{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:39:55Z","timestamp":1760060395696,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>With the growing use of anti-obesity medications (AOMs), particularly glucagon-like peptide-1 (GLP-1) receptor agonists, interest in their impact on chemosensory function has increased. We report a case of subjective olfactory discomfort that developed during AOM therapy despite normal objective test results. A 41-year-old woman received the GLP-1 receptor agonist semaglutide for 24 weeks. Thorough olfactory function evaluation was performed using the Questionnaire of Olfactory Disorders (a validated questionnaire), the Yonsei Olfactory Function Test (for psychophysical testing), and chemical gustometry. The tests were performed before treatment and after 24 weeks of AOM therapy. At baseline, the patient had no olfactory complaints and showed normal test results. After treatment, she reported significant subjective olfactory discomfort (visual analog scale score: 48, maximum: 50), with decreased quality of life and parosmia, despite stable Yonsei Olfactory Function scores and normal gustatory function. This case highlights the possible mismatch between subjective and objective olfactory assessment during AOM therapy. Comprehensive chemosensory evaluations and interdisciplinary collaboration are essential, and further large-scale long-term studies are required.<\/jats:p>","DOI":"10.3390\/life15091349","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T10:35:17Z","timestamp":1756204517000},"page":"1349","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subjective Olfactory Impairment in a Patient Undergoing Anti-Obesity Pharmacotherapy: A Case of Symptom\u2013Test Discrepancy"],"prefix":"10.3390","volume":"15","author":[{"given":"Hye Jun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Family Medicine, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong, Dongjak-gu, Seoul 06973, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-1350","authenticated-orcid":false,"given":"Hyun Jin","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chung-Ang University, 224-1 Heukseok-dong, Dongjak-gu, Seoul 06973, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155217","DOI":"10.1016\/j.metabol.2022.155217","article-title":"A 2022 update on the epidemiology of obesity and a call to action: As its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on","volume":"133","author":"Boutari","year":"2022","journal-title":"Metabolism"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"108923","DOI":"10.1016\/j.neuropharm.2021.108923","article-title":"Olfaction in the context of obesity and diabetes: Insights from animal models to humans","volume":"206","author":"Faour","year":"2022","journal-title":"Neuropharmacology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/ejn.14115","article-title":"Mitral cells and the glucagon-like peptide 1 receptor: The sweet smell of success?","volume":"49","author":"Bagnoli","year":"2019","journal-title":"Eur. 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