{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:45:16Z","timestamp":1772801116363,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union funding (MSCA fellowship CZ) within the Operational program Jan Amos Komensky (OP JAK), Priority Research and Development","award":["CZ.02.01.01\/00\/22_010\/0003414"],"award-info":[{"award-number":["CZ.02.01.01\/00\/22_010\/0003414"]}]},{"name":"Fondation Sant\u00e9 Research Grant in the Biomedical Sciences"},{"name":"Southern Medical University, Guangzhou, China","award":["C1034211"],"award-info":[{"award-number":["C1034211"]}]},{"name":"Southern Medical University, Guangzhou, China","award":["C1051004"],"award-info":[{"award-number":["C1051004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Psoriasis is a chronic inflammatory disease with a complex pathogenesis, and it is mainly driven by a dysregulation in immune responses. Therapeutic strategies constantly require novel compounds targeting immune modulation to substitute the current traditional drugs characterized by side effects and limited efficacy. In this study, we used a mannan-induced psoriasis-like inflammation mouse model to investigate the immunomodulatory potential of Iripin-3, a salivary serpin from the Ixodes ricinus ticks. Mice treated with Iripin-3 showed improvements in the severity of psoriasis-like lesions, as shown by the psoriasis area severity index (PASI) scores, epidermal thickness, and baker\u2019s scores. Iripin-3 modulated the immune cascade by inhibiting dendritic cells and \u03b3\u03b4 T cells expression in secondary immune organs while increasing macrophages and neutrophils in skin. On the other hand, Iripin-3 exhibited significant reductions in the expression of inflammatory cytokines such as TNF-\u03b1, IL-22, IL-23, and IL-17 family cytokines, indicating broad immunomodulatory effects. Our findings suggest that Iripin-3 offers a unique and targeted mechanism of action through modulation of the IL-23\/\u03b3\u03b4 T\/IL-17 axis involved in mannan-induced psoriasis-like inflammation and thus could be a promising therapeutic candidate for treating psoriasis. Further studies are required to explore its translational potential in wider clinical settings.<\/jats:p>","DOI":"10.3390\/life16030427","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T09:22:14Z","timestamp":1772788934000},"page":"427","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulatory Effects of a Tick Salivary Serpin on Psoriasis-like Inflammation"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9978-3409","authenticated-orcid":false,"given":"Mohamed Amine","family":"Jmel","sequence":"first","affiliation":[{"name":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"},{"name":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-5450","authenticated-orcid":false,"given":"Huimei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance C. F. M. J.","family":"Baaten","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands"},{"name":"Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-5803","authenticated-orcid":false,"given":"Xueqing","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-8197","authenticated-orcid":false,"given":"Kutty Selva","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7526-1876","authenticated-orcid":false,"given":"Michail","family":"Kotsyfakis","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 70013 Heracklion, Crete, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12016-018-8668-1","article-title":"Psoriasis: From Pathogenesis to Targeted Therapies","volume":"54","author":"Conrad","year":"2018","journal-title":"Clin. 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