{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:30:19Z","timestamp":1788910219760,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Skin and myocardial microvascular dysfunction in prediabetes remains underexplored, and limited studies have investigated the microcirculation in prediabetes in multiple vascular beds. This study aimed to examine microvascular alterations in patients with prediabetes, patients with type 2 diabetes mellitus (DM), and normoglycemic controls without established cardiovascular disease (CVD). Methods: In this cross-sectional study, the microcirculation was assessed using established and novel noninvasive techniques. The skin microvascular reactivity was evaluated using laser speckle contrast analysis (LASCA). The myocardial perfusion was assessed by the subendocardial viability ratio (SEVR). The retinal microvasculature was evaluated using digital nonmydriatic fundus photography, the renal microvascular damage through the urinary albumin-to-creatinine ratio (ACR), and the peripheral vasculopathy by the augmentation index (AIx). Results: Sixty-seven participants were included (22 controls, 24 with prediabetes, 21 with DM; aged: 55.9 \u00b1 9.4 years). Patients with prediabetes and DM showed significantly reduced baseline-to-peak skin flux responses in LASCA compared with controls (p = 0.006), and lower SEVR values (p = 0.001). Moreover, no significant differences were identified in the retinal, renal, or peripheral microvascular indices. In multivariate analysis, systolic blood pressure and glucose were independently associated with skin microvascular dysfunction, while the heart rate and arteriovenous ratio were associated with the SEVR. Conclusions: In this cross-sectional study, impaired skin and myocardial microvascular function were observed in patients with prediabetes in the absence of overt CVD. These findings suggest that LASCA and the SEVR may serve as sensitive markers for the detection of early, subclinical microvascular dysfunction in prediabetes.<\/jats:p>","DOI":"10.3390\/life16020326","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:52:21Z","timestamp":1770979941000},"page":"326","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Microvascular Dysfunction in Patients with Prediabetes: Novel Methods Identify Impaired Microcirculation"],"prefix":"10.3390","volume":"16","author":[{"given":"Stamatina","family":"Lamprou","sequence":"first","affiliation":[{"name":"First Propedeutic Department of Internal Medicine, Hypertension Outpatient Clinic and ESH Excellence Centre of First Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0519-1670","authenticated-orcid":false,"given":"Nikolaos","family":"Evangelidis","sequence":"additional","affiliation":[{"name":"First Propedeutic Department of Internal Medicine, Hypertension Outpatient Clinic and ESH Excellence Centre of First Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6976-2802","authenticated-orcid":false,"given":"Nikolaos","family":"Koletsos","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 54629 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Zografou","sequence":"additional","affiliation":[{"name":"Second Propedeutic Department of Internal Medicine, Hippokration General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5450-8313","authenticated-orcid":false,"given":"Anastasia","family":"Stoimeni","sequence":"additional","affiliation":[{"name":"Fourth Department of Pediatrics, Aristotle University of Thessaloniki, Faculty of Health Sciences, School of Medicine, Papageorgiou General Hospital, 54629 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4482-4410","authenticated-orcid":false,"given":"Gesthimani","family":"Mintziori","sequence":"additional","affiliation":[{"name":"Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 54629 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Gkolias","sequence":"additional","affiliation":[{"name":"Laboratory of Primary Health Care, General Practice and Health Services Research, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8110-938X","authenticated-orcid":false,"given":"Christina-Maria","family":"Trakatelli","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 54629 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Savopoulos","sequence":"additional","affiliation":[{"name":"First Propedeutic Department of Internal Medicine, Hypertension Outpatient Clinic and ESH Excellence Centre of First Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Doumas","sequence":"additional","affiliation":[{"name":"Second Propedeutic Department of Internal Medicine, Hippokration General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-0684","authenticated-orcid":false,"given":"Areti","family":"Triantafyllou","sequence":"additional","affiliation":[{"name":"First Propedeutic Department of Internal Medicine, Hypertension Outpatient Clinic and ESH Excellence Centre of First Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"The Emerging Risk Factors Collaboration (2011). Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death. N. Engl. J. Med., 364, 829\u2013841.","DOI":"10.1056\/NEJMoa1008862"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e011295","DOI":"10.1161\/JAHA.118.011295","article-title":"Diabetes Mellitus\u2013Related All-Cause and Cardiovascular Mortality in a National Cohort of Adults","volume":"8","author":"Raghavan","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Emerging Risk Factors Collaboration, Sarwar, N., Gao, P., Seshasai, S.R.K., Gobin, R., Kaptoge, S., Di Angelantonio, E., Ingelsson, E., Lawlor, D.A., and Selvin, E. (2010). Diabetes Mellitus, Fasting Blood Glucose Concentration, and Risk of Vascular Disease: A Collaborative Meta-Analysis of 102 Prospective Studies. Lancet, 375, 2215\u20132222.","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.2337\/dc25-1640","article-title":"Global and Regional Prediabetes Prevalence: Updates for 2024 and Projections for 2050","volume":"48","author":"Rooney","year":"2025","journal-title":"Diabetes Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"m2297","DOI":"10.1136\/bmj.m2297","article-title":"Association between Prediabetes and Risk of All Cause Mortality and Cardiovascular Disease: Updated Meta-Analysis","volume":"370","author":"Cai","year":"2020","journal-title":"BMJ"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lamprou, S., Koletsos, N., Mintziori, G., Anyfanti, P., Trakatelli, C., Kotsis, V., Gkaliagkousi, E., and Triantafyllou, A. (2023). Microvascular and Endothelial Dysfunction in Prediabetes. Life, 13.","DOI":"10.3390\/life13030644"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0272-6386(04)01079-0","article-title":"Albuminuria Is Evident in the Early Stages of Diabetes Onset: Results from the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)","volume":"44","author":"Tapp","year":"2004","journal-title":"Am. J. Kidney Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"15445","DOI":"10.1038\/s41598-017-15827-2","article-title":"Microalbuminuria as a Simple Predictor of Incident Diabetes over 8 Years in the Korean Genome and Epidemiology Study (KoGES)","volume":"7","author":"Jung","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.2337\/dc13-2357","article-title":"Cardiovascular Risk Profile in Subjects with Prediabetes and New-Onset Type 2 Diabetes Identified by HbA(1c) According to American Diabetes Association Criteria","volume":"37","author":"Scicali","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/cpf.12819","article-title":"Assessing Skin Microcirculation in Patients at Cardiovascular Risk by Using Laser Speckle Contrast Imaging. A Narrative Review","volume":"43","author":"Lazaridis","year":"2023","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12933-025-02628-5","article-title":"Impaired Microcirculation in the Skin and Subclinical Atherosclerosis in Individuals with Dysglycaemia in a Large Population-Based Cohort","volume":"24","author":"Cederqvist","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/CIRCULATIONAHA.116.023446","article-title":"Prediabetes and Type 2 Diabetes Are Associated with Generalized Microvascular Dysfunction: The Maastricht Study","volume":"134","author":"Houben","year":"2016","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1109\/RBME.2013.2243140","article-title":"V Laser Speckle Contrast Imaging: Theory, Instrumentation and Applications","volume":"6","author":"Senarathna","year":"2013","journal-title":"IEEE Rev. Biomed. Eng."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e032614","DOI":"10.1161\/JAHA.123.032614","article-title":"Research Progress and Clinical Value of Subendocardial Viability Ratio","volume":"13","author":"Xie","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1016\/j.numecd.2021.08.030","article-title":"High Glomerular Filtration Rate Is Associated with Impaired Arterial Stiffness and Subendocardial Viability Ratio in Prediabetic Subjects","volume":"31","author":"Scicali","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee for Diabetes (2026). 