{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:40:41Z","timestamp":1787499641061,"version":"build-2736575974"},"reference-count":17,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Amiodarone-induced thyrotoxicosis (AIT) is a serious thyroid dysfunction that represents a significant complication of pharmacological therapy in cardiology patients. The development of AIT can substantially complicate the management of cardiac arrhythmias, posing a major clinical challenge. We present the case of a patient in whom amiodarone was initially effective in the treatment of atrial fibrillation but subsequently led to type II amiodarone-induced thyrotoxicosis and exacerbation of the atrial arrhythmia. This case highlights the need for regular monitoring of patients treated with amiodarone, the challenges of managing arrhythmias in the setting of AIT, and the importance of close collaboration between cardiologists and endocrinologists in the diagnosis and treatment of AIT.<\/jats:p>","DOI":"10.3390\/life16071134","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:27:23Z","timestamp":1783520843000},"page":"1134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["To Be or Not to Be: Amiodarone as Both Savior and Foe\u2014A Therapeutic Paradox in Atrial Fibrillation Management and Ventricular Arrhythmia Associated with Amiodarone-Induced Thyrotoxicosis"],"prefix":"10.3390","volume":"16","author":[{"given":"Monika","family":"Amielan","sequence":"first","affiliation":[{"name":"Department of Invasive Cardiology, Internal Medicine with CICU and Laboratory of Hemodynamics, University Hospital in Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-4093","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Zalewska-Adamiec","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Internal Medicine with CICU and Laboratory of Hemodynamics, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Bach\u00f3rzewska-Gajewska","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Internal Medicine with CICU and Laboratory of Hemodynamics, University Hospital in Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Dobrzycki","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Internal Medicine with CICU and Laboratory of Hemodynamics, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/thy.1998.8.83","article-title":"Iodine-induced hyperthyroidism: Occurrence and epidemiology","volume":"8","author":"Stanbury","year":"1998","journal-title":"Thyroid. Off. J. Am. Thyroid. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103145","DOI":"10.1016\/j.cpcardiol.2025.103145","article-title":"Amiodarone: Get in rhythm or get off the dance floor. Analyzing the overuse of long term amiodarone in patients with atrial fibrillation","volume":"50","author":"Smith","year":"2025","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1001\/archinte.160.12.1741","article-title":"Practical guidelines for clinicians who treat patients with amiodarone. Practice Guidelines Subcommittee, North American Society of Pacing and Electrophysiology","volume":"160","author":"Goldschlager","year":"2000","journal-title":"Arch. Intern. 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J. Cardiol."},{"key":"ref_8","unstructured":"Feingold, K.R., Adler, R.A., Ahmed, S.F., Anawalt, B., Blackman, M.R., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., and Dungan, K. (2022, June 01). Amiodarone Induced Thyrotoxicosis, Endotext, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279030."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1210\/jc.2008-1907","article-title":"Amiodarone-induced thyrotoxicosis is a predictor of adverse cardiovascular outcome","volume":"94","author":"Yiu","year":"2009","journal-title":"J. Clin. Endocrinol. 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Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1161\/01.CIR.92.11.3255","article-title":"Randomized, double-blind comparison of intravenous amiodarone and bretylium in the treatment of patients with recurrent, hemodynamically destabilizing ventricular tachycardia or fibrillation","volume":"92","author":"Kowey","year":"1995","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000486957","article-title":"2018 European Thyroid Association (ETA) Guidelines for the Management of Amiodarone-Associated Thyroid Dysfunction","volume":"7","author":"Bartalena","year":"2018","journal-title":"Eur. Thyroid. 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Cardiol."},{"key":"ref_16","first-page":"13","article-title":"Zur Vorbeugung jodinduzierter Hyperthyreosen nach Koronarangiographie [Prevention of iodine-induced hyperthyroidism after coronary angiography]","volume":"20","author":"Fritzsche","year":"1993","journal-title":"Acta Medica Austriaca"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1204","DOI":"10.1210\/clinem\/dgae304","article-title":"Thyroid Dysfunction Risk After Iodinated Contrast Media Administration: A Prospective Longitudinal Cohort Analysis","volume":"110","author":"Sohn","year":"2025","journal-title":"J. Clin. Endocrinol. 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