{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:17:22Z","timestamp":1792124242089,"version":"4.4.0"},"reference-count":154,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["581-UNIOS-80"],"award-info":[{"award-number":["581-UNIOS-80"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"award":["581-UNIOS-80"],"award-info":[{"award-number":["581-UNIOS-80"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Hypertension and chronic kidney disease (CKD) are closely linked conditions and represent common global health problems. Hypertension is a leading risk factor for cardiovascular disease, which is the main cause of mortality in CKD. Endothelial injury underlies the etiopathogenesis of both hypertension and CKD. The endothelial glycocalyx (eGC) is a dynamic, negatively charged, carbohydrate-rich layer that covers the luminal surface of endothelial cells. Its primary physiological function is to protect the endothelium, including the regulation of vascular permeability and homeostasis. Damage to the eGC, known as \u201cshedding\u201d, is an early predictor of endothelial dysfunction and is driven by oxidative stress and low-grade inflammation. In hypertension, loss of eGC integrity\u2014often impaired by a high-salt diet\u2014can reduce the bioavailability of nitric oxide (NO) and increase arterial stiffness. Similarly, in CKD, uremic toxicity, hypertension, and inflammation damage the eGC, resulting in increased permeability, albuminuria, and higher cardiovascular risk. This review summarizes current evidence and underscores the potential of eGC shedding markers, especially syndecan 1 (SDC-1) and hyaluronic acid (HA), as early predictors of vascular risk and disease progression in hypertension and CKD.<\/jats:p>","DOI":"10.3390\/life16040642","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:08:12Z","timestamp":1775812092000},"page":"642","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Endothelial Glycocalyx in the Pathophysiology of Chronic Kidney Disease and Hypertension: From Molecular Mechanisms to Clinical Biomarkers"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5340-1072","authenticated-orcid":false,"given":"Ana","family":"Marin\u010di\u0107 \u017dagar","sequence":"first","affiliation":[{"name":"Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-8317","authenticated-orcid":false,"given":"Nikolina","family":"Kolobari\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-2779","authenticated-orcid":false,"given":"Petar","family":"\u0160u\u0161njara","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Sciences, Faculty of Kinesiology Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4463-0989","authenticated-orcid":false,"given":"Justina","family":"Mihaljevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Hospital Centre Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6631-071X","authenticated-orcid":false,"given":"Zrinka","family":"Mihaljevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-7721","authenticated-orcid":false,"given":"Ines","family":"Drenjan\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1067\/mnc.2001.114148","article-title":"The Endothelium: Dysfunction and Beyond","volume":"8","author":"Herrmann","year":"2001","journal-title":"J. Nucl. Cardiol."},{"key":"ref_2","first-page":"3527","article-title":"Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders","volume":"91","author":"Cines","year":"1998","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kr\u00fcger-Genge, A., Blocki, A., Franke, R.-P., and Jung, F. (2019). Vascular Endothelial Cell Biology: An Update. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184411"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Moncada, S., and Higgs, A. (2006). Normal Endothelium. The Vascular Endothelium I, Springer.","DOI":"10.1007\/3-540-32967-6"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0735-1097(03)00994-X","article-title":"The Clinical Implications of Endothelial Dysfunction","volume":"42","author":"Widlansky","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kolobari\u0107, N., Kozina, N., Mihaljevi\u0107, Z., and Drenjan\u010devi\u0107, I. (2024). Angiotensin II Exposure In Vitro Reduces High Salt-Induced Reactive Oxygen Species Production and Modulates Cell Adhesion Molecules\u2019 Expression in Human Aortic Endothelial Cell Line. Biomedicines, 12.","DOI":"10.3390\/biomedicines12122741"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00424-007-0212-8","article-title":"The Endothelial Glycocalyx: Composition, Functions, and Visualization","volume":"454","author":"Reitsma","year":"2007","journal-title":"Pflug. Arch."},{"key":"ref_8","first-page":"1773","article-title":"Fine Structures of Capillary and Endocapillary Layer as Revealed by Ruthenium Red","volume":"25","author":"Luft","year":"1966","journal-title":"Fed. Proc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0026-2862(80)90024-2","article-title":"A Fiber Matrix Model of Capillary Permeability","volume":"20","author":"Curry","year":"1980","journal-title":"Microvasc. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chevalier, L., Selim, J., Castro, C., Cuvilly, F., Baste, J.-M., Richard, V., Pareige, P., and Bellien, J. (2022). Combined Electron Microscopy Approaches for Arterial Glycocalyx Visualization. