{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:46:43Z","timestamp":1773816403114,"version":"3.50.1"},"reference-count":19,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Introduction: Annular Lichen Planus (ALP) of the penis is a rare variant of genital lichen planus. Clinically, it is characterized by violaceous plaques with an annular configuration and central clearing. The diagnosis can be challenging, especially considering its rarity, and histopathological confirmation is often necessary to differentiate it from other annular dermatoses. Methods: We report a rare case of genital ALP in a male patient, while reviewing previously reported cases to provide a comprehensive overview of this rare condition. Results: A 63-year-old white male was referred to our outpatient department presenting with symptomatic annular erythematous-violaceous lesions on the glans penis. A diagnosis of genital ALP was clinically suspected and subsequently confirmed by histopathology. The patient was started on topical tacrolimus 0.1% ointment twice daily, achieving a complete clinical resolution after 6 consecutive weeks of treatment. No signs of local recurrence were observed after a one-year follow-up. We carried out a systematic review of the literature which identified a limited number of similar cases. Conclusions: This review underscores the importance of clinical suspicion and biopsy for accurate diagnosis and effective management of penile ALP. Topical tacrolimus 0.1% ointment is a safe and effective treatment for penile ALP and can be used as an alternative of corticosteroids.<\/jats:p>","DOI":"10.3390\/life16030482","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:13:14Z","timestamp":1773659594000},"page":"482","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Annular Lichen Planus of the Penis Successfully Treated with Topical Tacrolimus 0.1% Ointment: A Case Report and Systematic Review of the Literature"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0669-1442","authenticated-orcid":false,"given":"Andrea","family":"D\u2019Arino","sequence":"first","affiliation":[{"name":"Oncologic and Preventive Dermatology Unit, San Gallicano Dermatological Institute-IRCCS, Via Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7249-2556","authenticated-orcid":false,"given":"Maria Concetta","family":"Fargnoli","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Di Tullio","sequence":"additional","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cota","sequence":"additional","affiliation":[{"name":"Dermatopathology Research Unit, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2788-6024","authenticated-orcid":false,"given":"Paola","family":"Pasquini","sequence":"additional","affiliation":[{"name":"Dermatopathology Research Unit, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Frascione","sequence":"additional","affiliation":[{"name":"Oncologic and Preventive Dermatology Unit, San Gallicano Dermatological Institute-IRCCS, Via Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0682-6148","authenticated-orcid":false,"given":"Victor Desmond","family":"Mandel","sequence":"additional","affiliation":[{"name":"Oncologic and Preventive Dermatology Unit, San Gallicano Dermatological Institute-IRCCS, Via Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1056\/NEJMcp1103641","article-title":"Clinical practice. Lichen planus","volume":"366","author":"Chosidow","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Boch, K., Langan, E.A., Kridin, K., Zillikens, D., Ludwig, R.J., and Bieber, K. (2021). Lichen Planus. Front. Med., 8.","DOI":"10.3389\/fmed.2021.737813"},{"key":"ref_3","first-page":"53","article-title":"Diagnosis and Treatment of Lichen Planus","volume":"84","author":"Usatine","year":"2011","journal-title":"Am. Fam. Physician"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/LGT.0b013e318247a907","article-title":"Mucosal lichen planus, a systemic disease requiring multidisciplinary care: A cross-sectional clinical review from a multidisciplinary perspective","volume":"16","author":"Ebrahimi","year":"2012","journal-title":"J. Low. Genit. Tract Dis."},{"key":"ref_5","first-page":"e1","article-title":"Cutaneous, genital and oral lichen planus: A descriptive study of 274 patients","volume":"24","year":"2019","journal-title":"Med. Oral Patol. Oral Cir. Buccal"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/01.JD9.0000559513.78062.fe","article-title":"Annular Secondary Syphilis on the Penis: A Case Report","volume":"2","author":"Zhao","year":"2019","journal-title":"Int. J. Dermatol. Venereol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1111\/ijd.15703","article-title":"Penile annular secondary syphilis mimicking annular lichen planus","volume":"61","author":"Trinh","year":"2022","journal-title":"Int. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4103\/0378-6323.82389","article-title":"Lichenoid tissue reaction\/interface dermatitis: Recognition, classification, etiology, and clinicopathological overtones","volume":"77","author":"Sehgal","year":"2011","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_9","first-page":"34","article-title":"Annular Lichen planus affecting Penis and Forearm","volume":"1","author":"Macleod","year":"1908","journal-title":"Proc. R. Soc. Med."},{"key":"ref_10","first-page":"116","article-title":"Asymptomatic penile lesions","volume":"51","author":"Barnette","year":"1993","journal-title":"Cutis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1046\/j.1365-2133.1998.02276.x","article-title":"Annular lichen planus showing a change in metallothionein expression on immunohistochemistry","volume":"138","author":"Matsuura","year":"1998","journal-title":"Br. J. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jaad.2003.08.011","article-title":"Annular lichen planus: A case series of 20 patients","volume":"50","author":"Reich","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_13","first-page":"31","article-title":"Isolated genital annular lichen planus","volume":"20","author":"Badri","year":"2011","journal-title":"Acta Dermatovenerol. Alp. Pannonica Adriat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/ajd.12169","article-title":"Penile lentigo (genital mucosal macule) following annular lichen planus: A possible association?","volume":"55","author":"Isbary","year":"2014","journal-title":"Australas. J. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jdcr.2015.04.008","article-title":"Generalized annular lichen planus with a unique morphology in a patient seropositive for HIV","volume":"1","author":"Chakraborty","year":"2015","journal-title":"JAAD Case Rep."},{"key":"ref_16","first-page":"A82","article-title":"P2.31 Annular lichen planus on penis treated with topical pimecrolimus 1%","volume":"93","author":"Natasatsekova","year":"2017","journal-title":"Sex. Transm. Infect."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1365-4632.2009.04062.x","article-title":"Lichen planus","volume":"48","author":"Lehman","year":"2009","journal-title":"Int. J. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"742826","DOI":"10.1155\/2014\/742826","article-title":"Cutaneous and mucosal lichen planus: A comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis","volume":"2014","author":"Gorouhi","year":"2014","journal-title":"Sci. World J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e148220","DOI":"10.1553\/skindeep.2025.148220","article-title":"Clinicopathological spectrum of lichen planus","volume":"1","author":"Cerroni","year":"2025","journal-title":"SKINdeep"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/3\/482\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:48:48Z","timestamp":1773812928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/3\/482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["life16030482"],"URL":"https:\/\/doi.org\/10.3390\/life16030482","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]}}}