{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:18:58Z","timestamp":1775197138600,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Sciatic scoliosis is a nonstructural, compensatory spinal deformity secondary to lumbar disc herniation. In adolescents and young adults, sciatic scoliosis is frequently misdiagnosed as adolescent idiopathic scoliosis due to the low prevalence of lumbar disc herniation in this demographic. Early clinical suspicion is essential, as radiographic features, particularly minimal or absent vertebral rotation on standing radiographs, help distinguish sciatic scoliosis from structural curves such as adolescent idiopathic scoliosis. Key differentiating features include painful scoliosis, a highly positive straight leg raise test, and minimal or absent vertebral rotation on standing radiographs. Delayed diagnosis or inappropriate management may result in residual deformity, highlighting the importance of early surgical decompression. Despite recognition for decades, the literature is fragmented, largely composed of case reports, small series, and retrospective studies, with heterogeneous definitions, radiological assessments, and outcome measures. Objective: Provide a comprehensive, up-to-date systematic synthesis of the clinical presentation, radiological characteristics, management strategies, and outcomes of lumbar disc herniation-associated sciatic scoliosis. Methods: Thirteen studies evaluating conventional open discectomy and minimally invasive endoscopic procedures (FEID\/PELD) were included. Data on demographics, surgical approach, clinical improvement (VAS, ODI, Macnab), and radiographic correction (Cobb angle, trunk list, sagittal alignment) were extracted and synthesized. Results: Surgical decompression consistently leads to clinical improvement. Trunk list and coronal deformity were rapidly corrected, with resolution rates \u2265 85% within 6 months across most series. Both open and endoscopic approaches were effective, with minimally invasive techniques offering advantages in tissue preservation and recovery. Conclusions: Sciatic Scoliosis is a reversible, nonstructural deformity that responds reliably to surgical decompression. Accurate recognition, particularly in adolescents and young adults, and timely intervention targeting the underlying nerve root compression are critical for optimal outcomes. This review consolidates fragmented evidence, providing a comprehensive synthesis of current knowledge.<\/jats:p>","DOI":"10.3390\/life16040589","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:09:54Z","timestamp":1775138994000},"page":"589","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics, Surgical Management and Outcomes of Sciatic Scoliosis Secondary to Lumbar Disc Herniation: A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2151-4902","authenticated-orcid":false,"given":"Marco","family":"Fava","sequence":"first","affiliation":[{"name":"Ortopedia Generale, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1\/10, 40136 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mendola","sequence":"additional","affiliation":[{"name":"Ortopedia Generale, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1\/10, 40136 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Perna","sequence":"additional","affiliation":[{"name":"Ortopedia Generale, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1\/10, 40136 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9394-2002","authenticated-orcid":false,"given":"Lavinia","family":"Raimondi","sequence":"additional","affiliation":[{"name":"Scienze e Tecnologie Chirurgiche, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1\/10, 40136 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-5969","authenticated-orcid":false,"given":"Gianluca","family":"Giavaresi","sequence":"additional","affiliation":[{"name":"Scienze e Tecnologie Chirurgiche, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1\/10, 40136 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0261-202X","authenticated-orcid":false,"given":"Angelo","family":"Toscano","sequence":"additional","affiliation":[{"name":"Ortopedia Generale, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1\/10, 40136 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3171\/2015.7.SPINE15441","article-title":"Economic value of treating lumbar disc herniation in Brazil","volume":"24","author":"Falavigna","year":"2016","journal-title":"J. Neurosurg. Spine"},{"key":"ref_2","first-page":"100757","article-title":"Real-world treatment patterns and management gaps of lumbar disc herniation in the United States","volume":"23","author":"Bhandutia","year":"2025","journal-title":"N. Am. Spine Soc. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100279","DOI":"10.1016\/j.wnsx.2024.100279","article-title":"Lumbar disc herniation: Epidemiology, clinical and radiologic diagnosis WFNS spine committee recommendations","volume":"22","author":"Pojskic","year":"2024","journal-title":"World Neurosurg. X"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1097\/BRS.0b013e318183a4a2","article-title":"Sciatica: Review of epidemiological studies and prevalence estimates","volume":"33","author":"Konstantinou","year":"2008","journal-title":"Spine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e14410","DOI":"10.1097\/MD.0000000000014410","article-title":"Comparison of treatments for lumbar disc herniation: Systematic review with network meta-analysis","volume":"98","author":"Arts","year":"2019","journal-title":"Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00007632-199802010-00010","article-title":"Significance of sciatic scoliotic list in operated patients with lumbar disc herniation","volume":"23","author":"Matsui","year":"1998","journal-title":"Spine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/rheumatology\/40.12.1427","article-title":"Lumbar scoliosis associated with a disc herniation in an adult","volume":"40","author":"Krishnan","year":"2001","journal-title":"Rheumatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13018-019-1300-0","article-title":"Coronal and sagittal spinal alignment in lumbar disc herniation with scoliosis and trunk shift","volume":"14","author":"Wu","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_9","first-page":"E457","article-title":"Sciatic Scoliosis Evolution after Lumbar Discectomy: A Comparison Between Adolescents and Young Adults","volume":"22","author":"Zhang","year":"2019","journal-title":"Pain Physician"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2147\/JPR.S341317","article-title":"Sciatica-Related Spinal Imbalance in Lumbar Disc Herniation Patients: Radiological Characteristics and Recovery Following Endoscopic Discectomy","volume":"15","author":"Wang","year":"2022","journal-title":"J. Pain Res."