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.840689"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.bpj.2020.02.010","article-title":"Endothelial Glycocalyx Layer Properties and Its Ability to Limit Leukocyte Adhesion","volume":"118","author":"Delgadillo","year":"2020","journal-title":"Biophys. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mvr.2013.02.001","article-title":"The Endothelial Glycocalyx in Syndecan-1 Deficient Mice","volume":"87","author":"Savery","year":"2013","journal-title":"Microvasc. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/vec.12925","article-title":"The Endothelial Glycocalyx: Structure and Function in Health and Critical Illness","volume":"30","author":"Gaudette","year":"2020","journal-title":"J. Vet. Emerg. Crit. Care"},{"key":"ref_14","unstructured":"Granger, D.N., and Senchenkova, E. (2010). Leukocyte\u2013Endothelial Cell Adhesion. Inflammation and the Microcirculation, Morgan & Claypool Life Sciences."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1182\/blood.V85.1.151.bloodjournal851151","article-title":"Lectin and Epidermal Growth Factor Domains of P-Selectin at Physiologic Density Are the Recognition Unit for Leukocyte Binding","volume":"85","author":"Gibson","year":"1995","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0092-8674(91)90393-D","article-title":"Leukocytes Roll on a Selectin at Physiologic Flow Rates: Distinction from and Prerequisite for Adhesion through Integrins","volume":"65","author":"Lawrence","year":"1991","journal-title":"Cell"},{"key":"ref_17","unstructured":"Varki, A., Cummings, R.D., Esko, J.D., Freeze, H.H., Stanley, P., Bertozzi, C.R., Hart, G.W., and Etzler, M.E. (2009). Proteoglycans and Sulfated Glycosaminoglycans. Essentials of Glycobiology, Cold Spring Harbor Laboratory Press."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/ckj\/sfz042","article-title":"The Role of Endothelial Glycocalyx in Health and Disease","volume":"12","author":"Yilmaz","year":"2019","journal-title":"Clin. Kidney J."},{"key":"ref_19","unstructured":"Garg, H.G., Linhardt, R.J., and Hales, C.A. (2011). Chemistry and Biology of Heparin and Heparan Sulfate, Elsevier."},{"key":"ref_20","first-page":"158","article-title":"Form Follows Function: The Endothelial Glycocalyx","volume":"247","author":"Suzuki","year":"2022","journal-title":"Transl. Res. J. Lab. Clin. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1002\/j.2040-4603.2022.tb00232.x","article-title":"Endothelial Glycocalyx","volume":"12","author":"Foote","year":"2022","journal-title":"Compr. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s10439-011-0427-x","article-title":"The Endothelial Glycocalyx as a Barrier to Leukocyte Adhesion and Its Mediation by Extracellular Proteases","volume":"40","author":"Lipowsky","year":"2012","journal-title":"Ann. Biomed. Eng."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ajpath.2019.07.021","article-title":"Nanomechanics of the Endothelial Glycocalyx: From Structure to Function","volume":"190","author":"Cosgun","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1161\/01.CIR.101.13.1500","article-title":"Oxidized Lipoproteins Degrade the Endothelial Surface Layer: Implications for Platelet-Endothelial Cell Adhesion","volume":"101","author":"Vink","year":"2000","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/01.RES.79.3.581","article-title":"Identification of Distinct Luminal Domains for Macromolecules, Erythrocytes, and Leukocytes within Mammalian Capillaries","volume":"79","author":"Vink","year":"1996","journal-title":"Circ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"H2848","DOI":"10.1152\/ajpheart.00117.2003","article-title":"Localization of the Permeability Barrier to Solutes in Isolated Arteries by Confocal Microscopy","volume":"285","author":"VanBavel","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/cvr\/cvq062","article-title":"Microvascular Fluid Exchange and the Revised Starling Principle","volume":"87","author":"Levick","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.bpj.2011.07.036","article-title":"Similar Endothelial Glycocalyx Structures in Microvessels from a Range of Mammalian Tissues: Evidence for a Common Filtering Mechanism?","volume":"101","author":"Arkill","year":"2011","journal-title":"Biophys. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1113\/expphysiol.1991.sp003549","article-title":"Capillary Filtration-Absorption Balance Reconsidered in Light of Dynamic Extravascular Factors","volume":"76","author":"Levick","year":"1991","journal-title":"Exp. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Woodcock, T.E., and Michel, C.C. (2021). Advances in the Starling Principle and Microvascular Fluid Exchange; Consequences and Implications for Fluid Therapy. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.623671"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ydbio.2012.07.009","article-title":"The Glycocalyx Is Present as Soon as Blood Flow Is Initiated and Is Required for Normal Vascular Development","volume":"369","author":"Jahnsen","year":"2012","journal-title":"Dev. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1213\/ANE.0000000000005315","article-title":"Elevated Plasma Concentrations of Syndecan-1 Do Not Correlate With Increased Capillary Leakage of 20% Albumin","volume":"132","author":"Hahn","year":"2021","journal-title":"Anesth. Analg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ccc.2019.12.009","article-title":"Nitric Oxide and Endothelial Dysfunction","volume":"36","author":"Cyr","year":"2020","journal-title":"Crit. Care Clin."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s13239-020-00485-9","article-title":"The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases","volume":"12","author":"Weinbaum","year":"2021","journal-title":"Cardiovasc. Eng. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zeng, Y., and Tarbell, J.M. (2014). The Adaptive Remodeling of Endothelial Glycocalyx in Response to Fluid Shear Stress. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086249"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1161\/01.RES.0000101744.47866.D5","article-title":"Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells","volume":"93","author":"Florian","year":"2003","journal-title":"Circ. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"C846","DOI":"10.1152\/ajpcell.00288.2015","article-title":"Mechanotransduction of the Endothelial Glycocalyx Mediates Nitric Oxide Production through Activation of TRP Channels","volume":"311","author":"Dragovich","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/978-1-0716-1398-6_40","article-title":"Procedures to Evaluate the Role of Heparan Sulfate on the Reactivity of Resistance and Conductance Arteries Ex Vivo","volume":"2303","author":"Cho","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Milusev, A., Rieben, R., and Sorvillo, N. (2022). The Endothelial Glycocalyx: A Possible Therapeutic Target in Cardiovascular Disorders. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.897087"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e22571","DOI":"10.1002\/jbt.22571","article-title":"A Review on the Physiological and Pathophysiological Role of Endothelial Glycocalyx","volume":"34","author":"Liu","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Qu, J., Cheng, Y., Wu, W., Yuan, L., and Liu, X. (2021). Glycocalyx Impairment in Vascular Disease: Focus on Inflammation. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.730621"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Koch, J., Hijmans, R.S., Ossa Builes, M., Dam, W.A., Pol, R.A., Bakker, S.J.L., Pas, H.H., Franssen, C.F.M., and van den Born, J. (2021). Direct Evidence of Endothelial Dysfunction and Glycocalyx Loss in Dermal Biopsies of Patients with Chronic Kidney Disease and Their Association with Markers of Volume Overload. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.733015"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40560-016-0182-z","article-title":"Glycocalyx and Its Involvement in Clinical Pathophysiologies","volume":"4","author":"Ushiyama","year":"2016","journal-title":"J. Intensive Care"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wang, J., Ma, L., Fang, Y., Ye, T., Li, H., and Lan, P. (2025). Factors Influencing Glycocalyx Degradation: A Narrative Review. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1490395"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Singh, A., Ramnath, R.D., Foster, R.R., Wylie, E.C., Frid\u00e9n, V., Dasgupta, I., Haraldsson, B., Welsh, G.I., Mathieson, P.W., and Satchell, S.C. (2013). Reactive Oxygen Species Modulate the Barrier Function of the Human Glomerular Endothelial Glycocalyx. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055852"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Gusev, E., Solomatina, L., Zhuravleva, Y., and Sarapultsev, A. (2021). The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111453"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive Oxygen Species in Inflammation and Tissue Injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-\u03baB in Oxidative Stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hong, Y., Boiti, A., Vallone, D., and Foulkes, N.S. (2024). Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution. Antioxidants, 13.","DOI":"10.3390\/antiox13030312"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood-2007-10-115758","article-title":"HIF-1\u03b1 Regulates Epithelial Inflammation by Cell Autonomous NF\u03baB Activation and Paracrine Stromal Remodeling","volume":"111","author":"Scortegagna","year":"2008","journal-title":"Blood"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/MCB.24.1.36-45.2004","article-title":"Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-\u039412,14-Prostaglandin J2","volume":"24","author":"Itoh","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cytogfr.2005.03.005","article-title":"Synergy in Cytokine and Chemokine Networks Amplifies the Inflammatory Response","volume":"16","author":"Gouwy","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/CIRCRESAHA.116.309326","article-title":"Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis","volume":"120","author":"Xia","year":"2017","journal-title":"Circ. