{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:06:28Z","timestamp":1780538788035,"version":"3.54.1"},"reference-count":46,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u00abDevelopment of a personalized approach to the implementation of reproductive function in patients with infertility using innovative technologies\u00bb","award":["\u211635-I26"],"award-info":[{"award-number":["\u211635-I26"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Recurrent intrauterine adhesions (IUA) and refractory thin endometrium are associated with impaired endometrial regeneration, reduced implantation, and poor live birth outcomes. Regenerative therapy using mesenchymal stromal cells (MSCs) has shown promising results; however, factors associated with reproductive success remain unclear. In this prospective, single-centre, single-arm uncontrolled observational study, 35 women with recurrent IUA and thin endometrium (&lt;7 mm) unresponsive to standard surgical and hormonal therapy received combined subendometrial and systemic administration of placenta-derived MSCs. The primary endpoint was live birth. Secondary endpoints included clinical pregnancy rate, time to pregnancy, endometrial thickness changes, uterine blood flow (resistance index, RI), and anti-M\u00fcllerian hormone (AMH) levels. Univariable logistic regression was performed to identify factors associated with live birth. Clinical pregnancy occurred in 13\/35 patients (37.1%), and live birth was achieved in 11\/35 (31.4%). Median time to pregnancy was 7 (5\u20138) months. Shorter duration of infertility or prior pregnancy loss (OR 1.55 per year; 95% CI 1.10\u20132.57), AFS stage I adhesions (OR 6.8; 95% CI 1.1\u201342; p = 0.04), lower baseline RI in uterine, arcuate and radial arteries, and higher baseline AMH (OR 2.59 per doubling; 95% CI 1.15\u20136.89) were significantly associated with live birth. Endometrial thickness increased after therapy but was not significantly associated with live birth. No severe adverse events were observed. Placenta-derived MSC therapy was followed by live birth in 31.4% of women with recurrent IUA and refractory thin endometrium. A shorter duration of reproductive disorders, less severe adhesions, lower baseline RI in uterine, arcuate and radial arteries, and higher AMH levels were associated with live birth after treatment and may help identify patients with a more favourable reproductive prognosis in future controlled studies.<\/jats:p>","DOI":"10.3390\/life16060871","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:42:18Z","timestamp":1779691338000},"page":"871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated with Live Birth After Placenta-Derived Mesenchymal Stromal Cell Therapy in Women with Recurrent Intrauterine Adhesions and Thin Endometrium"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1498-6520","authenticated-orcid":false,"given":"Tabeeva","family":"Giuzial","sequence":"first","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0581-9755","authenticated-orcid":false,"given":"Silachev","family":"Denis","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"},{"name":"Department of Functional Biochemistry of Biopolymers, A.N. Belozersky Research Institute of Physico-Chemical Biology, Moscow State University, 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-5209","authenticated-orcid":false,"given":"Asaturova","family":"Aleksandra","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shevtsova","family":"Yulya","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurin","family":"Alexander","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Popov","family":"Konstantin","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pronin","family":"Stanislav","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korshunov","family":"Alexey","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzhabiev","family":"Alan","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smetnik","family":"Antonina","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marchenko","family":"Larisa","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chernukha","family":"Galina","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhikh","family":"Gennady","sequence":"additional","affiliation":[{"name":"V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-cellbio-011723-021442","article-title":"Mechanisms of Regeneration and Fibrosis in the Endometrium","volume":"39","author":"Ang","year":"2023","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hooker, A.B., de Leeuw, R.A., Emanuel, M.H., Mijatovic, V., Brolmann, H.A.M., and Huirne, J.A.F. (2022). The Link between Intrauterine Adhesions and Impaired Reproductive Performance: A Systematic Review of the Literature. BMC Pregnancy Childbirth, 22.","DOI":"10.1186\/s12884-022-05164-2"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00404-009-1117-x","article-title":"Reproductive Outcome Following Hysteroscopic Adhesiolysis in Patients with Infertility due to Asherman\u2019s Syndrome","volume":"281","author":"Roy","year":"2010","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jmig.2016.10.018","article-title":"Reproductive Outcomes in Patients with Intrauterine Adhesions Following Hysteroscopic Adhesiolysis: Experience from the Largest Women\u2019s Hospital in China","volume":"24","author":"Chen","year":"2017","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"AAGL Elevating Gynecologic Surgery (2017). AAGL Practice Report: Practice Guidelines on Intrauterine Adhesions Developed in Collaboration with the European Society of Gynaecological Endoscopy (ESGE). Gynecol. Surg., 14, 6.","DOI":"10.1186\/s10397-017-1007-3"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.fertnstert.2008.02.096","article-title":"Asherman Syndrome\u2014One Century Later","volume":"89","author":"Yu","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1055\/s-0034-1376358","article-title":"Endometrial Receptivity and Intrauterine Adhesive Disease","volume":"32","author":"Young","year":"2014","journal-title":"Semin. Reprod. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.rbmo.2019.09.005","article-title":"Endometrial Thickness and IVF Cycle Outcomes: A Meta-Analysis","volume":"40","author":"Gao","year":"2020","journal-title":"Reprod. BioMed. Online"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/humupd\/dmu011","article-title":"Endometrial Thickness and Pregnancy Rates after IVF: A Systematic Review and Meta-Analysis","volume":"20","author":"Kasius","year":"2014","journal-title":"Hum. Reprod. 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Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e18848","DOI":"10.1097\/MD.0000000000018848","article-title":"Efficacy and Safety of Platelet-Rich Plasma for the Treatment of Thin Endometrium: A Protocol for Systematic Review and Meta-Analysis","volume":"99","author":"Du","year":"2020","journal-title":"Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejogrb.2017.04.022","article-title":"Use of Granulocyte Colony-Stimulating Factor in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis","volume":"214","author":"Kamath","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000447458","article-title":"Mesenchymal Stem\/Stromal Cells in Regenerative Medicine: Can Preconditioning Strategies Improve Therapeutic Efficacy?","volume":"43","author":"Spohn","year":"2016","journal-title":"Transfus. Med. Hemother."},{"key":"ref_16","first-page":"20","article-title":"Modern Possibilities of Cell Therapy for Asherman\u2019s Syndrome","volume":"7","author":"Sukhikh","year":"2018","journal-title":"Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3390\/endocrines4040048","article-title":"An Update on Experimental Therapeutic Strategies for Thin Endometrium","volume":"4","author":"Tang","year":"2023","journal-title":"Endocrines"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/rmb2.12339","article-title":"Mesenchymal Stem Cells for Restoring Endometrial Function: An Infertility Perspective","volume":"20","author":"Rungsiwiwut","year":"2021","journal-title":"Reprod. Med. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal Stem Cell Perspective: Cell Biology to Clinical Progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"npj Regen. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gao, J., Zhou, X., Jiang, N., Zhang, Y., Han, J., Jia, T., Jiang, Y., Ma, X., and Shen, H. (2025). Meta-Analysis of Mesenchymal Stem Cell Therapy for Intrauterine Adhesions: A Comprehensive Consideration of Efficacy and Safety. Front. Bioeng. Biotechnol., 13.","DOI":"10.3389\/fbioe.2025.1619778"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Yuan, F., Zhang, Y., Qian, Y., Zhou, X., Wang, M., Hu, H., Zhong, X., and Niu, H. (2025). Stem cell therapy for intrauterine adhesions: A systematic review and meta-analysis of clinical outcomes. BMC Pregnancy Childbirth, 26.","DOI":"10.1186\/s12884-025-08271-y"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"114949","DOI":"10.1016\/j.ejogrb.2026.114949","article-title":"Stem Cell Therapy in Thin Endometrium and Asherman\u2019s Syndrome: A Systematic Review and Meta-Analysis","volume":"319","author":"Adamyan","year":"2026","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1634\/stemcells.2007-0594","article-title":"Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells","volume":"26","author":"Parolini","year":"2008","journal-title":"Stem Cells"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Pelekanos, R.A., Sardesai, V.S., Futrega, K., Lott, W.B., Kuhn, M., and Doran, M.R. (2016). Isolation and Expansion of Mesenchymal Stem\/Stromal Cells Derived from Human Placenta Tissue. J. Vis. Exp., 54204.","DOI":"10.3791\/54204-v"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Sadeghi, B., Moretti, G., Arnberg, F., Sam\u00e9n, E., Kohein, B., Catar, R., Kamhieh-Milz, J., Geissler, S., Moll, G., and Holmin, S. (2019). Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02685"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13287-021-02682-2","article-title":"Human am-niotic mesenchymal stem cells combined with PPCNg facilitate injured endometrial regeneration","volume":"13","author":"Huang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ymthe.2025.09.035","article-title":"Phase 1 dose-escalation trial of sub-endometrial injection of human embryonic stem cells-derived immuni-ty-and-matrix-regulatory cells to promote endometrial angiogenesis in refractory intrauterine adhesion","volume":"34","author":"Li","year":"2026","journal-title":"Mol. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00404-025-07952-5","article-title":"Retrospective analysis of autologous bone marrow mesenchymal stem cells as adjuvant therapy in recurrent intrauterine adhesions","volume":"311","author":"Wang","year":"2025","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12015-021-10231-w","article-title":"Clinical Trials Based on Mesenchymal Stromal Cells are Exponentially Increasing: Where are We in Recent Years?","volume":"18","author":"Galderisi","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s13287-025-04644-4","article-title":"Efficacy and safety of mesenchymal stem\/stromal cells and their derived extracellular vesicles for acute respiratory distress syndrome: A systematic review and meta-analysis","volume":"16","author":"Wu","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Godoy, J.A.P., Paiva, R.M.A., Souza, A.M., Kondo, A.T., Kutner, J.M., and Okamoto, O.K. (2019). Clinical Translation of Mes-enchymal Stromal Cell Therapy for Graft Versus Host Disease. Front. Cell Dev. Biol., 7.","DOI":"10.3389\/fcell.2019.00255"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13287-015-0271-2","article-title":"Biodistribution, migration and homing of systemically applied mesenchymal stem\/stromal cells","volume":"7","author":"Leibacher","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","article-title":"Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6","volume":"5","author":"Lee","year":"2009","journal-title":"Cell Stem Cell."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.fertnstert.2013.10.053","article-title":"Rat bone marrow mesenchymal stem cells improve regeneration of thin endometrium in rat","volume":"101","author":"Jing","year":"2014","journal-title":"Fertil Steril."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13287-022-02717-2","article-title":"Synergistic regenerative therapy of thin endometrium by human placenta-derived mesenchymal stem cells encapsulated within hyaluronic acid hydrogels","volume":"13","author":"Lin","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1186\/s13287-021-02499-z","article-title":"Unresponsive thin endometrium caused by Asherman syndrome treated with umbilical cord mesenchymal stem cells on collagen scaffolds: A pilot study","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13287-022-02756-9","article-title":"Intrauterine infusion of clinically graded human umbilical cord-derived mesenchymal stem cells for the treatment of poor healing after uterine injury: A phase I clinical trial","volume":"13","author":"Huang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Guo, Q., Chang, Y., Li, J., Zhou, C., Huang, R., Yang, X., Liu, G., and Liang, X. (2022). Regenerative Effects of Locally or Intra-Arterially Administered BMSCs on the Thin Endometrium. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.735465"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8336","DOI":"10.15419\/z5w81w36","article-title":"Mesenchymal Stem Cell Therapy for Thin Endometrium: Mechanisms, Delivery Strategies, and Clinical Outcomes: A Systematic Review","volume":"13","author":"Lin","year":"2026","journal-title":"Biomed. Res. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"451","DOI":"10.55891\/wajm.v39i5.104","article-title":"A Comparative Study of Uterine Artery Doppler Parameters and Endometrial Characteristics in Women with Unexplained Infertility and Fertile Women","volume":"39","author":"Smart","year":"2022","journal-title":"West Afr. J. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41580-024-00733-z","article-title":"Epithelial\u2013Mesenchymal Transition in Tissue Repair and Degeneration","volume":"25","author":"Youssef","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1097\/GRH.0000000000000068","article-title":"Use of Autologous Adipose-Derived Mesenchymal Stem Cells for Ovarian Rejuvenation in Poor Responder IVF Patients: A Phase 1 Randomized Placebo-Controlled Double-Blind Crossover Study","volume":"8","author":"Cassim","year":"2023","journal-title":"Glob. Reprod. Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1517\/14712598.2015.1051528","article-title":"Human Umbilical Cord Mesenchymal Stem Cells: An Overview of Their Potential in Cell-Based Therapy","volume":"15","author":"Li","year":"2015","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_44","first-page":"163","article-title":"Comparison of Human Mesenchymal Stromal Cells from Four Neonatal Tissues: Amniotic Membrane, Chorionic Membrane, Placental Decidua and Umbilical Cord","volume":"8","author":"Salton","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.21037\/sci-2022-025","article-title":"Adverse Events, Side Effects and Complications in Mesenchymal Stromal Cell-Based Therapies","volume":"9","author":"Baranovskii","year":"2022","journal-title":"Stem Cell Investig."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11427-023-2403-7","article-title":"Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women: A randomized, controlled trial","volume":"67","author":"Zhu","year":"2024","journal-title":"Sci. China Life Sci."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/6\/871\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:21:12Z","timestamp":1780536072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/6\/871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["life16060871"],"URL":"https:\/\/doi.org\/10.3390\/life16060871","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]}}}