{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:43:53Z","timestamp":1766990633975,"version":"3.48.0"},"reference-count":13,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Wound-related issues such as delayed healing and patient discomfort remain common challenges in oncoplastic breast surgery and may negatively affect early postoperative recovery. This single-centre, retrospective, within-patient study explored the feasibility and safety of a breast-shaped polyurethane and polyester dressing impregnated with an oxygen-enriched oleic matrix, designed to provide a controlled, low-level release of reactive oxygen species involved in physiological tissue repair. Sixty patients undergoing unilateral lumpectomy with contralateral breast remodelling were included. The advanced dressing was applied to the oncologic breast, while standard premedicated patches were used on the contralateral side, allowing each patient to serve as her own control. Early postoperative outcomes, including wound dehiscence, infection, delayed healing, and qualitative user experience, were assessed descriptively over the first postoperative month. The oxygen-enriched oleic matrix dressing was well tolerated and associated with good skin hydration, comfort, and ease of use. No infections, hematomas, or reoperations were observed, and no relevant differences in early complication patterns emerged between the treated and control sides. Both patients and healthcare personnel reported favourable handling characteristics and comfort, with no device-related adverse events. These preliminary, hypothesis-generating findings suggest that oxygen-enriched oleic matrix breast-shaped dressings are a feasible and safe option for early postoperative wound management in oncoplastic breast surgery. Prospective, adequately powered multicentre studies are warranted to further investigate their potential role within standardized postoperative care pathways.<\/jats:p>","DOI":"10.3390\/life16010051","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:25:51Z","timestamp":1766989551000},"page":"51","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary Experience with Oxygen-Enriched Oleic Matrix Breast-Shaped Dressings in Oncoplastic Breast Surgery"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5629-4031","authenticated-orcid":false,"given":"Agostino","family":"Rodda","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical and Health Sciences, Plastic and Reconstructive Surgery Unit, University of Trieste, 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bottosso","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Ospedale di Cattinara, ASUGI (Azienda Sanitaria Universitaria Giuliano Isontina), 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-5633","authenticated-orcid":false,"given":"Andrea","family":"Lisa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy"},{"name":"PhD Program in Applied Medical-Surgical Sciences, Department of Surgical Sciences, University of Rome \u201cTor Vergata\u201d, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Renzi","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Ospedale di Cattinara, ASUGI (Azienda Sanitaria Universitaria Giuliano Isontina), 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Bascialla","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, European Institute of Oncology, IRCCS, via Ripamonti 435, 20141 Milano, Italy"},{"name":"Division of Plastic and Reconstructive Surgery, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia Benedetta","family":"Sidoti","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Health Sciences, Plastic and Reconstructive Surgery Unit, University of Trieste, 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germana","family":"Lissidini","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, European Institute of Oncology, IRCCS, via Ripamonti 435 Milano, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Papa","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Health Sciences, Plastic and Reconstructive Surgery Unit, University of Trieste, 34149 Trieste, Italy"},{"name":"Plastic Surgery Department, Ospedale di Cattinara, ASUGI (Azienda Sanitaria Universitaria Giuliano Isontina), 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/jso.23659","article-title":"Therapeutic mammaplasty","volume":"110","author":"Macmillan","year":"2014","journal-title":"J. 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Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.breast.2005.09.011","article-title":"Breast reduction and subsequent cancer: A prophylactic perspective","volume":"15","author":"Palmieri","year":"2006","journal-title":"Breast"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/tbj.12590","article-title":"Periareolar Approach in Oncoplastic Breast Conservative Surgery","volume":"22","author":"Klinger","year":"2016","journal-title":"Breast J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"103601","DOI":"10.1016\/j.breast.2023.103601","article-title":"Oncoplastic and reconstructive surgery in SENONETWORK Italian breast centers: Lights and shadows","volume":"73","author":"Ghilli","year":"2024","journal-title":"Breast"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e5355","DOI":"10.1097\/GOX.0000000000005355","article-title":"Oncoplastic Breast Reduction: A Systematic Review of Postoperative Complications","volume":"11","author":"Benedict","year":"2023","journal-title":"Plast. 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Wound Care."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/PRS.0000000000008822","article-title":"Comparing Outcomes after Oncoplastic Breast Reduction and Breast Reduction for Benign Macromastia","volume":"149","author":"Marano","year":"2022","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.21037\/gs-22-499","article-title":"A bibliometric and visualized study on global trends of breast augmentation complications, 2011\u20132021","volume":"12","author":"Zhang","year":"2023","journal-title":"Gland Surg."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/1\/51\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:39:01Z","timestamp":1766990341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/1\/51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["life16010051"],"URL":"https:\/\/doi.org\/10.3390\/life16010051","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]}}}