{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:48:44Z","timestamp":1776084524992,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union, the European Regional Development Fund","award":["GR24038"],"award-info":[{"award-number":["GR24038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Chronic kidney disease is defined as a progressive pathology that affects more than 10% of the world\u2019s population, affecting waste filtration capacity. Sarcopenia, characterized by loss of muscle mass and strength, is a common complication in patients with chronic kidney disease undergoing hemodialysis. It is associated with inflammation, malnutrition and reduced quality of life. Hemodialysis is the fundamental treatment for people with chronic kidney disease, as it is key to the elimination of toxins from the body. Objective: The objective of this study was to determine the prevalence of probable sarcopenia in patients with chronic kidney disease in the Dialysis Unit of Extremadura (Spain). Material and Methods: This is a descriptive study in which 33 patients with chronic kidney disease receiving hemodialysis were selected as participants in the assessment of functional capacity and physical fitness. The procedure was performed prior to the dialysis session. Socio-demographic, clinical and physical variables were assessed. The assessment of probable sarcopenia was carried out using manual grip strength test (dynamometry), physical performance (4-meter walk test) and phase angle (PhA) (single frequency 50 Hz bioimpedance). The Charlson Comorbidity Index (CCI) was used to determine the severity of chronic disease and its impact, and analytical variables such as albumin, C-reactive protein (CRP), Neutrophil\/Lymphocyte Index (NLI), Lymphocyte\u2013Platelet Index (LPI) and total protein (TP), among others, were also included. Results: The prevalence of probable sarcopenia was 93.9% according to the criteria for muscle strength and physical performance (EWGSOP2). PhA showed statistically significant differences between the groups with and without sarcopenia (p = 0.039), suggesting its usefulness as a nutritional marker. No statistically significant differences were found between sarcopenia and age, albumin, Neutrophil\/Lymphocyte Index or C-reactive protein (p &gt; 0.05). Conclusions: There is a high prevalence of probable sarcopenia, associated with decreased handgrip strength and gait speed in patients with chronic kidney disease in hemodialysis. In addition, PhA stands out as an influential factor in the development of sarcopenia.<\/jats:p>","DOI":"10.3390\/life16040649","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:38:26Z","timestamp":1776080306000},"page":"649","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Cross-Sectional Pilot Study of Probable Sarcopenia in Hemodialysis Patients"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-1496","authenticated-orcid":false,"given":"Juan","family":"Rodr\u00edguez-Mansilla","sequence":"first","affiliation":[{"name":"ADOLOR Research Group, Department of Medical-Surgical Therapy, Medicine Faculty and Health Sciences, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Becerra Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"ICOT Arnao Hospital, 35200 Telde, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-6850","authenticated-orcid":false,"given":"Mar\u00eda Victoria","family":"Mart\u00edn Hidalgo-Barquero","sequence":"additional","affiliation":[{"name":"Nephrology Department, Badajoz University Hospital, 06006 Badajoz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6438-0626","authenticated-orcid":false,"given":"Mar\u00eda","family":"Jim\u00e9nez-Palomares","sequence":"additional","affiliation":[{"name":"ADOLOR Research Group, Department of Medical-Surgical Therapy, Medicine Faculty and Health Sciences, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-9583","authenticated-orcid":false,"given":"Blanca","family":"Gonz\u00e1lez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"ADOLOR Research Group, Department of Medical-Surgical Therapy, Medicine Faculty and Health Sciences, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4403-3029","authenticated-orcid":false,"given":"Elisa Mar\u00eda","family":"Garrido-Ardila","sequence":"additional","affiliation":[{"name":"ADOLOR Research Group, Department of Medical-Surgical Therapy, Medicine Faculty and Health Sciences, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.37551\/52254-28842022031","article-title":"Prevenci\u00f3n de la enfermedad renal cr\u00f3nica en adultos: Una revisi\u00f3n bibliogr\u00e1fica","volume":"25","year":"2022","journal-title":"Enferm. 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