{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:51:26Z","timestamp":1782841886861,"version":"3.54.5"},"reference-count":135,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>This systematic literature review synthesizes available data from published case reports and case studies describing de novo myasthenia gravis (MG) following confirmed SARS-CoV-2 infection, focusing on clinical presentation, immunological characteristics, temporal relationship, management, and outcomes. The study addresses the following research question: What are the clinical, immunological, temporal, and outcome characteristics of de novo MG following SARS-CoV-2 infection based on published case reports and case studies? Following the PRISMA 2020 guidelines, the analysis included 44 studies describing 48 patients. The findings suggest that MG temporally associated with COVID-19 typically occurred within a relatively short latency period, with a median interval of 21 days. Most patients presented with generalized onset and were predominantly positive for AChR-Abs, consistent with the established clinical and serological profile of classical MG, in which AChR-Abs represent the most common subtype, particularly in generalized disease. MuSK and LRP4-positive cases were less frequent; ICU admission, myasthenic crisis, and respiratory failure were frequently reported. Importantly, most patients responded well to conventional MG therapies.<\/jats:p>","DOI":"10.3390\/life16071100","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:56:55Z","timestamp":1782838615000},"page":"1100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New-Onset Myasthenia Gravis Associated with SARS-CoV-2 Infection: A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"given":"Amalia L.","family":"C\u0103linoiu","sequence":"first","affiliation":[{"name":"\u201cProf. Dr. Agrippa Ionescu\u201d Emergency Clinical Hospital, 011356 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7739-253X","authenticated-orcid":false,"given":"Alexandra","family":"Minc\u0103","sequence":"additional","affiliation":[{"name":"\u201cProf. Dr. Agrippa Ionescu\u201d Emergency Clinical Hospital, 011356 Bucharest, Romania"},{"name":"Public Health and Management Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8236-1242","authenticated-orcid":false,"given":"Claudiu C.","family":"Popescu","sequence":"additional","affiliation":[{"name":"Rheumatology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9187-894X","authenticated-orcid":false,"given":"Ileana M.","family":"Vod\u0103","sequence":"additional","affiliation":[{"name":"Bucharest University Emergency Hospital, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2961-2169","authenticated-orcid":false,"given":"Alexandra M.","family":"Cristea","sequence":"additional","affiliation":[{"name":"Pneumology I Department, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drago\u0219 I.","family":"Minc\u0103","sequence":"additional","affiliation":[{"name":"Rheumatology Department, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, October 30). 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