},{"key":"ref_11","first-page":"3606","article-title":"Meta-analysis of lumbar disc herniation in Chinese adolescents","volume":"93","author":"Xu","year":"2013","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/00007632-200103150-00009","article-title":"Effects of electrical stimulation of the sciatic nerve on background electromyography and static stretch reflex activity of the trunk muscles in rats: Possible implications of neuronal mechanisms in the development of sciatic scoliosis","volume":"26","author":"Hirayama","year":"2001","journal-title":"Spine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1177\/21925682221126123","article-title":"Characteristics of Sciatic Scoliotic List in Lumbar Disc Herniation","volume":"14","author":"Zhao","year":"2024","journal-title":"Glob. Spine J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s005860050111","article-title":"The natural history of trunk list, its associated disability and the influence of McKenzie management","volume":"7","author":"Gillan","year":"1998","journal-title":"Eur. Spine J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.jocn.2009.01.023","article-title":"When is the appropriate time for surgical intervention of the herniated lumbar disc in the adolescent?","volume":"16","author":"Fakouri","year":"2009","journal-title":"J. Clin. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhu, Z., Zhao, Q., Wang, B., Yu, Y., Qian, B., Ding, Y., and Qiu, Y. (2011). Scoliotic posture as the initial symptom in adolescents with lumbar disc herniation: Its curve pattern and natural history after lumbar discectomy. BMC Musculoskelet. Disord., 12.","DOI":"10.1186\/1471-2474-12-216"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.tcmj.2012.10.006","article-title":"Sciatic Scoliosis: An easily misdiagnosed disease in adolescent and young adults","volume":"24","author":"Hsu","year":"2012","journal-title":"Tzu Chi Med. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness","year":"2021","journal-title":"Res. Synth. Methods"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4274\/jtss.galenos.2022.70288","article-title":"A great mimicker of adolescent idiopathic scoliosis: Sciatic scoliosis. A retrospective review of 18 adolescent patients with at least 2 years of follow-up","volume":"33","year":"2022","journal-title":"J. Turk. Spinal Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e70026","DOI":"10.1111\/ases.70026","article-title":"Characteristics of Sciatic Scoliosis in Lumbar Disc Herniation and Comparative Radiographic Outcomes After Treatment with Full-Endoscopic Interlaminar Discectomy","volume":"18","author":"Pluemvitayaporn","year":"2025","journal-title":"Asian J. Endosc. Surg."},{"key":"ref_23","first-page":"E63","article-title":"Early Experience of Full-Endoscopic Interlaminar Discectomy for Adolescent Lumbar Disc Herniation with Sciatic Scoliosis","volume":"21","author":"Tu","year":"2018","journal-title":"Pain Physician"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.7887\/jcns.22.535","article-title":"Analysis of Sciatic Scoliosis caused by Lumbar Disc Herniation and the Surgical Results of Discectomy","volume":"22","author":"Takahashi","year":"2013","journal-title":"Jpn. J. Neurosurg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00007632-200103150-00023","article-title":"Lumbosacral scoliotic list by lumbar disc herniation","volume":"26","author":"Suk","year":"2001","journal-title":"Spine"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yang, J., Luan, H., Ren, J., Tao, J., Sheng, W., Guo, H., and Deng, Q. (2024). Percutaneous endoscopic lumbar discectomy for single and double segment lumbar disc herniation with sciatic scoliosis in adults: A retrospective study. BMC Surg., 24.","DOI":"10.1186\/s12893-024-02314-5"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Liang, C., Sun, J., Cui, X., Jiang, Z., Zhang, W., and Li, T. (2016). Spinal sagittal imbalance in patients with lumbar disc herniation: Its spinopelvic characteristics, strength changes of the spinal musculature and natural history after lumbar discectomy. BMC Musculoskelet. Disord., 17.","DOI":"10.1186\/s12891-016-1164-y"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.36076\/ppj.2015\/18\/555","article-title":"The Incidence and Risk Factors for Lumbar or Sciatic Scoliosis in Lumbar Disc Herniation and the Outcomes after Percutaneous Endoscopic Discectomy","volume":"18","author":"Kim","year":"2015","journal-title":"Pain Physician"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yang, J., Luan, H., Xie, X., Sheng, W., Guo, H., and Deng, Q. (2025). Percutaneous Endoscopic Lumbar Discectomy for Single-Level Lumbar Disc Herniation with Sciatic Scoliosis in Adults: A Retrospective Study of 76 Patients. Clin. Spine Surg.","DOI":"10.1097\/BSD.0000000000001943"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1302\/0301-620X.68B2.3958002","article-title":"The iliolumbar ligament. A study of its anatomy, development and clinical significance","volume":"68","author":"Luk","year":"1986","journal-title":"J. Bone Joint Surg. Br."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1097\/00007632-199011010-00010","article-title":"The role of the iliolumbar ligament in the lumbosacral junction","volume":"15","author":"Yamamoto","year":"1990","journal-title":"Spine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/00007632-198709000-00005","article-title":"The biomechanical functions of the iliolumbar ligament in maintaining stability of the lumbosacral junction","volume":"12","author":"Leong","year":"1987","journal-title":"Spine"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/4\/589\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:19:18Z","timestamp":1775189958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/4\/589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["life16040589"],"URL":"https:\/\/doi.org\/10.3390\/life16040589","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}