{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:19:46Z","timestamp":1785403186209,"version":"3.56.0"},"reference-count":34,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022428","name":"University of Opole","doi-asserted-by":"crossref","award":["P-2025-003"],"award-info":[{"award-number":["P-2025-003"]}],"id":[{"id":"10.13039\/501100022428","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100022428","name":"University of Opole","doi-asserted-by":"crossref","award":["P-2025-004"],"award-info":[{"award-number":["P-2025-004"]}],"id":[{"id":"10.13039\/501100022428","id-type":"DOI","asserted-by":"crossref"}]},{"award":["P-2025-003"],"award-info":[{"award-number":["P-2025-003"]}],"id":[{"id":"https:\/\/ror.org\/04gbpnx96","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P-2025-004"],"award-info":[{"award-number":["P-2025-004"]}],"id":[{"id":"https:\/\/ror.org\/04gbpnx96","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Good Ilizarov treatment outcomes are associated with low complication rates, rapid formation of strong bone regenerate, and relatively early removal of the Ilizarov external fixator. Some authors recommend the use of pharmaceutical agents that facilitate and accelerate bone union. There are no previous studies evaluating Osteogenon in Ilizarov osteotomies. The purpose of our study was to assess radiological and clinical effects of Osteogenon in patients undergoing osteotomy combined with Ilizarov fixation. Methods: In this retrospective study we assessed 35 patients who had undergone lower leg lengthening osteotomies with the Ilizarov method in the years 2021\u20132022 and received adjunctive Osteogenon. The control group comprised 60 patients matched for age, sex, BMI, and comorbidities, who did not receive Osteogenon. We assessed the following clinical and radiological parameters: the duration of fixation, total initial limb shortening, total limb lengthening, achieving bone union following osteotomy, elongation index, alignment index, complications, analgesic use, and satisfaction with treatment. Results: The median duration of fixation was worse (longer) in the Osteogenon group (183 days) compared to the control group (143 days), p = 0.014. There were no differences between groups in initial limb shortening, median limb lengthening, median elongation index, median alignment index, and complication rate. A proportion of 22.9% of patients in the Osteogenon group and 80% patients in the control group took analgesics on post-treatment follow-up, p &lt; 0.001. In the study, 65.71% of Osteogenon patients and 55% of control patients were very satisfied with the treatment. Conclusions: Taking Osteogenon improves patient\u2019s satisfaction with treatment and limits analgesic use following osteotomies combined with Ilizarov fixation. Osteogenon was associated with a significantly longer external fixation period and failed to demonstrate measurable improvements in radiological outcomes. Any considerations regarding the potential benefits of using Osteogenon should be treated with caution.<\/jats:p>","DOI":"10.3390\/life16081244","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:54:26Z","timestamp":1785153266000},"page":"1244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Ossein\u2013Hydroxyapatite Complex Improve the Results of Lower-Leg Lengthening Osteotomies with the Ilizarov Method?"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-666X","authenticated-orcid":false,"given":"Piotr","family":"Morasiewicz","sequence":"first","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, Institute of Medical Sciences, University of Opole, Al. Witosa 26, 45-401 Opole, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3264-011X","authenticated-orcid":false,"given":"Monika","family":"Zaborska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical Sciences, University of Opole, Ul. Oleska 48, 45-052 Opole, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-0111","authenticated-orcid":false,"given":"\u0141ukasz","family":"Tomczyk","sequence":"additional","affiliation":[{"name":"Department of Food Safety and Quality Management, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-8897","authenticated-orcid":false,"given":"Katarzyna","family":"Sznajder","sequence":"additional","affiliation":[{"name":"Clinical Department of Imaging Diagnostics, Institute of Medical Sciences, University of Opole, Al. Witosa 26, 45-401 Opole, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8486-3636","authenticated-orcid":false,"given":"Igor","family":"Kowal","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, Multidisciplinary Hospital in Zgorzelec, Luba\u0144ska 11-12, 59-900 Zgorzelec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystian","family":"Kazubski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Trauma Surgery, Institute of Medical Sciences, University of Opole, Al. Witosa 26, 45-401 Opole, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref_1","first-page":"e4973","article-title":"Ilizarov External Fixation: Percutaneous Gigli Saw Versus Multiple Drill-hole