{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:41:41Z","timestamp":1782859301760,"version":"3.54.5"},"reference-count":74,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Troyasil HPLC Column Technologies"},{"name":"ACG Publications"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>In this study, phenolic compounds of methanol extracts obtained from the leaves and branches of Satureja aintabensis P.H. Davis and Satureja spicigera (K. Koch) Boiss. species were determined as mg\/kg extract using the liquid chromatography high resolution mass spectrometry technique. The in vitro inhibitory effects of these extracts against enzymes associated with neurodegenerative Alzheimer\u2019s disease (AD) were also evaluated. The relationship between secondary metabolite structures and biological activities was discussed. The major components of S. aintabensis were determined as hesperidin (6.465% of the extract; 64.65 g\/kg), syringic acid (5.964% of the extract; 59.64 g\/kg), rosmarinic acid (5.248% of the extract; 52.48 g\/kg) and naringenin (0.395% of the extract; 3946.84 mg\/kg), while syringic acid (3.081% of the extract; 30.81 g\/kg), rosmarinic acid (2.757% of the extract; 27.57 g\/kg), hesperidin (1.723% of the extract; 17.23 g\/kg), and luteolin-7-O-rutinoside (1.682% of the extract; 16.82 g\/kg) were determined in S. spicigera. AChE and BChE enzyme inhibition of the extracts were analyzed. The species showed moderate inhibition against AChE enzyme and low inhibition against BChE enzyme. The antioxidant properties of both plant extracts were evaluated by measuring three radical scavenging capacities and the ability to reduce Fe3+, and Cu2+ ions. S. aintabensis showed better antioxidant capacity in all methods except DPPH scavaging assay. These data clearly show that both species, especially S. aintabensis, have emerged as a new and important natural source of hesperidin, syringic acid and rosmarinic acid and an antioxidant agent for pharmaceutical and nutraceutical applications.<\/jats:p>","DOI":"10.3390\/life15081272","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T14:32:36Z","timestamp":1754922756000},"page":"1272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Secondary Metabolite Profiling of Satureja aintabensis P.H. Davis and Satureja spicigera (K. Koch) Boiss. by LC-HRMS and Evaluation of Antioxidant and Anticholinergic Activities"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2952-5165","authenticated-orcid":false,"given":"Ay\u015fe Nur","family":"Y\u0131ld\u0131z","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Institute of Health Sciences, Bezmialem Vakif University, Fatih, Istanbul 34093, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-9926","authenticated-orcid":false,"given":"Sema","family":"\u00c7ar\u0131k\u00e7\u0131","sequence":"additional","affiliation":[{"name":"Vocational School, Izmir Demokrasi University, Izmir 35140, T\u00fcrkiye"},{"name":"The Sustainable Environmental Studies Application and Research Centre, Izmir Demokrasi University, Izmir 35140, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3038-6904","authenticated-orcid":false,"given":"Tuncay","family":"Dirmenci","sequence":"additional","affiliation":[{"name":"Department of Biology Education, Necatibey Faculty of Education, Balikesir University, Bal\u0131kesir 10145, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3538-2769","authenticated-orcid":false,"given":"Murat","family":"Kartal","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Bezmialem Vakif University, Fatih, Istanbul 34093, T\u00fcrkiye"},{"name":"Phytotheraphy Research Center, Bezmialem Vakif University, Istanbul 34093, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"G\u00fclcin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Atat\u00fcrk University, Erzurum 25240, T\u00fcrkiye"},{"name":"Rectorate of Agri Ibrahim Cecen University, Yeni \u00dcniversite Caddesi No: 2 AE\/1, A\u011fr\u0131 04100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-130X","authenticated-orcid":false,"given":"Ahmet C.","family":"G\u00f6ren","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Basic Sciences, Gebze Technical University, Gebze 41400, T\u00fcrkiye"},{"name":"Troyasil HPLC Column Technologies, Doruk Analitik, Mehmet Akif Mah, Yumurcak Sok, No. 43, Istanbul 34744, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"ref_1","first-page":"167","article-title":"The Families and Genera of Vascular Plants","volume":"Volume 7","author":"Kadereit","year":"2004","journal-title":"Labiatae"},{"key":"ref_2","first-page":"14","article-title":"Systematic and bio-geographic overview of Lamiaceae in Turkey","volume":"4","author":"Celep","year":"2017","journal-title":"Nat. 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