{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:39:30Z","timestamp":1760060370206,"version":"build-2065373602"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Perineuriomas are a rare form of peripheral nerve sheath tumors, with occurrences in the oral cavity being exceptionally uncommon. This scarcity underscores the clinical significance of each documented case, as it facilitates enhanced diagnostic precision among oral health professionals. We hereby present a case involving a 68-year-old female patient with an extraneural perineurioma (EPN) located on the mandibular region. A laser-assisted excisional biopsy was performed, and the diagnosis of EPN was confirmed through histopathological examination complemented by immunohistochemical analysis. The lesion was surgically excised, and no recurrence was observed during a one-year follow-up period. Accurate recognition of EPNs in the oral cavity is crucial to prevent unnecessary aggressive surgical interventions. Misdiagnoses may occur in cases of fibromas, neurofibromas, schwannomas, ossifying fibromas, or low-grade malignancies, which can potentially result in overtreatment that may compromise both function and aesthetics. Given the rarity of oral EPN, precise diagnosis and appropriate management are essential to avoid unwarranted invasive procedures and to mitigate potential medico-legal implications originating from misdiagnosis or suboptimal treatment. Ensuring comprehensive informed consent and meticulous documentation is also vital in minimizing medico-legal risks.<\/jats:p>","DOI":"10.3390\/life15091343","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:25:57Z","timestamp":1756189557000},"page":"1343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extraneural Soft Tissue Perineurioma of the Oral Cavity: A Rare Case with Medico-Legal Implications and Literature Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8885-0496","authenticated-orcid":false,"given":"Daniele","family":"Pergolini","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1431-7204","authenticated-orcid":false,"given":"Mohamed","family":"Mohsen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5741-7139","authenticated-orcid":false,"given":"Simona","family":"Zaami","sequence":"additional","affiliation":[{"name":"Department of Anatomical, Histological, Forensic and Orthopedic Sciences, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4631-1061","authenticated-orcid":false,"given":"Lina","family":"De Paola","sequence":"additional","affiliation":[{"name":"Department of Anatomical, Histological, Forensic and Orthopedic Sciences, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Rocchetti","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Angileri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Troiani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-0560","authenticated-orcid":false,"given":"Cira Rosaria Tiziana","family":"Di Gioia","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, \u201cSapienza\u201d University of Rome, Viale Regina Elena 326, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Coppola","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, \u201cSapienza\u201d University of Rome, Viale Regina Elena 326, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-2255","authenticated-orcid":false,"given":"Gaspare","family":"Palaia","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"329.e1","DOI":"10.1016\/j.joms.2018.09.032","article-title":"Perineurioma of the Tongue: A Case Report and Review of the Literature","volume":"77","author":"Schadel","year":"2019","journal-title":"J. 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