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.freeradbiomed.2023.08.008","article-title":"When Nitrosative Stress Hits the Endoplasmic Reticulum: Possible Implications in oxLDL\/Oxysterols-Induced Endothelial Dysfunction","volume":"208","author":"Nasoni","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jth.14371","article-title":"Derangement of the Endothelial Glycocalyx in Sepsis","volume":"17","author":"Iba","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"41985","DOI":"10.1038\/s41598-025-25983-5","article-title":"Endothelial Glycocalyx Shedding and Oxidative Stress in Neuronal Damage after Return of Spontaneous Circulation in Cardiac Arrest","volume":"15","author":"Miranda","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101888","DOI":"10.1016\/j.redox.2021.101888","article-title":"The Glyco-Redox Interplay: Principles and Consequences on the Role of Reactive Oxygen Species during Protein Glycosylation","volume":"42","author":"Kietzmann","year":"2021","journal-title":"Redox Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0304-4165(95)00010-9","article-title":"The Chemical Modification of Glycosaminoglycan Structure by Oxygen-Derived Species in Vitro","volume":"1244","author":"Moseley","year":"1995","journal-title":"Biochim. Biophys. Acta BBA-Gen. Subj."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Berdiaki, A., Neagu, M., Spyridaki, I., Kuskov, A., Perez, S., and Nikitovic, D. (2023). Hyaluronan and Reactive Oxygen Species Signaling\u2014Novel Cues from the Matrix?. Antioxidants, 12.","DOI":"10.3390\/antiox12040824"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lin, X., Moreno, I.Y., Nguyen, L., Gesteira, T.F., and Coulson-Thomas, V.J. (2023). ROS-Mediated Fragmentation Alters the Effects of Hyaluronan on Corneal Epithelial Wound Healing. Biomolecules, 13.","DOI":"10.3390\/biom13091385"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1074\/jbc.M807001200","article-title":"Oxidative Stress Alters Syndecan-1 Distribution in Lungs with Pulmonary Fibrosis","volume":"284","author":"Kliment","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.freeradbiomed.2011.02.014","article-title":"Extracellular Superoxide Dismutase Protects Cardiovascular Syndecan-1 from Oxidative Shedding","volume":"50","author":"Kliment","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Valachov\u00e1, K., and \u0160olt\u00e9s, L. (2021). Assessment of the Substance Antioxidative Profile by Hyaluronan, Cu(II) and Ascorbate. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111815"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Valachov\u00e1, K., Mach, M., and \u0160olt\u00e9s, L. (2020). Oxidative Degradation of High-Molar-Mass Hyaluronan: Effects of Some Indole Derivatives to Hyaluronan Decay. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165609"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"26734","DOI":"10.1074\/jbc.272.42.26734","article-title":"Hydroxyl Radicals Depolymerize Glomerular Heparan Sulfate in Vitro and in Experimental Nephrotic Syndrome","volume":"272","author":"Raats","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00125-011-2110-z","article-title":"Reactive Oxygen Species Mediate High Glucose-Induced Heparanase-1 Production and Heparan Sulphate Proteoglycan Degradation in Human and Rat Endothelial Cells: A Potential Role in the Pathogenesis of Atherosclerosis","volume":"54","author":"Rao","year":"2011","journal-title":"Diabetologia"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Liao, Y.-E., Liu, J., and Arnold, K. (2023). Heparan Sulfates and Heparan Sulfate Binding Proteins in Sepsis. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1146685"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1089\/ars.2013.5294","article-title":"Redox-Relevant Aspects of the Extracellular Matrix and Its Cellular Contacts via Integrins","volume":"20","author":"Eble","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Cabral-Pacheco, G.A., Garza-Veloz, I., Castruita-De la Rosa, C., Ramirez-Acu\u00f1a, J.M., Perez-Romero, B.A., Guerrero-Rodriguez, J.F., Martinez-Avila, N., and Martinez-Fierro, M.L. (2020). The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249739"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"H647","DOI":"10.1152\/ajpheart.00090.2018","article-title":"Role of Matrix Metalloproteinases and Histone Deacetylase in Oxidative Stress-Induced Degradation of the Endothelial Glycocalyx","volume":"316","author":"Ali","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"104381","DOI":"10.1016\/j.mvr.2022.104381","article-title":"Doxycycline Can Reduce Glycocalyx Shedding by Inhibiting Matrix Metalloproteinases in Patients Undergoing Cardiopulmonary Bypass: A Randomized Controlled Trial","volume":"142","author":"Gao","year":"2022","journal-title":"Microvasc. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bcp.2019.03.033","article-title":"A Disintegrin and Metalloproteinase (ADAM) and ADAM with Thrombospondin Motifs (ADAMTS) Family in Vascular Biology and Disease","volume":"164","author":"Zhong","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2373855","DOI":"10.1080\/13102818.2024.2373855","article-title":"An Overview of the Role of MMP-8 and ADAM-33 in Bronchial Asthma","volume":"38","author":"Celik","year":"2024","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"117659","DOI":"10.1016\/j.lfs.2020.117659","article-title":"MMPs and ADAMs\/ADAMTS Inhibition Therapy of Abdominal Aortic Aneurysm","volume":"253","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Kato, T., Hagiyama, M., and Ito, A. (2018). Renal ADAM10 and 17: Their Physiological and Medical Meanings. Front. Cell Dev. Biol., 6.","DOI":"10.3389\/fcell.2018.00153"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/ckj\/sfad135","article-title":"Leukocyte\u2013Endothelial Interaction in CKD","volume":"16","author":"Sarakpi","year":"2023","journal-title":"Clin. Kidney J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-3-319-96445-4_3","article-title":"Role of the Glycocalyx as a Barrier to Leukocyte-Endothelium Adhesion","volume":"1097","author":"Lipowsky","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"R508","DOI":"10.1152\/ajpregu.00340.2020","article-title":"The Glycocalyx: A Central Regulator of Vascular Function","volume":"320","author":"Moore","year":"2021","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"H1282","DOI":"10.1152\/ajpheart.00117.2002","article-title":"Role of Glycocalyx in Leukocyte-Endothelial Cell Adhesion","volume":"283","author":"Mulivor","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Patterson, E.K., Cepinskas, G., and Fraser, D.D. (2022). Endothelial Glycocalyx Degradation in Critical Illness and Injury. Front. Med., 9.","DOI":"10.3389\/fmed.2022.898592"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"H1672","DOI":"10.1152\/ajpheart.00832.2003","article-title":"Inflammation- and Ischemia-Induced Shedding of Venular Glycocalyx","volume":"286","author":"Mulivor","year":"2004","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00395-008-0749-5","article-title":"TNF-Alpha Induced Shedding of the Endothelial Glycocalyx Is Prevented by Hydrocortisone and Antithrombin","volume":"104","author":"Chappell","year":"2009","journal-title":"Basic Res. Cardiol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Queiroz, T.M., Lakkappa, N., and Lazartigues, E. (2020). ADAM17-Mediated Shedding of Inflammatory Cytokines in Hypertension. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.01154"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/01.RES.86.12.1259","article-title":"Interleukin-1beta and Tumor Necrosis Factor-Alpha Decrease Collagen Synthesis and Increase Matrix Metalloproteinase Activity in Cardiac Fibroblasts in Vitro","volume":"86","author":"Siwik","year":"2000","journal-title":"Circ. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"100095","DOI":"10.1016\/j.mbplus.2021.100095","article-title":"Targeting the \u201cSweet Spot\u201d in Septic Shock\u2014A Perspective on the Endothelial Glycocalyx Regulating Proteins Heparanase-1 and -2","volume":"12","author":"Pape","year":"2021","journal-title":"Matrix Biol. Plus"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Villalba, N., Baby, S., and Yuan, S.Y. (2021). The Endothelial Glycocalyx as a Double-Edged Sword in Microvascular Homeostasis and Pathogenesis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.711003"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"672395","DOI":"10.1155\/2010\/672395","article-title":"DAMPening Inflammation by Modulating TLR Signalling","volume":"2010","author":"Piccinini","year":"2010","journal-title":"Mediators Inflamm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"35237","DOI":"10.1074\/jbc.R114.619304","article-title":"Complexity of Danger: The Diverse Nature of Damage-Associated Molecular Patterns","volume":"289","author":"Schaefer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"V\u00e9n\u00e9reau, E., Ceriotti, C., and Bianchi, M.E. (2015). DAMPs from Cell Death to New Life. Front. Immunol., 6.","DOI":"10.3389\/fimmu.2015.00422"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Hu, Z., Cano, I., and D\u2019Amore, P.A. (2021). Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.734276"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/bs.ai.2015.09.001","article-title":"Mechanism of Diapedesis: Importance of the Transcellular Route","volume":"129","author":"Filippi","year":"2016","journal-title":"Adv. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.immuni.2007.04.015","article-title":"Transcellular Diapedesis Is Initiated by Invasive Podosomes","volume":"26","author":"Carman","year":"2007","journal-title":"Immunity"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Sluiter, T.J., Buul, J.D., Huveneers, S., Quax, P.H.A., and Vries, M.R. (2021). Endothelial Barrier Function and Leukocyte Transmigration in Atherosclerosis. Biomedicines, 9.","DOI":"10.3390\/biomedicines9040328"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11897-017-0320-5","article-title":"Endothelial Glycocalyx as Biomarker for Cardiovascular Diseases: Mechanistic and Clinical Implications","volume":"14","author":"Kim","year":"2017","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/ija.IJA_751_18","article-title":"Endothelial Glycocalyx: Role in Body Fluid Homeostasis and Fluid Management","volume":"63","author":"Kundra","year":"2019","journal-title":"Indian J. Anaesth."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3803\/EnM.2023.1915","article-title":"Lipid Variability Induces Endothelial Dysfunction by Increasing Inflammation and Oxidative Stress","volume":"39","author":"Rhee","year":"2024","journal-title":"Endocrinol. Metab."