{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:05:51Z","timestamp":1780653951075,"version":"3.54.1"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>(1) Background: The reconstruction of periacetabular defects after tumor resection remains one of the most challenging procedures in orthopaedic oncology. The modular LUMiC\u00ae system was designed to improve fixation stability and reduce implant-related complications compared with earlier hemipelvic prostheses. We investigated patient and implant survival after LUMiC\u00ae reconstruction, complication types and functional outcomes. (2) Methods: Eighteen patients (8 men, 10 women; mean age 58.9 years) underwent LUMiC\u00ae endoprosthetic reconstruction between 2011 and 2025. Kaplan\u2013Meier analysis was used to estimate patient and implant survival. Complications were categorized according to Henderson. Functional results were evaluated at follow-up using MSTS and TESS. (3) Results: Mean follow-up was 35.52 months (SD 36.89). Overall implant survival was 72.2%. Instability (27.8%) and infection (16.7%) were the leading complications. Two-thirds of patients required at least one revision (mean 3.1 revisions per case). Metastatic disease reduced patient survival (p = 0.012) but did not affect implant longevity (p = 0.31). Functional outcomes were available for only 3 of 18 patients and should therefore be regarded as exploratory. Mean MSTS was 58.9% (SD 21.43) and mean TESS was 73.4% (SD 6.836). (4) Conclusions: Despite high revision rates, the LUMiC\u00ae prosthesis provides durable fixation. Early revision does not appear to compromise implant survival. However, the small and heterogeneous cohort represents a limiting factor of this study.<\/jats:p>","DOI":"10.3390\/life16060955","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:43:04Z","timestamp":1780648984000},"page":"955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes and Complications After LUMiC\u00ae Endoprosthetic Reconstruction of Periacetabular Defects\u2014A Retrospective Cohort Analysis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-5049","authenticated-orcid":false,"given":"Adrian Su","family":"Niemann","sequence":"first","affiliation":[{"name":"Department of Trauma Surgery, Hannover Medical School, 30161 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0436-2415","authenticated-orcid":false,"given":"Ricardo","family":"Ramon","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Hannover Medical School, 30161 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2313-0846","authenticated-orcid":false,"given":"Jorge","family":"Mayor","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Hannover Medical School, 30161 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Koblenzer","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Hannover Medical School, 30161 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0646-8156","authenticated-orcid":false,"given":"G\u00f6kmen","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Hannover Medical School, 30161 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek Omar","family":"Pacha","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Hannover Medical School, 30161 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Decker","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Hannover Medical School, 30161 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-1945","authenticated-orcid":false,"given":"Tilman","family":"Graulich","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Hannover Medical School, 30161 Hannover, Germany"},{"name":"Department of Orthopaedic and Trauma Surgery, Pius Hospital Carl von Ossietzky University of Oldenburg, 26219 Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/1097-0142(197903)43:3<806::AID-CNCR2820430305>3.0.CO;2-Y","article-title":"Internal Hemipelvectomy\u2014Excision of the Hemipelvis with Limb Preservation. An Alternative to Hemipelvectomy","volume":"43","author":"Eilber","year":"1979","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100396","DOI":"10.1016\/j.jbo.2021.100396","article-title":"Periacetabular Reconstruction Following Limb-Salvage Surgery for Pelvic Sarcomas","volume":"31","author":"Fujiwara","year":"2021","journal-title":"J. Bone Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s11999-012-2625-8","article-title":"Constrained Total Hip Megaprosthesis for Primary Periacetabular Tumors","volume":"471","author":"Ueda","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Atzmon, R., Drexler, M., Dolkart, O., Goldstein, Y., Dubin, J., Sternheim, A., Gortzak, Y., and Bickels, J. (2022). Less Is Better than More with Resection of Periacetabular Tumors\u2014A Retrospective 16 Years Study and Literature Review. Front. Surg., 9.","DOI":"10.3389\/fsurg.2022.1036640"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2106\/00004623-197860060-00002","article-title":"Resection and Reconstruction for Primary Neoplasms Involving the Innominate Bone","volume":"60","author":"Enneking","year":"1978","journal-title":"J. Bone Jt. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1302\/0301-620X.72B6.2246283","article-title":"The Saddle Prosthesis for Salvage of the Destroyed Acetabulum","volume":"72-B","author":"Nieder","year":"1990","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.5301\/hipint.5000306","article-title":"Reconstruction of Periacetabular Tumours with Saddle Prosthesis or Custom-Made Prosthesis, Functional Results and Complications","volume":"26","author":"Mermerkaya","year":"2016","journal-title":"HIP Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s11999-012-2631-x","article-title":"Poor Long-Term Clinical Results of Saddle Prosthesis After Resection of Periacetabular Tumors","volume":"471","author":"Jansen","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.21037\/aoj.2019.06.04","article-title":"Pelvic Reconstruction Using Pedestal Endoprosthesis\u2014Experience from Europe","volume":"4","author":"Lowe","year":"2019","journal-title":"Ann. Jt."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s13018-024-04697-w","article-title":"Biomechanical and Clinical Outcomes of 3D-Printed versus Modular Hemipelvic Prostheses for Limb-Salvage Reconstruction Following Periacetabular Tumor Resection: A Mid-Term Retrospective Cohort Study","volume":"19","author":"Hu","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/jso.26088","article-title":"Outcomes Following Periacetabular Tumor Resection: A 25-year Institutional Experience","volume":"122","author":"Ippolito","year":"2020","journal-title":"J. Surg. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejso.2012.10.002","article-title":"Modular Hemipelvic Endoprosthesis Reconstruction-Experience in 100 Patients with Mid-Term Follow-up Results","volume":"39","author":"Ji","year":"2013","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/jso.1127","article-title":"Complications and Functional Evaluation of 17 Saddle Prostheses for Resection of Periacetabular Tumors","volume":"78","author":"Cottias","year":"2001","journal-title":"J. Surg. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00003086-200203000-00030","article-title":"Implantation of Hemipelvic Prosthesis After Resection of Sarcoma","volume":"396","author":"Ozaki","year":"2002","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2106\/00004623-200703000-00015","article-title":"Pelvic Reconstruction with a Structural Pelvic Allograft After Resection of a Malignant Bone Tumor","volume":"89","author":"Delloye","year":"2007","journal-title":"J. Bone Jt. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0748-7983(04)00140-4","article-title":"Complications Following Operative Treatment of Primary Malignant Bone Tumours in the Pelvis","volume":"30","author":"Zeifang","year":"2004","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/17453679609002326","article-title":"High Complication Rates with Pelvic Allografts. Experience of 22 Sarcoma Resections","volume":"67","author":"Ozaki","year":"1996","journal-title":"Acta Orthop. Scand."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00064-025-00922-9","article-title":"Interne Hemipelvektomie: Periazetabul\u00e4re Resektion Mit Femurtransposition (H\u00fcftverschiebeplastik)","volume":"38","author":"Andreou","year":"2026","journal-title":"Oper. Orthop. Traumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1302\/0301-620X.107B12.BJJ-2025-0173.R2","article-title":"Prosthetic Reconstruction or Hip Transposition after Periacetabular Tumour Resection?","volume":"107-B","author":"Wang","year":"2025","journal-title":"Bone Jt. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/01.blo.0000081933.75404.f8","article-title":"Correction of Leg-Length Discrepancy After Hip Transposition","volume":"416","author":"Gosheger","year":"2003","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1097\/CORR.0000000000002696","article-title":"Hip Transposition Can Provide Early Walking Function After Periacetabular Tumor Resection: A Multicenter Study","volume":"481","author":"Zhang","year":"2023","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jso.21820","article-title":"Hip Transposition as a Limb Salvage Procedure Following the Resection of Periacetabular Tumors","volume":"103","author":"Gebert","year":"2011","journal-title":"J. Surg. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s11999-016-4805-4","article-title":"LUMiC\u00ae Endoprosthetic Reconstruction After Periacetabular Tumor Resection: Short-Term Results","volume":"475","author":"Bus","year":"2017","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2106\/JBJS.23.01082","article-title":"LUMiC Endoprosthetic Reconstruction of Periacetabular Tumor Defects: A Multicenter Follow-up Study","volume":"106","author":"Evenhuis","year":"2024","journal-title":"J. Bone Jt. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2106\/JBJS.J.00834","article-title":"Failure Mode Classification for Tumor Endoprostheses: Retrospective Review of Five Institutions and a Literature Review","volume":"93","author":"Henderson","year":"2011","journal-title":"J. Bone Jt. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ahmed, A.A., Mooar, P.A., Kleiner, M., Torg, J.S., and Miyamoto, C.T. (2011). Hypertensive Patients Show Delayed Wound Healing Following Total Hip Arthroplasty. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023224"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/SAP.0b013e31829778e1","article-title":"Reconstruction after Internal Hemipelvectomy: Outcomes and Reconstructive Algorithm","volume":"74","author":"Chao","year":"2015","journal-title":"Ann. Plast. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.ejso.2009.04.011","article-title":"Limb-Salvage Reconstruction with MUTARS\u00ae Hemipelvic Endoprosthesis: A Prospective Multicenter Study","volume":"35","author":"Witte","year":"2009","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/jso.27181","article-title":"LUMiC\u00ae Endoprosthesis for Pelvic Reconstruction: A Canadian Experience","volume":"127","author":"Rizkallah","year":"2023","journal-title":"J. Surg. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0140-6736(18)31859-2","article-title":"Survival of Total Hip Replacements","volume":"393","author":"Sodhi","year":"2019","journal-title":"Lancet"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2106\/JBJS.18.00836","article-title":"Multiflora and Gram-Negative Microorganisms Predominate in Infections Affecting Pelvic Endoprostheses Following Tumor Resection","volume":"101","author":"Sanders","year":"2019","journal-title":"J. Bone Jt. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.arth.2011.04.022","article-title":"Dislocation and Infection After Revision Total Hip Arthroplasty","volume":"26","author":"Kosashvili","year":"2011","journal-title":"J. Arthroplast."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00003086-198401000-00015","article-title":"Factors Influencing the Incidence and Outcome of Infection Following Total Joint Arthroplasty","volume":"182","author":"Poss","year":"1984","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"94568","DOI":"10.52965\/001c.94568","article-title":"Hip Arthroplasty Outcomes in Patients with Metastatic Bone Disease","volume":"16","author":"Tepper","year":"2024","journal-title":"Orthop. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.2106\/00004623-200408000-00011","article-title":"Patient Survival After Hip Arthroplasty for Metastatic Disease of the Hip","volume":"86","author":"Schneiderbauer","year":"2004","journal-title":"J. Bone Jt. Surg.-Am. Vol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"593","DOI":"10.5604\/15093492.1193013","article-title":"Zastosowanie Protezy LUMIC w Leczeniu Przerzut\u00f3w Zlokalizowanych w Panewce Stawu Biodrowego","volume":"17","author":"Guzik","year":"2015","journal-title":"Ortop. Traumatol. Rehabil."},{"key":"ref_37","first-page":"86","article-title":"Scoops of Success: Outcomes in a Series of 13 Patients Using a Cone Cup Prosthesis for Acetabular Reconstruction","volume":"23","author":"Klopper","year":"2024","journal-title":"S. Afr. Orthop. J."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/6\/955\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T09:22:22Z","timestamp":1780651342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/6\/955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["life16060955"],"URL":"https:\/\/doi.org\/10.3390\/life16060955","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]}}}