{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:39:49Z","timestamp":1791689989471,"version":"4.3.4"},"reference-count":174,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a key cytokine in the pathogenesis of rheumatoid arthritis, an autoimmune disease distinguished by synovial inflammation and progressive joint destruction. GM-CSF orchestrates the activation, proliferation, and differentiation of myeloid cells (mainly macrophages and neutrophils) thereby sustaining the pro-inflammatory synovial milieu. Recent advances in monoclonal antibody immunotherapy have enabled selective inhibition of GM-CSF or its receptor. Clinical data on several monoclonal antibodies are presented, focusing on their pharmacodynamic properties and efficacy results documented in phase II and III clinical studies. Cumulative evidence supports GM-CSF inhibition as a compelling strategy for modulating inflammation and improving clinical outcomes in rheumatoid arthritis.<\/jats:p>","DOI":"10.3390\/life15111737","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T08:58:47Z","timestamp":1762937927000},"page":"1737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Targeting GM-CSF in Rheumatoid Arthritis: Advances in Cytokine-Directed Immunotherapy and Clinical Implications"],"prefix":"10.3390","volume":"15","author":[{"given":"Mario","family":"Garc\u00eda-Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Program of Immunology and Immunotherapy, CIMA-Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Department of Immunology and Immunotherapy, Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e509","DOI":"10.1002\/mco2.509","article-title":"Rheumatoid arthritis: Pathogenesis and therapeutic advances","volume":"5","author":"Gao","year":"2024","journal-title":"MedComm"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"102400","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Scherer","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rom\u00e3o, V.C., and Fonseca, J.E. (2021). Etiology and Risk Factors for Rheumatoid Arthritis: A State-of-the-Art Review. Front. Med., 8.","DOI":"10.3389\/fmed.2021.689698"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bj.2020.06.010","article-title":"Innate immunity drives pathogenesis of rheumatoid arthritis","volume":"44","author":"Edilova","year":"2021","journal-title":"Biomed. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/25785826.2021.1930371","article-title":"Adaptive immunity in the joint of rheumatoid arthritis","volume":"45","author":"Yamada","year":"2022","journal-title":"Immunol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cyto.2015.08.260","article-title":"The role of cytokines in the pathogenesis of rheumatoid arthritis\u2014Practical and potential application of cytokines as biomarkers and targets of personalized therapy","volume":"76","author":"Brzustewicz","year":"2015","journal-title":"Cytokine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cca.2016.02.010","article-title":"Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis","volume":"455","author":"Mateen","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fujimoto, S., and Niiro, H. (2025). Pathogenic Role of Cytokines in Rheumatoid Arthritis. J. Clin. Med., 14.","DOI":"10.3390\/jcm14186409"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Fuentelsaz-Romero, S., Cuervo, A., Estrada-Capetillo, L., Celis, R., Garc\u00eda-Campos, R., Ram\u00edrez, J., Sastre, S., Samaniego, R., Puig-Kr\u00f6ger, A., and Ca\u00f1ete, J.D. (2021). GM-CSF Expression and Macrophage Polarization in Joints of Undifferentiated Arthritis Patients Evolving to Rheumatoid Arthritis or Psoriatic Arthritis. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.613975"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13075-024-03373-y","article-title":"Serum GM-CSF level is a predictor of treatment response to tocilizumab in rheumatoid arthritis patients: A prospective observational cohort study","volume":"26","author":"Su","year":"2024","journal-title":"Arthritis Res. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s41232-016-0014-5","article-title":"GM-CSF as a therapeutic target in autoimmune diseases","volume":"36","author":"Shiomi","year":"2016","journal-title":"Inflamm. Regen."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2147\/ITT.S262566","article-title":"GM-CSF: A Promising Target in Inflammation and Autoimmunity","volume":"9","author":"Lee","year":"2020","journal-title":"Immunotargets Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1182\/blood.V90.8.3005","article-title":"The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF, interleukin-3, or interleukin-5","volume":"90","author":"Woodcock","year":"1997","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cell.2008.05.053","article-title":"The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation","volume":"134","author":"Hansen","year":"2008","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: From bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Nagenborg, J., Jin, H., Ruder, A.V., Temmerman, L., Mees, B., Schalkwijk, C., M\u00fcller-Klieser, D., Berg, T., Goossens, P., and Donners, M.M.P.C. (2023). GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1165306"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-4933-2-6","article-title":"The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging","volume":"2","author":"Larbi","year":"2005","journal-title":"Immun. Ageing"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3390\/cimb44020037","article-title":"Resveratrol Downregulates Granulocyte-Macrophage Colony-Stimulating Factor-Induced Oncostatin M Production through Blocking of PI3K\/Akt\/NF-\u03baB Signal Cascade in Neutrophil-like Differentiated HL-60 Cells","volume":"44","author":"Han","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1186\/s12967-025-06911-7","article-title":"GM-CSF potentiates macrophages to retain an inflammatory feature from their circulating monocyte precursors in rheumatoid arthritis","volume":"23","author":"Chen","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lotfi, N., Thome, R., Rezaei, N., Zhang, G.X., Rezaei, A., Rostami, A., and Esmaeil, N. (2019). Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01265"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e20190945","DOI":"10.1084\/jem.20190945","article-title":"GM-CSF in inflammation","volume":"217","author":"Hamilton","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_23","first-page":"116","article-title":"Evolving strategies in the treatment of rheumatoid arthritis: A historical perspective","volume":"63","year":"2025","journal-title":"Reumatologia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"152561","DOI":"10.1016\/j.semarthrit.2024.152561","article-title":"Disease-modifying antirheumatic drugs and risk of incident interstitial lung disease among patients with rheumatoid arthritis: A systematic review and meta-analysis","volume":"69","author":"Zhang","year":"2024","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/ard-2022-223356","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update","volume":"82","author":"Smolen","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s40265-019-01192-z","article-title":"Targeting Granulocyte-Monocyte Colony-Stimulating Factor Signaling in Rheumatoid Arthritis: Future Prospects","volume":"79","author":"Crotti","year":"2019","journal-title":"Drugs"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e648","DOI":"10.1016\/S2665-9913(20)30352-0","article-title":"The efficacy and safety of targeting GM-CSF in arthritis","volume":"2","author":"Bykerk","year":"2020","journal-title":"Lancet Rheumatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1136\/ard-2023-224449","article-title":"Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: A phase III randomised trial (contRAst 3)","volume":"82","author":"Taylor","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/art.40323","article-title":"A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis","volume":"70","author":"Weinblatt","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e677","DOI":"10.1016\/S2665-9913(20)30229-0","article-title":"Efficacy, patient-reported outcomes, and safety of the anti-granulocyte macrophage colony-stimulating factor antibody otilimab (GSK3196165) in patients with rheumatoid arthritis: A randomised, phase 2b, dose-ranging study","volume":"2","author":"Buckley","year":"2020","journal-title":"Lancet Rheumatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e473","DOI":"10.1016\/S2665-9913(21)00146-6","article-title":"Targeting GM-CSF in rheumatological conditions: Risk of PAP\u2014Authors\u2019 reply","volume":"3","author":"Genovese","year":"2021","journal-title":"Lancet Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Gao, X., Liu, S., Wang, Q., Wang, Y., Hou, S., Wang, J., and Zhang, Y. (2025). Global, regional, and national epidemiology of rheumatoid arthritis among people aged 20\u201354 years from 1990 to 2021. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-92150-1"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Maranini, B., Bortoluzzi, A., Silvagni, E., and Govoni, M. (2022). Focus on Sex and Gender: What We Need to Know in the Management of Rheumatoid Arthritis. J. Pers. Med., 12.","DOI":"10.3390\/jpm12030499"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.berh.2007.05.006","article-title":"The course of established rheumatoid arthritis","volume":"21","author":"Scott","year":"2007","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5114\/reum.2019.83236","article-title":"Cardiac and vascular complications in rheumatoid arthritis","volume":"57","author":"Rawla","year":"2019","journal-title":"Reumatologia"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Wu, D., Luo, Y., Li, T., Zhao, X., Lv, T., Fang, G., Ou, P., Li, H., Luo, X., and Huang, A. (2022). Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1051082"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1093\/rheumatology\/keaa232","article-title":"The genetics of rheumatoid arthritis","volume":"59","author":"Dedmon","year":"2020","journal-title":"Rheumatology"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Wysocki, T., Olesi\u0144ska, M., and Paradowska-Gorycka, A. (2020). Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis\u2013From Research to Clinical Practice. Cells, 9.","DOI":"10.3390\/cells9051127"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/art.40790","article-title":"The Contribution of PTPN22 to Rheumatic Disease","volume":"71","author":"Mustelin","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bravo-Villagra, K.M., Mu\u00f1oz-Valle, J.F., Ba\u00f1os-Hern\u00e1ndez, C.J., Cerpa-Cruz, S., Navarro-Zarza, J.E., Parra-Rojas, I., Aguilar-Vel\u00e1zquez, J.A., Garc\u00eda-Arellano, S., and L\u00f3pez-Quintero, A. (2024). STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico. Genes, 15.","DOI":"10.3390\/genes15020241"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"19397","DOI":"10.18632\/aging.203349","article-title":"Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: A meta-analysis","volume":"13","author":"Zhou","year":"2021","journal-title":"Aging"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"a028944","DOI":"10.1101\/cshperspect.a028944","article-title":"Lifestyle and Environmental Factors in Multiple Sclerosis","volume":"9","author":"Alfredsson","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Li, Y., Guo, R., Oduro, P.K., Sun, T., Chen, H., Yi, Y., Zeng, W., Wang, Q., Leng, L., and Yang, L. (2022). The Relationship Between Porphyromonas Gingivalis and Rheumatoid Arthritis: A Meta-Analysis. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.956417"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","article-title":"Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis","volume":"8","author":"Konig","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e003338","DOI":"10.1136\/rmdopen-2023-003338","article-title":"Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: A prospective cohort study with 223 526 participants","volume":"10","author":"Jiang","year":"2024","journal-title":"RMD Open"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Shuai, Z., Zheng, S., Wang, K., Wang, J., Leung, P.S.C., and Xu, B. (2022). Reestablish immune tolerance in rheumatoid arthritis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1012868"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Carl\u00e9, C., Degboe, Y., Ruyssen-Witrand, A., Arleevskaya, M.I., Clavel, C., and Renaudineau, Y. (2023). Characteristics of the (Auto)Reactive T Cells in Rheumatoid Arthritis According to the Immune Epitope Database. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054296"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1002\/eji.201646375","article-title":"Increased autophagy in CD4+ T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance","volume":"46","author":"Rossetti","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1302\/2046-3758.117.BJR-2021-0594.R1","article-title":"Immunomodulatory role of T helper cells in rheumatoid arthritis: A comprehensive research review","volume":"11","author":"Luo","year":"2022","journal-title":"Bone Jt. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00018-022-04563-0","article-title":"Regulatory T cells in rheumatoid arthritis: Functions, development, regulation, and therapeutic potential","volume":"79","author":"Yan","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"102304","DOI":"10.1016\/j.coph.2022.102304","article-title":"Targeting fibroblast-like synoviocytes in rheumatoid arthritis","volume":"67","author":"Tsaltskan","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1600088","DOI":"10.1002\/prca.201600088","article-title":"Secretion of pro-inflammatory cytokines and chemokines and loss of regulatory signals by fibroblast-like synoviocytes in juvenile idiopathic arthritis","volume":"11","author":"Brescia","year":"2017","journal-title":"Proteom. Clin. Appl."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s12016-021-08890-1","article-title":"Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings","volume":"63","author":"Sokolova","year":"2022","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.4049\/jimmunol.1102310","article-title":"Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice","volume":"188","author":"Banda","year":"2012","journal-title":"J. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/art.1780330306","article-title":"The relationship between CD5-expressing B lymphocytes and serologic abnormalities in rheumatoid arthritis patients and their relatives","volume":"33","author":"Youinou","year":"1990","journal-title":"Arthritis Rheum."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/art.42857","article-title":"Correlation of Professional Antigen-Presenting Tbet+CD11c+ B Cells With Bone Destruction in Untreated Rheumatoid Arthritis","volume":"76","author":"McGrath","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.2147\/JIR.S503144","article-title":"Neutrophils in Rheumatoid Arthritis Synovium: Implications on Disease Activity and Inflammation State","volume":"18","author":"Deng","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Wei, K., Jiang, P., Zhao, J., Shan, Y., Shi, Y., Zhao, F., Chang, C., Li, Y., and Zhou, M. (2024). Macrophage polarization in rheumatoid arthritis: Signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1394108"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.acthis.2013.02.005","article-title":"Tissue factor expression in rheumatoid synovium: A potential role in pannus invasion of rheumatoid arthritis","volume":"115","author":"Chen","year":"2013","journal-title":"Acta Histochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.17296.1","article-title":"RANKL is a therapeutic target of bone destruction in rheumatoid arthritis","volume":"8","author":"Tanaka","year":"2019","journal-title":"F1000Research"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"De Leon-Oliva, D., Barrena-Bl\u00e1zquez, S., Jim\u00e9nez-\u00c1lvarez, L., Fraile-Martinez, O., Garc\u00eda-Montero, C., L\u00f3pez-Gonz\u00e1lez, L., Torres-Carranza, D., Garc\u00eda-Puente, L.M., Carranza, S.T., and \u00c1lvarez-Mon, M.\u00c1. (2023). The RANK\u2013RANKL\u2013OPG System: A Multifaceted Regulator of Homeostasis, Immunity, and Cancer. Medicina, 59.","DOI":"10.3390\/medicina59101752"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Rolph, D., and Das, H. (2020). Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00937"},{"key":"ref_64","first-page":"427","article-title":"Rheumatoid arthritis: A review of the key clinical features and ongoing challenges of the disease","volume":"66","author":"Emery","year":"2024","journal-title":"Panminerva Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s00296-025-05908-1","article-title":"Late-onset rheumatoid arthritis: Clinical features, diagnostic challenges, and treatment approaches","volume":"45","author":"Zimba","year":"2025","journal-title":"Rheumatol. Int."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Pavlov-Dolijanovic, S., Bogojevic, M., Nozica-Radulovic, T., Radunovic, G., and Mujovic, N. (2023). Elderly-Onset Rheumatoid Arthritis: Characteristics and Treatment Options. Medicina, 59.","DOI":"10.3390\/medicina59101878"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Chmielewski, G., Majewski, M.S., Kuna, J., Mikiewicz, M., and Krajewska-W\u0142odarczyk, M. (2023). Fatigue in Inflammatory Joint Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512040"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jcyt.2021.10.003","article-title":"Rheumatoid arthritis: From synovium biology to cell-based therapy","volume":"24","author":"Debreova","year":"2022","journal-title":"Cytotherapy"},{"key":"ref_69","first-page":"286","article-title":"Extra-articular Manifestations in Rheumatoid Arthritis","volume":"5","author":"Cojocaru","year":"2010","journal-title":"Maedica"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/CRD.0000000000000486","article-title":"Cardiovascular Manifestations in Rheumatoid Arthritis","volume":"32","author":"Sanghavi","year":"2024","journal-title":"Cardiol. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and Management of Rheumatoid Arthritis: A Review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"vi5","DOI":"10.1093\/rheumatology\/kes279","article-title":"ACR\/EULAR 2010 rheumatoid arthritis classification criteria","volume":"51","author":"Kay","year":"2012","journal-title":"Rheumatology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/art.24827","article-title":"Anti-citrullinated peptide antibody assays and their role in the diagnosis of rheumatoid arthritis","volume":"61","author":"Aggarwal","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_74","first-page":"1316","article-title":"The role of imaging in rheumatoid arthritis","volume":"22","author":"Kgoebane","year":"2018","journal-title":"SA J. Radiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1182\/blood-2008-12-164004","article-title":"The granulocyte-macrophage colony-stimulating factor receptor: Linking its structure to cell signaling and its role in disease","volume":"114","author":"Hercus","year":"2009","journal-title":"Blood"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1182\/blood.V126.23.3589.3589","article-title":"The GM-CSF Receptor Alpha Chain (CSF2RA) Functions As a Novel Ligand-Independent Tumor Suppressor in t(8;21) AML","volume":"126","author":"Weng","year":"2015","journal-title":"Blood"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1042\/BJ20091745","article-title":"The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation","volume":"426","author":"Mirza","year":"2010","journal-title":"Biochem. J."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Pundavela, J., Hall, A., Dinglasan, S.A., Choi, K., Rizvi, T.A., Trapnell, B.C., Wu, J., and Ratner, N. (2025). Granulocyte-Macrophage Colony Stimulating Factor Receptor Contributes to Plexiform Neurofibroma Initiation. Cancers, 17.","DOI":"10.3390\/cancers17050905"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0092-8674(01)00213-6","article-title":"Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration","volume":"104","author":"Carr","year":"2001","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.bbamcr.2019.06.005","article-title":"Endocytosis of GM-CSF receptor \u03b2 is essential for signal transduction regulating mesothelial-macrophage transition","volume":"1866","author":"Zsiros","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"13814","DOI":"10.1074\/jbc.270.23.13814","article-title":"The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain","volume":"270","author":"Zhao","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1182\/blood.V93.7.2369","article-title":"Constitutive activation of the JAK2\/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines","volume":"93","author":"Liu","year":"1999","journal-title":"Blood"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1182\/blood-2009-04-216390","article-title":"The transcription factors STAT5A\/B regulate GM-CSF-mediated granulopoiesis","volume":"114","author":"Kimura","year":"2009","journal-title":"Blood"},{"key":"ref_84","first-page":"769795","article-title":"M-CSF and GM-CSF regulation of STAT5 activation and DNA binding in myeloid cell differentiation is disrupted in nonobese diabetic mice","volume":"2008","author":"Elf","year":"2008","journal-title":"Clin. Dev. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e0056524","DOI":"10.1128\/iai.00565-24","article-title":"GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection","volume":"93","author":"Dresler","year":"2025","journal-title":"Infect. Immun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s00018-024-05196-1","article-title":"Macrophage re-programming by JAK inhibitors relies on MAFB","volume":"81","author":"Schiaffino","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e73796","DOI":"10.7554\/eLife.73796","article-title":"Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway","volume":"11","author":"Boyer","year":"2022","journal-title":"Elife"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"27817","DOI":"10.1074\/jbc.270.46.27817","article-title":"Identification of a new adapter protein that may link the common beta subunit of the receptor for granulocyte\/macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase","volume":"270","author":"Feldman","year":"1995","journal-title":"J. Bol. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Mafi, S., Mansoori, B., Taeb, S., Sadeghi, H., Abbasi, R., Cho, W.C., and Rostamzadeh, D. (2022). mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.774103"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"de Carvalho Oliveira, V., Tatsiy, O., and McDonald, P.P. (2023). Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1042686"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0898-6568(01)00201-7","article-title":"Activation of Raf\/ERK1\/2 MAP kinase pathway is involved in GM-CSF-induced proliferation and survival but not in erythropoietin-induced differentiation of TF-1 cells","volume":"13","author":"Kolonics","year":"2001","journal-title":"Cell Signal."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.exer.2009.06.008","article-title":"GM-CSF regulates the ERK1\/2 pathways and protects injured retinal ganglion cells from induced death","volume":"89","author":"Schallenberg","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/1742-2094-9-268","article-title":"GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia","volume":"9","author":"Parajuli","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"24561","DOI":"10.1074\/jbc.M115.668871","article-title":"Role of Erk1\/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF","volume":"290","author":"Hu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.celrep.2019.09.035","article-title":"Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-\/M-CSF Signaling Axis in Human Monocytes","volume":"29","author":"Rodriguez","year":"2019","journal-title":"Cell Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1182\/blood-2002-12-3753","article-title":"GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta","volume":"102","author":"Ebner","year":"2003","journal-title":"Blood"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1182\/blood.2024024330","article-title":"GM-CSF receptor expression determines opposing innate memory phenotypes at different stages of myelopoiesis","volume":"143","author":"Guerrero","year":"2024","journal-title":"Blood"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13075-016-1185-9","article-title":"Granulocyte macrophage colony-stimulating factor receptor \u03b1 expression and its targeting in antigen-induced arthritis and inflammation","volume":"18","author":"Cook","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Yoshitomi, H. (2019). Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01395"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Tu, J., Hong, W., Zhang, P., Wang, X., K\u00f6rner, H., and Wei, W. (2018). Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01467"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"106566","DOI":"10.1016\/j.phrs.2022.106566","article-title":"Targeting CSF-1R represents an effective strategy in modulating inflammatory diseases","volume":"187","author":"Xiang","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Zhan, Y., Lew, A.M., and Chopin, M. (2019). The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02679"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"P\u00e9rez, S., and Rius-P\u00e9rez, S. (2022). Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective. Antioxidants, 11.","DOI":"10.3390\/antiox11071394"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Lotfi, N., Zhang, G.X., Esmaeil, N., and Rostami, A. (2020). Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-58131-2"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.immuni.2013.09.006","article-title":"Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival","volume":"39","author":"Porollo","year":"2013","journal-title":"Immunity"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Takeuchi, Y., Hirota, K., and Sakaguchi, S. (2019). Synovial Tissue Inflammation Mediated by Autoimmune T Cells. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01989"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1189\/jlb.0204071","article-title":"Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia","volume":"76","author":"Fuhler","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.4049\/jimmunol.161.6.3071","article-title":"Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through prostaglandin-dependent and -independent mechanisms","volume":"161","author":"Zhang","year":"1998","journal-title":"J. Immunol."