{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:05:12Z","timestamp":1779959112472,"version":"3.53.1"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Catestatin is a chromogranin A\u2013derived peptide involved in sympathetic, cardiovascular, inflammatory, and metabolic regulation, but its longitudinal profile during pregnancy remains insufficiently defined. This prospective cohort study aimed to evaluate changes in serum catestatin concentrations from the first to the third trimester and to explore their associations with blood pressure and metabolic parameters in initially low-risk singleton pregnancies. Fifty pregnant women were followed longitudinally from 11\u201313 + 6\/7 to 30\u201341 + 5\/7weeks of gestation. Clinical and biochemical parameters were assessed at both visits, and serum catestatin concentrations were measured using a commercial enzyme immunoassay. Serum catestatin concentrations were significantly lower in the third trimester than in the first trimester (median [IQR]: 9.4 [4.9\u201315.5] vs. 13.4 [9.9\u201324.6] ng\/mL; p &lt; 0.001). Longitudinal changes in catestatin were positively associated with third-trimester insulin concentrations after adjustment for selected covariates. Third-trimester catestatin concentrations were positively correlated with systolic blood pressure (r = 0.356, p = 0.011) and remained associated with systolic blood pressure in a limited multivariable model. These findings suggest that catestatin concentrations decline from early to late pregnancy and may reflect selected metabolic and hemodynamic changes. Larger longitudinal studies including pathological pregnancy cohorts are needed to clarify its clinical relevance.<\/jats:p>","DOI":"10.3390\/life16060896","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:36:56Z","timestamp":1779892616000},"page":"896","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Dynamics of Catestatin Across Gestation: Links to Metabolic and Hemodynamic Adaptation"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4939-4967","authenticated-orcid":false,"given":"Zdenka","family":"Sunjic Lovric","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8912-1771","authenticated-orcid":false,"given":"Jasminka Resic","family":"Karara","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia"},{"name":"Department of Health Studies, University of Split, Rudera Boskovica 35, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5230-1698","authenticated-orcid":false,"given":"Vedran","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianka","family":"Mimica","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9696-3359","authenticated-orcid":false,"given":"Marko","family":"Kumric","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia"},{"name":"Laboratory for Cardiometabolic Research, School of Medicine, University of Split, Soltanska 2A, 21000 Split, Croatia"},{"name":"Department of Pathophysiology, School of Medicine, University of Split, Soltanska 2A, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Supe-Domic","sequence":"additional","affiliation":[{"name":"Department of Health Studies, University of Split, Rudera Boskovica 35, 21000 Split, Croatia"},{"name":"Laboratory Diagnostics, Department of Medical, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3112-0656","authenticated-orcid":false,"given":"Roko","family":"Santic","sequence":"additional","affiliation":[{"name":"Laboratory for Cardiometabolic Research, School of Medicine, University of Split, Soltanska 2A, 21000 Split, Croatia"},{"name":"Department of Pathophysiology, School of Medicine, University of Split, Soltanska 2A, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-0635","authenticated-orcid":false,"given":"Josko","family":"Bozic","sequence":"additional","affiliation":[{"name":"Laboratory for Cardiometabolic Research, School of Medicine, University of Split, Soltanska 2A, 21000 Split, Croatia"},{"name":"Department of Pathophysiology, School of Medicine, University of Split, Soltanska 2A, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/HJH.0000000000000090","article-title":"A Longitudinal Study of Maternal Cardiovascular Function from Preconception to the Postpartum Period","volume":"32","author":"Mahendru","year":"2014","journal-title":"J. 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Res. Med. Sci."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/6\/896\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:20:16Z","timestamp":1779956416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/6\/896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["life16060896"],"URL":"https:\/\/doi.org\/10.3390\/life16060896","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]}}}