{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:46:52Z","timestamp":1785833212518,"version":"3.56.0"},"reference-count":65,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Clinical Specialty Discipline Construction Project of China","award":["Z155080000004"],"award-info":[{"award-number":["Z155080000004"]}]},{"name":"Shanghai Research Center of Rehabilitation Medicine","award":["2023ZZ02027"],"award-info":[{"award-number":["2023ZZ02027"]}]},{"name":"Shanghai Hospital Development Center Foundation\u2014Shanghai Municipal Hospital Rehabilitation Medicine Specialty Alliance","award":["SHDC22026304"],"award-info":[{"award-number":["SHDC22026304"]}]},{"award":["SHDC22026304"],"award-info":[{"award-number":["SHDC22026304"]}],"id":[{"id":"https:\/\/ror.org\/02zrtve16","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Shanghai Disabled Persons\u2019 Federation Key Laboratory of Intelligent Rehabilitation Assistive Appliance and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Choroidal neovascularization (CNV) is a common and serious complication in various retinal diseases that involves the growth of new blood vessels from the choroid into the subretinal space, leading to a visual threat. Its underlying mechanism has not been fully uncovered. Discovering new genes related to CNV is an important way to reveal its molecular mechanisms. In this study, we used DisGeNET as the initial data source to identify genes related to CNV. The gene cluster method and additional screening tests were designed to explore the genetic landscape related to CNV. Our comprehensive analysis revealed many genes with high confidence, specifically identifying novel candidates that traditional topological methods missed. Notably, we identified SERPINE1, COL1A1, and ANGPT1 as unique gene signatures using our network embedding approach. Functionally, SERPINE1 regulates the plasminogen activation system to control proteolytic balance, COL1A1 maintains the structural integrity of the extracellular matrix during invasion, and ANGPT1 is critical for the maturation and stabilization of nascent vessels. Meanwhile, some genes were also identified by other methods, such as MMP2, a regulator of extracellular matrix degradation. The newly found genes are essential for understanding the process that initiates CNV.<\/jats:p>","DOI":"10.3390\/life16081263","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:55:11Z","timestamp":1785419711000},"page":"1263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Choroidal Neovascularization-Associated Genes with GenePlexus in a Protein\u2013Protein Interaction Network"],"prefix":"10.3390","volume":"16","author":[{"given":"Lihua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai 201619, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3825-0796","authenticated-orcid":false,"given":"Yuhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiming","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Bao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China"},{"name":"National Clinical Research Center for Eye Diseases, Shanghai 200080, China"},{"name":"Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China"},{"name":"Shanghai Municipal Hospital Ophthalmology Specialist Alliance, Shanghai 200080, China"},{"name":"Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China"},{"name":"Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref_1","first-page":"a041160","article-title":"Vascular organization: Lessons from development and disease","volume":"15","author":"Spurgin","year":"2025","journal-title":"Cold Spring Harb. 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