{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:43:54Z","timestamp":1766990634246,"version":"3.48.0"},"reference-count":93,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Vitamin B1 (thiamine) is a water-soluble B vitamin. As a cofactor of many enzymes, it is essential for the proper functioning of many body systems and organs, including metabolic and energy metabolism. In extreme cases, vitamin B1 deficiency causes neurodegenerative disorders, including beri-beri, or cognitive impairment resulting from encephalopathy. B1 avitaminosis may result from increased demand, dietary errors, malabsorption, or excessive loss. Thiamine supplementation is used in cases of vitamin B1 deficiency or for preventative measures in situations of increased demand. Vitamin B1 can be administered enterally or parenterally (intravenously, intramuscularly, subcutaneously). The route and dose depend on the individual patient\u2019s clinical situation. Hypersensitivity to vitamin B1 is rare and appears to be primarily associated with rapid intravenous infusion of large doses of thiamine hydrochloride over a short period (intravenous bolus). Hypersensitivity to thiamine administered by routes other than intravenous or intramuscular injection appears to be an incidental phenomenon. Thiamine should also be considered as an occupational allergen. The mechanism of thiamine hypersensitivity has not been clearly elucidated. However, considering the clinical nature and dynamics of the reaction, the most likely reaction seems to be an immediate type of hypersensitivity reaction (immunoglobulin E (IgE)-dependent), in which thiamine (but not its metabolites) acts as a hapten. Diagnosing hypersensitivity to vitamin B1 is difficult due to the lack of validated tests for additional testing. In individuals requiring thiamine supplementation who have experienced hypersensitivity to intramuscular or intravenous administration of this vitamin, switching to oral administration may be considered (provided this does not reduce treatment efficacy). This form of supplementation is usually well tolerated by individuals allergic to parenteral thiamine. However, if enteral supplementation does not guarantee the maintenance of therapeutic potential, thiamine desensitization may be considered, which seems to be an effective therapeutic method in such a clinical situation.<\/jats:p>","DOI":"10.3390\/life16010050","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:25:51Z","timestamp":1766989551000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Etiopathological Perspective of Vitamin B1 Hypersensitivity and an Example of a Desensitization Protocol"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-8468","authenticated-orcid":false,"given":"Kinga","family":"Lis","sequence":"first","affiliation":[{"name":"Department of Allergology, Clinical Immunology and Internal Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, ul. Ujejskiego 75, 85-168 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Egbuna, C., and Dable Tupas, G. (2020). Vitamins and Minerals: Types, Sources and their Functions. Functional Foods and Nutraceuticals, Springer.","DOI":"10.1007\/978-3-030-42319-3"},{"key":"ref_2","unstructured":"Sight and Life Press. c\/o Sight and Life\/DSM Nutritional Products Ltd. (2025, November 12). Vitamins and Minerals: A Brief Guide. Available online: https:\/\/cms.sightandlife.org\/wp-content\/uploads\/2023\/03\/SAL_MVLex_web.pdf."},{"key":"ref_3","unstructured":"Sinclair, J., and Wilson, A. (2025, October 29). Vitamins and Minerals. DR. GUIDE BOOK SERIES. 2015. Mediscript Communications Inc. Canada. Available online: https:\/\/mediscript.net\/wp-content\/uploads\/2018\/09\/Vitamins-and-Minerals_Ebook-SAMPLE.pdf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/B978-0-7020-4087-0.00059-0","article-title":"Hydrosoluble vitamins","volume":"120","author":"Chawla","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"ref_5","unstructured":"Lykstad, J., and Sharma, S. (2025, October 29). Biochemistry, Water Soluble Vitamins. [Updated 6 March 2023], StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538510\/."},{"key":"ref_6","unstructured":"Steinberg, F.M., Rucker, R.B., Ye, L., and Eitenmiller, R. (2005). The Water-Soluble Vitamins. Handbook of Food Science, Technology, and Engineering, CRC Press."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e766","DOI":"10.1002\/hsr2.766","article-title":"Allergic contact dermatitis from vitamins: A systematic review","volume":"5","author":"Foti","year":"2022","journal-title":"Health Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.tifs.2021.01.056","article-title":"The bioaccessibility of water-soluble vitamins: A review","volume":"109","author":"Yaman","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1042\/BJ20110326","article-title":"Intestinal absorption of water-soluble vitamins in health and disease","volume":"437","author":"Said","year":"2011","journal-title":"Biochem. J."