{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:42:45Z","timestamp":1792622565676,"version":"4.5.0"},"reference-count":103,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Life"],"abstract":"<jats:p>Introduction: Chronic spontaneous urticaria (CSU), vitiligo, and Hashimoto\u2019s thyroiditis (HT) frequently co-occur in the same patients, suggesting a shared autoimmune pathogenesis. These conditions are increasingly recognized as components of polyautoimmunity, with overlapping clinical, immunological, and pathogenetic features. Among the proposed common mechanisms, vitamin D deficiency and oxidative stress (OS) have emerged as key contributors. We aimed to explore the shared immunopathogenic pathways linking these conditions, with a focus on the interplay between vitamin D status and redox imbalance. Methods: An extensive narrative review of the current literature regarding the associations among CSU, vitiligo, and HT, focusing on the role of vitamin D status, OS, and nitrosative stress, and shared immunological pathways was conducted. Discussion: Vitamin D deficiency was consistently observed across all three conditions and is associated with increased disease activity and poorer clinical outcomes. Several polymorphisms in the vitamin D receptor (VDR) and binding protein genes correlate with disease susceptibility. OS and nitrosative stress markers, such as malondialdehyde (MDA) and nitric oxide (NO) metabolites, are elevated in patients with CSU, vitiligo, and HT, and are linked to tissue-specific immune activation, apoptosis, and loss of self-tolerance. Evidence suggests that vitamin D and antioxidant supplementation may provide clinical benefit. In vitiligo, narrowband ultraviolet B (NB-UVB) phototherapy not only promotes repigmentation through melanocyte stimulation but also reduces ROS production and modulates local immune responses. Conclusions: The coexistence of CSU, vitiligo, and HT reflects a broader systemic autoimmune tendency, with vitamin D deficiency and redox imbalance serving as potential unifying mechanisms. Routine assessment of vitamin D levels and OS parameters may enhance diagnostic precision and inform therapeutic strategies. Antioxidant-based interventions represent promising avenues in the integrated management of autoimmune skin and endocrine disorders.<\/jats:p>","DOI":"10.3390\/life15101535","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T08:21:51Z","timestamp":1759220511000},"page":"1535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Shared Immunopathogenic Mechanisms in Chronic Spontaneous Urticaria, Vitiligo, and Hashimoto\u2019s Thyroiditis: The Role of Oxidative Stress and Vitamin D"],"prefix":"10.3390","volume":"15","author":[{"given":"Rossella","family":"Casella","sequence":"first","affiliation":[{"name":"Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6760-9468","authenticated-orcid":false,"given":"Federica","family":"Li Pomi","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-8441","authenticated-orcid":false,"given":"Francesco","family":"Borgia","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eustachio","family":"Nettis","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Gangemi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000506103","article-title":"Vitiligo: A Review","volume":"236","author":"Bergqvist","year":"2020","journal-title":"Dermatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12020-012-9703-2","article-title":"The incidence and prevalence of thyroid autoimmunity","volume":"42","author":"McLeod","year":"2012","journal-title":"Endocrine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/bjd.13286","article-title":"High prevalence of circulating autoantibodies against thyroid hormones in vitiligo and correlation with clinical and historical parameters of patients","volume":"171","author":"Colucci","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00244-015-0138-7","article-title":"Correlation of Serum Thyroid Hormones Autoantibodies with Self-Reported Exposure to Thyroid Disruptors in a Group of Nonsegmental Vitiligo Patients","volume":"69","author":"Colucci","year":"2015","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/japtr.JAPTR_342_18","article-title":"Relationship between Chronic urticaria and autoimmune thyroid disease","volume":"9","author":"Najafipour","year":"2018","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102649","DOI":"10.1016\/j.autrev.2020.102649","article-title":"Hashimoto\u2019s thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation","volume":"19","author":"Ralli","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.autrev.2017.10.003","article-title":"Autoimmune comorbidity in chronic spontaneous urticaria: A systematic review","volume":"16","author":"Kolkhir","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"566","DOI":"10.5114\/ada.2017.72464","article-title":"Thyroid function and thyroid autoantibodies in patients with chronic spontaneous urticaria","volume":"34","author":"Jenerowicz","year":"2017","journal-title":"Postep. Dermatol. Alergol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s40291-023-00672-z","article-title":"Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review","volume":"27","author":"Czajkowski","year":"2023","journal-title":"Mol. Diagn. Ther."