{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:25:28Z","timestamp":1787030728184,"version":"build-2736575974"},"reference-count":89,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007700","name":"Carol Davila University of Medicine and Pharmacy","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007700","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/04fm87419","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Non-infectious uveitis (NIU) is an inflammatory ocular condition often associated with systemic immune-mediated disorders. The pathogenesis of NIU is complex and involves genes from the Human Leukocyte Antigen (HLA) class I system. Endoplasmic reticulum aminopeptidase 1 (ERAP1) cleaves antigenic peptides to an optimal length for loading and presentation on HLA I molecules. In this systematic review, we aimed to summarize the current knowledge regarding how susceptibility to developing NIU is linked to single-nucleotide polymorphisms (SNPs) in the ERAP1 gene, a locus well known for its connection to autoinflammatory disorders. Methods: We performed a PRISMA protocol-guided systematic review in various databases. Results: Out of the 311 screened studies, only 12 met the inclusion criteria. Five of them are Genome-Wide Association Studies. We found relevant research for three types of NIU: acute anterior uveitis, Beh\u00e7et\u2019s uveitis, and birdshot chorioretinopathy. A frequently observed association between ERAP1 SNPs and disease risk was noted when analyzing the HLA-carriers (B*27, B*51, A*29), which points toward an epistatic interaction between ERAP1 and the MHC class I complex. Conclusions: Our findings suggest that ERAP1 gene variation is understudied in relation to NIU. A significant amount of research has also concentrated on risk stratification, and reliable markers for patient selection are needed, especially in view of emerging anti-ERAP therapies.<\/jats:p>","DOI":"10.3390\/life16081340","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:05:41Z","timestamp":1786953941000},"page":"1340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Involvement of ERAP1 in the Pathogenesis of Non-Infectious Uveitis: A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9187-0821","authenticated-orcid":false,"given":"Ioana-Maria","family":"Rizea","sequence":"first","affiliation":[{"name":"Doctoral School, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-6319","authenticated-orcid":false,"given":"Horia Tudor","family":"Stanca","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Clinical Department of Ophthalmology, \u201cProf. Dr. Agrippa Ionescu\u201d Emergency Hospital, 011356 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Potop","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Clinical Department of Ophthalmology, \u201cProf. Dr. Mircea Olteanu\u201d Clinical Institute for Ophthalmological Emergencies, 010464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6421-9675","authenticated-orcid":false,"given":"Dana-Margareta-Cornelia","family":"D\u0103sc\u0103lescu","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Clinical Department of Ophthalmology, \u201cProf. Dr. Mircea Olteanu\u201d Clinical Institute for Ophthalmological Emergencies, 010464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Ioana","family":"Andrei","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Friedrich-Alexander University Erlangen\u2013N\u00fcrnberg, 91012 Erlangen, Germany"},{"name":"Department of Internal Medicine II, Th\u00fcringen Clinics \u201cGeorgius Agricola\u201d, 07318 Saalfeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Teodora","family":"Tofolean","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Clinical Department of Ophthalmology, \u201cProf. Dr. Mircea Olteanu\u201d Clinical Institute for Ophthalmological Emergencies, 010464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-6571","authenticated-orcid":false,"given":"Alina","family":"Popa-Cherecheanu","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Clinical Department of Ophthalmology, University Emergency Hospital, 050098, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9526-2211","authenticated-orcid":false,"given":"Mihnea","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Cherciu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Immunology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia-Mihaela","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Immunology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s10238-022-00954-6","article-title":"Pathogenesis and Current Therapies for Non-Infectious Uveitis","volume":"23","author":"Wu","year":"2023","journal-title":"Clin. 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