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hrub\u0161a, M., Siatka, T., Nejmanov\u00e1, I., Vopr\u0161alov\u00e1, M., Kujovsk\u00e1 Kr\u010dmov\u00e1, L., Matou\u0161ov\u00e1, K., Javorsk\u00e1, L., Mac\u00e1kov\u00e1, K., Mercolini, L., and Remi\u00e3o, F. (2022). Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5. Nutrients, 14.","DOI":"10.3390\/nu14030484"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1017\/S0954422425100097","article-title":"Biological properties of vitamins of the B-complex, part 2\u2014Vitamins B6 and B7 (biotin, vitamin H)","volume":"38","author":"Dias","year":"2025","journal-title":"Nutr. Res. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7812\/TPP\/21.204","article-title":"B Vitamins: Functions and Uses in Medicine","volume":"26","author":"Hanna","year":"2022","journal-title":"Perm. J."},{"key":"ref_13","first-page":"42","article-title":"Vitamin B complex: B group vitamins and their role in the body","volume":"120","author":"Knight","year":"2024","journal-title":"Nurs. Times"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.56782\/pps.159","article-title":"Thiamine (vitamin b1): Overview of history of discovery, mechanism of action, role and deficiency","volume":"21","year":"2023","journal-title":"Prospect. Pharm. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000319165","article-title":"Casimir Funk: His discovery of the vitamins and their deficiency disorders","volume":"57","author":"Piro","year":"2010","journal-title":"Ann. Nutr. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000343109","article-title":"The discovery of thiamin","volume":"61","author":"Carpenter","year":"2012","journal-title":"Ann. Nutr. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1001751522263","article-title":"Christiaan Eijkman. First bacteriologist at Utrecht University, Nobel laureate for his work on vitamins","volume":"75","author":"Verhoef","year":"1999","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_18","first-page":"341","article-title":"The etiology of the deficiency diseases. Beri-beri, polyneuritis in birds, epidemic dropsy, scurvy, experimental scurvy in animals, infantile scurvy, ship beri-beri, pellagra","volume":"20","author":"Funk","year":"1912","journal-title":"J. State Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/jn\/102.9.1105","article-title":"Casimir Funk: A Biographical Sketch (1884\u20131967)","volume":"102","author":"Griminger","year":"1972","journal-title":"J. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ka\u017amierczak-Bara\u0144ska, J., Halczuk, K., and Karwowski, B.T. (2025). Thiamine (Vitamin B1)\u2014An Essential Health Regulator. Nutrients, 17.","DOI":"10.3390\/nu17132206"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"BSR20230374","DOI":"10.1042\/BSR20230374","article-title":"The importance of thiamine (vitamin B1) in humans","volume":"43","author":"Mrowicka","year":"2023","journal-title":"Biosci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/B978-0-12-386479-6.00004-4","article-title":"Vitamin B1 (Thiamine): A Cofactor for Enzymes Involved in the Main Metabolic Pathways and an Environmental Stress Protectant","volume":"58","year":"2011","journal-title":"Adv. Bot. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/1533210110392941","article-title":"Thiamine (Vitamin B1)","volume":"16","year":"2011","journal-title":"J. Evid.-Based Complement. Altern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"447","DOI":"10.5604\/17322693.951633","article-title":"Thiamine and its derivatives in the regulation of cell metabolism","volume":"65","author":"Tylicki","year":"2011","journal-title":"Post\u0119py Hig. Med. Do\u015bwiadczalnej"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/ecam\/nek009","article-title":"A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives","volume":"3","author":"Lonsdale","year":"2006","journal-title":"Evid.-Based. Complement. Altern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.amjms.2018.06.015","article-title":"Thiamine Deficiency: An Important Consideration in Critically Ill Patients","volume":"356","author":"Attaluri","year":"2018","journal-title":"Am. J. Med. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Bettendorff, L. (2021). Update on Thiamine Triphosphorylated Derivatives and Metabolizing Enzymatic Complexes. Biomolecules, 11.","DOI":"10.3390\/biom11111645"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Pacei, F., Tesone, A., Laudi, N., Laudi, E., Cretti, A., Pnini, S., Varesco, F., and Colombo, C. (2020). The Relevance of Thiamine Evaluation in a Practical Setting. Nutrients, 12.","DOI":"10.3390\/nu12092810"},{"key":"ref_29","first-page":"229","article-title":"B vitamins\u2014Natural sources, role in the body, effects of vitamin deficiency","volume":"4","year":"2009","journal-title":"Post. Fitoter."