-ups and to achieving better management of associated risk factors.<\/jats:p>","DOI":"10.3390\/life15081186","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T14:40:02Z","timestamp":1753454402000},"page":"1186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Multimodal Approach to Managing Severe Psoriasis Vulgaris: A Case Report Leveraging Natural Therapies for Flare Control"],"prefix":"10.3390","volume":"15","author":[{"given":"Ada","family":"Radu","sequence":"first","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-7826","authenticated-orcid":false,"given":"Tunde","family":"Jurca","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7625-8177","authenticated-orcid":false,"given":"Andrei-Flavius","family":"Radu","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora Maria","family":"Bodog","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruxandra Florina","family":"Bodog","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Endres","sequence":"additional","affiliation":[{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"},{"name":"Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s12016-024-08991-7","article-title":"The Immunology of Psoriasis-Current Concepts in Pathogenesis","volume":"66","author":"Sieminska","year":"2024","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kimmel, G.W., and Lebwohl, M. (2018). Psoriasis: Overview and Diagnosis. Evidence-Based Psoriasis Diagnosis and Treatment, Springer.","DOI":"10.1007\/978-3-319-90107-7_1"},{"key":"ref_3","first-page":"79","article-title":"A Brief Summary of Clinical Types of Psoriasis","volume":"3","author":"Sarac","year":"2016","journal-title":"North Clin. Istanb."},{"key":"ref_4","first-page":"278","article-title":"Diagnosis and Management of Psoriasis","volume":"63","author":"Kim","year":"2017","journal-title":"Can. Fam. Physician"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/ijd.ijd_420_23","article-title":"Disease Assessment in Psoriasis","volume":"68","author":"Manchanda","year":"2023","journal-title":"Indian J. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Campanati, A., Marani, A., Martina, E., Diotallevi, F., Radi, G., and Offidani, A. (2021). Psoriasis as an Immune-Mediated and Inflammatory Systemic Disease: From Pathophysiology to Novel Therapeutic Approaches. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111511"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kim, J., Moreno, A., and Krueger, J.G. (2022). The Imbalance between Type 17 T-Cells and Regulatory Immune Cell Subsets in Psoriasis Vulgaris. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1005115"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113388","DOI":"10.1016\/j.intimp.2024.113388","article-title":"Current Therapeutic Overview and Future Perspectives Regarding the Treatment of Psoriasis","volume":"143","author":"Ferrara","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jaad.2020.07.087","article-title":"Joint AAD\u2013NPF Guidelines of Care for the Management and Treatment of Psoriasis with Topical Therapy and Alternative Medicine Modalities for Psoriasis Severity Measures","volume":"84","author":"Elmets","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/1574886315666200128095958","article-title":"Treatment of Psoriasis: A Comprehensive Review of Entire Therapies","volume":"15","author":"Bakshi","year":"2020","journal-title":"Curr. Drug Saf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/jdv.18126","article-title":"Prevalence and Characterization of Treatment-Refractory Psoriasis and Super-Responders to Biologic Treatment: A Nationwide Study","volume":"36","author":"Loft","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s10787-024-01602-z","article-title":"Naturally Derived Bioactive Compounds as Precision Modulators of Immune and Inflammatory Mechanisms in Psoriatic Conditions","volume":"33","author":"Radu","year":"2024","journal-title":"Inflammopharmacology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3923\/pjbs.2012.306.315","article-title":"Histological Evaluation of the Healing Properties of Dead Sea Black Mud on Full-Thickness Excision Cutaneous Wounds in BALB\/c Mice","volume":"15","year":"2012","journal-title":"Pakistan J. Biol. Sci. PJBS"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2147\/PTT.S328581","article-title":"Dietary Intervention and Supplements in the Management of Psoriasis: Current Perspectives","volume":"12","author":"Chung","year":"2022","journal-title":"Psoriasis"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/ijd.14032","article-title":"Stress and Psoriasis","volume":"57","author":"Rousset","year":"2018","journal-title":"Int. J. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Rudnicka, L., Olszewska, M., Goldust, M., Wa\u015bkiel-Burnat, A., Warszawik-Hendzel, O., Doro\u017cy\u0144ski, P., Tur\u0142o, J., and Rakowska, A. (2021). Efficacy and Safety of Different Formulations of Calcipotriol\/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment. J. Clin. Med., 10.","DOI":"10.3390\/jcm10235589"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Gisondi, P., Gracia-Caza\u00f1a, T., Kurzen, H., and Galv\u00e1n, J. (2024). Calcipotriol\/Betamethasone Dipropionate for the Treatment of Psoriasis: Mechanism of Action and Evidence of Efficacy and Safety versus Topical Corticosteroids. J. Clin. Med., 13.","DOI":"10.3390\/jcm13154484"},{"key":"ref_18","first-page":"22","article-title":"Topical Corticosteroid Therapy for Psoriasis\u2014A Review of Clobetasol Propionate 0.025% Cream and the Clinical Relevance of Penetration Modification","volume":"13","year":"2020","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.2147\/IJN.S345430","article-title":"Cubosomal Betamethasone-Salicylic Acid Nano Drug Delivery System for Enhanced Management of Scalp Psoriasis","volume":"17","author":"Shalaby","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Dallo, M., Patel, K., and Hebert, A.A. (2023). Topical Antibiotic Treatment in Dermatology. Antibiotics, 12.","DOI":"10.3390\/antibiotics12020188"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000530180","article-title":"Individualized Homeopathic Medicines in the Treatment of Psoriasis Vulgaris: Double-Blind, Randomized, Placebo-Controlled Trial","volume":"30","author":"Balamurugan","year":"2023","journal-title":"Complement. Med. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"General Assembly of the World Medical Association (2014). World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. J. Am. Coll. Dent., 81, 14\u201318.","DOI":"10.1515\/jwiet-2014-0117"},{"key":"ref_23","first-page":"560","article-title":"Plaque Psoriasis","volume":"19","author":"Badri","year":"2023","journal-title":"Pract. Nurs."},{"key":"ref_24","first-page":"101879","article-title":"Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis","volume":"2015","author":"Cabaleiro","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2147\/PTT.S323281","article-title":"Risk Factors for Psoriasis Flares: A Narrative Review","volume":"14","author":"Potestio","year":"2024","journal-title":"Psoriasis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e70019","DOI":"10.1111\/apha.70019","article-title":"Proinflammatory Cytokines and Neuropeptides in Psoriasis, Depression, and Anxiety","volume":"241","author":"Keenan","year":"2025","journal-title":"Acta Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/jdv.17053","article-title":"Addressing Challenges Associated with Long-Term Topical Treatment and Benefits of Proactive Management in Patients with Psoriasis","volume":"35","author":"Lebwohl","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_28","first-page":"869764","article-title":"Current Insights on Treatment Adherence in Prevalent Dermatological Conditions and Strategies To Optimize Adherence Rates","volume":"16","author":"Radu","year":"2024","journal-title":"Cureus"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jhip.2024.01.005","article-title":"Vitamins Strategies for Psoriasis: An Update on Current Scientific Evidence","volume":"4","author":"Agnihotri","year":"2023","journal-title":"J. Holist. Integr. Pharm."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s10787-023-01178-0","article-title":"Review of Natural Compounds for Potential Psoriasis Treatment","volume":"31","author":"Elkhawaga","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.18231\/j.ijced.2021.031","article-title":"Correlation of Hypocalcaemia with Severity and Type of Psoriasis: A Cross-Sectional Study","volume":"7","author":"Maheswari","year":"2021","journal-title":"IP Indian J. Clin. Exp. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s00403-024-03468-1","article-title":"Trace Elements in Psoriasis Presentation and Treatment","volume":"316","author":"Patra","year":"2024","journal-title":"Arch. Dermatol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jdcr.2021.03.024","article-title":"A Pustular Psoriasis Flare Treated with Calcium Supplementation","volume":"12","author":"Masson","year":"2021","journal-title":"JAAD Case Rep."},{"key":"ref_34","first-page":"e48855","article-title":"The Association of Psoriasis, Diabetes Mellitus, and Hypertension: A Meta-Analysis","volume":"15","author":"Mirghani","year":"2023","journal-title":"Cureus"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10787-020-00690-x","article-title":"Selenium and Selenoproteins: It\u2019s Role in Regulation of Inflammation","volume":"28","author":"Hariharan","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"D\u0119bniak, T., Baszuk, P., Duchnik, E., Rowi\u0144ska, K., Rogo\u017ca-Janiszewska, E., Boer, M., Kiedrowicz, M., Marchlewicz, M., Watola, D., and Feherpataky, M. (2024). Selenium and Arsenic Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism, and Psoriasis Disease. Biomedicines, 12.","DOI":"10.3390\/biomedicines12051082"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Lv, J., Ai, P., Lei, S., Zhou, F., Chen, S., and Zhang, Y. (2020). Selenium Levels and Skin Diseases: Systematic Review and Meta-Analysis. J. Trace Elem. Med. Biol., 62.","DOI":"10.1016\/j.jtemb.2020.126548"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Duchnik, E., Kruk, J., Tuchowska, A., and Marchlewicz, M. (2023). The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence. Nutrients, 15.","DOI":"10.3390\/nu15040840"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Gangadevi, V., Thatikonda, S., Pooladanda, V., Devabattula, G., and Godugu, C. (2021). Selenium Nanoparticles Produce a Beneficial Effect in Psoriasis by Reducing Epidermal Hyperproliferation and Inflammation. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-00842-3"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1007\/s13555-021-00611-y","article-title":"Urea in Dermatology: A Review of Its Emollient, Moisturizing, Keratolytic, Skin Barrier Enhancing and Antimicrobial Properties","volume":"11","author":"Granger","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_41","first-page":"1136","article-title":"Climatotherapy at the Dead Sea for Psoriasis Is a Highly Effective Anti-Inflammatory Treatment in the Short Term: An Immunohistochemical Study","volume":"31","author":"Emmanuel","year":"2022","journal-title":"Exp. Dermatol."},{"key":"ref_42","first-page":"237","article-title":"Dead Sea Bath Salt for the Treatment of Psoriasis Vulgaris: A Double-Blind Controlled Study","volume":"9","author":"Halevy","year":"1997","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/ijd.15304","article-title":"The Cutaneous Effects of Long-Term Use of Dead Sea Mud on Healthy Skin: A 4-Week Study","volume":"60","author":"Hamed","year":"2021","journal-title":"Int. J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Dai, D., Ma, X., Yan, X., and Bao, X. (2023). The Biological Role of Dead Sea Water in Skin Health: A Review. Cosmetics, 10.","DOI":"10.3390\/cosmetics10010021"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Li Pomi, F., Papa, V., Borgia, F., Vaccaro, M., Allegra, A., Cicero, N., and Gangemi, S. (2023). Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases. Antioxidants, 12.","DOI":"10.3390\/antiox12030680"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"106074","DOI":"10.1016\/j.fitote.2024.106074","article-title":"Rosemary (Rosmarinus officinalis L.) Polyphenols and Inflammatory Bowel Diseases: Major Phytochemicals, Functional Properties, and Health Effects","volume":"177","author":"Zhang","year":"2024","journal-title":"Fitoterapia"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"De Oliveira, J.R., Camargo, S.E.A., and De Oliveira, L.D. (2019). Rosmarinus officinalis L. (Rosemary) as Therapeutic and Prophylactic Agent. J. Biomed. Sci., 26.","DOI":"10.1186\/s12929-019-0499-8"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nieto, G., Ros, G., and Castillo, J. (2018). Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review. Medicines, 5.","DOI":"10.3390\/medicines5030098"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/1535370216688571","article-title":"Biological Activities of Rosmarinus officinalis L. (Rosemary) Extract as Analyzed in Microorganisms and Cells","volume":"242","author":"Figueira","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sahlabgi, A., Lupuliasa, D., Stanciu, G., Lup\u0219or, S., Vlaia, L.L., Rotariu, R., Predescu, N.C., R\u0103dulescu, C., Olteanu, R.-L., and St\u0103nescu, S.-G. (2025). The Development and Comparative Evaluation of Rosemary Hydroalcoholic Macerate-Based Dermatocosmetic Preparations: A Study on Antioxidant, Antimicrobial, and Anti-Inflammatory Properties. Gels, 11.","DOI":"10.3390\/gels11030149"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"de Macedo, L.M., Santos, \u00c9.M.d., Milit\u00e3o, L., Tundisi, L.L., Ataide, J.A., Souto, E.B., and Mazzola, P.G. (2020). Rosemary (Rosmarinus officinalis L., Syn Salvia rosmarinus Spenn.) and Its Topical Applications: A Review. Plants, 9.","DOI":"10.3390\/plants9050651"},{"key":"ref_52","first-page":"e56530","article-title":"Randomized, Double-Blind, Placebo-Controlled, Clinical Study of Passiflora Incarnata in Participants With Stress and Sleep Problems","volume":"16","author":"Harit","year":"2024","journal-title":"Cureus"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.clnu.2025.02.005","article-title":"Evidence-Based Dietary Recommendations for Patients with Psoriasis: A Systematic Review","volume":"47","author":"Wang","year":"2025","journal-title":"Clin. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/10408398.2020.1818053","article-title":"Very Low-Calorie Ketogenic Diet (VLCKD) in Patients with Psoriasis and Obesity: An Update for Dermatologists and Nutritionists","volume":"62","author":"Barrea","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/8\/1186\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:16:07Z","timestamp":1760033767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/8\/1186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":54,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["life15081186"],"URL":"https:\/\/doi.org\/10.3390\/life15081186","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]}}}