{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:06:47Z","timestamp":1792789607838,"version":"4.5.0"},"reference-count":54,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"},{"id":[{"id":"https:\/\/ror.org\/04fm87419","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background\/Objectives: Fuchs endothelial corneal dystrophy (FECD) affects not only the corneal endothelium and Descemet membrane, but also the corneal thickness, shape, and optical quality. This study aimed to evaluate the quantitative and qualitative corneal changes after a Descemet membrane endothelial keratoplasty (DMEK) in patients with FECD and to compare the postoperative remodeling between eyes with subclinical corneal edema (F-SCE) and those with clinically evident corneal edema (F-CE). Methods: This retrospective observational study included 48 eyes of 40 patients with FECD who underwent DMEK between April 2023 and October 2025. The following parameters were assessed preoperatively and at 6 months postoperatively: central corneal thickness (CCT), mean pupillary power (MPP), anterior and posterior corneal astigmatism, total corneal higher-order aberrations (HOAs), anterior and posterior optical path difference (OPD), point spread function (PSF), anterior and posterior corneal surface regularity (RMS\/A), and Gullstrand anterior\/posterior (A\/P) and posterior\/anterior (P\/A) ratios. The corneal data was obtained using a CSO MS-39 (Costruzione Strumenti Oftalmici, Firenze, Italy). Results: In the F-SCE subgroup, significant postoperative improvement was observed in the CCT (\u0394 = \u221284.6 \u00b1 48.1 \u00b5m, p &lt; 0.001), MPP (\u0394 = \u22121.010 \u00b1 2.183, p &lt; 0.001), posterior corneal regularity (posterior RMS\/A) (\u0394 = \u22120.117 \u00b1 0.229, p = 0.004), and both Gullstrand ratios (A\/P: \u0394 = +0.111 \u00b1 0.089, p &lt; 0.001; P\/A: \u0394 = \u22120.078 \u00b1 0.064, p &lt; 0.001). No significant change was detected in the anterior corneal regularity, anterior or posterior astigmatic metrics, total corneal higher-order aberrations, or PSF. In the F-CE subgroup, the postoperative response was greater, with significant improvement in the BCVA, CCT, thinnest corneal point, MPP, anterior and posterior corneal astigmatism, cylinder, total corneal HOAs, anterior and posterior corneal HOAs, PSF, anterior and posterior corneal regularity, and both Gullstrand ratios. Compared with the F-SCE eyes, the F-CE eyes showed significantly greater postoperative change in most structural and optical parameters, although most 6-month postoperative values were no longer significantly different between groups. Conclusions: DMEK induced significant corneal remodeling in both subclinical and clinically evident FECD. The eyes with subclinical edema demonstrated meaningful recovery in visual acuity, pachymetry, and posterior corneal regularity, supporting the presence of functional corneal impairment before a clinically visible edema. The eyes with clinically evident edema showed a broader and greater postoperative response, while the final postoperative values largely converged between groups.<\/jats:p>","DOI":"10.3390\/life16050805","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:33:54Z","timestamp":1779687234000},"page":"805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Corneal Remodeling After DMEK in Fuchs Endothelial Dystrophy Patients: Quantitative and Qualitative Changes"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4802-1472","authenticated-orcid":false,"given":"Ana Maria","family":"Arghirescu","sequence":"first","affiliation":[{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Ophthalmology, Clinical Institute of Ophthalmological Emergencies \u201cProf. Dr. Mircea Olteanu\u201d, 010464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-6112","authenticated-orcid":false,"given":"Alina-Gabriela","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Clinical Institute of Ophthalmological Emergencies \u201cProf. Dr. Mircea Olteanu\u201d, 010464 Bucharest, Romania"},{"name":"Department of Ophthalmology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-8809","authenticated-orcid":false,"given":"Maria Cristina","family":"Marinescu","sequence":"additional","affiliation":[{"name":"Medical Physiology Discipline, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana-Margareta-Cornelia","family":"Dascalescu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Clinical Institute of Ophthalmological Emergencies \u201cProf. Dr. Mircea Olteanu\u201d, 010464 Bucharest, Romania"},{"name":"Department of Ophthalmology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Potop","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Clinical Institute of Ophthalmological Emergencies \u201cProf. Dr. Mircea Olteanu\u201d, 010464 Bucharest, Romania"},{"name":"Department of Ophthalmology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea-Gabriela","family":"Schmitzer","sequence":"additional","affiliation":[{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Ophthalmology, Clinical Institute of Ophthalmological Emergencies \u201cProf. Dr. Mircea Olteanu\u201d, 010464 