{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:18:37Z","timestamp":1783678717311,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Camellia japonica L. (Theaceae) seed oil is an essential component for skin protection, attributed to its antioxidant properties and anti-aging effects. In this study, Camellia japonica seed oil underwent fermentation with Sporidiobolus pararoseus (Fell &amp; Tallman, CGMCC No. 39106, commercial name: Longevity yeast of 1021-year-Camellia japonica). The post-fermented oil, designated Longevity Yeast Oil (LYO), was used in the present research. Gas chromatography\u2013mass spectrometry analysis demonstrated that methyl esterification of LYO afforded twelve fatty acid methyl esters. We used an aging model in human epidermal keratinocytes and human skin fibroblasts exposed to ultraviolet B (UVB) to explore the anti-skin aging effects and mechanisms of LYO. The results of the CCK-8 assay demonstrated that LYO exhibited no cytotoxicity but instead displayed potential proliferative activity, indicating its excellent safety profile. Quantitative real-time polymerase chain reaction analyses confirmed that LYO downregulated the expression of autophagy marker p62 and upregulated LC3B, thereby activating the autophagic pathway. Further investigation revealed that LYO protected against UVB-induced apoptosis, promoted the synthesis of collagen and elastin, and upregulated the expression of loricrin, filaggrin, and ceramides, effectively reversing UVB-induced skin cellular aging. Notably, we further revealed that LYO alleviated UVB-induced cutaneous photoaging via activating cellular autophagy pathway. In conclusion, LYO demonstrated biocompatibility and conferred protection to skin cells against photoaging, thereby establishing a theoretical basis for the development of innovative autophagy-targeted anti-aging therapies.<\/jats:p>","DOI":"10.3390\/life16071145","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:46:47Z","timestamp":1783676807000},"page":"1145","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Camellia japonica Seed Oil Fermented by Sporidiobolus pararoseus Prevents Skin Cellular Photoaging by Inducing Autophagy"],"prefix":"10.3390","volume":"16","author":[{"given":"Bai","family":"Lv","sequence":"first","affiliation":[{"name":"School of Pharmacy, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangtao","family":"Li","sequence":"additional","affiliation":[{"name":"Anti-Cellular Senescence Joint Research Laboratory of Forest Cabin, Shanghai Jiao Tong University, Shanghai 201600, China"},{"name":"Shanghai Forest Cabin Cosmetics Group Co., Ltd., Shanghai 201600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqi","family":"Gao","sequence":"additional","affiliation":[{"name":"Anti-Cellular Senescence Joint Research Laboratory of Forest Cabin, Shanghai Jiao Tong University, Shanghai 201600, China"},{"name":"Shanghai Forest Cabin Cosmetics Group Co., Ltd., Shanghai 201600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Anti-Cellular Senescence Joint Research Laboratory of Forest Cabin, Shanghai Jiao Tong University, Shanghai 201600, China"},{"name":"Shanghai Forest Cabin Cosmetics Group Co., Ltd., Shanghai 201600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1368-5681","authenticated-orcid":false,"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Qingdao University, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/ics.12779","article-title":"Facial skin ageing: Key concepts and overview of processes","volume":"44","author":"Zargaran","year":"2022","journal-title":"Int. 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