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Locatelli, M., Rottoli, D., Mahmoud, R., Abbate, M., Corna, D., Cerullo, D., Tomasoni, S., Remuzzi, G., Zoja, C., and Benigni, A. (2023). Endothelial Glycocalyx of Peritubular Capillaries in Experimental Diabetic Nephropathy: A Target of ACE Inhibitor-Induced Kidney Microvascular Protection. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216543"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.jhh.1001693","article-title":"Arterial Stiffness in Diabetes and Hypertension","volume":"18","author":"Lim","year":"2004","journal-title":"J. Hum. Hypertens."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/cvr\/27.6.942","article-title":"Diminished Arterial Elasticity in Diabetes: Association with Fluorescent Advanced Glycosylation End Products in Collagen","volume":"27","author":"Airaksinen","year":"1993","journal-title":"Cardiovasc. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1464-5491.1992.tb01746.x","article-title":"Arterial Wall Compliance in Diabetes","volume":"9","author":"Lehmann","year":"1992","journal-title":"Diabet. Med. J. Br. Diabet. Assoc."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/HYPERTENSIONAHA.116.08560","article-title":"Synergistic Interaction of Hypertension and Diabetes in Promoting Kidney Injury and the Role of Endoplasmic Reticulum Stress","volume":"69","author":"Wang","year":"2017","journal-title":"Hypertension"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e101061","DOI":"10.5812\/ijem.101061","article-title":"Diabetes, Hypertension, and Incidence of Chronic Kidney Disease: Is There Any Multiplicative or Additive Interaction?","volume":"19","author":"Erfanpoor","year":"2020","journal-title":"Int. J. Endocrinol. Metab."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Francekovi\u0107, P., and Gliemann, L. (2023). Endothelial Glycocalyx Preservation\u2014Impact of Nutrition and Lifestyle. Nutrients, 15.","DOI":"10.3390\/nu15112573"},{"key":"ref_105","unstructured":"GBD 2023 Chronic Kidney Disease Collaborators (2025). Global, Regional, and National Burden of Chronic Kidney Disease in Adults, 1990-2023, and Its Attributable Risk Factors: A Systematic Analysis for the Global Burden of Disease Study 2023. Lancet, 406, 2461\u20132482."},{"key":"ref_106","unstructured":"GBD Chronic Kidney Disease Collaboration (2020). Global, Regional, and National Burden of Chronic Kidney Disease, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study 2017. Lancet, 395, 709\u2013733."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.atherosclerosis.2014.03.016","article-title":"Damage of the Endothelial Glycocalyx in Chronic Kidney Disease","volume":"234","author":"Padberg","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1159\/000528560","article-title":"Cardiovascular Risk Prediction in Chronic Kidney Disease","volume":"53","author":"Li","year":"2022","journal-title":"Am. J. Nephrol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Lee, D.H., Dane, M.J.C., van den Berg, B.M., Boels, M.G.S., van Teeffelen, J.W., de Mutsert, R., den Heijer, M., Rosendaal, F.R., van der Vlag, J., and van Zonneveld, A.J. (2014). Deeper Penetration of Erythrocytes into the Endothelial Glycocalyx Is Associated with Impaired Microvascular Perfusion. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096477"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/01.CIR.91.6.1732","article-title":"Impaired Endothelium-Dependent Vasodilation in Patients with Essential Hypertension. Evidence That Nitric Oxide Abnormality Is Not Localized to a Single Signal Transduction Pathway","volume":"91","author":"Panza","year":"1995","journal-title":"Circulation"},{"key":"ref_111","unstructured":"Kaur, J., and Rout, P. (2026). Physiology, Renin Angiotensin System. StatPearls, StatPearls Publishing."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1681\/ASN.2014050430","article-title":"Role of the Vascular Wall in Sodium Homeostasis and Salt Sensitivity","volume":"26","author":"Rorije","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5049\/EBP.2015.13.1.7","article-title":"Salt Sensitivity and Hypertension: A Paradigm Shift from Kidney Malfunction to Vascular Endothelial Dysfunction","volume":"13","author":"Choi","year":"2015","journal-title":"Electrolyte Blood Press. E BP"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00424-011-0999-1","article-title":"Salt Overload Damages the Glycocalyx Sodium Barrier of Vascular Endothelium","volume":"462","author":"Oberleithner","year":"2011","journal-title":"Pflugers Arch."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.3109\/07853890.2011.653397","article-title":"Two Barriers for Sodium in Vascular Endothelium?","volume":"44","author":"Oberleithner","year":"2012","journal-title":"Ann. Med."},{"key":"ref_116","first-page":"240","article-title":"Vascular Endothelium: A Vulnerable Transit Zone for Merciless Sodium","volume":"29","author":"Oberleithner","year":"2014","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc.-Eur. Ren. Assoc."