Bucharest, Romania"},{"name":"Department of Ophthalmology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Mary","family":"Voinea","sequence":"additional","affiliation":[{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Constantin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Ovidius University, 900470 Constanta, Romania"},{"name":"Clinical Emergency Hospital \u201cSf Apostol Andrei\u201d, 900591 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Constantin","family":"Ciuluvica","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/ICO.0000000000003420","article-title":"IC3D Classification of Corneal Dystrophies-Edition 3","volume":"43","author":"Weiss","year":"2024","journal-title":"Cornea"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100863","DOI":"10.1016\/j.preteyeres.2020.100863","article-title":"Fuchs Endothelial Corneal Dystrophy: The Vicious Cycle of Fuchs Pathogenesis","volume":"80","author":"Kocaba","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.2353\/ajpath.2010.100279","article-title":"Evidence of Oxidative Stress in the Pathogenesis of Fuchs Endothelial Corneal Dystrophy","volume":"177","author":"Jurkunas","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1167\/iovs.13-13041","article-title":"Objective Assessment of the Corneal Endothelium in Fuchs\u2019 Endothelial Dystrophy","volume":"55","author":"McLaren","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100883","DOI":"10.1016\/j.preteyeres.2020.100883","article-title":"TCF4-Mediated Fuchs Endothelial Corneal Dystrophy: Insights into a Common Trinucleotide Repeat-Associated Disease","volume":"81","author":"Fautsch","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/00003226-199809000-00006","article-title":"In Vivo Confocal Microscopy of Fuchs\u2019 Endothelial Dystrophy","volume":"17","author":"Mustonen","year":"1998","journal-title":"Cornea"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ophtha.2012.09.022","article-title":"Fuchs\u2019 Endothelial Corneal Dystrophy: Subjective Grading versus Objective Grading Based on the Central-to-Peripheral Thickness Ratio","volume":"120","author":"Repp","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.ophtha.2015.05.005","article-title":"Corneal High-Order Aberrations and Backscatter in Fuchs\u2019 Endothelial Corneal Dystrophy","volume":"122","author":"Wacker","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0039-6257(93)90099-S","article-title":"Fuchs\u2019 Endothelial Dystrophy of the Cornea","volume":"38","author":"Adamis","year":"1993","journal-title":"Surv. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ajo.2018.08.040","article-title":"In Vivo Confocal Microscopy Shows Alterations in Nerve Density and Dendritiform Cell Density in Fuchs\u2019 Endothelial Corneal Dystrophy","volume":"196","author":"Aggarwal","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tsedilina, T.R., Sharova, E., Iakovets, V., and Skorodumova, L.O. (2023). Systematic Review of SLC4A11, ZEB1, LOXHD1, and AGBL1 Variants in the Development of Fuchs\u2019 Endothelial Corneal Dystrophy. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1153122"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-vision-091718-014852","article-title":"Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects","volume":"5","author":"Matthaei","year":"2019","journal-title":"Annu. Rev. Vis. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"103103","DOI":"10.1016\/j.arr.2026.103103","article-title":"The Aging Cornea: From Mechanisms to Clinical Applications","volume":"118","author":"Zheng","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s42003-024-06046-3","article-title":"A Multi-Ancestry GWAS of Fuchs Corneal Dystrophy Highlights the Contributions of Laminins, Collagen, and Endothelial Cell Regulation","volume":"7","author":"Gorman","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3091695","DOI":"10.1155\/2022\/3091695","article-title":"Global Prevalence of Fuchs Endothelial Corneal Dystrophy (FECD) in Adult Population: A Systematic Review and Meta-Analysis","volume":"2022","author":"Aiello","year":"2022","journal-title":"J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ophtha.2005.12.014","article-title":"Prevalence and Risk Factors for Cornea Guttata in the Reykjavik Eye Study","volume":"113","author":"Zoega","year":"2006","journal-title":"Ophthalmology"},{"key":"ref_17","first-page":"1","article-title":"The Prevalence of Fuchs\u2019 Endothelial Corneal Dystrophy in Cataract Patients within the Czech Population","volume":"81","year":"2025","journal-title":"Czech Slovak Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41598-025-85138-4","article-title":"Ten-Year Outcomes after DMEK, DSAEK, and PK: Insights on Graft Survival, Endothelial Cell Density Loss, Rejection and Visual Acuity","volume":"15","author":"Wilhelm","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10792-024-02994-1","article-title":"Fuchs Endothelial Corneal Dystrophy: An Updated Review","volume":"44","author":"Altamirano","year":"2024","journal-title":"Int. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/ICO.0000000000003130","article-title":"Long-Term Outcomes of Descemet Membrane Endothelial Keratoplasty: Effect of Surgical Indication and Disease Severity","volume":"42","author":"Vasiliauskaite","year":"2023","journal-title":"Cornea"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/ICO.0000000000002302","article-title":"Descemet Membrane Endothelial Keratoplasty in Asian Eyes: Intraoperative and Postoperative Complications: Intraoperative and Postoperative Complications","volume":"39","author":"Ang","year":"2020","journal-title":"Cornea"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4274\/tjo.galenos.2021.28227","article-title":"Evolving Techniques and Indications of Descemet Membrane Endothelial Keratoplasty","volume":"51","author":"Kemer","year":"2021","journal-title":"Turk. J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/ICO.0000000000001111","article-title":"Ten-Year Clinical Outcome of the First Patient Undergoing Descemet Membrane Endothelial Keratoplasty","volume":"36","author":"Baydoun","year":"2017","journal-title":"Cornea"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1097\/ICO.0000000000003343","article-title":"Systematic Review of the Diagnostic Criteria and Severity Classification for Fuchs Endothelial Corneal Dystrophy","volume":"42","author":"Oie","year":"2023","journal-title":"Cornea"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40662-020-00209-z","article-title":"Automated Diagnosis and Staging of Fuchs\u2019 Endothelial Cell Corneal Dystrophy Using Deep Learning","volume":"7","author":"Eleiwa","year":"2020","journal-title":"Eye Vis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ophtha.2019.09.033","article-title":"Predicting the Prognosis of Fuchs Endothelial Corneal Dystrophy by Using Scheimpflug Tomography","volume":"127","author":"Patel","year":"2020","journal-title":"Ophthalmology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ophtha.2018.07.005","article-title":"Determining Subclinical Edema in Fuchs Endothelial Corneal Dystrophy: Revised Classification Using Scheimpflug Tomography for Preoperative Assessment","volume":"126","author":"Sun","year":"2019","journal-title":"Ophthalmology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e914","DOI":"10.1111\/aos.14690","article-title":"New Severity Grading System for Fuchs Endothelial Corneal Dystrophy Using Anterior Segment Optical Coherence Tomography","volume":"99","author":"Yasukura","year":"2021","journal-title":"Acta Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.ophtha.2015.06.019","article-title":"Relationship between Corneal Guttae and Quality of Vision in Patients with Mild Fuchs\u2019 Endothelial Corneal Dystrophy","volume":"122","author":"Watanabe","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ophtha.2011.08.034","article-title":"Corneal Higher-Order Aberrations after Descemet\u2019s Membrane Endothelial Keratoplasty","volume":"119","author":"Rudolph","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Gavin Sancho, A., Romero Sanz, M., Idoipe Corta, M., Mateo Orobia, A., Sanchez Perez, A., Garcia-Martin, E., and Satue Palacian, M. (2017). Evaluation of visual quality parameters after Descemet membrane endotelial keratoplasty (DMEK). Acta Ophthalmol., 95.","DOI":"10.1111\/j.1755-3768.2017.0S012"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Torras-Sanvicens, J., Blanco-Dom\u00ednguez, I., S\u00e1nchez-Gonz\u00e1lez, J.-M., Rachwani-Anil, R., Spencer, J.-F., Sabater-Cruz, N., Peraza-Nieves, J., and Rocha-de-Lossada, C. (2021). Visual Quality and Subjective Satisfaction in Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UT-DSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK): A Fellow-Eye Comparison. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030419"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mencucci, R., Romualdi, G., De Vitto, C., and Cennamo, M. (2024). Enhanced Monofocal Intraocular Lenses in Fuchs\u2019 Endothelial Dystrophy Patients: Results from Triple Descemet Membrane Endothelial Keratoplasty Procedure. Life, 14.","DOI":"10.3390\/life14020243"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.optom.2017.08.003","article-title":"Visual Outcome of Penetrating Keratoplasty, Deep Anterior Lamellar Keratoplasty and Descemet Membrane Endothelial Keratoplasty","volume":"11","author":"Garrido","year":"2017","journal-title":"J. Optom."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Vestri, G., Versaci, F., and Savini, G. (2024). CSO MS-39: Principles and Applications. Essentials in Ophthalmology, Springer International Publishing.","DOI":"10.1007\/978-3-031-50666-6_29"},{"key":"ref_36","first-page":"3055722","article-title":"Changes in Corneal Parameters after DMEK Surgery: A Swept-Source Imaging Analysis at 12-Month Follow-up Time","volume":"2021","author":"Kuligowska","year":"2021","journal-title":"J. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s40123-025-01260-6","article-title":"Tomographic Differences in Thin Corneas Following DMEK in Fuchs Dystrophy: A Case-Control Study","volume":"15","author":"Bourleau","year":"2026","journal-title":"Ophthalmol. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.jcrs.2011.02.033","article-title":"Refractive Change and Stability after Descemet Membrane Endothelial Keratoplasty. Effect of Corneal Dehydration-Induced Hyperopic Shift on Intraocular Lens Power Calculation: Effect of Corneal Dehydration-Induced Hyperopic Shift on Intraocular Lens Power Calculation","volume":"37","author":"Ham","year":"2011","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s10792-021-01850-w","article-title":"Refractive Outcome and Tomographic Changes after Descemet Membrane Endothelial Keratoplasty in Pseudophakic Eyes with Fuchs\u2019 Endothelial Dystrophy","volume":"41","author":"Agha","year":"2021","journal-title":"Int. Ophthalmol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1097\/ICO.0000000000000842","article-title":"Changes in Corneal Refractive Power for Patients with Fuchs Endothelial Dystrophy after DMEK","volume":"35","author":"Alnawaiseh","year":"2016","journal-title":"Cornea"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ajo.2022.07.009","article-title":"Changes in Corneal Power up to 2 Years after Endothelial Keratoplasty: Results from the Randomized Controlled Descemet Endothelial Thickness Comparison Trial","volume":"245","author":"Chamberlain","year":"2023","journal-title":"Am. J. Ophthalmol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1016\/j.ophtha.2011.06.002","article-title":"Descemet\u2019s Membrane Endothelial Keratoplasty: Prospective Study of 1-Year Visual Outcomes, Graft Survival, and Endothelial Cell Loss","volume":"118","author":"Guerra","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jcrs.2019.02.002","article-title":"Characteristics of Preoperative and Postoperative Astigmatism in Patients Having Descemet Membrane Endothelial Keratoplasty","volume":"45","author":"Shajari","year":"2019","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"972","DOI":"10.3928\/1081597X-20100212-08","article-title":"Pentacam Characterization of Corneas with Fuchs Dystrophy Treated with Descemet Membrane Endothelial Keratoplasty","volume":"26","author":"Kwon","year":"2010","journal-title":"J. Refract. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Storp, J.J., Lahme, L., Al-Nawaiseh, S., Eter, N., and Alnawaiseh, M. (2023). Descemet Membrane Endothelial Keratoplasty (DMEK) Reduces the Corneal Epithelial Thickness in Fuchs\u2019 Patients. J. Clin. Med., 12.","DOI":"10.3390\/jcm12103573"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8193","DOI":"10.1167\/iovs.11-8047","article-title":"Histological and Confocal Microscopy Changes in Chronic Corneal Edema: Implications for Endothelial Transplantation","volume":"52","author":"Alomar","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"100214","DOI":"10.1016\/j.xops.2022.100214","article-title":"Loss of Corneal Nerves and Corneal Haze in Patients with Fuchs\u2019 Endothelial Corneal Dystrophy with the Transcription Factor 4 Gene Trinucleotide Repeat Expansion","volume":"3","author":"Gillings","year":"2023","journal-title":"Ophthalmol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hayashi, T., Kobayashi, A., Takahashi, H., Oyakawa, I., Kato, N., and Yamaguchi, T. (2020). Optical Characteristics after Descemet Membrane Endothelial Keratoplasty: 1-Year Results. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0240458"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ophtha.2019.02.007","article-title":"Corneal Higher-Order Aberrations in Descemet Membrane Endothelial Keratoplasty versus Ultrathin DSAEK in the Descemet Endothelial Thickness Comparison Trial: A Randomized Clinical Trial","volume":"126","author":"Duggan","year":"2019","journal-title":"Ophthalmology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ajo.2014.04.008","article-title":"Optical Quality of the Cornea after Descemet Membrane Endothelial Keratoplasty","volume":"158","author":"Droutsas","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2012560","DOI":"10.1155\/2018\/2012560","article-title":"Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea?","volume":"2018","author":"Satue","year":"2018","journal-title":"J. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ajo.2016.11.019","article-title":"Two-Year Course of Corneal Densitometry after Descemet Membrane Endothelial Keratoplasty","volume":"175","author":"Schaub","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ajo.2018.10.002","article-title":"Corneal Densitometry as a Predictive Diagnostic Tool for Visual Acuity Results after Descemet Membrane Endothelial Keratoplasty","volume":"198","author":"Schaub","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/ICO.0000000000003698","article-title":"Preoperative Posterior Stromal Ripples as Predictive Biomarkers of Visual Recovery after Descemet Membrane Endothelial Keratoplasty","volume":"44","author":"Ventura","year":"2024","journal-title":"Cornea"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/5\/805\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:49:22Z","timestamp":1779688162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/5\/805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["life16050805"],"URL":"https:\/\/doi.org\/10.3390\/life16050805","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]}}}