{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T23:52:30Z","timestamp":1770076350972,"version":"3.49.0"},"reference-count":32,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Eosinophilia, defined as peripheral blood eosinophil counts &gt; 0.5 K\/\u03bcL, is associated with various clinical conditions, including allergic, infectious, and malignant diseases. Emerging evidence suggests that eosinophils may contribute to thrombo-inflammatory processes, but their association with thromboembolic events and mortality remains insufficiently characterized. This study aimed to evaluate whether eosinophilia is independently associated with increased risk of thromboembolic events and mortality in hospitalized patients. Methods: We conducted a retrospective cohort study using electronic medical records from Sheba Medical Center (2011\u20132020). Eosinophilia was classified as mild (0.5\u20131.5 K\/\u03bcL) or hypereosinophilia (HE, &gt;1.5 K\/\u03bcL). Patients with eosinophilia were matched 1:1 to controls with normal eosinophil counts based on age, sex, and follow-up duration. Results: Among 93,320 patients (46,660 with eosinophilia and 46,660 controls), thromboembolic events occurred in 20.9% of eosinophilic patients vs. 9.8% of controls. Eosinophilia was independently associated with thrombosis (OR = 1.33; 95% CI, 1.28\u20131.38; p &lt; 0.0001), with increased risk from counts \u2265 0.7 K\/\u03bcL. Mortality was also higher among eosinophilic patients (HR = 1.17; 95% CI, 1.13\u20131.20; p &lt; 0.0001). Conclusions: Eosinophilia is associated with increased thromboembolic and mortality risk, highlighting the importance of eosinophil monitoring in clinical practice.<\/jats:p>","DOI":"10.3390\/life16020241","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:00:47Z","timestamp":1770033647000},"page":"241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eosinophilia and Risk of Thrombosis and Mortality in Hospitalized Patients: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6496-8270","authenticated-orcid":false,"given":"Ronen","family":"Shavit","sequence":"first","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv 52621, Israel"},{"name":"Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Kidron","sequence":"additional","affiliation":[{"name":"Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"},{"name":"Department of Urology, Tel Aviv Soourasky Medical Center, Tel Aviv 64239, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-2462","authenticated-orcid":false,"given":"Ramit","family":"Maoz Segal","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Niznik","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soad","family":"Haj Yahia","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv 52621, Israel"},{"name":"Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Iancovici-Kidon","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv 52621, Israel"},{"name":"Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Offengenden","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diti","family":"Machnes Maayan","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Lifshitz-Tunitsky","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv 52621, Israel"},{"name":"Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liraz","family":"Olmer","sequence":"additional","affiliation":[{"name":"Bio-Statistical and Bio-Mathematical Unit, The Gertner Institute of Epidemiology and Health Policy Research, Sheba Medical Center, Tel Aviv 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Agmon-Levin","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv 52621, Israel"},{"name":"Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-pathmechdis-012419-032756","article-title":"Contributions of Eosinophils to Human Health and Disease","volume":"15","author":"Klion","year":"2020","journal-title":"Annu. 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