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/HYPERTENSIONAHA.117.09026","article-title":"Prevalence, Correlates, and Prognosis of Healthy Vascular Aging in a Western Community-Dwelling Cohort: The Framingham Heart Study","volume":"70","author":"Niiranen","year":"2017","journal-title":"Hypertension"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/2012.jama.10503","article-title":"Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension","volume":"308","author":"Kaess","year":"2012","journal-title":"JAMA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"37733","DOI":"10.1038\/s41598-025-25475-6","article-title":"Circulating Vascular Biomarkers in Relation to Physiological Indices of Aortic Stiffness and Endothelial Function in Hypertension","volume":"15","author":"Jekell","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2018.10.006","article-title":"High Salt-Induced Hypertrophy of Human Vascular Smooth Muscle Cells Associated with a Decrease in Glycocalyx","volume":"125","author":"Bkaily","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"H328","DOI":"10.1152\/ajpheart.00656.2021","article-title":"Microcirculatory and Glycocalyx Properties Are Lowered by High-Salt Diet but Augmented by Western Diet in Genetically Heterogeneous Mice","volume":"322","author":"Zheng","year":"2022","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/ATVBAHA.122.318439","article-title":"Endothelial Damage Arising from High Salt Hypertension Is Elucidated by Vascular Bed Systematic Profiling","volume":"43","author":"Vinaiphat","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e12454","DOI":"10.1111\/micc.12454","article-title":"Increase in Perfused Boundary Region of Endothelial Glycocalyx Is Associated with Higher Prevalence of Ischemic Heart Disease and Lesions of Microcirculation and Vascular Wall","volume":"25","author":"Gorshkov","year":"2018","journal-title":"Microcirculation"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/jch.13236","article-title":"Association of Impaired Endothelial Glycocalyx with Arterial Stiffness, Coronary Microcirculatory Dysfunction, and Abnormal Myocardial Deformation in Untreated Hypertensives","volume":"20","author":"Ikonomidis","year":"2018","journal-title":"J. Clin. Hypertens."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1681\/ASN.2011121181","article-title":"Damage of the Endothelial Glycocalyx in Dialysis Patients","volume":"23","author":"Vlahu","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s12265-021-10180-2","article-title":"Impaired Endothelial Glycocalyx Predicts Adverse Outcome in Subjects Without Overt Cardiovascular Disease: A 6-Year Follow-up Study","volume":"15","author":"Ikonomidis","year":"2022","journal-title":"J Cardiovasc. Transl. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2215\/CJN.08160813","article-title":"Association of Kidney Function with Changes in the Endothelial Surface Layer","volume":"9","author":"Dane","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Liew, H., Roberts, M.A., Pope, A., and McMahon, L.P. (2021). Endothelial Glycocalyx Damage in Kidney Disease Correlates with Uraemic Toxins and Endothelial Dysfunction. BMC Nephrol., 22.","DOI":"10.1186\/s12882-020-02219-4"},{"key":"ref_129","first-page":"452","article-title":"Renal Circulation and Microcirculation during Intra-Abdominal Hypertension in a Porcine Model","volume":"20","author":"Sui","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/01.CCM.0000259527.89927.F9","article-title":"Relationship between Sublingual and Intestinal Microcirculatory Perfusion in Patients with Abdominal Sepsis","volume":"35","author":"Boerma","year":"2007","journal-title":"Crit. Care Med."},{"key":"ref_131","first-page":"173","article-title":"Susceptibility of Erythrocytes from Non-Insulin-Dependent Diabetes Mellitus and Hemodialysis Patients, Cigarette Smokers and Normal Subjects to in Vitro Oxidative Stress and Loss of Deformability","volume":"22","author":"Srour","year":"2000","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1159\/000517317","article-title":"Markers of the Endothelial Glycocalyx Are Improved Following Kidney Transplantation","volume":"46","author":"Liew","year":"2021","journal-title":"Kidney Blood Press. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ki.2010.531","article-title":"Lower Estimated GFR and Higher Albuminuria Are Associated with Adverse Kidney Outcomes in Both General and High-Risk Populations","volume":"80","author":"Gansevoort","year":"2011","journal-title":"Kidney Int."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.transproceed.2024.12.031","article-title":"Syndecan-1 in the Serum of Deceased Kidney Donors as a Potential Biomarker of Kidney Function","volume":"57","author":"Navratil","year":"2025","journal-title":"Transplant. Proc."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1016\/j.ekir.2025.04.055","article-title":"Serum Syndecan-1 Is Associated with Kidney and Cardiovascular Outcomes in Idiopathic Nephrotic Syndrome","volume":"10","author":"Bauer","year":"2025","journal-title":"Kidney Int. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Claro, L.M., Moreno-Amaral, A.N., Gadotti, A.C., Dolenga, C.J., Nakao, L.S., Azevedo, M.L.V., De Noronha, L., Olandoski, M., De Moraes, T.P., and Stinghen, A.E.M. (2018). The Impact of Uremic Toxicity Induced Inflammatory Response on the Cardiovascular Burden in Chronic Kidney Disease. Toxins, 10.","DOI":"10.3390\/toxins10100384"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"118807","DOI":"10.1016\/j.lfs.2020.118807","article-title":"Indoxyl Sulfate Induces ROS Production via the Aryl Hydrocarbon Receptor-NADPH Oxidase Pathway and Inactivates NO in Vascular Tissues","volume":"265","author":"Nakagawa","year":"2021","journal-title":"Life Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/hr.2008.29","article-title":"Oral Adsorbent AST-120 Ameliorates Endothelial Dysfunction Independent of Renal Function in Rats with Subtotal Nephrectomy","volume":"32","author":"Namikoshi","year":"2009","journal-title":"Hypertens. Res. Off. J. Jpn. Soc. Hypertens."