{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T01:48:24Z","timestamp":1782352104158,"version":"3.54.5"},"reference-count":46,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health Studies Center of the Governador Ozanam Coelho University Center","award":["2-2022\/2"],"award-info":[{"award-number":["2-2022\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Systemic arterial hypertension (SAH) is a multifaceted condition marked by sustained elevations in arterial blood pressure. Its occurrence is closely related to alterations in target organs, such as the liver. Non-pharmacological treatments have been proposed for these effects. Thus, the aim of this study was to investigate the effects of a\u00e7a\u00ed supplementation and resistance training, applied individually or in combination, on blood pressure and liver structural parameters. An experimental, quantitative, and longitudinal study was conducted using young Wistar rats (~60 days old) and spontaneously hypertensive rat (SHR) strains. Fifty rats were divided into five experimental groups: Wistar Control (C), Hypertensive Control (H), Hypertensive Trained (HT), Hypertensive A\u00e7a\u00ed-Supplemented (HA), and Hypertensive Trained plus A\u00e7a\u00ed Supplementation (HAT). Each group consisted of ten animals. Subsequently, analyses were performed for the antioxidant capacity and proximate composition of the a\u00e7a\u00ed pulp, systolic blood pressure assessment, and histological evaluation of the liver. The a\u00e7a\u00ed used exhibited high antioxidant capacity. At the end of the experimental period, the trained groups increased their maximal load carried, along with a reduction in systolic blood pressure in all treated groups. A\u00e7a\u00ed supplementation resulted in lower relative liver mass compared with the H group. The hypertensive condition promoted extracellular matrix expansion and a reduction in hepatocyte proportion. Both interventions attenuated these effects, and the combined treatment (HAT) produced the greatest improvement, indicating an additive response. Hypertension also elevated hepatic glycogen concentration, and the treatments reduced this alteration. It is concluded that a\u00e7a\u00ed supplementation and resistance training could promote positive adaptations in the liver of hypertensive animals.<\/jats:p>","DOI":"10.3390\/life16071056","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T01:03:56Z","timestamp":1782349436000},"page":"1056","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acai Supplementation and Resistance Training: A Preliminary Study of the Effects on Liver Parameters in Hypertensive Rats"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7506-7514","authenticated-orcid":false,"given":"\u00c2ngela Quinelato","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Physical Education and Nutrition, Governador Ozanam Coelho University Center, Ub\u00e1 36506-022, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar Barbosa","family":"de Meireles","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Nutrition, Governador Ozanam Coelho University Center, Ub\u00e1 36506-022, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willian Cruz","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Nutrition, Governador Ozanam Coelho University Center, Ub\u00e1 36506-022, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-1327","authenticated-orcid":false,"given":"Luciano Bernardes","family":"Leite","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biology, Federal University of Vi\u00e7osa, Vi\u00e7osa 36590-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-6780","authenticated-orcid":false,"given":"Pedro","family":"Forte","sequence":"additional","affiliation":[{"name":"Department of Sports, Instituto Polit\u00e9cnico de Bragan\u00e7a, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Research Center for Active Living and Wellbeing (LiveWell), Instituto Polit\u00e9cnico de Bragan\u00e7a, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Malheiro","sequence":"additional","affiliation":[{"name":"Research Center for Active Living and Wellbeing (LiveWell), Instituto Polit\u00e9cnico de Bragan\u00e7a, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1077-7233","authenticated-orcid":false,"given":"Pedro","family":"Afonso","sequence":"additional","affiliation":[{"name":"Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal"},{"name":"Biosciences Higher School of Elvas, Polytechnic Institute of Portalegre, 7300-110 Portalegre, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselmo Gomes","family":"de Moura","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Nutrition, Governador Ozanam Coelho University Center, Ub\u00e1 36506-022, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Coutinho","family":"de Miranda","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Nutrition, Governador Ozanam Coelho University Center, Ub\u00e1 36506-022, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-2492","authenticated-orcid":false,"given":"Luiz Ot\u00e1vio","family":"Guimar\u00e3es-Ervilha","sequence":"additional","affiliation":[{"name":"Departament of Biological Sciences, Federal University of Vi\u00e7osa, Vi\u00e7osa 36590-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-3529","authenticated-orcid":false,"given":"Mariana","family":"Machado-Neves","sequence":"additional","affiliation":[{"name":"Departament of Biological Sciences, Federal University of Vi\u00e7osa, Vi\u00e7osa 36590-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-4024","authenticated-orcid":false,"given":"Ant\u00f4nio Jos\u00e9","family":"Natali","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biology, Federal University of Vi\u00e7osa, Vi\u00e7osa 36590-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Neiva","family":"Lavorato","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Nutrition, Governador Ozanam Coelho University Center, Ub\u00e1 36506-022, MG, Brazil"},{"name":"Federal Institute of Mato Grosso do Sul, Ponta Por\u00e3 Campus, Ponta Por\u00e3 79909-000, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","first-page":"e20250001","article-title":"Diretriz Brasileira de Hipertens\u00e3o Arterial\u20142025","volume":"122","author":"Rodrigues","year":"2025","journal-title":"Arq. 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