{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:37:20Z","timestamp":1772822240099,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Periprosthetic joint infection (PJI) caused by Streptococcus bovis (S. bovis) is rare but clinically significant due to its established association with colorectal neoplasia. Early recognition and interdisciplinary management are essential to ensure favorable outcomes. We report the case of a 68-year-old woman who presented with a chronic fistula and signs of active infection 20 years after uncemented total hip arthroplasty. Cultures from the wound identified S. bovis, prompting further evaluation. Imaging and laboratory tests supported a diagnosis of chronic PJI. A two-stage revision was performed, beginning with implant removal, debridement, and placement of a vancomycin\/gentamicin-loaded spacer. Given the pathogen\u2019s known link to gastrointestinal malignancy, the patient underwent colonoscopy, which revealed a tubulovillous adenoma with carcinoma in situ. Surgical resection was performed with curative intent. Six months later, the patient underwent successful reimplantation. At three-month follow-up, clinical and radiographic assessments showed favorable recovery. This case reinforces the importance of gastrointestinal screening in patients with S. bovis PJI, as early detection of associated colorectal lesions may impact treatment strategies and prognosis.<\/jats:p>","DOI":"10.3390\/life15091385","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T13:27:44Z","timestamp":1756733264000},"page":"1385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Periprosthetic Joint Infection by Streptococcus bovis Reveals Hidden Colorectal Cancer: A Case Report"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9539-7736","authenticated-orcid":false,"given":"George","family":"Viscopoleanu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3842-9212","authenticated-orcid":false,"given":"Mihai-Sebastian","family":"Valeanu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2805-2708","authenticated-orcid":false,"given":"Bogdan-Sorin","family":"Capitanu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-1684","authenticated-orcid":false,"given":"Serban","family":"Dragosloveanu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania"},{"name":"Department of Orthopaedics and Traumatology, The \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-6393","authenticated-orcid":false,"given":"Cristian","family":"Scheau","sequence":"additional","affiliation":[{"name":"Department of Physiology, The \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Radiology and Medical Imaging, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"ref_1","unstructured":"Ayoade, F., Li, D., Mabrouk, A., and Todd, J.R. (2025). Periprosthetic Joint Infection. StatPearls, StatPearls Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.arth.2023.01.045","article-title":"2022 American Association of Hip and Knee Surgeons Symposium: Periprosthetic Joint Infection","volume":"38","author":"Tarabichi","year":"2023","journal-title":"J. Arthroplast."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1186\/s13018-023-04060-5","article-title":"Incidence of periprosthetic joint infection after primary total hip arthroplasty is underestimated: A synthesis of meta-analysis and bibliometric analysis","volume":"18","author":"Zeng","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1302\/0301-620X.103B1.BJJ-2020-1381.R1","article-title":"The EBJIS definition of periprosthetic joint infection","volume":"103-B","author":"McNally","year":"2021","journal-title":"Bone Jt. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1186\/s12879-022-07532-x","article-title":"Streptococcal and Staphylococcus aureus prosthetic joint infections: Are they really different?","volume":"22","author":"Kherabi","year":"2022","journal-title":"BMC Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tsikopoulos, K., and Meroni, G. (2023). Periprosthetic Joint Infection Diagnosis: A Narrative Review. Antibiotics, 12.","DOI":"10.3390\/antibiotics12101485"},{"key":"ref_7","unstructured":"Boffetta, P., and Hainaut, P. (2019). Microbiota and Colon Cancer: Orchestrating Neoplasia Through DNA Damage and Immune Dysregulation. Encyclopedia of Cancer, Academic Press. [3rd ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1080\/23744235.2022.2089730","article-title":"Bacteraemia and infective endocarditis with Streptococcus bovis-Streptococcus equinus-complex: A retrospective cohort study","volume":"54","author":"Bo","year":"2022","journal-title":"Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"E283","DOI":"10.1073\/pnas.1715112115","article-title":"Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization","volume":"115","author":"Aymeric","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/jbji.36923","article-title":"Streptococcus bovis Hip and Knee Periprosthetic Joint Infections: A Series of 9 Cases","volume":"5","author":"Thompson","year":"2020","journal-title":"J. Bone Jt. Infect."