},{"key":"ref_30","first-page":"383","article-title":"Prophylactic and therapeutic application of thiamine (vitamin B1)\u2014A new point of view","volume":"59","author":"Poprawski","year":"2006","journal-title":"Wiad. Lek."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/0148607114565245","article-title":"Thiamin in clinical practice","volume":"39","author":"Frank","year":"2015","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gasperi, V., Sibilano, M., Savini, I., and Catani, M.V. (2019). Niacin in the central nervous system: An update of biological aspects and clinical applications. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040974"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/0884533611426149","article-title":"Thiamine in nutrition therapy","volume":"27","author":"Sriram","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_34","first-page":"26","article-title":"Thiamine deficiency and delirium","volume":"10","author":"Osiezagha","year":"2013","journal-title":"Innov. Clin. Neurosci."},{"key":"ref_35","unstructured":"Wiley, K.D., and Gupta, M. (2025). Vitamin B1 (Thiamine) Deficiency. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_36","unstructured":"Institute of Medicine (US) (1998). Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline, National Academies Press."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000547719","article-title":"An Overview of Beriberi","volume":"1","author":"Pereira","year":"2025","journal-title":"Med. Princ. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.14594","article-title":"A fresh look at thiamine deficiency-new analyses by the global thiamine alliance","volume":"1498","author":"Bourassa","year":"2021","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/nyas.14536","article-title":"Thiamine deficiency disorders: A clinical perspective","volume":"1498","author":"Smith","year":"2021","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.36347\/sjmcr.2023.v11i02.021","article-title":"Beri-beri Disease: Forgotten but Not Gone!","volume":"11","author":"Bouraghda","year":"2023","journal-title":"Sch. J. Med. Case Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"330","DOI":"10.12659\/AJCR.914051","article-title":"Dry Beri-beri Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke\u2019s Encephalopathy Mimicking Guillain-Barr\u00e9 syndrome: A Case Report and Review of the Literature","volume":"20","author":"Shible","year":"2019","journal-title":"Am. J. Case Rep."},{"key":"ref_42","unstructured":"Akhouri, S., Kuhn, J., and Newton, E.J. (2025, October 29). Wernicke-Korsakoff Syndrome. [Updated 26 June 2023], StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430729\/."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.2147\/NDT.S130078","article-title":"Korsakoff\u2019s syndrome: A critical review","volume":"13","author":"Arts","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0278-5846(03)00155-6","article-title":"Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre","volume":"27","author":"Harper","year":"2003","journal-title":"Prog. Neuro-Psychopharmacol. Boil. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bonnan, M. (2025). Protocols of Thiamine Supplementation: Clinically Driven Rationality vs. Biological Commonsense. J. Clin. Med., 14.","DOI":"10.3390\/jcm14113787"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.nwh.2024.02.003","article-title":"Use of Thiamine Supplementation in Pregnant Women Diagnosed With Hyperemesis Gravidarum and Wernicke Encephalopathy","volume":"28","author":"Clark","year":"2024","journal-title":"Nurs. Women\u2019s Health"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.clnu.2024.01.030","article-title":"ESPEN practical short micronutrient guideline","volume":"43","author":"Berger","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.japh.2019.12.005","article-title":"Safety of intravenous push thiamine administration at a tertiary academic medical center","volume":"60","author":"McLaughlin","year":"2003","journal-title":"J. Am. Pharm. Assoc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"368504221096539","DOI":"10.1177\/00368504221096539","article-title":"Evaluation of the safety of 500 mg intravenous push thiamine at a tertiary academic medical center","volume":"105","author":"Aldhaeefi","year":"2022","journal-title":"Sci. Prog."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/0897190019872584","article-title":"Evaluation of the Safety of Intravenous Thiamine Administration in a Large Academic Medical Center","volume":"34","author":"Tjugum","year":"2021","journal-title":"J. Pharm. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1001\/jama.1941.72820290004005c","article-title":"Sensitization to thiamine hydrochloride","volume":"117","author":"Laws","year":"1941","journal-title":"JAMA"},{"key":"ref_52","first-page":"150","article-title":"Vitamin B1 hypersensitivity with desensitization","volume":"15","author":"Mitrani","year":"1944","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_53","first-page":"364","article-title":"Sensitivity to thiamine hydrochloride, review of the literature and report of a case","volume":"6","author":"Baird","year":"1946","journal-title":"Med. Bull. (N. Y.)"},{"key":"ref_54","first-page":"491","article-title":"Sudden death following intravenous injection of thiamine hydrochloride","volume":"130","author":"Reingold","year":"1946","journal-title":"J. Am. Med. Assoc."},{"key":"ref_55","first-page":"349","article-title":"Sensitivity to thiamine hydrochloride; report of a case","volume":"5","author":"Shapero","year":"1947","journal-title":"Ann. Allergy"},{"key":"ref_56","first-page":"178","article-title":"Anaphylactic shock following intravenous administration of thiamine chloride; report of a case","volume":"72","author":"Armanino","year":"1950","journal-title":"Calif. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/archderm.1950.01530120149018","article-title":"Contact dermatitis due to thiamine","volume":"61","author":"Combes","year":"1950","journal-title":"Arch. Dermatol. Syphilol."},{"key":"ref_58","first-page":"291","article-title":"Thiamine intolerance","volume":"10","author":"Jaros","year":"1952","journal-title":"Ann. Allergy"},{"key":"ref_59","first-page":"1183","article-title":"Hazards of vitamin B1 injections","volume":"96","year":"1952","journal-title":"Ned. Tijdschr. Geneeskd."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"134","DOI":"10.7326\/0003-4819-45-1-134","article-title":"Anaphylactic shock following intramuscular thiamine chloride","volume":"45","author":"Tetreault","year":"1956","journal-title":"Ann. Intern. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/jid.1958.51","article-title":"Contact dermatitis from vitamin B1 (thiamine); relapse after ingestion of thiamine, cross-sensitization to cocarboxylase","volume":"30","author":"Hjorth","year":"1958","journal-title":"J. Investig. Dermatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"30","DOI":"10.32902\/2663-0338-2021-3-30-39","article-title":"The problem of hypersensitivity to vitamin preparations","volume":"4","author":"Zaikov","year":"2021","journal-title":"Infus. Chemother."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S1081-1206(10)62927-4","article-title":"Anaphylaxis to riboflavin (vitamin B2)","volume":"87","author":"Ou","year":"2001","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0196-0644(89)80215-X","article-title":"A toxicity study of parenteral thiamine hydrochloride","volume":"18","author":"Wrenn","year":"1989","journal-title":"Ann. Emerg. Med."},{"key":"ref_65","first-page":"1036","article-title":"A case of anaphylactic shock due to vitamin B1 derivative (thiamine monophosphate disulfide)","volume":"12","author":"Hiratani","year":"1992","journal-title":"Arerugi No Rinsho (Allergy Pract.)"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1398-9995.1997.tb01258.x","article-title":"Anaphylaxis to thiamine (vitamin B1)","volume":"52","author":"Fernandez","year":"1997","journal-title":"Allergy"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0735-6757(00)90303-6","article-title":"Anaphylaxis from intravenous thiamine\u2014Long forgotten?","volume":"18","author":"Johri","year":"2000","journal-title":"Am. J. Emerg. Med."},{"key":"ref_68","first-page":"368","article-title":"A case of anaphylactic shock due to thiamine monophosphate disulfide, a derivative of vitamin B1","volume":"6","author":"Takahashi","year":"2012","journal-title":"J. Environ. Dermatol. Cutan. Allergol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"bcr2013009648","DOI":"10.1136\/bcr-2013-009648","article-title":"Anaphylactic shock and cardiac arrest caused by thiamine infusion","volume":"2013","author":"Juel","year":"2013","journal-title":"BMJ Case Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.alit.2022.01.004","article-title":"Anaphylaxis due to thiamine disulfide phosphate, a derivative of vitamin B1; a case report and literature review","volume":"71","author":"Amano","year":"2022","journal-title":"Allergol. Int."},{"key":"ref_71","first-page":"479","article-title":"A case of anaphylaxis induced by vitamin B1 derivative infusion formulation for intravenous injection","volume":"72","author":"Kumagai","year":"2023","journal-title":"Arerugi"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0735-6757(95)90221-X","article-title":"Thiamine-induced anaphylactic shock","volume":"13","author":"Ramaekers","year":"1995","journal-title":"Am. J. Emerg. Med."