{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:53:10Z","timestamp":1781506390494,"version":"3.54.1"},"reference-count":20,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Mohs Micrographic Surgery (MMS) is considered the most conservative and preserving procedure for removing cutaneous tumors. The major disadvantage of MMS is that tumor involvement in tissue may be underestimated. This may lead to large excisions necessitating complex reconstruction with profound effects on cosmetic results. Some patients refuse complex reconstruction and demand simple closure of post-MMS skin defects. This retrospective cohort study describes our technique of serial Mohs excisions of large non-melanoma skin cancers for patients refusing flaps or skin graft reconstructions. A total of 51 patients who underwent MMS according to the described technique February 2020\u2013May 2021 were included. The mean age was 76.5 (range 63\u201394) years and 55% were male. More than half of the lesions were on the nose. Mean lesion sizes were 14.25\u201355 mm depending on location. Most cases required two surgeries and only one needed a third surgery. Postsurgical defects were repaired using primary closure in 90% of cases. Mean follow-up was 31 months (range 6\u201348) with no evidence of local recurrence. In conclusion, this approach of serial excisions with MMS can be performed safely and achieve better cosmetic outcomes for patients presenting with large skin tumors of the face or other functionally important areas.<\/jats:p>","DOI":"10.3390\/life16061005","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:59:47Z","timestamp":1781503187000},"page":"1005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Two-Stage Mohs Micrographic Surgery Technique to Avoid Complex Reconstruction of Large Skin Lesions"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3705-5454","authenticated-orcid":false,"given":"Ariel","family":"Berl","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Gray School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Shir-az","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Gray School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-2959","authenticated-orcid":false,"given":"Biader Samih","family":"Bilal","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Gray School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8435-8848","authenticated-orcid":false,"given":"Din","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Gray School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-1650","authenticated-orcid":false,"given":"Avshalom","family":"Shalom","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Gray School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/archsurg.1941.01210080079004","article-title":"Chemosurgery: A microscopically controlled method of cancer excision","volume":"42","author":"Mohs","year":"1941","journal-title":"Arch. 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Wkly."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/6\/1005\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:15:24Z","timestamp":1781504124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/6\/1005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["life16061005"],"URL":"https:\/\/doi.org\/10.3390\/life16061005","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]}}}