{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:53:04Z","timestamp":1787028784085,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Intensive care medicine represents one of the most challenging setting in modern healthcare, where specific mechanisms intertwine and form a dynamic biological model, where organ dysfunction can easily evolve to multi-organ dysfunction, continuously reshaping the patient\u2019s clinical course. The critically ill patient represents a biological system resulted from interaction between maladaptive and adaptative mechanisms, therefore generates a large volume of data that can exceeds human cognitive capacity. Artificial intelligence can integrate multimodal physiological, laboratory, and clinical data into a dynamic representation of the patient\u2019s biological trajectory. AI-tools and machine learning technologies have evolved to potential clinical support tools, with great perspectives for future implementation, but currently with limited use in clinical practice. This article is a narrative review of artificial intelligence in ICU, aiming to present current evidence and limitations.<\/jats:p>","DOI":"10.3390\/life16081254","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:45:14Z","timestamp":1785325514000},"page":"1254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physiological Data Integration and Predictive Modeling in Intensive Care"],"prefix":"10.3390","volume":"16","author":[{"given":"Bianca Liana","family":"Grigorescu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Department of Anesthesiology and Intensive Care Medicine, Emergency County Hospital, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Azamfirei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Department of Anesthesiology and Intensive Care Medicine, Emergency County Hospital, 540136 Targu Mures, Romania"},{"name":"Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e2nziana","family":"Bora","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Emergency County Hospital, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3921-4417","authenticated-orcid":false,"given":"Dorin","family":"Bica","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Information Technology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-3644","authenticated-orcid":false,"given":"Irina","family":"S\u0103pl\u0103can","sequence":"additional","affiliation":[{"name":"Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2173-4740","authenticated-orcid":false,"given":"Raduly","family":"Gergo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Emergency County Hospital, 540136 Targu Mures, Romania"},{"name":"Department of Anatomy and Embryology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4759-0274","authenticated-orcid":false,"given":"Mihaly","family":"Veres","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Department of Anesthesiology and Intensive Care, Emergency Institute for Cardiovascular Diseases and Transplantation, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1001\/jamainternmed.2018.3674","article-title":"The Complexity and Challenges of Intensive Care Unit Admissions and Discharges: Similarities with All Hospitalized Patients","volume":"178","author":"Safavi","year":"2018","journal-title":"JAMA Intern. 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