{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:02:51Z","timestamp":1779696171183,"version":"3.53.1"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Women with abnormal uterine bleeding (AUB) is reported in 10\u201330% of women and is a significant cause of iron deficiency anemia (IDA), with long-term effects on women\u2019s quality of life. This retrospective study looked at the underlying causes of AUB and the contributory factors that required blood transfusions. Objectives: This study aimed to identify the treatable causes of AUB in patients who needed blood transfusion and parenteral iron in the reproductive age group and provide appropriate treatment to these underlying pathologies. Methods: A retrospective study was conducted in reproductive age group women with anemia due to AUB over a period of 10 years from January 2013 to December 2022. All women with significant uterine bleeding, who required blood transfusion were included in this study. Women with pregnancy, and hemolytic anemia, were excluded from the study. Results: During the study period 266 women needed blood transfusion for AUB. The mean age was 37.66 \u00b1 11.4 years, mean parity 3, mean body mass index (BMI): 29.4 \u00b1 8.9 kg\/m2, and most reported regular cycles. The most common etiology of AUB was uterine fibroids in 37.9% followed by ovulatory dysfunction in 15%. The mean hemoglobin was at 5.7 \u00b1 1.14 gm\/L, mean ferritin was 11.01 \u00b1 21.88 ng\/mL, mean number of blood transfusion was 2.83 \u00b1 1.2 at first presentation and about 24% needed further transfusions. About 70% of them preferred oral hormonal treatment. Surgical management was required in about 35% of patients. Conclusion: The main cause of AUB was leiomyoma and anovulation. The morbidity of blood transfusion was easily avoidable in these women.<\/jats:p>","DOI":"10.3390\/life16050855","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:42:18Z","timestamp":1779691338000},"page":"855","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anemia Secondary to Abnormal Uterine Bleeding Requiring Blood Transfusion in the Reproductive Age Group\u2014A Retrospective Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Asha","family":"Santhosh","sequence":"first","affiliation":[{"name":"Hinchingbrooke Hospital, Cambridgeshire PE29 6NT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Jesrani","sequence":"additional","affiliation":[{"name":"Department of Obst Gyne, University Medical City, Sultan Qaboos University Hospital, Muscat 123, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumana","family":"Al Mahruki","sequence":"additional","affiliation":[{"name":"Oman Medical Specialty Board, Muscat 132, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahnai","family":"Al Badi","sequence":"additional","affiliation":[{"name":"Oman Medical Specialty Board, Muscat 132, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7530-5023","authenticated-orcid":false,"given":"Maryam","family":"Al Shukri","sequence":"additional","affiliation":[{"name":"Department of Obst Gyne, University Medical City, Sultan Qaboos University Hospital, Muscat 123, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7055-336X","authenticated-orcid":false,"given":"Vaidyanathan","family":"Gowri","sequence":"additional","affiliation":[{"name":"Department of Obst Gyne, University Medical City, Sultan Qaboos University Hospital, Muscat 123, Oman"},{"name":"Department of Obst Gyne, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Jose","sequence":"additional","affiliation":[{"name":"Oman Medical Specialty Board, Muscat 132, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/AOG.0000000000003693","article-title":"Abnormal Uterine Bleeding in the Adolescent","volume":"135","author":"Hernandez","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.18203\/2320-1770.ijrcog20212946","article-title":"An analytical study of abnormal uterine bleeding in women of child bearingage group","volume":"10","author":"Shah","year":"2021","journal-title":"Int. J. Reprod. Contracept. Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1055\/s-0042-1760235","article-title":"Abnormal uterine bleeding and chronic iron deficiency","volume":"44","author":"Barros","year":"2022","journal-title":"Rev. Bras. Ginecol. Obs."},{"key":"ref_4","first-page":"99","article-title":"Abnormal uterine bleeding in adolescents: Causes, challenges and concerns","volume":"3","author":"Saule","year":"2022","journal-title":"Gynecol. Reprod. Endocrinol. Metab. GERM"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jemermed.2020.05.006","article-title":"Management of Nonpregnant Women Presenting to the Emergency Department With Iron Deficiency Anemia Caused by Uterine Blood Loss: A Retrospective Cohort Study","volume":"59","author":"Boone","year":"2020","journal-title":"J. Emerg. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1055\/s-0031-1287662","article-title":"The FIGO recommendations on terminologies and definitions for normal and abnormal uterine bleeding","volume":"29","author":"Fraser","year":"2011","journal-title":"Semin. Reprod. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/humrep\/del478","article-title":"Can we achieve international agreement on terminologies and definitions used to describe abnormalities of menstrual bleeding?","volume":"22","author":"Fraser","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.11648\/j.jgo.20251304.12","article-title":"Blood Transfusion Practices in Obstetrics & Gynecology\u2014A 3-Year Retrospective Study at Ibri Regional Hospital, Oman","volume":"13","author":"Waleem","year":"2025","journal-title":"J. Gynecol. Obstet."