Osteotomy Techniques for Distraction Osteogenesis","volume":"11","author":"Makhdoom","year":"2019","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Depaoli, A., Magnani, M., Casamenti, A., Cerasoli, T., Ramella, M., Menozzi, G.C., Mordenti, M., Rocca, G., and Trisolino, G. (2023). Is the High Healing Index a Complication of Progressive Long Bone Lengthening? Observations from a Cohort of 178 Children Treated with Circular External Fixation for Lower Limb Length Discrepancy. Children, 10.","DOI":"10.3390\/children10101586"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1080\/17453670610012971","article-title":"No difference in tibial lengthening index by use of Taylor spatial frame or Ilizarov external fixator","volume":"77","author":"Kristiansen","year":"2006","journal-title":"Acta Orthop."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5005\/jp-journals-10080-1513","article-title":"Cost Comparison of Tibial Distraction Osteogenesis Using External Lengthening and Then Nailing vs Internal Magnetic Lengthening Nails","volume":"16","author":"Dvorzhinskiy","year":"2021","journal-title":"Strateg. Trauma Limb Reconstr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s00264-006-0133-8","article-title":"Deformity correction and lengthening of lower legs with an external fixator","volume":"30","author":"Matsubara","year":"2006","journal-title":"Int. Orthop."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00003086-199404000-00024","article-title":"Long-term cost comparison of major limb salvage using the Ilizarov method versus amputation","volume":"301","author":"Williams","year":"1994","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.14744\/SEMB.2023.03185","article-title":"The Use of Ilizarov Method at the Lower Extremity Deformity Management","volume":"57","author":"Armagan","year":"2023","journal-title":"Sisli Etfal Hastan. Tip. Bul."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jor.2020.03.014","article-title":"Lower limb lengthening and deformity correction in polyostotic fibrous dysplasia using external fixation and flexible intramedullary nailing","volume":"21","author":"Popkov","year":"2020","journal-title":"J. Orthop."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1177\/230949901101900215","article-title":"Ilizarov technique of lengthening and then nailing for height increase","volume":"19","author":"Emara","year":"2011","journal-title":"J. Orthop. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s00064-013-0233-8","article-title":"Correction of posttraumatic lower leg deformities using the Taylor Spatial Frame","volume":"26","author":"Krappinger","year":"2014","journal-title":"Oper. Orthop. Traumatol."},{"key":"ref_11","first-page":"411","article-title":"Combined external fixation and intramedullary alignment in correction of limb length discrepancies","volume":"79","author":"Bukva","year":"2013","journal-title":"Acta Orthop. Belg."},{"key":"ref_12","first-page":"21","article-title":"Ossein-hydroxyapatite complex in the treatment of patients with pseudoarthrosis of the femur and shin bones, complicated by systemic osteoporosis","volume":"2","author":"Gulnazurova","year":"2006","journal-title":"Bull. Traum"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.17816\/vto100413","article-title":"Experience with the use of osteogenon in traumatology and orthopedics","volume":"8","author":"Rodionova","year":"2001","journal-title":"NWN Priorov J. Traumatol. Orthop."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Morasiewicz, P., Zaborska, M., Sobczak, M., Tomczyk, \u0141., Leyko, P., Bobi\u0144ski, A., Kocha\u0144ska-Bieri, J., Pili, D., and Kazubski, K. (2024). The Use of Osteogenon as an Adjunctive Treatment in Lower Leg Fractures. Pharmaceuticals, 17.","DOI":"10.3390\/ph17111531"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/BF03256920","article-title":"Comparison of the effects of ossein-hydroxyapatite complex and calcium carbonate on bone metabolism in women with senile osteoporosis: A randomized, open-label, parallel-group, controlled, prospective study","volume":"31","author":"Manasanch","year":"2011","journal-title":"Clin. Drug Investig."},{"key":"ref_16","first-page":"52","article-title":"Osteogenon in therapy of distal radial bone fractures in patients with secondary osteoporosis","volume":"79","author":"Varga","year":"2007","journal-title":"Ter. Arkh."