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes\u20142026. Diabetes Care, 49, S261\u2013S276.","DOI":"10.2337\/dc26-S012"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.numecd.2017.12.005","article-title":"Prediabetes Is Associated with Microalbuminuria, Reduced Kidney Function and Chronic Kidney Disease in the General Population: The KORA (Cooperative Health Research in the Augsburg Region) F4-Study","volume":"28","author":"Markus","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2021). 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes\u20142021. Diabetes Care, 44, S15\u2013S33.","DOI":"10.2337\/dc21-S002"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA, 310, 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH Guidelines for the Management of Arterial Hypertension the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension","volume":"41","author":"Mancia","year":"2023","journal-title":"J. Hypertens."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lamprou, S., Koletsos, N., Zografou, I., Lazaridis, A., Mintziori, G., Trakatelli, C.M., Kotsis, V., Gkaliagkousi, E., Doumas, M., and Triantafyllou, A. (2024). Skin Microvascular Dysfunction in Type 2 Diabetes Mellitus Using Laser Speckle Contrast Analysis and Association with Carotid Intima-Media Thickness. J. Clin. Med., 13.","DOI":"10.3390\/jcm13164957"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1093\/rheumatology\/keaa722","article-title":"Skin Microvascular Dysfunction in Systemic Lupus Erythematosus Patients with and without Cardiovascular Risk Factors","volume":"60","author":"Koletsos","year":"2021","journal-title":"Rheumatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1549-8719.2011.00129.x","article-title":"Non-Invasive Assessment of Skin Microvascular Function in Humans: An Insight into Methods","volume":"19","author":"Roustit","year":"2012","journal-title":"Microcirculation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tips.2013.05.007","article-title":"Assessment of Endothelial and Neurovascular Function in Human Skin Microcirculation","volume":"34","author":"Roustit","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/01.RES.30.1.67","article-title":"Experimental Subendocardial Ischemia in Dogs with Normal Coronary Arteries","volume":"30","author":"Buckberg","year":"1972","journal-title":"Circ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert Consensus Document on Arterial Stiffness: Methodological Issues and Clinical Applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur. Heart J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"23151","DOI":"10.1038\/s41598-024-74162-5","article-title":"Reference Equations for Pulse Wave Velocity, Augmentation Index, Amplitude of Forward and Backward Wave in a European General Adult Population","volume":"14","author":"Azizzadeh","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.artres.2017.03.001","article-title":"Waves and Windkessels Reviewed","volume":"18","author":"Westerhof","year":"2017","journal-title":"Artery Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s44200-022-00023-z","article-title":"Viewpoint: The Case for Non-Invasive Central Aortic Pressure Monitoring in the Management of Hypertension","volume":"28","author":"Kesten","year":"2022","journal-title":"Artery Res."},{"key":"ref_30","unstructured":"Manikis, G.C., Sakkalis, V., Zabulis, X., Karamaounas, P., Triantafyllou, A., Douma, S., Zamboulis, C., and Marias, K. (2011, January 24\u201326). An Image Analysis Framework for the Early Assessment of Hypertensive Retinopathy Signs. Proceedings of the 2011 E-Health and Bioengineering Conference (EHB), Ia\u0219i, Romania."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/ajh\/hps040","article-title":"Divergent Retinal Vascular Abnormalities in Normotensive Persons and Patients with Never-Treated, Masked, White Coat Hypertension","volume":"26","author":"Triantafyllou","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/ajh\/hpu074","article-title":"Association between Retinal Vessel Caliber and Arterial Stiffness in a Population Comprised of Normotensive to Early-Stage Hypertensive Individuals","volume":"27","author":"Triantafyllou","year":"2014","journal-title":"Am. J. Hypertens."