{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:05:44Z","timestamp":1784822744804,"version":"3.55.0"},"reference-count":52,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Cancer rates are increasing significantly worldwide, with surgical intervention being the most convenient intervention. Transversus abdominis plane (TAP) block has been proven to enhance postoperative opioid use and its associated complications. Additionally, dexmedetomidine has been reported to provide effective analgesia with relatively minimal respiratory complications. This systematic review and meta-analysis aims to explore the efficacy of combining dexmedetomidine with transversus abdominis plane (TAP) block compared to transversus abdominis plane (TAP) block alone in patients undergoing various cancer surgeries as outcomes may also be influenced by surgical and patient-related factors. Methods: We conducted a comprehensive literature search across PubMed\/MEDLINE, Scopus, Web of Science, Cochrane CENTRAL, and Embase to identify randomized controlled trials evaluating the efficacy and safety of dexmedetomidine as an adjunct to transversus abdominis plane (TAP) block in patients undergoing cancer surgery. Data were extracted from the six eligible randomized controlled trials that met the predefined inclusion criteria, and a random-effects meta-analysis was performed using RevMan software Version 5.4. Results: The meta-analysis found that dexmedetomidine as an adjunct to transversus abdominis plane (TAP) block was more effective than transversus abdominis plane (TAP) block alone in reducing the mean arterial pressure and the mean heart rate 2 h postoperatively (MD \u22126.46, 95% CI [\u22128.63; \u22124.30], p &lt; 0.0001) and (MD \u22125.44, 95% CI [\u22127.67; \u22123.20], p &lt; 0.0001). The duration until the first rescue analgesia was significantly longer in the TAP\u2013DEX group (MD 3.75, 95% CI [3.08; 4.43], p &lt; 0.0001). The overall patient satisfaction with postoperative pain management demonstrated statistically significant improvement compared to the TAP group (RR 1.31, 95% CI [1.13; 1.53], p = 0.0005). visual analog scale (VAS) pain scores, which are used to assess pain intensity, were significantly lower at rest and during movement 2 h postoperatively in the TAP-DEX group, although some complex patients may have difficulty using visual analog scale (VAS) pain scores accurately. Therefore, the Numeric Rating Scale (NRS) may be considered as an alternative tool. Conclusions: Compared to transversus abdominis plane (TAP) block alone, the dexmedetomidine and transversus abdominis plane (TAP) block arm showed a statistically significant difference in time to first rescue analgesia, patient overall satisfaction, nausea, and vomiting. However, no statistical significance difference was found across the remaining outcomes.<\/jats:p>","DOI":"10.3390\/life16081217","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:05:42Z","timestamp":1784819142000},"page":"1217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dexmedetomidine as an Adjunct to Transversus Abdominis Plane Block in Patients Undergoing Cancer Surgeries: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5933-1529","authenticated-orcid":false,"given":"Rana Abdulmohsen","family":"Alotaibi","sequence":"first","affiliation":[{"name":"College of Pharmacy, Taif University, Taif 21944, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Owaid","family":"Alharthi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Taif University, Taif 21944, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem Ibrahim","family":"Shokry","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care, Ohud Hospital, Minisrty of Heakth, Al Madinah Al Munawwarah 42394, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz Fahad","family":"Samandar","sequence":"additional","affiliation":[{"name":"College of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5239-3878","authenticated-orcid":false,"given":"Wafaa T.","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Northern Border University, Arar 91431, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzun Hamed","family":"Aljohani","sequence":"additional","affiliation":[{"name":"\u202aCollege of Pharmacy, Taibah University, Al Madinah Al Munawwarah 42353, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatha Salem","family":"Alhamed","sequence":"additional","affiliation":[{"name":"Community Pharmacy Outlet Plus, Alhusiba, Dumat al-Jandal 74821, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal Hussain Al","family":"Mutairi","sequence":"additional","affiliation":[{"name":"Royal Medical Service, Amman 11855, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaf Abdullah","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences (SCMB), The University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan Ahmed","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"\u202aCollege of Pharmacy, Al Baha University, Al Baha 65431, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Tariq","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8591-0031","authenticated-orcid":false,"given":"Areej Jarbou","family":"Bahrawi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaf Mohammed","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour Abdulrahman","family":"Alkhulayfi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Taif University, Taif 21944, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"ref_1","unstructured":"Global Cancer Observatory (2025, February 02). 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