},{"key":"ref_109","first-page":"1281","article-title":"NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene","volume":"10","author":"Schreck","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"245804","DOI":"10.1155\/2013\/245804","article-title":"IRF5 is a specific marker of inflammatory macrophages in vivo","volume":"2013","author":"Weiss","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.immuni.2015.12.014","article-title":"Alive but Confused: Heterogeneity of CD11c(+) MHC Class II(+) Cells in GM-CSF Mouse Bone Marrow Cultures","volume":"44","author":"Helft","year":"2016","journal-title":"Immunity"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1814620","DOI":"10.1080\/2162402X.2020.1814620","article-title":"Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response","volume":"9","author":"Mashima","year":"2020","journal-title":"Oncoimmunology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"jcs260298","DOI":"10.1242\/jcs.260298","article-title":"GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner","volume":"135","author":"Korniotis","year":"2022","journal-title":"J. Cell Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41541-024-00869-1","article-title":"High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists","volume":"9","author":"Gilmour","year":"2024","journal-title":"npj Vaccines"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.immuni.2018.04.009","article-title":"Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis","volume":"48","author":"Hirota","year":"2018","journal-title":"Immunity"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/sj.leu.2400607","article-title":"Functional features of neutrophils induced by G-CSF and GM-CSF treatment: Differential effects and clinical implications","volume":"11","author":"Spiekermann","year":"1997","journal-title":"Leukemia"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1128\/MCB.18.8.4883","article-title":"mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response","volume":"18","author":"Chao","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/2211-5463.13445","article-title":"G-CSF\/GM-CSF-induced hematopoietic dysregulation in the progression of solid tumors","volume":"12","author":"He","year":"2022","journal-title":"FEBS Open Bio"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Chen, J., Cao, Y., Xiao, J., Hong, Y., and Zhu, Y. (2024). The emerging role of neutrophil extracellular traps in the progression of rheumatoid arthritis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1438272"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cyto.2015.05.030","article-title":"GM-CSF: An immune modulatory cytokine that can suppress autoimmunity","volume":"75","author":"Bhattacharya","year":"2015","journal-title":"Cytokine"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.2967\/jnumed.115.167387","article-title":"GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo","volume":"57","author":"Singh","year":"2016","journal-title":"J. Nucl. Med."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Sun, H.W., Wu, W.C., Chen, H.T., Xu, Y.T., Yang, Y.Y., Chen, J., Yu, X.J., Wang, Z., Shuang, Z.Y., and Zheng, L. (2021). Glutamine Deprivation Promotes the Generation and Mobilization of MDSCs by Enhancing Expression of G-CSF and GM-CSF. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.616367"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/1756-185X.13395","article-title":"Pharmacodynamic biomarkers and differential effects of TNF- and GM-CSF-targeting biologics in rheumatoid arthritis","volume":"22","author":"Guo","year":"2019","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.18688.1","article-title":"Emerging therapies in rheumatoid arthritis: Focus on monoclonal antibodies","volume":"8","author":"Senolt","year":"2019","journal-title":"F1000Research"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Kumar, A., Taghi Khani, A., Sanchez Ortiz, A., and Swaminathan, S. (2022). GM-CSF: A Double-Edged Sword in Cancer Immunotherapy. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.901277"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e088869","DOI":"10.1136\/bmjopen-2024-088869","article-title":"Long-term safety and efficacy of anti-GM-CSF otilimab in patients with rheumatoid arthritis: Long-term extension of three phase 3 randomised trials (contRAst X)","volume":"15","author":"Weinblatt","year":"2025","journal-title":"BMJ Open"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13075-017-1267-3","article-title":"Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis","volume":"19","author":"Huizinga","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/annrheumdis-2021-220873","article-title":"Blocking GM-CSF receptor \u03b1 with mavrilimumab reduces infiltrating cells, pro-inflammatory markers and neoangiogenesis in ex vivo cultured arteries from patients with giant cell arteritis","volume":"81","author":"Muralidharan","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1136\/ard.2010.146225","article-title":"Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-\u03b1, in subjects with rheumatoid arthritis: A randomised, double-blind, placebo-controlled, phase I, first-in-human study","volume":"70","author":"Burmester","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4161\/mabs.2.5.12833","article-title":"Properties of a general PK\/PD model of antibody-ligand interactions for therapeutic antibodies that bind to soluble endogenous targets","volume":"2","author":"Davda","year":"2010","journal-title":"MAbs"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/ar318","article-title":"Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): Requirement for GM-CSF in the effector phase of disease","volume":"3","author":"Cook","year":"2001","journal-title":"Arthritis Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1002\/art.30354","article-title":"Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritis","volume":"63","author":"Cook","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1136\/annrheumdis-2014-205234","article-title":"Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis","volume":"74","author":"Greven","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1476-5381.2012.02173.x","article-title":"Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis","volume":"168","author":"Minter","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/ard-2023-224482","article-title":"Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: Two phase 3 randomised trials (contRAst 1 and contRAst 2)","volume":"82","author":"Fleischmann","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e666","DOI":"10.1016\/S2665-9913(20)30224-1","article-title":"MRI of the joint and evaluation of the granulocyte-macrophage colony-stimulating factor-CCL17 axis in patients with rheumatoid arthritis receiving otilimab: A phase 2a randomised mechanistic study","volume":"2","author":"Genovese","year":"2020","journal-title":"Lancet Rheumatol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13075-019-1879-x","article-title":"Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: A randomized, controlled trial","volume":"21","author":"Taylor","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Kivitz, A., Hazan, L., Hoffman, K., and Wallin, B. (2016). FRI0209 MORAb-022, an Anti-Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Monoclonal Antibody (MAB): RESULTS of the First Study in Patients with Mild-to-Moderate Rheumatoid Arthritis (RA), BMJ Publishing Group Ltd.","DOI":"10.1136\/annrheumdis-2016-eular.3186"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1136\/annrheumdis-2013-204816","article-title":"MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: Results of a phase Ib\/IIa randomised, double-blind, placebo-controlled, dose-escalation trial","volume":"74","author":"Behrens","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1136\/annrheumdis-2012-202450","article-title":"Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis","volume":"72","author":"Burmester","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1136\/annrheumdis-2015-eular.1945","article-title":"Efficacy and safety of mavrilimumab, A fully human Gm\u2013CSFR-Alpha monoclonal antibody in patients with rheumatoid arthritis: Primary results from the Earth Explorer 1 Study","volume":"74","author":"Burmester","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/annrheumdis-2016-210624","article-title":"A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis","volume":"76","author":"Burmester","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1136\/annrheumdis-2015-eular.4241","article-title":"AB0445\u2005Exposure\u2013Efficacy Analysis of Mavrilimumab in Rheumatoid Arthritis: Modeling and Simulation of Phase II Clinical Data","volume":"74","author":"Jin","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/art.40420","article-title":"Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor \u03b1 Monoclonal Antibody: Long-Term Safety and Efficacy in Patients with Rheumatoid Arthritis","volume":"70","author":"Burmester","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"S717","DOI":"10.1136\/annrheumdis-2016-eular.3453","article-title":"Earth explorer 2, a phase IIb exploratory study evaluating efficacy and safety of mavrilimumab, a fully human granulocyte-macrophage colony-stimulating factor receptor-alpha monoclonal antibody, and the tumor necrosis factor antagonist golimumab in rheumatoid arthritis","volume":"75","author":"Weinblatt","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Chen, Y., Li, F., Hua, M., Liang, M., and Song, C. (2023). Role of GM-CSF in lung balance and disease. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1158859"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Lazarus, H.M., Pitts, K., Wang, T., Lee, E., Buchbinder, E., Dougan, M., Armstrong, D.G., Paine, R., Ragsdale, C.E., and Boyd, T. (2023). Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1069444"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"McCormick, T.S., Hejal, R.B., Leal, L.O., and Ghannoum, M.A. (2022). GM-CSF: Orchestrating the Pulmonary Response to Infection. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.735443"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"106588","DOI":"10.1016\/j.jinf.2025.106588","article-title":"Neutralizing GM-CSF autoantibodies impair neutrophil antifungal effector function in a patient with aspergillosis","volume":"91","author":"Wishart","year":"2025","journal-title":"J. Infect."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Ataya, A., Knight, V., Carey, B.C., Lee, E., Tarling, E.J., and Wang, T. (2021). The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.752856"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2301233","DOI":"10.1183\/13993003.01233-2023","article-title":"Inhaled recombinant GM-CSF reduces the need for whole lung lavage and improves gas exchange in autoimmune pulmonary alveolar proteinosis patients","volume":"63","author":"Campo","year":"2024","journal-title":"Eur. Respir. J."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/clim.2002.5301","article-title":"Anti-GM-CSF titer predicts response to GM-CSF therapy in pulmonary alveolar proteinosis","volume":"105","author":"Bonfield","year":"2002","journal-title":"Clin. Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Campo, I., Meloni, F., Gahlemann, M., Sauter, W., Ittrich, C., Schoelch, C., Trapnell, B.C., and Gupta, A. (2022). An exploratory study investigating biomarkers associated with autoimmune pulmonary alveolar proteinosis (aPAP). Sci. Rep., 12.","DOI":"10.1038\/s41598-022-11446-8"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Chen, W., Feng, X., Yao, L.K., Li, X., Yang, Z.M., Qin, X.Y., Li, Y., and Qiu, Y. (2025). Exogenous GM-CSF therapy for autoimmune pulmonary alveolar proteinosis: A systematic literature review. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1552566"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Chen, H., Gao, N., Fan, D., Wu, J., Zhu, J., Li, J., Wang, J., Chen, Y., and An, J. (2012). Suppressive effects on the immune response and protective immunity to a JEV DNA vaccine by co-administration of a GM-CSF-expressing plasmid in mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034602"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/annonc\/mdl158","article-title":"Opposite immune functions of GM-CSF administered as vaccine adjuvant in cancer patients","volume":"18","author":"Parmiani","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1080\/21645515.2016.1221551","article-title":"Novel GM-CSF-based vaccines: One small step in GM-CSF gene optimization, one giant leap for human vaccines","volume":"12","author":"Yu","year":"2016","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11882-016-0624-7","article-title":"Unintended Immunological Consequences of Biologic Therapy","volume":"16","author":"Henrickson","year":"2016","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"eadj1252","DOI":"10.1126\/sciadv.adj1252","article-title":"Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset","volume":"10","author":"Hanlon","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1172\/JCI87828","article-title":"Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation","volume":"126","author":"Achuthan","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2147\/OARRR.S372610","article-title":"Towards Personalized Medicine in Rheumatoid Arthritis","volume":"16","author":"Sharma","year":"2024","journal-title":"Open Access Rheumatol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/intimm\/dxaf020","article-title":"Immunogenomic precision medicine: A personalized approach based on immunogenomic cancer evolution","volume":"37","author":"Momoi","year":"2025","journal-title":"Int. Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"156408","DOI":"10.1016\/j.cyto.2023.156408","article-title":"The dichotomic role of single cytokines: Fine-tuning immune responses","volume":"173","author":"Silva","year":"2024","journal-title":"Cytokine"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/hep.21560","article-title":"Combined GM-CSF and IL-12 gene therapy synergistically suppresses the growth of orthotopic liver tumors","volume":"45","author":"Chang","year":"2007","journal-title":"Hepatology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jconrel.2021.12.022","article-title":"Rational administration sequencing of immunochemotherapy elicits powerful anti-tumor effect","volume":"341","author":"Zhu","year":"2022","journal-title":"J. Control Release"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Kwon, O.C., Lee, E.J., Chang, E.J., Youn, J., Ghang, B., Hong, S., Lee, C.K., Yoo, B., and Kim, Y.G. (2018). IL-17A+GM-CSF+ Neutrophils Are the Major Infiltrating Cells in Interstitial Lung Disease in an Autoimmune Arthritis Model. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01544"},{"key":"ref_168","first-page":"15","article-title":"Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies","volume":"3","author":"Rahman","year":"2010","journal-title":"Pharmgenom. Pers. Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/art.30655","article-title":"Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: Findings of a prospective pilot study","volume":"64","author":"Gent","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Bruijnen, S.T.G., Verweij, N.J.F., Gent, Y.Y.J., Huisman, M.C., Windhorst, A.D., Kassiou, M., van de Ven, P.M., Lammertsma, A.A., Hoekstra, O.S., and Voskuyl, A.E. (2019). Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0222844"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/acr.21767","article-title":"Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity","volume":"64","author":"Curtis","year":"2012","journal-title":"Arthritis Care Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3899\/jrheum.090262","article-title":"Testing of the OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage in rheumatoid arthritis: A systematic literature search on 5 candidate biomarkers","volume":"36","author":"Syversen","year":"2009","journal-title":"J. Rheumatol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/art.38647","article-title":"T cell expression of granulocyte-macrophage colony-stimulating factor in juvenile arthritis is contingent upon Th17 plasticity","volume":"66","author":"Piper","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/art.42104","article-title":"Role for Granulocyte Colony-Stimulating Factor in Neutrophilic Extramedullary Myelopoiesis in a Murine Model of Systemic Juvenile Idiopathic Arthritis","volume":"74","author":"Bernaerts","year":"2022","journal-title":"Arthritis Rheumatol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/11\/1737\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T09:01:26Z","timestamp":1762938086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/11\/1737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":174,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["life15111737"],"URL":"https:\/\/doi.org\/10.3390\/life15111737","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]}}}