},{"key":"ref_10","first-page":"326","article-title":"Oxidative stress as a key feature of autoimmune thyroiditis: An update","volume":"45","author":"Ruggeri","year":"2020","journal-title":"Minerva Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.5114\/ada.2017.71110","article-title":"Involvement of new oxidative stress markers in chronic spontaneous urticaria","volume":"34","author":"Nettis","year":"2017","journal-title":"Postep. Dermatol. Alergol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.jaad.2016.04.029","article-title":"Rethinking screening for thyroid autoimmunity in vitiligo","volume":"75","author":"Liu","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1586\/1744666X.2016.1171143","article-title":"Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis","volume":"12","author":"Quirk","year":"2016","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102350","DOI":"10.1016\/j.autrev.2019.102350","article-title":"Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications","volume":"18","author":"Murdaca","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13601-018-0234-7","article-title":"Relationship between vitamin D and chronic spontaneous urticaria: A systematic review","volume":"4","author":"Tuchinda","year":"2018","journal-title":"Clin. Transl. Allergy"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jaci.2013.10.055","article-title":"Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population","volume":"133","author":"Cheng","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12948-017-0078-z","article-title":"Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement","volume":"15","author":"Ariaee","year":"2017","journal-title":"Clin. Mol. Allergy"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"S\u00eerbe, C., Rednic, S., Grama, A., and Pop, T.L. (2022). An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179784"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"104866","DOI":"10.1016\/j.yexmp.2023.104866","article-title":"A review of the critical role of vitamin D axis on the immune system","volume":"132\u2013133","author":"Daryabor","year":"2023","journal-title":"Exp. Mol. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/bjd.12077","article-title":"Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults","volume":"168","author":"Heine","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_21","first-page":"445","article-title":"Serum vitamin D level-the effect on the clinical course of psoriasis","volume":"33","year":"2016","journal-title":"Postep. Dermatol. Alergol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lim, S.K., Ha, J.M., Lee, Y.H., Lee, Y., Seo, Y.J., Kim, C.D., Lee, J.-H., and Im, M. (2016). Comparison of vitamin D levels in patients with and without acne: A case-control study combined with a randomized controlled trial. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161162"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa1306357","article-title":"Vitamin D-binding protein and vitamin D status of black Americans and white Americans","volume":"369","author":"Powe","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nsmb.2046","article-title":"DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex","volume":"18","author":"Zhang","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_25","first-page":"438","article-title":"Vitamin D and autoimmune diseases: Is vitamin D receptor (VDR) polymorphism the culprit?","volume":"19","author":"Bizzaro","year":"2017","journal-title":"Isr. Med. Assoc. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/qjmed\/hcx223","article-title":"Evaluation of 1,25-dihydroxyvitamin D3 pathway in patients with chronic urticaria","volume":"111","author":"Abdi","year":"2018","journal-title":"QJM"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.5021\/ad.2015.27.4.423","article-title":"Vitamin D as a marker for disease severity in chronic urticaria and its possible role in pathogenesis","volume":"27","author":"Woo","year":"2015","journal-title":"Ann. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1515\/cclm-2013-1014","article-title":"25-Hydroxy vitamin D levels in chronic urticaria and its correlation with disease severity from a tertiary care centre in South India","volume":"52","author":"Chandrashekar","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2500\/aap.2010.31.3322","article-title":"Vitamin D treatment of idiopathic itch, rash, and urticaria\/angioedema","volume":"31","author":"Goetz","year":"2010","journal-title":"Allergy Asthma Proc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.anai.2012.07.025","article-title":"Resolution of chronic urticaria coincident with vitamin D supplementation","volume":"109","author":"Sindher","year":"2012","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100238","DOI":"10.1016\/j.clinme.2024.100238","article-title":"Secondary hyperparathyroidism in chronic kidney disease: A narrative review focus on therapeutic strategy","volume":"24","author":"Tsai","year":"2024","journal-title":"Clin. Med."},{"key":"ref_32","first-page":"389","article-title":"The association between serum vitamin D levels and urticaria: A meta-analysis of observational studies","volume":"153","author":"Wang","year":"2018","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e11506","DOI":"10.1097\/MD.0000000000011506","article-title":"Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1365-2133.2012.11132.x","article-title":"The association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with generalized vitiligo","volume":"167","author":"Li","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/phpp.12241","article-title":"Low 25-hydroxyvitamin D levels are associated with vitiligo: A systematic review and meta-analysis","volume":"32","author":"Upala","year":"2016","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.clnesp.2016.05.006","article-title":"Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study","volume":"15","author":"Sakarya","year":"2016","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/ijd.13363","article-title":"Evaluation of the correlation between serum levels of vitamin D and vitamin D receptor gene polymorphisms in an Egyptian population","volume":"55","author":"Sobeih","year":"2016","journal-title":"Int. J. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/phpp.12016","article-title":"Evaluation of serum 25-hydroxyvitamin D levels in vitiligo patients with and without autoimmune diseases","volume":"29","author":"Saleh","year":"2013","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_39","first-page":"110","article-title":"Investigation of vitamin D levels in patients with vitiligo vulgaris","volume":"22","author":"Ustun","year":"2014","journal-title":"Acta Dermatovenerol. Croat."},{"key":"ref_40","first-page":"e20733","article-title":"Vitamin D Deficiency in Patients with Vitiligo: A Cross-Sectional Study From Basrah, Iraq","volume":"13","author":"Mahmmod","year":"2021","journal-title":"Cureus"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"108789","DOI":"10.1016\/j.intimp.2022.108789","article-title":"Vitamin D analogs combined with different types of phototherapy in the treatment of vitiligo: A systematic review of randomized trials and within-patient studies","volume":"109","author":"Liu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"750","DOI":"10.4103\/0378-6323.120720","article-title":"The role of vitamin Din melanogenesis with an emphasis on vitiligo","volume":"79","author":"AlGhamdi","year":"2013","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"725","DOI":"10.4103\/ijd.ijd_442_23","article-title":"Vitamin D and Interleukin-17: Are These Serum Biomarkers Useful in Non-Segmental Vitiligo? A Case Control Study from Central India","volume":"68","author":"George","year":"2023","journal-title":"Indian J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Vieira, I.H., Rodrigues, D., and Paiva, I. (2020). Vitamin D and Autoimmune Thyroid Disease-Cause, Consequence, or a Vicious Cycle?. Nutrients, 12.","DOI":"10.3390\/nu12092791"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10238-014-0290-9","article-title":"TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adults","volume":"15","author":"Barchetta","year":"2015","journal-title":"Clin. Exp. Med."