{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:55:48Z","timestamp":1773554148109,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82305065"],"award-info":[{"award-number":["82305065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["ZR2024QH185"],"award-info":[{"award-number":["ZR2024QH185"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["ZR2023QH078"],"award-info":[{"award-number":["ZR2023QH078"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2025T181085"],"award-info":[{"award-number":["2025T181085"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The second batch of Shandong University of Traditional Chinese Medicine Scientific Research Fund","award":["KYZK2024Q10"],"award-info":[{"award-number":["KYZK2024Q10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The \u03b3-aminobutyric acid type A receptor subunit delta (GABRD) constitutes a critical component of the principal inhibitory neurotransmitter receptors within the brain. Recent investigations have revealed aberrant expression of GABRD across a spectrum of non-neural malignancies, including breast, colorectal, and gastric cancers, wherein it exhibits a multifaceted and paradoxical role in oncogenesis. This review delineates the biological characteristics of GABRD and its involvement in cancer pathophysiology. Specifically, the activation of GABRD is implicated in the initiation of key downstream signaling pathways that facilitate the proliferation, invasion, and metastasis of cancer cells. Additionally, the review examines the interaction between GABRD and the tumor microenvironment. Furthermore, it provides an analysis of the diverse roles and mechanisms attributed to GABRD across various cancer types. In conclusion, this review encapsulates the current advancements in understanding the oncogenic functions of GABRD and deliberates on its potential and challenges as a novel target for therapeutic intervention.<\/jats:p>","DOI":"10.3390\/life16030468","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:12:25Z","timestamp":1773400345000},"page":"468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GABRD as an Emerging Oncogene: Exploring Functions and Therapeutic Implications Across Cancers"],"prefix":"10.3390","volume":"16","author":[{"given":"Tingru","family":"Ji","sequence":"first","affiliation":[{"name":"School of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyu","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1204-4869","authenticated-orcid":false,"given":"You","family":"Li","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieying","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6171-6174","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"},{"name":"Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"},{"name":"Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"},{"name":"Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-2954","authenticated-orcid":false,"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"},{"name":"Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"},{"name":"Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"},{"name":"Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0896-6273(94)90152-X","article-title":"How quickly can GABAA receptors open?","volume":"12","author":"Maconochie","year":"1994","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"40224","DOI":"10.1074\/jbc.R112.386664","article-title":"Structure, Function, and Modulation of GABAA Receptors","volume":"287","author":"Sigel","year":"2012","journal-title":"J. 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