{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:32:01Z","timestamp":1792607521753,"version":"4.5.0"},"reference-count":137,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Artificial intelligence (AI) is increasingly transforming gastrointestinal endoscopy by supporting lesion detection, lesion characterization, quality assessment, and clinical risk prediction. Hemostatic decision-making represents a particularly complex field for AI integration, as therapeutic decisions are often made rapidly in the presence of active bleeding, impaired visualization, unstable patients, and variable lesion accessibility. This review critically examines the current evidence for AI-assisted decision-making in gastrointestinal endoscopy and endoscopic hemostasis, with emphasis on gastrointestinal bleeding, prediction of hemostatic therapy requirements, bleeding-risk stratification, rebleeding prediction, transfusion support, and post-procedural monitoring. Available studies suggest that machine learning and deep learning models may outperform conventional scoring systems in selected retrospective or validation cohorts, improve recognition of high-risk lesions, support less experienced endoscopists, and contribute to more individualized management of non-variceal bleeding, variceal bleeding, and capsule endoscopy findings. However, prospective interventional evidence remains sparse, and most available models are limited by retrospective design, single-center datasets, incomplete external validation, black-box decision-making, heterogeneous reporting, workflow barriers, and uncertain cost-effectiveness. AI should therefore be regarded as an adjunctive decision-support tool rather than an autonomous replacement for clinical judgment. Its future value will depend on prospective multicenter validation, explainability, real-time usability, regulatory clarity, post-deployment surveillance, and evidence of improved patient-centered outcomes before widespread implementation in emergency endoscopy practice.<\/jats:p>","DOI":"10.3390\/life16050845","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:42:18Z","timestamp":1779691338000},"page":"845","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Artificial Intelligence in Gastrointestinal Endoscopy and Hemostatic Decision-Making: Current Evidence, Clinical Implications and Implementation Barriers"],"prefix":"10.3390","volume":"16","author":[{"given":"Olga","family":"Brusnic","sequence":"first","affiliation":[{"name":"Department of Internal Medicine VII, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu Street No. 38, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-1585","authenticated-orcid":false,"given":"Adrian","family":"Boicean","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9111-6088","authenticated-orcid":false,"given":"Cristian","family":"Ichim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3106-7905","authenticated-orcid":false,"given":"Paula","family":"Anderco","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-9109","authenticated-orcid":false,"given":"Danusia","family":"Onisor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine VII, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu Street No. 38, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Li, Z., Koban, K.C., Schenck, T.L., Giunta, R.E., Li, Q., and Sun, Y. 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