},{"key":"ref_46","first-page":"267","article-title":"Vitamin d deficiency and its association with thyroid disease","volume":"7","author":"Mackawy","year":"2013","journal-title":"Int. J. Health Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"152421","DOI":"10.1016\/j.tox.2020.152421","article-title":"The way forward for assessing the human health safety of cosmetics in the EU\u2014Workshop proceedings","volume":"436","author":"Rogiers","year":"2020","journal-title":"Toxicology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12020-017-1425-z","article-title":"Vitamin D deficiency affects thyroid autoimmunity and dysfunction in iodine-replete area: Korea national health and nutrition examination survey","volume":"58","author":"Kim","year":"2017","journal-title":"Endocrine"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"152412","DOI":"10.1016\/j.tox.2020.152412","article-title":"Sub-chronic exposure to Kalach 360 SL, Glyphosate-based Herbicide, induced bone rarefaction in female Wistar rats","volume":"436","author":"Hamdaoui","year":"2020","journal-title":"Toxicology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4158\/EP12376.OR","article-title":"The association between severity of vitamin D deficiency and Hashimoto\u2019s thyroiditis","volume":"19","author":"Bozkurt","year":"2013","journal-title":"Endocr. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zhao, R., Zhang, W., Ma, C., Zhao, Y., Xiong, R., Wang, H., Chen, W., and Zheng, S.G. (2021). Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.574967"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"106890","DOI":"10.1016\/j.imlet.2024.106890","article-title":"Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17\/Treg cell differentiation via YAP\/JAK1\/STAT1 axis","volume":"269","author":"Zhang","year":"2024","journal-title":"Immunol. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e36759","DOI":"10.1097\/MD.0000000000036759","article-title":"Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto\u2019s thyroiditis: A systematic review and meta-analysis","volume":"102","author":"Tang","year":"2023","journal-title":"Medicine"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tywanek, E., Michalak, A., \u015awirska, J., and Zwolak, A. (2024). Autoimmunity, New Potential Biomarkers and the Thyroid Gland-The Perspective of Hashimoto\u2019s Thyroiditis and Its Treatment. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094703"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1507\/endocrj.EJ18-0166","article-title":"Vitamin D in Hashimoto\u2019s thyroiditis and its relationship with thyroid function and inflammatory status","volume":"65","author":"Botelho","year":"2018","journal-title":"Endocr. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/s41430-019-0395-z","article-title":"Effects of vitamin D supplements on frequency of CD4+ T-cell subsets in women with Hashimoto\u2019s thyroiditis: A double-blind placebo-controlled study","volume":"73","author":"Nodehi","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/thy.2023.0556","article-title":"Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"34","author":"Huwiler","year":"2024","journal-title":"Thyroid"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/jcem.87.4.8421","article-title":"Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations","volume":"87","author":"Gasnier","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Szklarz, M., Gontarz-Nowak, K., Matuszewski, W., and Bandurska-Stankiewicz, E. (2022). Iron: Not Just a Passive Bystander in AITD. Nutrients, 14.","DOI":"10.3390\/nu14214682"},{"key":"ref_60","first-page":"221","article-title":"Prevalence of vitamin B-12 deficiency among patients with thyroid dysfunction","volume":"25","author":"Collins","year":"2016","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Wang, K., Wei, H., Zhang, W., Li, Z., Ding, L., Yu, T., Tan, L., Liu, Y., Liu, T., and Wang, H. (2018). Severely low serum magnesium is associated with increased risks of positive anti-thyroglobulin antibody and hypothyroidism: A cross-sectional study. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-28362-5"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e1639","DOI":"10.1097\/MD.0000000000001639","article-title":"Lower serum 25-hydroxyvitamin D level is associated with 3 types of autoimmune thyroid diseases","volume":"94","author":"Ma","year":"2015","journal-title":"Medicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4158\/EP14191.OR","article-title":"Low vitamin D status is associated with increased thyrotropin-receptor antibody titer in Graves disease","volume":"21","author":"Zhang","year":"2015","journal-title":"Endocr. Pract."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e7700","DOI":"10.1097\/MD.0000000000007700","article-title":"Serum 25-hydroxyvitamin D might be an independent prognostic factor for Graves disease recurrence","volume":"96","author":"Ahn","year":"2017","journal-title":"Medicine"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1507\/endocrj.EJ16-0547","article-title":"25-Hydroxyvitamin D serum level in Hashimoto\u2019s thyroiditis, but not Graves\u2019 disease is relatively deficient","volume":"64","author":"Ke","year":"2017","journal-title":"Endocr. J."