{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:05:20Z","timestamp":1772647520703,"version":"3.50.1"},"reference-count":62,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NUTEGA CCPA group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Gilts have a lower capacity for voluntary feed intake and body reserves than multiparous sows, which limits their ability to cope with the needs of gestation and lactation. In this study, a nutritional supplement was formulated to support gilts during the peripartum period. Both control (C, n = 64) and treatment (T, n = 63) groups received standard commercial diets. Group T received 300gr of supplement per gilt and day for the last 35 days of gestation until the fifth day of lactation. This supplement contained calcium (Ca; 4.1%), sodium (Na; 4.0%), lysine (Lys; 1.96%), methionine (Met; 1.32%), vitamin B12 (0.3 mg\/kg), choline chloride (600 mg\/kg), betaine (475 mg\/kg), and L-carnitine (500 mg\/kg). Supplementation significantly reduced (p &lt; 0.050) stillbirth rate, neonatal diarrhea, postpartum hypophagia, and both \u03b2-hydroxybutyrate (BHBA) and creatinine (CREA) concentrations (effect sizes: 0.240\u20130.993). Also, supplementation significantly increased (p &lt; 0.050) piglet weight at birth and at 15 days of lactation and maternal backfat thickness at 26 days of lactation (effect sizes: 0.491\u20130.719). The concentrations of BHBA and CREA showed significant and negative associations with several productive parameters (p &lt; 0.05); the strength of the associations was low\u2013medium. Targeted peripartum supplementation represents a feasible nutritional strategy for commercial herds characterized by large litter sizes and limited voluntary feed intake capacity.<\/jats:p>","DOI":"10.3390\/life16030416","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:01:07Z","timestamp":1772636467000},"page":"416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic and Reproductive Responses to Peripartum Feed Supplementation in Hyperprolific Gilts"],"prefix":"10.3390","volume":"16","author":[{"given":"Julia","family":"Cantin","sequence":"first","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Cantin","sequence":"additional","affiliation":[{"name":"Independent Researcher, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9907-2941","authenticated-orcid":false,"given":"Olga","family":"Mitjana","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 50013 Zaragoza, Spain"},{"name":"Agroalimentary Institute of Aragon-IA2, Department of Animal Pathology, Universidad de Zaragoza-CITA, 50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-5144","authenticated-orcid":false,"given":"Maria Teresa","family":"Tejedor","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Embryology and Animal Genetics, CIBERV, University of Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Gil-Rubio","sequence":"additional","affiliation":[{"name":"Veterinary Technical Service Nutega, CCPA Group, 28823 Coslada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria","family":"Garrido","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Victoria","family":"Falceto","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, University of Zaragoza, 50013 Zaragoza, Spain"},{"name":"Agroalimentary Institute of Aragon-IA2, Department of Animal Pathology, Universidad de Zaragoza-CITA, 50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2527\/jas.2015-9491","article-title":"Colostrum and milk production in multiparous sows fed supplementary arginine during gestation and lactation","volume":"94","author":"Krogh","year":"2016","journal-title":"J. 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