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/ckj\/sfad051","article-title":"Plasma Glycocalyx Pattern: A Mirror of Endothelial Damage in Chronic Kidney Disease","volume":"16","author":"Valera","year":"2023","journal-title":"Clin. Kidney J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ajpath.2022.11.003","article-title":"Reduction of Endothelial Glycocalyx on Peritubular Capillaries in Chronic Kidney Disease","volume":"193","author":"Ermert","year":"2023","journal-title":"Am. J. Pathol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"104997","DOI":"10.1016\/j.yexmp.2025.104997","article-title":"Glycocalyx Shedding as a Clinical Biomarker in Critical Illness","volume":"144","author":"Inoda","year":"2025","journal-title":"Exp. Mol. Pathol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Sampei, S., Okada, H., Tomita, H., Takada, C., Suzuki, K., Kinoshita, T., Kobayashi, R., Fukuda, H., Kawasaki, Y., and Nishio, A. (2021). Endothelial Glycocalyx Disorders May Be Associated with Extended Inflammation During Endotoxemia in a Diabetic Mouse Model. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.623582"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Braunstein, M., Annecke, T., Frey, K., Kusmenkov, T., W\u00f6rnle, M., Ney, L., B\u00f6cker, W., and Bogner-Flatz, V. (2024). Effect on Syndecan-1 and Hyaluronan Levels Depending on Multiple Organ Failure, Coagulopathy and Survival: An Observational Study in Major Trauma Patients. J. Clin. Med., 13.","DOI":"10.3390\/jcm13226768"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/rheumatology\/keaa370","article-title":"Serum Syndecan-1, Hyaluronan and Thrombomodulin Levels in Patients with Lupus Nephritis","volume":"60","author":"Yu","year":"2021","journal-title":"Rheumatology"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/bph.14397","article-title":"Soluble Syndecans: Biomarkers for Diseases and Therapeutic Options","volume":"176","author":"Bertrand","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ajpath.2019.11.016","article-title":"Endothelial Glycocalyx Impairment in Disease: Focus on Hyaluronan Shedding","volume":"190","author":"Flamion","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mvr.2014.04.004","article-title":"Endocan Is Useful Biomarker of Survival and Severity in Sepsis","volume":"93","author":"Mihajlovic","year":"2014","journal-title":"Microvasc. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s13054-017-1895-7","article-title":"Hyaluronic Acid Is Associated with Organ Dysfunction in Acute Respiratory Distress Syndrome","volume":"21","author":"Esposito","year":"2017","journal-title":"Crit. Care"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"104269","DOI":"10.1016\/j.mvr.2021.104269","article-title":"Kawasaki Disease and Increased Cardiovascular Risk: Is There a Link to Circulating Glycocalyx Biomarkers?","volume":"140","author":"Jakob","year":"2022","journal-title":"Microvasc. Res."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Buijsers, B., Yanginlar, C., de Nooijer, A., Grondman, I., Maciej-Hulme, M.L., Jonkman, I., Janssen, N.A.F., Rother, N., de Graaf, M., and Pickkers, P. (2020). Increased Plasma Heparanase Activity in COVID-19 Patients. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.575047"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"113262","DOI":"10.1016\/j.isci.2025.113262","article-title":"Matrix Metalloproteinase-9 Mediates Endothelial Glycocalyx Degradation and Correlates with Severity of Hemorrhagic Fever with Renal Syndrome","volume":"28","author":"Jacquet","year":"2025","journal-title":"iScience"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"H363","DOI":"10.1152\/ajpheart.00687.2013","article-title":"Sphingosine-1-Phosphate Protects Endothelial Glycocalyx by Inhibiting Syndecan-1 Shedding","volume":"306","author":"Zeng","year":"2014","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Wei, R., Wang, W., Pan, Q., and Guo, L. (2022). Effects of SGLT-2 Inhibitors on Vascular Endothelial Function and Arterial Stiffness in Subjects with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.826604"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1111\/bph.15153","article-title":"Recombinant Thrombomodulin Protects against LPS-Induced Acute Respiratory Distress Syndrome via Preservation of Pulmonary Endothelial Glycocalyx","volume":"177","author":"Suzuki","year":"2020","journal-title":"Br. J. Pharmacol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/4\/642\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T04:11:10Z","timestamp":1775967070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/4\/642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":154,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["life16040642"],"URL":"https:\/\/doi.org\/10.3390\/life16040642","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]}}}