{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:07:47Z","timestamp":1773414467981,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Metastatic melanoma is one of the most common malignancies associated with the spread of the primary tumor. The primary site is usually the skin or the eyes. The most frequent site of metastases is the gastrointestinal tract, accounting for 60% of cases at autopsy. In 2% of patients, metastases occur without a detectable primary tumor. We present a rare case of upper digestive bleeding caused by multiple gastrointestinal tract metastases from an amelanotic melanoma. This case report describes a 65-year-old male who arrived at the emergency department after experiencing an episode of upper gastrointestinal bleeding (melena). One week prior to admission, he had been treated with nonsteroidal anti-inflammatory drugs for lower back pain due to L4\u2013L5 disc herniation. Upper digestive endoscopy revealed multiple polypoid masses in the stomach and duodenum, and capsule endoscopy showed additional lesions in the small bowel. Histopathological examination confirmed the diagnosis: metastases from an amelanotic malignant melanoma. Abdominal and cranial computed tomography scans revealed multiple secondary lesions in the brain, gallbladder, retroperitoneal area, gastrointestinal tract, and peritoneum. Localized radiotherapy was applied to the cerebral metastasis, and systemic chemotherapy with dacarbazine was initiated, resulting in a partial clinical response. Unfortunately, the disease progressed, and the patient died one month after diagnosis. Metastatic melanoma of the gastrointestinal tract is an exceedingly rare cause of upper digestive bleeding.<\/jats:p>","DOI":"10.3390\/life16030469","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:12:25Z","timestamp":1773400345000},"page":"469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Unusual Case of Upper Digestive Bleeding\u2014Metastatic Amelanotic Melanoma: Case Report and Literature Review"],"prefix":"10.3390","volume":"16","author":[{"given":"Mihaela","family":"Dranga","sequence":"first","affiliation":[{"name":"Department of Medical Science, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, Sf. Spiridon Emergency Clinical Hospital Iasi, Bulevardul Independen\u021bei nr. 1, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Cijevschi Prelipcean","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology and Hepatology, Sf. Spiridon Emergency Clinical Hospital Iasi, Bulevardul Independen\u021bei nr. 1, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otilia","family":"Nedelciuc","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, Sf. Spiridon Emergency Clinical Hospital Iasi, Bulevardul Independen\u021bei nr. 1, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1694-3970","authenticated-orcid":false,"given":"Alina-Ecaterina","family":"Jucan","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, Sf. Spiridon Emergency Clinical Hospital Iasi, Bulevardul Independen\u021bei nr. 1, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1372-707X","authenticated-orcid":false,"given":"Georgiana-Elena","family":"S\u00e2rbu","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, Sf. Spiridon Emergency Clinical Hospital Iasi, Bulevardul Independen\u021bei nr. 1, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atodiresei","family":"Carmen","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, Sf. Spiridon Emergency Clinical Hospital Iasi, Bulevardul Independen\u021bei nr. 1, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-8839","authenticated-orcid":false,"given":"Iolanda Valentina","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"},{"name":"Department of Internal Medicine, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Nem\u021beanu","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, Sf. Spiridon Emergency Clinical Hospital Iasi, Bulevardul Independen\u021bei nr. 1, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Ciortescu","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, Sf. Spiridon Emergency Clinical Hospital Iasi, Bulevardul Independen\u021bei nr. 1, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Ianole","sequence":"additional","affiliation":[{"name":"Department of Pathology, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-9224","authenticated-orcid":false,"given":"Catalina","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Grigore T. Popa University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, Sf. Spiridon Emergency Clinical Hospital Iasi, Bulevardul Independen\u021bei nr. 1, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4065\/81.4.511","article-title":"Metastatic malignant melanoma of the gastrointestinal tract","volume":"81","author":"Liang","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00008390-200502000-00013","article-title":"Melanoma of unknown primary: Experience at Massachusetts General Hospital and Dana-Farber Cancer Institute","volume":"15","author":"Katz","year":"2005","journal-title":"Melanoma Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1177\/030089161009600321","article-title":"Metastatic gastric melanoma: A