{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:04:57Z","timestamp":1779725097516,"version":"3.53.1"},"reference-count":71,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Arthritis (RA) is characterized by immune-mediated chronic inflammation and endothelial dysfunction, ultimately resulting in clinically overt cardiovascular complications. As a prototypical disease of microvascular dysfunction, RA represents an ideal model to study microvascular alterations. The dermal capillary network offers an easily accessible window to the peripheral microcirculation, whose function can be easily assessed using Nailfold videocapillaroscopy (NVC) or laser techniques. Whereas the clinical significance of structural alterations is not always clear, functional abnormalities may provide more direct insight into the dynamic status of the microvasculature and endothelial integrity. The present narrative review aims to provide an integrative overview of available studies evaluating functional abnormalities of the dermal microcirculation in RA, with particular emphasis on the emerging role of NVC as a dynamic vascular assessment tool. Several studies in RA have assessed the structure and morphology of the peripheral microvasculature using NVC, but far fewer data exist on functional alterations assessed with this method. The study of functional alterations of the dermal microvascular network in RA has largely been based on laser techniques, which consistently point towards altered microvascular reactivity. By contrast, functional NVC-related approaches remain limited, despite their potential ability to simultaneously assess structural and dynamic capillary abnormalities in vivo. Available evidence supports that NVC may be reframed as a promising functional vascular biomarker in RA. However, the available literature is characterized by small sample sizes, predominantly cross-sectional designs, and methodological heterogeneity, highlighting the need for standardized prospective studies.<\/jats:p>","DOI":"10.3390\/life16060883","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:05:08Z","timestamp":1779721508000},"page":"883","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Capillary Microvascular Dysfunction in Rheumatoid Arthritis: The Promising Role of Nailfold Videocapillaroscopy\u2014A Narrative Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-7915","authenticated-orcid":false,"given":"Elena","family":"Angeloudi","sequence":"first","affiliation":[{"name":"Third Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5658-4629","authenticated-orcid":false,"given":"Panagiota","family":"Anyfanti","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5764-1320","authenticated-orcid":false,"given":"Konstantinos","family":"Tragiannidis","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Korki","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Aintinidou","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3540-6525","authenticated-orcid":false,"given":"Vasiliki","family":"Dimitriadou","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1217-5513","authenticated-orcid":false,"given":"Paraskevi","family":"Avgerou","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Kitas","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Russells Hall Hospital, Dudley Group NHS Foundation Trust, Dudley DY1 2HQ, UK"},{"name":"School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-1642","authenticated-orcid":false,"given":"Theodoros","family":"Dimitroulas","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.31138\/mjr.20230801.oo","article-title":"Overview of Rheumatoid Arthritis and Scientific Understanding of the Disease","volume":"34","author":"Jahid","year":"2023","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","article-title":"Global, regional, and national burden of rheumatoid arthritis, 1990\u20132020, and projections to 2050: A systematic analysis of the Global Burden of Disease Study 2021","volume":"5","author":"Black","year":"2023","journal-title":"Lancet. Rheumatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"102776","DOI":"10.1016\/j.autrev.2021.102776","article-title":"Rheumatoid arthritis: Extra-articular manifestations and comorbidities","volume":"20","author":"Figus","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.31138\/mjr.301223.eaf","article-title":"Epidemiology and Risk Factors for Rheumatoid Arthritis Development","volume":"34","author":"Venetsanopoulou","year":"2023","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.31138\/mjr.310824.cri","article-title":"Cardiovascular Risk in Rheumatoid Arthritis: Considerations on Assessment and Management","volume":"35","author":"Anyfanti","year":"2024","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.31138\/mjr.241124.ath","article-title":"State of the Art in Novel Treatment Strategies in Rheumatoid Arthritis: A Brief Review","volume":"36","author":"Nascimento","year":"2025","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/ard-2022-223356","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update","volume":"82","author":"Smolen","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.31138\/mjr.311025.eti","article-title":"Optimising Conventional Therapy in Rheumatoid