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Morasiewicz, P., Zaborska, M., Sobczak, M., Tomczyk, \u0141., Pili, D., Kazubski, K., and Leyko, P. (2025). The Use of Ossein-Hydroxyapatite Complex in Conjunction with the Ilizarov Method in the Treatment of Tibial Nonunion. J. Clin. Med., 14.","DOI":"10.3390\/jcm14103353"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.maturitas.2015.02.265","article-title":"Comparison of the effects of calcium carbonate and ossein-hydroxyapatite complex on back and knee pain and quality of life in osteopenic perimenopausal women","volume":"81","author":"Alvarez","year":"2015","journal-title":"Maturitas"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/13697137.2019.1685488","article-title":"Efficacy and safety of ossein-hydroxyapatite complex versus calcium carbonate to prevent bone loss","volume":"23","author":"Palacios","year":"2020","journal-title":"Climacteric"},{"key":"ref_20","first-page":"36","article-title":"Efficacy of Ossein-Hydroxyapatite Complex as a Pharmacological Corrector of Bone Loss (Review)","volume":"334","author":"Yakovleva","year":"2023","journal-title":"Georgian Med. News"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.5604\/01.3001.0014.4151","article-title":"Osteoporotic Fractures During and after Pandemic Time\u2014Always Required Treatment. Approach of the Physician, Comments of the Professor","volume":"22","author":"Malachowski","year":"2020","journal-title":"Ortop. Traumatol. Rehabil."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/13697137.2014.929107","article-title":"Use of ossein-hydroxyapatite complex in the prevention of bone loss: A review","volume":"18","year":"2015","journal-title":"Climacteric"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2165\/00044011-200727040-00001","article-title":"Prevention of osteoporosis: Four-year follow-up of a cohort of postmenopausal women treated with an ossein-hydroxyapatite compound","volume":"27","author":"Palazuelos","year":"2007","journal-title":"Clin. Drug Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"119591","DOI":"10.1016\/j.biomaterials.2019.119591","article-title":"Oral delivery of novel human IGF-1 bioencapsulated in lettuce cells promotes musculoskeletal cell proliferation, differentiation and diabetic fracture healing","volume":"233","author":"Park","year":"2019","journal-title":"Biomaterials"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/ki.1996.164","article-title":"Pharmacokinetics of insulin-like growth factor-1 in advanced chronic renal failure","volume":"49","author":"Rabkin","year":"1996","journal-title":"Kidney Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1210\/endo.131.4.1382964","article-title":"Determination of the pharmacokinetic profiles of insulin-like growth factor binding proteins-1 and -2 in rats","volume":"131","author":"Young","year":"1992","journal-title":"Endocrinology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4292\/wjgpt.v11.i5.79","article-title":"Oral encapsulated transforming growth factor \u03b21 reduces endogenous levels: Effect on inflammatory bowel disease","volume":"11","author":"Hammer","year":"2020","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1023\/A:1018995005775","article-title":"Pharmacokinetics and tissue distribution of recombinant human transforming growth factor beta1 after topical and intravenous administration in male rats","volume":"11","author":"Zioncheck","year":"1994","journal-title":"Pharm. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/000164702317281486","article-title":"Reduced lengthening index by use of bifocal osteotomy in the tibia: Comparison of monofocal and bifocal procedures with the Ilizarov external fixator","volume":"73","author":"Kristiansen","year":"2002","journal-title":"Acta Orthop. Scand."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s00264-013-1962-x","article-title":"S-osteotomy with lengthening and then nailing compared with traditional Ilizarov method","volume":"37","author":"Lan","year":"2013","journal-title":"Int. Orthop."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2106\/00004623-199601000-00004","article-title":"Results of the Wagner and Ilizarov methods of limb-lengthening","volume":"78","author":"Aaron","year":"1996","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e068033","DOI":"10.1136\/bmj-2021-068033","article-title":"Fracture risk reduction and safety by osteoporosis treatment compared with placebo or active comparator in postmenopausal women: Systematic review, network meta-analysis, and meta-regression analysis of randomised clinical trials","volume":"381","author":"Cardoso","year":"2023","journal-title":"BMJ"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7326\/M22-0684","article-title":"Effectiveness and Safety of Treatments to Prevent Fractures in People with Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians","volume":"176","author":"Ayers","year":"2023","journal-title":"Ann. Intern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11657-024-01447-7","article-title":"Efficacy and safety of teriparatide vs. bisphosphonates and denosumab vs. bisphosphonates in osteoporosis not previously treated with bisphosphonates: A systematic review and meta-analysis of randomized controlled trials","volume":"19","author":"Li","year":"2024","journal-title":"Arch. Osteoporos."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/8\/1244\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:33:56Z","timestamp":1785299636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/16\/8\/1244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":34,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["life16081244"],"URL":"https:\/\/doi.org\/10.3390\/life16081244","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}