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Cho, Y.Y., and Chung, Y.J. (2020). Vitamin D supplementation does not prevent the recurrence of Graves\u2019 disease. Sci. Rep., 10.","DOI":"10.1038\/s41598-019-55107-9"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1210\/en.2008-1191","article-title":"Vitamin D deficiency modulates Graves\u2019 hyperthyroidism induced in BALB\/c mice by thyrotropin receptor immunization","volume":"150","author":"Misharin","year":"2009","journal-title":"Endocrinology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jid.2022.10.021","article-title":"Comorbidities in Patients with Vitiligo: A Systematic Review and Meta-Analysis","volume":"143","author":"Lee","year":"2023","journal-title":"J. Investig. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1080\/00325481.2021.1974689","article-title":"Association between alopecia areata and thyroid dysfunction","volume":"133","author":"Naik","year":"2021","journal-title":"Postgrad. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.aller.2010.06.012","article-title":"Oxidative stress status in patients with chronic idiopathic urticaria","volume":"39","author":"Sagdic","year":"2011","journal-title":"Allergol. Immunopathol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1440313","DOI":"10.3389\/fimmu.2024.1440313","article-title":"The antioxidant barrier, oxidative\/nitrosative stress, and protein glycation in allergy: From basic research to clinical practice","volume":"15","author":"Biedrzycki","year":"2024","journal-title":"Front Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2174\/1568010054526386","article-title":"Oxidative stress in allergic and inflammatory skin diseases","volume":"4","author":"Okayama","year":"2005","journal-title":"Curr. Drug Targets-Inflamm. Allergy"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000453334","article-title":"Nitrosative stress in children with chronic spontaneous urticaria","volume":"172","author":"Dilek","year":"2017","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_74","first-page":"729","article-title":"Platelet oxidative stress and antioxidant enzyme activity in patients with chronic idiopathic urticaria: Effects of desloratadine treatment","volume":"18","author":"Cassano","year":"2005","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Galiniak, S., Mo\u0142o\u0144, M., Biesiadecki, M., Bo\u017cek, A., and Rachel, M. (2022). The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria. Antioxidants, 11.","DOI":"10.3390\/antiox11081590"},{"key":"ref_76","first-page":"99","article-title":"The role of oxidative stress in skin diseases","volume":"50","author":"Karadag","year":"2017","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2265.2005.02324.x","article-title":"Relation of anti-TPO autoantibody titre and T-lymphocyte cytokine production patterns in Hashimoto\u2019s thyroiditis","volume":"63","author":"Karanikas","year":"2005","journal-title":"Clin. Endocrinol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1364-3703.2012.00799.x","article-title":"The NADPH oxidase-mediated production of hydrogen peroxide (H2O2) and resistance to oxidative stress in the necrotrophic pathogen Alternaria alternata of citrus","volume":"13","author":"Yang","year":"2012","journal-title":"Mol. Plant Pathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1530\/EJE-15-0617","article-title":"The relationship between oxidative stress and autoimmunity in Hashimoto\u2019s thyroiditis","volume":"173","author":"Ates","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s40618-020-01231-7","article-title":"Serum levels of advanced glycation end products (AGEs) are increased and their soluble receptor (sRAGE) reduced in Hashimoto\u2019s thyroiditis","volume":"43","author":"Ruggeri","year":"2020","journal-title":"J. Endocrinol. Investig."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kochman, J., Jakubczyk, K., Bargiel, P., and Janda-Milczarek, K. (2021). The Influence of Oxidative Stress on Thyroid Diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10091442"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Gowen, B.H., Reyes, M.V., Joseph, L.C., and Morrow, J.P. (2020). Mechanisms of Chronic Metabolic Stress in Arrhythmias. Antioxidants, 9.","DOI":"10.3390\/antiox9101012"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1297658","DOI":"10.1155\/2017\/1297658","article-title":"Selenium and Thyroid Disease: From Pathophysiology to Treatment","volume":"2017","author":"Ventura","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jaut.2009.09.001","article-title":"Environmental triggers of autoimmune thyroiditis","volume":"33","author":"Burek","year":"2009","journal-title":"J. Autoimmun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.endinu.2019.03.018","article-title":"Selenium supplementation in patients with subclinical hypothyroidism affected by autoimmune thyroiditis: Results of the SETI study","volume":"67","author":"Pirola","year":"2020","journal-title":"Endocrinol. Diabetes Nutr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1089\/thy.2009.0351","article-title":"Selenium supplementation in the treatment of Hashimoto\u2019s thyroiditis: A systematic review and a meta-analysis","volume":"20","author":"Toulis","year":"2010","journal-title":"Thyroid"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1111\/cts.12993","article-title":"Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto\u2019s thyroiditis: A prospective randomized-controlled trial","volume":"14","author":"Hu","year":"2021","journal-title":"Clin. Transl. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: Physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Chang, W.L., and Ko, C.H. (2023). The Role of Oxidative Stress in Vitiligo: An Update on Its Pathogenesis and Therapeutic Implications. Cells, 12.","DOI":"10.3390\/cells12060936"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.abd.2021.09.008","article-title":"Update on the pathogenesis of vitiligo","volume":"97","author":"Marchioro","year":"2022","journal-title":"An. Bras. Dermatol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jdermsci.2015.03.002","article-title":"IgE autoantibodies in bullous pemphigoid: Supporting role, or leading player?","volume":"78","author":"Ujiie","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/jid.2014.65","article-title":"Melanocytes as instigators and victims of oxidative stress","volume":"134","author":"Denat","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Touni, A.A., Shivde, R.S., Echuri, H., Abdel-Aziz, R.T.A., Abdel-Wahab, H., Kundu, R.V., and Le Poole, I.C. (2023). Melanocyte-keratinocyte cross-talk in vitiligo. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1176781"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1242\/jcs.107.4.983","article-title":"E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro","volume":"107","author":"Tang","year":"1994","journal-title":"J. Cell Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1038\/jid.2015.25","article-title":"Altered E-Cadherin Levels and Distribution in Melanocytes Precede Clinical Manifestations of Vitiligo","volume":"135","author":"Wagner","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1365-2133.2003.05024.x","article-title":"Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo","volume":"148","author":"Gauthier","year":"2003","journal-title":"Br. J. Dermatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3193670","DOI":"10.1155\/omcl\/3193670","article-title":"An Overview of the Biological Complexity of Vitiligo","volume":"2024","author":"Matarrese","year":"2024","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/1346-8138.15743","article-title":"Vitiligo: A focus on pathogenesis and its therapeutic implications","volume":"48","author":"Bergqvist","year":"2021","journal-title":"J. Dermatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jaad.2017.06.014","article-title":"Wilms tumor screening in diffuse capillary malformation with overgrowth and macrocephaly-capillary malformation: A retrospective study","volume":"77","author":"Peterman","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Peterle, L., Sanfilippo, S., Borgia, F., Li Pomi, F., Vadal\u00e0, R., Costa, R., Cicero, N., and Gangemi, S. (2023). The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential. Foods, 12.","DOI":"10.3390\/foods12132629"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Borgia, F., Li Pomi, F., Vaccaro, M., Alessandrello, C., Papa, V., and Gangemi, S. (2022). Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives. Biomolecules, 12.","DOI":"10.3390\/biom12121904"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Allegra, A., Pioggia, G., Tonacci, A., Musolino, C., and Gangemi, S. (2020). Oxidative Stress and Photodynamic Therapy of Skin Cancers: Mechanisms, Challenges and Promising Developments. Antioxidants, 9.","DOI":"10.3390\/antiox9050448"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Li Pomi, F., Gammeri, L., Borgia, F., Di Gioacchino, M., and Gangemi, S. (2025). Oxidative Stress and Skin Diseases: The Role of Lipid Peroxidation. Antioxidants, 14.","DOI":"10.3390\/antiox14050555"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/10\/1535\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T04:25:45Z","timestamp":1759292745000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/10\/1535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":103,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["life15101535"],"URL":"https:\/\/doi.org\/10.3390\/life15101535","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]}}}