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.18203\/issn.2455-4510.IntJResOrthop20232624","article-title":"When prosthetic joint infection may lead to premalignant colorectal lesion detection","volume":"9","author":"Posse","year":"2023","journal-title":"Int. J. Res. Orthop."},{"key":"ref_12","first-page":"e74264","article-title":"Prosthetic Joint Infection by Streptococcus lutetiensis (Bovis) With Noncancerous Polyps and Negative Blood Cultures: A Case Report","volume":"16","author":"Shanti","year":"2024","journal-title":"Cureus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00167-011-1646-2","article-title":"Streptococcus gallolyticus prosthetic joint infection associated with undiagnosed colonic malignancy","volume":"20","author":"Liddle","year":"2012","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1001\/archsurg.139.7.760","article-title":"Association of Streptococcus bovis bacteremia with colonic neoplasia and extracolonic malignancy","volume":"139","author":"Gold","year":"2004","journal-title":"Arch. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10096-013-1940-7","article-title":"Is colonoscopy necessary in cases of infection by Streptococcus bovis biotype II?","volume":"33","author":"Corredoira","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.eimc.2021.09.005","article-title":"Streptococcus gallolyticus subsp. gallolyticus knee periprosthetic joint infection","volume":"40","year":"2022","journal-title":"Enfermedades Infecc. Microbiol. Cl\u00ednica (Engl. Ed.)"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S835","DOI":"10.14309\/00000434-201810001-01456","article-title":"Streptococcus bovis Bactremia and Colon Cancer: A Well Established but Frequently Forgotten Association: 1456","volume":"113","author":"Meseeha","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e921886","DOI":"10.12659\/MSM.921886","article-title":"Streptococcus bovis Contributes to the Development of Colorectal Cancer via Recruiting CD11b+TLR-4+ Cells","volume":"26","author":"Deng","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1756-9966-30-11","article-title":"The association of Streptococcus bovis\/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role","volume":"30","author":"Abdulamir","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.3748\/wjg.v21.i18.5663","article-title":"Association of Streptococcus bovis presence in colonic content with advanced colonic lesion","volume":"21","author":"Paritsky","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_21","first-page":"1503928","article-title":"Never mind the bug: No differences in infection-free survival after periprosthetic joint infections with Staphylococcus aureus, Coagulase-negative Staphylococcus, or Streptococcus","volume":"15","author":"Hailer","year":"2024","journal-title":"Front. Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1080\/23744235.2025.2476530","article-title":"Frequency of haematogenous periprosthetic joint infection due to bacteraemia caused by gram-positive cocci","volume":"57","author":"Thompson","year":"2025","journal-title":"Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Pompilio, A., Di Bonaventura, G., and Gherardi, G. (2019). An Overview on Streptococcus bovis\/Streptococcus equinus Complex Isolates: Identification to the Species\/Subspecies Level and Antibiotic Resistance. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030480"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1128\/JCM.02977-15","article-title":"An Update on the Streptococcus bovis Group: Classification, Identification, and Disease Associations","volume":"54","author":"Dekker","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/carcin\/bgh091","article-title":"Carcinogenic properties of proteins with pro-inflammatory activity from Streptococcus infantarius (formerly S.bovis)","volume":"25","author":"Biarc","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jisako.2024.01.011","article-title":"The influence of gut microbiome on periprosthetic joint infections: State-of-the art","volume":"9","author":"Longo","year":"2024","journal-title":"J. ISAKOS"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/1874325001307010184","article-title":"One-stage revision arthroplasty for infected hip replacements","volume":"7","author":"Gallart","year":"2013","journal-title":"Open Orthop. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2106\/00004623-199807000-00004","article-title":"Direct-exchange arthroplasty for the treatment of infection after total hip replacement. An average ten-year follow-up","volume":"80","author":"Ure","year":"1998","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.arth.2025.02.068","article-title":"Reinfection Patterns Following Two-Stage Exchange for Periprosthetic Joint Infection: A Retrospective Analysis","volume":"40","author":"Chandler","year":"2025","journal-title":"J. Arthroplast."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/9\/1385\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:37:13Z","timestamp":1760035033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/9\/1385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["life15091385"],"URL":"https:\/\/doi.org\/10.3390\/life15091385","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}