{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T05:19:30Z","timestamp":1763097570978,"version":"3.45.0"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Immune thrombocytopenia (ITP) is an autoimmune disorder often triggered by prior viral infections. Although there is considerable evidence suggesting platelets act as passive bystanders during viral illnesses, they are increasingly recognised as active participants in their interactions with viruses. Our descriptive observational retrospective study, conducted at a tertiary hospital in Romania, aimed to evaluate the impact of viral infections on the incidence and outcomes of ITP. This cohort study focused on newly diagnosed ITP cases over a 10-year period, comparing two patient groups: the first group (I-306 patients) from the viral outbreak period (2020\u20132024) and the second (II-213 patients) from an epidemic-free period (2015\u20132019). Despite non-pharmacological measures implemented to prevent respiratory infection spread, the number (p = 0.05) and incidence (p = 0.001) of newly diagnosed ITP cases in hospitalised children increased significantly, mainly associated with severe acute respiratory syndrome coronavirus 2 (r = 0.967, p = 0.007), Epstein\u2013Barr virus (r = 0.974, p = 0.004), and influenza (r = 0.901, p = 0.037), with mild thrombocytopenia (p = 0.028). The severity and persistence or chronicity of ITP remained unchanged. The rise in newly diagnosed ITP cases, even without increased severity or chronic evolution, may impose a substantial burden of medical and non-medical costs, highlighting the need for preventive measures during risky viral infection outbreaks.<\/jats:p>","DOI":"10.3390\/life15111736","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:58:32Z","timestamp":1762934312000},"page":"1736","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paediatric Hospitalised Immune Thrombocytopenia in Real-Life Recent Viral Infection Outbreaks: A Retrospective Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-3741","authenticated-orcid":false,"given":"Cristina Emilia","family":"Ursu","sequence":"first","affiliation":[{"name":"Onco-Haematology Research Unit, Romanian Academy of Medical Sciences, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d Timi\u0219oara, European Haemophilia Treatment Centre, 300011 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0468-7172","authenticated-orcid":false,"given":"Margit","family":"\u0218erban","sequence":"additional","affiliation":[{"name":"Onco-Haematology Research Unit, Romanian Academy of Medical Sciences, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d Timi\u0219oara, European Haemophilia Treatment Centre, 300011 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian Marius","family":"Jinca","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Onco-Haematology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estera","family":"Boeriu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Onco-Haematology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Ionita","sequence":"additional","affiliation":[{"name":"Department of Haematology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Coriu","sequence":"additional","affiliation":[{"name":"Haematology (Clinic and Laboratory) Discipline-Fundeni Clinical Institute, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Haematology and Bone Marrow Transplant, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melen","family":"Br\u00eenz\u0103","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplant, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-1519","authenticated-orcid":false,"given":"Ciprian","family":"Tomuleasa","sequence":"additional","affiliation":[{"name":"Department of Haematology, Research Center for Functional Genomics and Translational Medicine, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400012 Cluj Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora Smaranda","family":"Arghirescu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Onco-Haematology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood.2020006480","article-title":"An update on pediatric ITP: Differentiating primary ITP, IPD, and PID","volume":"140","author":"Grace","year":"2022","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejim.2022.11.022","article-title":"Current approaches for the diagnosis and management of immune thrombocytopenia","volume":"108","year":"2023","journal-title":"Eur. 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