{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:47:40Z","timestamp":1785419260136,"version":"3.56.0"},"reference-count":68,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Primary cardiac tumors are exceedingly rare, accounting for less than 0.2% of cases in autopsy series. Myxomas represent the majority, while hemangiomas are exceptionally uncommon, accounting for less than 2% of benign cardiac tumors. Their rarity, nonspecific clinical presentation, and overlapping imaging features make preoperative diagnosis particularly challenging. Case presentation: We report the case of a 47-year-old woman with exertional dyspnoea and a large right atrial mass initially suggestive of myxoma on transthoracic echocardiography. Coronary angiography revealed a small fistulous connection, raising suspicion of a vascular lesion. Surgical resection was performed, and histopathological examination confirmed a cavernous hemangioma. The postoperative course was favorable, with no residual mass on follow-up imaging. Discussion: Cardiac hemangiomas are often misdiagnosed as myxomas due to similar clinical and echocardiographic appearances. This case illustrates the diagnostic challenges posed by cardiac hemangiomas and the importance of correlating multiple imaging modalities when assessing atypical atrial masses. Our case highlights the potential role of multimodal imaging, including contrast echocardiography, cardiac MRI, and coronary angiography, in differentiating vascular from non-vascular cardiac tumors. Based on recurrent patterns in the literature, we outline a conceptual diagnostic framework that may assist preoperative evaluation. Conclusions: Although rare, cardiac hemangiomas should be considered in the differential diagnosis of atrial masses. Multimodal imaging may improve diagnostic accuracy, but additional data from multicenter registries are required to establish validated diagnostic pathways.<\/jats:p>","DOI":"10.3390\/life15121816","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:25:16Z","timestamp":1764239116000},"page":"1816","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac Hemangioma in the Right Atrium: Diagnostic Challenges, Imaging Clues, and a Novel Algorithm for Differential Diagnosis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-9946","authenticated-orcid":false,"given":"Andrei Emanuel","family":"Grigorescu","sequence":"first","affiliation":[{"name":"Department VI Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, E. Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Advanced Research Center, Institute for Cardiovascular Diseases, 300310 Timisoara, Romania"},{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Cardiovascular Surgery, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona Cristina","family":"Novaconi","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Cardiovascular Surgery, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9501-5530","authenticated-orcid":false,"given":"Iulia Raluca","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Advanced Research Center, Institute for Cardiovascular Diseases, 300310 Timisoara, Romania"},{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Cardiovascular Surgery, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"},{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, E. Murgu Sq. No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6744-8261","authenticated-orcid":false,"given":"Andrei Raul","family":"Manzur","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Cardiovascular Surgery, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"},{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, E. Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Department of Pulmonology, Center for Research and Innovation in Precision Medicine of Respiratory Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3377-1465","authenticated-orcid":false,"given":"Adrian Sebastian","family":"Zus","sequence":"additional","affiliation":[{"name":"Department VI Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, E. Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Advanced Research Center, Institute for Cardiovascular Diseases, 300310 Timisoara, Romania"},{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Cardiovascular Surgery, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"},{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, E. Murgu Sq. No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai-Andrei","family":"Lazar","sequence":"additional","affiliation":[{"name":"Department VI Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, E. Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Advanced Research Center, Institute for Cardiovascular Diseases, 300310 Timisoara, Romania"},{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Cardiovascular Surgery, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2951-8010","authenticated-orcid":false,"given":"Oana Raluca","family":"Voinescu","sequence":"additional","affiliation":[{"name":"Department VI Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, E. Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Cardiovascular Surgery, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8760-5605","authenticated-orcid":false,"given":"Simina","family":"Cri\u0219an","sequence":"additional","affiliation":[{"name":"Department VI Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, E. Murgu Sq. No. 2, 300041 Timisoara, Romania"},{"name":"Advanced Research Center, Institute for Cardiovascular Diseases, 300310 Timisoara, Romania"},{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Cardiovascular Surgery, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-8249","authenticated-orcid":false,"given":"Horea Bogdan","family":"Feier","sequence":"additional","affiliation":[{"name":"Department VI Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, E. Murgu Sq. 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