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1016\/S0161-6420(99)90525-0","article-title":"Methods for Evaluation of Retinal Microvascular Abnormalities Associated with Hypertension\/Sclerosis in the Atherosclerosis Risk in Communities Study","volume":"106","author":"Hubbard","year":"1999","journal-title":"Ophthalmology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1210\/JC.2015-2230","article-title":"Urine Albumin-to-Creatinine Ratio: A Marker of Early Endothelial Dysfunction in Youth","volume":"100","author":"Bartz","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"107702","DOI":"10.1016\/j.jdiacomp.2020.107702","article-title":"Albuminuria Rather than Glomerular Filtration Rate Is Associated with Vascular Endothelial Function in Patients with Type 2 Diabetes","volume":"34","author":"Kakutani","year":"2020","journal-title":"J. Diabetes Complicat."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2021). 11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes-2021. Diabetes Care, 44, S151\u2013S167.","DOI":"10.2337\/dc21-S011"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jdiacomp.2016.12.007","article-title":"Assessment of Microvascular Endothelial Function in Type 1 Diabetes Using Laser Speckle Contrast Imaging","volume":"31","author":"Clemente","year":"2017","journal-title":"J. Diabetes Complicat."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical Power Analyses Using G*Power 3.1: Tests for Correlation and Regression Analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav. Res. Methods"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10103-016-2117-2","article-title":"Combining Laser-Doppler Flowmetry Measurements with Spectral Analysis to Study Different Microcirculatory Effects in Human Prediabetic and Diabetic Subjects","volume":"32","author":"Hu","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1053\/j.ajkd.2015.10.025","article-title":"Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study","volume":"67","author":"Melsom","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.2337\/dc08-0148","article-title":"Diabetes Prevention Program Research Group Value of Urinary Albumin-to-Creatinine Ratio as a Predictor of Type 2 Diabetes in Pre-Diabetic Individuals","volume":"31","author":"Friedman","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/j.diabres.2014.09.004","article-title":"Prediabetes Is Not Independently Associated with Microalbuminuria in Korean General Population: The Korea National Health and Nutrition Examination Survey 2011\u20132012 (KNHANES V-2,3)","volume":"106","author":"Kim","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1136\/bjophthalmol-2020-317414","article-title":"Prediabetes Influences the Structure of the Macula: Thinning of the Macula in the Northern Finland Birth Cohort","volume":"105","author":"Huru","year":"2021","journal-title":"Br. J. Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"506","DOI":"10.2337\/diabetes.55.02.06.db05-0546","article-title":"Retinal Vessel Diameters and Risk of Impaired Fasting Glucose or Diabetes: The Rotterdam Study","volume":"55","author":"Ikram","year":"2006","journal-title":"Diabetes"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"112189","DOI":"10.1016\/j.diabres.2025.112189","article-title":"Triglycerides to High Density Lipoprotein Cholesterol Ratio (TG\/HDL), but Not Triglycerides and Glucose Product (TyG) Index, Is Associated with Arterial Stiffness in Prediabetes","volume":"224","author":"Scilletta","year":"2025","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1210\/jc.2013-3519","article-title":"Prediabetes: The Effects on Arterial Thickness and Stiffness in Obese Youth","volume":"99","author":"Shah","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Cavero-Redondo, I., Saz-Lara, A., Lugones-S\u00e1nchez, C., Pozuelo-Carrascosa, D.P., G\u00f3mez-S\u00e1nchez, L., L\u00f3pez-Gil, J.F., Garc\u00eda-Ortiz, L., Bruno, R.M., and G\u00f3mez-Marcos, M.\u00c1. (2023). Comparative Effect of Antihypertensive Drugs in Improving Arterial Stiffness in Adults with Hypertension (RIGIPREV Study). A Network Meta-Analysis. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1225795"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9792","DOI":"10.1161\/JAHA.118.009792","article-title":"Effects of Simvastatin on Augmentation Index Are Transient: Outcomes From a Randomized Controlled Trial","volume":"8","author":"Gepner","year":"2019","journal-title":"J. Am. Heart Assoc."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/2\/326\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:12:10Z","timestamp":1770981130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/2\/326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["life16020326"],"URL":"https:\/\/doi.org\/10.3390\/life16020326","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]}}}