{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T14:06:46Z","timestamp":1779458806418,"version":"3.53.1"},"reference-count":19,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Headache is a frequent but often underestimated complaint in patients with sarcoidosis. In clinical practice, headache is commonly interpreted as secondary to neurosarcoidosis, potentially overlooking the presence of primary headache disorders, particularly migraine. The prevalence and clinical relevance of migraine in sarcoidosis remain insufficiently characterized. Objective: To investigate the prevalence and clinical characteristics of migraine in patients with sarcoidosis and to explore its association with pulmonary functional outcomes. Methods: The OUtcome and Clinical characteristics of primary Headache in patients with Sarcoidosis (OUCH!) Study is a multicenter, retrospective, observational study including adult patients evaluated at pulmonology outpatient clinics and headache centers between January 2019 and January 2021. Demographic, clinical, radiological, and pulmonary function data were collected. Patients were stratified according to the presence or absence of migraine. Pulmonary function parameters were compared using non-parametric statistical tests. Results: Seventy-two patients with sarcoidosis were included; 21 (29.2%) were diagnosed with migraine. Migraine prevalence was higher than expected for the general population. Pulmonary involvement was the most frequent disease manifestation. Patients with migraine showed significantly lower DLCO values compared with those without migraine (median (IQR): 55 (40\u201370) vs. 78 (65\u201390); p = 0.0009). No significant differences were observed in spirometric parameters or radiological patterns between groups. Conclusions: Migraine is a common comorbidity in sarcoidosis and is associated with reduced DLCO, suggesting a link with greater functional disease burden rather than structural lung damage. Migraine should be recognized as a primary headache disorder in this population, rather than automatically attributed to neurosarcoidosis. These findings support a multidisciplinary, patient-centered approach and warrant prospective studies to clarify shared inflammatory, vascular, and neuroimmune mechanisms.<\/jats:p>","DOI":"10.3390\/life16050762","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:06:21Z","timestamp":1777860381000},"page":"762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["OUtcome and Clinical Characteristics of Primary Headache in Patients with Sarcoidosis: The OUCH! Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-7866","authenticated-orcid":false,"given":"Claudio","family":"Tana","sequence":"first","affiliation":[{"name":"Internal Medicine Unit, Eastern Hospital, ASL Taranto, 74024 Manduria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol","family":"Bernardinello","sequence":"additional","affiliation":[{"name":"Respiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1895-689X","authenticated-orcid":false,"given":"Giacomo","family":"Giulianelli","sequence":"additional","affiliation":[{"name":"Respiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samanta","family":"Moffa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, G. D\u2019Annunzio University of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-5850","authenticated-orcid":false,"given":"Francesco","family":"Cinetto","sequence":"additional","affiliation":[{"name":"Rare Diseases Referral Center, Internal Medicine 1, Ca\u2019 Foncello Hospital, University of Padova, 31100 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Martino","sequence":"additional","affiliation":[{"name":"Respiratory Disease Unit, ASL2 Lanciano Vasto Chieti, 66034 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Buzzelli","sequence":"additional","affiliation":[{"name":"Headache Center, ASL2 Lanciano Vasto Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Adele","family":"Giamberardino","sequence":"additional","affiliation":[{"name":"Headache Center, ASL2 Lanciano Vasto Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cipollone","sequence":"additional","affiliation":[{"name":"Headache Center, ASL2 Lanciano Vasto Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Martone","sequence":"additional","affiliation":[{"name":"Amici Contro la Sarcoidosi Italia (ACSI), 40137 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-9870","authenticated-orcid":false,"given":"Marco","family":"Tana","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, ASL2 Lanciano Vasto Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Moffa","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinic and Internal Medicine Department, G. D\u2019Annunzio University of Chieti, ASL2 Lanciano Vasto Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-0596","authenticated-orcid":false,"given":"Paolo","family":"Spagnolo","sequence":"additional","affiliation":[{"name":"Respiratory Disease Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"key":"ref_1","first-page":"1404","article-title":"Sarcoidosis","volume":"358","author":"Bergot","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"106576","DOI":"10.1016\/j.ejim.2025.106576","article-title":"Multidisciplinary strategies and new technologies in the management of sarcoidosis","volume":"144","author":"Tana","year":"2025","journal-title":"Eur. J. 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