{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:06:14Z","timestamp":1776722774493,"version":"3.51.2"},"reference-count":21,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Cerebral toxoplasmosis is a rare but potentially fatal opportunistic infection in renal transplant recipients receiving long-term immunosuppressive therapy. It may result from donor-derived transmission or reactivation of latent infection. We report the case of a 70-year-old female who underwent kidney transplantation from a deceased donor in 2004 for end-stage renal disease due to glomerulonephritis. She was maintained on cyclosporine, mycophenolate mofetil, and prednisone. In September 2024, she presented with headache, mood changes, and right-sided hemiparesis. Brain multislice computed tomography revealed a large temporoparietal lesion initially suspected to be glioblastoma. Craniotomy and histopathological analysis demonstrated encysted Toxoplasma gondii bradyzoites within gliotic tissue. Polymerase chain reaction testing confirmed the presence of T. gondii DNA, while human immunodeficiency virus testing was negative. The patient reported frequent contact with domestic cats. Treatment with pyrimethamine, sulfadiazine, and leucovorin, alongside adjustment of immunosuppressive therapy, led to marked neurological improvement and radiological regression of the lesion. However, nine months later, she succumbed to multidrug-resistant urosepsis. This case highlights the diagnostic challenges of cerebral toxoplasmosis in transplant recipients, as radiological findings are often nonspecific and can mimic neoplastic or lymphoproliferative lesions. Polymerase chain reaction and histopathological analysis remain essential for definitive diagnosis. Awareness of this rare complication is critical for early recognition and prompt initiation of anti-toxoplasma therapy, which can significantly improve outcomes. Although cerebral toxoplasmosis is uncommon after kidney transplantation, it should be considered in immunosuppressed patients presenting with neurological symptoms. Early detection and targeted therapy are key to reducing morbidity and mortality in this population.<\/jats:p>","DOI":"10.3390\/life16030471","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:06:22Z","timestamp":1773414382000},"page":"471","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebral Toxoplasmosis in a Renal Transplant Recipient\u2014A Rare Complication"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-4154","authenticated-orcid":false,"given":"Dubravka","family":"Mihaljevi\u0107","sequence":"first","affiliation":[{"name":"Department of Nephrology, Clinical Hospital Centre Osijek, 31000 Osijek, Croatia"},{"name":"Department of Internal Medicine and History of Medicine, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvonimir","family":"Sita\u0161","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Clinical Hospital Centre Osijek, 31000 Osijek, Croatia"},{"name":"Department of Internal Medicine and History of Medicine, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7285-7859","authenticated-orcid":false,"given":"Josip","family":"Hanulak","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Clinical Hospital Centre Osijek, 31000 Osijek, Croatia"},{"name":"Department of Internal Medicine and History of Medicine, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petar","family":"Vranji\u0107","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Clinical Hospital Centre Osijek, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justina","family":"Mihaljevi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Institute for Diagnostic and Interventional Radiology, Clinical Hospital Centre Osijek, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","unstructured":"Gilbert, S.J., and Weiner, D.E. (2019). Infection in Renal Transplant Recipients. Chronic Kidney Disease, Dialysis, and Transplantation, Elsevier."},{"key":"ref_2","unstructured":"Gabardi, S. (2018). Infection in Kidney Transplantation. Contemporary Kidney Transplantation, Springer."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4103\/0971-5916.195041","article-title":"Molecular appraisal of intestinal parasitic infection in transplant recipients","volume":"144","author":"Yadav","year":"2016","journal-title":"Indian J. Med. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.transproceed.2007.01.025","article-title":"Parasitic infection in renal transplant recipients","volume":"39","author":"Valar","year":"2007","journal-title":"Transplant. Proc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpara.2020.11.001","article-title":"Control of human toxoplasmosis","volume":"51","author":"Smith","year":"2021","journal-title":"Int. J. Parasitol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e00421","DOI":"10.1016\/j.parepi.2025.e00421","article-title":"Seroprevalence and risk factors for Toxoplasma gondii infection in solid organ transplant patients: A global systematic review and meta-analysis","volume":"29","author":"Mamizadeh","year":"2025","journal-title":"Parasite Epidemiol. Control"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1574-6976.2010.00215.x","article-title":"Protozoa traversal of the blood-brain barrier to invade the central nervous system","volume":"34","author":"Elsheikha","year":"2010","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1086\/317471","article-title":"Toxoplasmosis in hematopoietic stem cell transplant recipients","volume":"31","author":"Martino","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e00115-19","DOI":"10.1128\/CMR.00115-19","article-title":"Epidemiology, Pathophysiology, Diagnosis, and Management of Cerebral Toxoplasmosis","volume":"34","author":"Elsheikha","year":"2021","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_10","unstructured":"European Commission (2003). Human Organ Transplantation in Europe: An Overview, European Commission. Available online: http:\/\/ec.europa.eu\/health\/ph_threats\/human_substance\/documents\/organ_survey.pdf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/clind\/24.4.625","article-title":"Toxoplasmosis in Kidney Transplant Recipients: Report of Six Cases and Review","volume":"24","author":"Renoult","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1111\/j.1432-2277.2010.01173.x","article-title":"Toxoplasma gondii primary infection in renal transplant recipients. Two case reports and literature review","volume":"24","author":"Martina","year":"2011","journal-title":"Transpl. Int."},{"key":"ref_13","first-page":"210","article-title":"Toxoplasmosis in transplant recipients, Europe, 2010\u20132014","volume":"20","author":"Belaz","year":"2015","journal-title":"Euro Surveill."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e260412","DOI":"10.1136\/bcr-2024-260412","article-title":"Disseminated toxoplasmosis infection 20 years post kidney transplant","volume":"17","author":"Chandler","year":"2024","journal-title":"BMJ Case Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3347\/kjp.2022.60.1.35","article-title":"Delayed cerebral toxoplasmosis in a kidney transplant patient: A case report","volume":"60","author":"Myeong","year":"2022","journal-title":"Korean J. Parasitol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/ndtplus\/sfq113","article-title":"Late presentation of toxoplasmosis in renal transplant recipients","volume":"3","author":"Clissold","year":"2010","journal-title":"Clin. Kidney J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100021","DOI":"10.1016\/j.clinpr.2020.100021","article-title":"Primary toxoplasmosis complicated by possible IRIS 15 years after renal transplantation","volume":"7\u20138","author":"Abbas","year":"2020","journal-title":"Clin. Infect. Pract."},{"key":"ref_18","first-page":"1349","article-title":"Central nervous system toxoplasmosis in the era of highly active antiretroviral therapy","volume":"22","author":"Post","year":"2001","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_19","first-page":"280","article-title":"Infectious complications of transplantation","volume":"13","author":"Kotton","year":"2013","journal-title":"Am. J. Transplant."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJM199309303291403","article-title":"Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome","volume":"329","author":"Luft","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"ref_21","first-page":"776","article-title":"Comparison of pyrimethamine\u2013sulfadiazine and trimethoprim\u2013sulfamethoxazole for treatment of toxoplasmic encephalitis","volume":"323","author":"Hughes","year":"1990","journal-title":"N. Engl. J. 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