},{"key":"ref_73","first-page":"94","article-title":"A Case of Anaphylaxis to Intramuscular but Not to Oral Application of Thiamine (Vitamin B1)","volume":"17","author":"Aurich","year":"2018","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.alit.2017.07.008","article-title":"Urticaria by thiamine (vitamin B1)","volume":"67","year":"2018","journal-title":"Allergol. Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0091-6749(95)70111-7","article-title":"Specific IgE and IgG serum antibodies to thiamine associated with anaphylactic reaction","volume":"95","author":"Proebstle","year":"1995","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"bcr2013200558","DOI":"10.1136\/bcr-2013-200558","article-title":"Angioneurotic oedema secondary to oral thiamine","volume":"2013","author":"Osman","year":"2013","journal-title":"BMJ Case Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/cod.12115","article-title":"Systemic allergic dermatitis caused by thiamine after iontophoresis","volume":"69","author":"Arruti","year":"2013","journal-title":"Contact Dermat."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/j.1398-9995.2005.00848.x","article-title":"Occupational asthma induced by thiamine in a vitamin supplement for breakfast cereals","volume":"60","author":"Drought","year":"2005","journal-title":"Allergy"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1600-0536.1989.tb03186.x","article-title":"Allergic contact dermatitis from thiamine","volume":"20","author":"Larsen","year":"1989","journal-title":"Contact Dermat."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/13813459509007560","article-title":"Intestinal alkaline phosphatase can transphosphorylate thiamin to thiamin monophosphate during intestinal transport in the rat","volume":"103","author":"Rindi","year":"1995","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"355","DOI":"10.5694\/j.1326-5377.1993.tb137886.x","article-title":"Thiamine anaphylaxis","volume":"159","author":"Leung","year":"1993","journal-title":"Med. J. Aust."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/all.12698","article-title":"The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease","volume":"70","author":"Hoffmann","year":"2015","journal-title":"Allergy"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/all.15957","article-title":"Flow-based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper","volume":"79","author":"Mayorga","year":"2024","journal-title":"Allergy"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/0310057X241232420","article-title":"Basophil activation test in the diagnostic workup of perioperative anaphylaxis due to neuromuscular blocking agents: A case series and implications for practice","volume":"52","author":"Baig","year":"2024","journal-title":"Anaesth. Intensive Care"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"151","DOI":"10.32932\/rpia.2024.09.145","article-title":"Folic acid allergy and the role of the basophil activation test","volume":"32","author":"Gouveia","year":"2024","journal-title":"Rev. Port. Imunoalergologia"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"144","DOI":"10.18176\/jiaci.1048","article-title":"Basophil Activation Test: An Additional Diagnostic Tool in Vitamin B12 Allergy","volume":"35","year":"2025","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/ACI.0b013e3280108716","article-title":"Desensitization for drug allergy","volume":"6","author":"Castells","year":"2006","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.iac.2009.04.012","article-title":"Rapid desensitization for hypersensitivity reactions to medications","volume":"29","author":"Castells","year":"2009","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000335637","article-title":"Desensitization for hypersensitivity reactions to medications","volume":"97","author":"Breslow","year":"2012","journal-title":"Chem. Immunol. Allergy"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Vultaggio, A., Matucci, A., Nencini, F., Bormioli, S., Vivarelli, E., and Maggi, E. (2020). Mechanisms of Drug Desensitization: Not Only Mast Cells. Front. Pharmacol., 23.","DOI":"10.3389\/fphar.2020.590991"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.iac.2021.12.004","article-title":"The Who, What, Where, When, Why, and How of Drug Desensitization","volume":"42","author":"Yang","year":"2022","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s12016-016-8556-5","article-title":"Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies","volume":"54","author":"Castells","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3904\/kjim.2021.438","article-title":"Desensitization for the prevention of drug hypersensitivity reactions","volume":"37","author":"Kang","year":"2022","journal-title":"Korean J. Intern. 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