Arthritis","volume":"37","author":"Drosos","year":"2026","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.31138\/mjr.33.2.201","article-title":"A Clinical Audit of Cardiovascular Risk Factors and Disease in Patients with Rheumatoid Arthritis\u2014SURF-RA","volume":"33","author":"Semb","year":"2022","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6893","DOI":"10.2147\/JIR.S276986","article-title":"Monitoring and Managing Cardiovascular Risk in Immune Mediated Inflammatory Diseases","volume":"14","author":"Anyfanti","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.semarthrit.2013.05.001","article-title":"Heart involvement in rheumatoid arthritis: Multimodality imaging and the emerging role of cardiac magnetic resonance","volume":"43","author":"Mavrogeni","year":"2013","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e12451","DOI":"10.1111\/micc.12451","article-title":"Dermal capillary rarefaction as a marker of microvascular damage in patients with rheumatoid arthritis: Association with inflammation and disorders of the microcirculation","volume":"25","author":"Anyfanti","year":"2018","journal-title":"Microcirculation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/HJH.0000000000003503","article-title":"The importance of microvascular inflammation in ageing and age-related diseases: A position paper from the ESH working group on small arteries, section of microvascular inflammation","volume":"41","author":"Mengozzi","year":"2023","journal-title":"J. Hypertens."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Anyfanti, P., Angeloudi, E., Dara, A., Arvanitaki, A., Bekiari, E., Kitas, G.D., and Dimitroulas, T. (2022). Nailfold Videocapillaroscopy for the Evaluation of Peripheral Microangiopathy in Rheumatoid Arthritis. Life, 12.","DOI":"10.3390\/life12081167"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11906-020-01064-y","article-title":"Endothelial Dysfunction in Patients with Rheumatoid Arthritis: The Role of Hypertension","volume":"22","author":"Anyfanti","year":"2020","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/injr.injr_254_21","article-title":"Arterial stiffness in rheumatoid arthritis: Current knowledge and future perspectives","volume":"17","author":"Anyfanti","year":"2022","journal-title":"Indian J. Rheumatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/RHU.0b013e3182290dbf","article-title":"The Relationship Between Carotid Intima-Media Thickness and the Activity of Rheumatoid Arthritis","volume":"17","author":"Majdan","year":"2011","journal-title":"JCR J. Clin. Rheumatol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Battistoni, A., Dimitroulas, T., and Anyfanti, P. (2025). Editorial: Vascular injury in systemic diseases: Current concepts and future perspectives. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1656542"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gavriilaki, E., and Anyfanti, P. (2023). Editorial: Endotheliopathies: Current concepts and importance in clinical practice. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1162121"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Naderi-Meshkin, H., and Setyaningsih, W.A.W. (2024). Endothelial Cell Dysfunction: Onset, Progression, and Consequences. Front. Biosci., 29.","DOI":"10.31083\/j.fbl2906223"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41584-018-0022-8","article-title":"Microvascular endothelial dysfunction in rheumatoid arthritis","volume":"14","author":"Bordy","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1172\/JCI66843","article-title":"Linking endothelial dysfunction with endothelial cell activation","volume":"123","author":"Liao","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"730","DOI":"10.2741\/s183","article-title":"The endothelium in compliance and resistance vessels","volume":"3","author":"Triggle","year":"2011","journal-title":"Front. Biosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3109\/03009742.2011.585350","article-title":"Anti-CCP and RF IgM: Predictors of impaired endothelial function in rheumatoid arthritis patients","volume":"40","author":"Hjeltnes","year":"2011","journal-title":"Scand. J. Rheumatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s12016-021-08890-1","article-title":"Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings","volume":"63","author":"Sokolova","year":"2022","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Holers, V.M., and Banda, N.K. (2018). Complement in the Initiation and Evolution of Rheumatoid Arthritis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01057"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s10067-017-3659-9","article-title":"Subendocardial viability ratio in patients with rheumatoid arthritis: Comparison with healthy controls and identification of prognostic factors","volume":"36","author":"Anyfanti","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_28","first-page":"1507","article-title":"Skin microcirculation dynamics are impaired in patients with rheumatoid arthritis and no cardiovascular comorbidities","volume":"41","author":"Anyfanti","year":"2023","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11239-021-02517-0","article-title":"Patients with autoimmune chronic inflammatory diseases present increased biomarkers of thromboinflammation and