},{"key":"ref_9","unstructured":"WHO (2024). Guideline on Haemoglobin Cutoffs to Define Anaemia in Individuals and Populations, World Health Organization."},{"key":"ref_10","first-page":"234","article-title":"Clinical assessment of hemodynamically unstable patients","volume":"15","author":"Sevransky","year":"2009","journal-title":"Curr. Opin. Crit. Care."},{"key":"ref_11","unstructured":"National Institute for Health and Care Excellence (NICE) (2026, April 18). Blood Transfusion. NICE Guideline [NG24]. Available online: https:\/\/www.nice.org.uk\/guidance\/ng24."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijgo.2010.11.011","article-title":"FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age","volume":"113","author":"Munro","year":"2011","journal-title":"Int. J. Gynaecol. Obstet. Off. Organ. Int. Fed. Gynaecol. Obstet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1586\/17474108.4.2.179","article-title":"Health-related quality of life and economic burden of abnormal uterine bleeding","volume":"4","author":"Fraser","year":"2009","journal-title":"Expert Rev. Obstet. Gynecol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e1775","DOI":"10.1016\/S2214-109X(23)00416-3","article-title":"Prevalence of heavy menstrual bleeding and associations with physical health and wellbeing in low-income and middle-income countries: A multinational cross-sectional study","volume":"11","author":"Sinharoy","year":"2023","journal-title":"Lancet Glob. Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1210\/er.2009-0041","article-title":"Thyroid function and human reproductive health","volume":"31","author":"Krassas","year":"2010","journal-title":"Endocr. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"110","author":"Teede","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"9825","DOI":"10.18632\/aging.103247","article-title":"Association between metabolic syndrome and endometrial cancer risk: A systematic review and meta-analysis of observational studies","volume":"12","author":"Wang","year":"2020","journal-title":"Aging"},{"key":"ref_18","first-page":"101241","article-title":"The effects of obesity on the menstrual cycle","volume":"52","author":"Itriyeva","year":"2022","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.18203\/2320-1770.ijrcog20204826","article-title":"Correlation of body mass index andabnormal uterine bleeding in premenopausal women","volume":"9","author":"Akalyaa","year":"2020","journal-title":"Int. J. Reprod. Contracept. Obs. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.33545\/gynae.2024.v8.i6a.1533","article-title":"Study of clinical and histopathological correlation of abnormal uterine bleeding","volume":"8","author":"Sri","year":"2024","journal-title":"Int. J. Clin. Obstet. Gynaecol."},{"key":"ref_21","first-page":"101185","article-title":"Abnormal uterine bleeding in adolescents","volume":"52","author":"Kabra","year":"2022","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Tolkien, Z., Stecher, L., Mander, A.P., Pereira, D.I., and Powell, J.J. (2015). Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: A systematic review and meta-analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117383"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bpobgyn.2017.01.001","article-title":"The current status of hormonal therapies for heavy menstrual bleeding","volume":"40","author":"Heikinheimo","year":"2017","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_24","first-page":"CD002126","article-title":"Progestogen-releasing intrauterine systems for heavy menstrual bleeding","volume":"6","author":"Lethaby","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"(2021). Management of symptomatic uterine leiomyomas. ACOG practice bulletin No 228. Am. Coll. Obstet. Gynecol., 137, e100\u2013e115.","DOI":"10.1097\/AOG.0000000000004401"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4103\/0974-1208.121421","article-title":"Ultrasound diagnosis of adenomyosis, leiomyoma, or combined with histopathological correlation","volume":"6","author":"Hanafi","year":"2013","journal-title":"J. Hum. Reprod. Sci."},{"key":"ref_27","first-page":"QC09","article-title":"Prevalence of Abnormal Uterine Bleeding and its Associated Risk Factors in Women of Perimenopausal Age Group\u2014A Retrospective Study","volume":"16","author":"Vaidya","year":"2022","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.18410\/jebmh\/2020\/6","article-title":"Histopathological evaluation of endometrium in cases of abnormal uterine bleeding\u2014An institutional experience in a tertiary care center","volume":"7","author":"Behera","year":"2020","journal-title":"J. Evid. Based Med. Healthc."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Committee on Practice Bulletins\u2014Gynecology (2012). Practice bulletin no. 128: Diagnosis of abnormal uterine bleeding in reproductive-aged women. Obstet. Gynecol., 120, 197\u2013206.","DOI":"10.1097\/AOG.0b013e318262e320"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/5\/855\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:11:14Z","timestamp":1779693074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/5\/855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["life16050855"],"URL":"https:\/\/doi.org\/10.3390\/life16050855","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}