challenging diagnosis","volume":"96","author":"Bahat","year":"2010","journal-title":"Tumori J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.2169\/internalmedicine.49.3637","article-title":"Metastatic malignant melanoma of the gastric mucosa","volume":"49","author":"Matsubayashi","year":"2010","journal-title":"Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1007\/s00464-019-07225-8","article-title":"Primary and metastatic melanoma of the GI tract: Clinical presentation, endoscopic findings, and patient outcomes","volume":"34","author":"Kozarek","year":"2020","journal-title":"Surg. Endosc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/CMR.0b013e328333bc04","article-title":"Melanoma of unknown primary site: A 33-year experience at the Turin Melanoma Centre","volume":"20","author":"Savoia","year":"2010","journal-title":"Melanoma Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1111\/j.1572-0241.1999.01604.x","article-title":"Melanoma in the gastrointestinal tract","volume":"94","author":"Blecker","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"31972","DOI":"10.3402\/jchimp.v6.31972","article-title":"Melanoma with gastric metastases","volume":"6","author":"Wong","year":"2016","journal-title":"J. Community Hosp. Intern. Med. Perspect."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archsurg.1964.01310240065013","article-title":"Metastatic melanoma of the gastrointestinal tract","volume":"88","author":"DasGupta","year":"1964","journal-title":"Arch. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0002-9610(78)90171-X","article-title":"Metastatic pattern of malignant melanoma: A study of 216 autopsy cases","volume":"135","author":"Patel","year":"1978","journal-title":"Am. J. Surg."},{"key":"ref_11","first-page":"479","article-title":"An unusual indication for central pancreatectomy-late pancreatic metastasis of ocular malignant melanoma","volume":"103","author":"Dima","year":"2008","journal-title":"Chirurgia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1055\/s-0030-1256357","article-title":"Algorithm for detection of small-bowel metastasis in malignant melanoma of the skin","volume":"43","author":"Albert","year":"2011","journal-title":"Endoscopy"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijscr.2017.01.028","article-title":"A first reported case of metastatic anorectal amelanotic melanoma with a marked response to anti-PD-1 antibody nivolumab: A case report","volume":"31","author":"Tokuhara","year":"2017","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_14","first-page":"327","article-title":"Amelanotic metastatic melanoma of the stomach presenting with iron deficiency anemia","volume":"80","author":"Iadevaia","year":"2017","journal-title":"Acta Gastro-Enterol. Belg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e230454","DOI":"10.1136\/bcr-2019-230454","article-title":"Haemorrhagic small bowel melanoma metastasis: A clinical rarity","volume":"12","author":"Ho","year":"2019","journal-title":"BMJ Case Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2298\/AOO0602060B","article-title":"Metastatic melanoma of the stomach and the duodenum","volume":"14","author":"Nagorni","year":"2006","journal-title":"Arch. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12328-013-0380-3","article-title":"Primary amelanotic malignant melanoma of the small intestine diagnosed by esophagogastroduodenoscopy before surgical resection","volume":"6","author":"Suganuma","year":"2013","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/ajg.2014.434","article-title":"An unusual presentation of malignant melanoma: Amelanotic gastric metastasis","volume":"110","author":"Ozturk","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000431304","article-title":"Metastatic Disease in the Stomach","volume":"2","author":"Weigt","year":"2015","journal-title":"Gastrointest. Tumors"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1080\/02688697.2020.1834511","article-title":"Mulltifocal meningeal melanomas mimicking lymphoma: A case report and literature review","volume":"37","author":"Cao","year":"2020","journal-title":"Br. J. Neurosurg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.wneu.2018.10.199","article-title":"Amelanotic Meningeal Melanoma with Leptomeningeal Dissemination: A Case Report and Systematic Literature Review","volume":"122","author":"Zhang","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_22","first-page":"20180032","article-title":"Gallbladder and small bowel metastasis of regressive melanoma: A case report","volume":"5","author":"Ercolino","year":"2018","journal-title":"BJR Case Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1634\/theoncologist.2009-0237","article-title":"Long-term survival in patients with metastatic melanoma treated with DTIC or temozolomide","volume":"15","author":"Kim","year":"2010","journal-title":"Oncologists"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.clon.2016.11.007","article-title":"Treatment related Death in Cancer Patients Treated with Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis","volume":"29","author":"Helbling","year":"2017","journal-title":"Clin. 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