endothelial dysfunction in the absence of flares and cardiovascular comorbidities","volume":"53","author":"Anyfanti","year":"2022","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/ard.62.7.630","article-title":"Increased inflammatory activity parallels increased basal nitric oxide production and blunted response to nitric oxide in vivo in rheumatoid arthritis","volume":"62","author":"Bergholm","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1002\/art.23798","article-title":"The presentation and outcome of heart failure in patients with rheumatoid arthritis differs from that in the general population","volume":"58","author":"Davis","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/rheumatology\/kex038","article-title":"Rheumatoid arthritis-specific cardiovascular risk scores are not superior to general risk scores: A validation analysis of patients from seven countries","volume":"56","author":"Crowson","year":"2017","journal-title":"Rheumatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.mvr.2010.05.012","article-title":"Excellent reproducibility of laser speckle contrast imaging to assess skin microvascular reactivity","volume":"80","author":"Roustit","year":"2010","journal-title":"Microvasc. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.mvr.2011.07.007","article-title":"Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function","volume":"82","author":"Tew","year":"2011","journal-title":"Microvasc. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/j.2040-4603.2020.tb00131.x","article-title":"Human Skin Microcirculation","volume":"10","author":"Cracowski","year":"2020","journal-title":"Compr. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tips.2013.05.007","article-title":"Assessment of endothelial and neurovascular function in human skin microcirculation","volume":"34","author":"Roustit","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.atherosclerosis.2006.05.034","article-title":"Inflammatory suppression rapidly attenuates microvascular dysfunction in rheumatoid arthritis","volume":"192","author":"Datta","year":"2007","journal-title":"Atherosclerosis"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/HJH.0b013e3280b0157e","article-title":"Forearm haemodynamics, arterial stiffness and microcirculatory reactivity in rheumatoid arthritis","volume":"25","author":"Arosio","year":"2007","journal-title":"J. Hypertens."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3899\/jrheum.090699","article-title":"Inflammation and microvascular and macrovascular endothelial dysfunction in rheumatoid arthritis: Effect of treatment","volume":"37","author":"Foster","year":"2010","journal-title":"J. Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10067-011-1750-1","article-title":"Microvascular function is preserved in newly diagnosed rheumatoid arthritis and low systemic inflammatory activity","volume":"30","author":"Dijkmans","year":"2011","journal-title":"Clin. Rheumatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1365-2362.2011.02607.x","article-title":"An observational study of endothelial function in early arthritis","volume":"42","author":"Foster","year":"2012","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1186\/ar3374","article-title":"The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: A cross-sectional study","volume":"13","author":"Sandoo","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"R117","DOI":"10.1186\/ar3847","article-title":"The role of inflammation and cardiovascular disease risk on microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: A cross-sectional and longitudinal study","volume":"14","author":"Sandoo","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/ar4287","article-title":"The association between functional and morphological assessments of endothelial function in patients with rheumatoid arthritis: A cross-sectional study","volume":"15","author":"Sandoo","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3233\/CH-15112","article-title":"Alterations in skin microvascular function in patients with rheumatoid arthritis and ankylosing spondylitis","volume":"65","author":"Klimek","year":"2017","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.trsl.2016.12.003","article-title":"Tocilizumab improves the proatherothrombotic profile of rheumatoid arthritis patients modulating endothelial dysfunction, NETosis, and inflammation","volume":"183","author":"Ortega","year":"2017","journal-title":"Transl. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/rheumatology\/kex053","article-title":"Sedentary behaviour in rheumatoid arthritis: Definition, measurement and implications for health","volume":"57","author":"Fenton","year":"2018","journal-title":"Rheumatology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00296-019-04503-5","article-title":"A prospective, longitudinal monocentric study on laser Doppler imaging of microcirculation: Comparison with macrovascular pathophysiology and effect of adalimumab treatment in early rheumatoid arthritis","volume":"40","author":"Mohamed","year":"2020","journal-title":"Rheumatol. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3899\/jrheum.090417","article-title":"Clinical improvement in rheumatoid arthritis is associated with healthier microvascular function in patients who respond to antirheumatic therapy","volume":"37","author":"Galarraga","year":"2010","journal-title":"J. Rheumatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00296-007-0397-3","article-title":"Microvascular dysfunction in rheumatoid arthritis assessed by laser Doppler anemometry: Relationship to soluble adhesion molecules and extraarticular manifestations","volume":"28","author":"Meyer","year":"2007","journal-title":"Rheumatol. Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"112","DOI":"10.31138\/mjr.28.3.112","article-title":"Important Considerations for Examining Endothelial Dysfunction in Rheumatoid Arhritis","volume":"28","author":"Sandoo","year":"2017","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11906-015-0543-3","article-title":"Capillary Rarefaction as an Index for the Microvascular Assessment of Hypertensive Patients","volume":"17","author":"Triantafyllou","year":"2015","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/HJH.0000000000003873","article-title":"Nailfold videocapillaroscopy as a non-invasive tool for the assessment of peripheral microangiopathy in cardiovascular diseases","volume":"43","author":"Baroutidou","year":"2025","journal-title":"J. Hypertens."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101849","DOI":"10.1016\/j.berh.2023.101849","article-title":"Nailfold capillaroscopy","volume":"37","author":"Smith","year":"2023","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"R605","DOI":"10.1152\/ajpregu.00339.2019","article-title":"Reactive hyperemia: A review of methods, mechanisms, and considerations","volume":"318","author":"Rosenberry","year":"2020","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mvr.2015.04.001","article-title":"Regarding the quantification of peripheral microcirculation\u2014Comparing responses evoked in the in vivo human lower limb by postural changes, suprasystolic occlusion and oxygen breathing","volume":"99","author":"Silva","year":"2015","journal-title":"Microvasc. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"102458","DOI":"10.1016\/j.autrev.2020.102458","article-title":"Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud\u2019s phenomenon and systemic sclerosis","volume":"19","author":"Smith","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/2397198319833486","article-title":"Nailfold capillaroscopy in systemic sclerosis\u2014State of the art: The evolving knowledge about capillaroscopic abnormalities in systemic sclerosis","volume":"4","author":"Lambova","year":"2019","journal-title":"J. Scleroderma Relat. Disord."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000547636","article-title":"Noninvasive Bedside Approaches for Assessing Microvascular Dysfunction","volume":"62","author":"Widaeus","year":"2025","journal-title":"J. Vasc. Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Bottino, D.A., and Bouskela, E. (2022). Non-invasive techniques to access in vivo the skin microcirculation in patients. Front. Med., 9.","DOI":"10.3389\/fmed.2022.1099107"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1024\/0301-1526\/a000851","article-title":"Microcirculatory assessment of vascular diseases","volume":"49","author":"Marcoccia","year":"2020","journal-title":"Vasa"},{"key":"ref_62","first-page":"1197","article-title":"Increased capillary permeability in systemic rheumatoid vasculitis detection by dynamic fluorescence nailfold videomicroscopy","volume":"21","author":"Hachulla","year":"1994","journal-title":"J. Rheumatol."},{"key":"ref_63","first-page":"CR616","article-title":"Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis","volume":"8","author":"Pache","year":"2002","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Caraba, A., Stancu, O., Cri\u0219an, V., and Georgescu, D. (2024). Anti TNF-Alpha Treatment Improves Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25189925"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1161\/01.HYP.34.4.655","article-title":"Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality","volume":"34","author":"Antonios","year":"1999","journal-title":"Hypertension"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/01.HYP.38.2.238","article-title":"Impaired skin capillary recruitment in essential hypertension is caused by both functional and structural capillary rarefaction","volume":"38","author":"Gans","year":"2001","journal-title":"Hypertension"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1590\/S1807-59322008000500008","article-title":"Treatment of essential hypertension does not normalize capillary rarefaction","volume":"63","author":"Penna","year":"2008","journal-title":"Clinics"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"E732","DOI":"10.1152\/ajpendo.90477.2008","article-title":"Impaired microvascular perfusion: A consequence of vascular dysfunction and a potential cause of insulin resistance in muscle","volume":"295","author":"Clark","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41440-020-0525-y","article-title":"Microcirculatory function deteriorates with advancing stages of chronic kidney disease independently of arterial stiffness and atherosclerosis","volume":"44","author":"Schoina","year":"2021","journal-title":"Hypertens. 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