{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:53:02Z","timestamp":1787028782602,"version":"build-2736575974"},"reference-count":156,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["NSTC 113-2314-B-030-007"],"award-info":[{"award-number":["NSTC 113-2314-B-030-007"]}]},{"name":"National Science and Technology Council","award":["NSTC 113-2515-S-030-001"],"award-info":[{"award-number":["NSTC 113-2515-S-030-001"]}]},{"name":"National Science and Technology Council","award":["NSTC 114-2918-I-030-001"],"award-info":[{"award-number":["NSTC 114-2918-I-030-001"]}]},{"name":"Teaching practice research program","award":["MOE-114-TPRGE-1002-030Y1"],"award-info":[{"award-number":["MOE-114-TPRGE-1002-030Y1"]}]},{"DOI":"10.13039\/501100013784","name":"Ministry of Education, Taiwan, and Fu Jen Catholic University","doi-asserted-by":"publisher","award":["FJCU 114-A0114005"],"award-info":[{"award-number":["FJCU 114-A0114005"]}],"id":[{"id":"10.13039\/501100013784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Neurodegenerative diseases, including Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and stroke, are among the most devastating neurological disorders worldwide. Glioblastoma (GBM) is a rapidly growing cancer that originates in astrocytes in the brain. It invades and damages the nervous system. Current treatment options remain limited, primarily due to poor blood\u2013brain barrier penetration, lack of targeted delivery, and limited efficacy in slowing disease progression or promoting functional recovery. In recent years, magnetic fields (MFs) have emerged as a promising therapeutic approach, with mechanisms of action that include direct neuromodulation and the guidance of magnetically responsive nanocarriers to the lesion. Magnetic nanoparticles (MNPs), owing to their unique magnetic properties, biocompatibility, and responsiveness to external MFs, have emerged as promising therapeutic agents for the treatment of neurological diseases and glioblastoma. Exosome\u2013magnetic complexes combine biological carriers with magnetic responsiveness to enhance targeting and biocompatibility for the treatment of neurological diseases and glioblastoma. This review highlights recent advances in magnetic field- and MNP-based neuroprotective strategies and explores new methods for targeted intervention and translational research using exosome\u2013MNP complexes.<\/jats:p>","DOI":"10.3390\/life16020293","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:41:02Z","timestamp":1770630062000},"page":"293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Magnetic\u00a0Field-Guided Magnetic Nanoparticles as Neurotherapeutics for Neurological Disorders and Glioblastoma"],"prefix":"10.3390","volume":"16","author":[{"given":"Ming-Chang","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Life Science, College of Science and Engineering, Fu Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-7676","authenticated-orcid":false,"given":"Yu-Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"},{"name":"Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J. B.","family":"Nicol","sequence":"additional","affiliation":[{"name":"Departments of Pathology & Molecular Medicine and Biomedical & Molecular Sciences, and Cancer Biology and Genetics Division, Sinclair Cancer Research Institute, Queen\u2019s University, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Toader, C., Tataru, C.P., Munteanu, O., Serban, M., Covache-Busuioc, R.-A., Ciurea, A.V., and Enyedi, M. (2024). Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer\u2019s, Parkinson\u2019s, and ALS. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252312613"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Yang, Y.P., Nicol, C.J.B., and Chiang, M.C. (2025). 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